YASUI Kiyoshi 安井潔

… Alternative Names

Yasui Kiyoshi 安井潔

安井潔ヤスイキヨシ

Less

Researcher Number	50372777
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 助教
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2019 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2015 – 2017: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手 2004 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55020:Digestive surgery-related Except Principal Investigator General medical chemistry / Basic Section 55020:Digestive surgery-related / Virology / Molecular biology / Biological Sciences
Keywords	Principal Investigator がん免疫 / 腫瘍不均一性 / CAR-T / 免疫逃避 / デザイナー細胞 / 移植療法 / MHC / 移植医療 / T細胞 / NK細胞 … More / IRFファミリー / CD47 / ステルスT細胞 / HLA-E / MHC Class I / T細胞輸注療法 … More Except Principal Investigator リン酸化 / ヒストン / クロマチン / 遺伝子転写 / ヌクレオソーム / transcription / chromatin / nucleosome / phosphorylation / acetylation / histone / 再構築 / 翻訳後修飾 / ユビキチン化 / エピジェネティクス / アセチル化 / 細胞輸注療法 / 細胞傷害性T細胞 / 腫瘍殺傷 / T細胞 / 腫瘍免疫 / ワクチン / キラーT細胞 / 抗原欠損バリアント / 養子免疫療法 / interferon / IFI6 / FAT10 / IDO1 / インターフェロン / HIV / expression control / genome / gene / 脱リン酸化 / 発現制御 / ゲノム / 遺伝子 / 転写開始 / クロストーク / 脱ユビキチン化 / 肝再生 / DNA高次構造 / DNA高次構浩 Less

フェロトーシス誘導を用いて腫瘍不均一性を克服する固形癌に有効なCAR-T療法の開発Principal Investigator
- Principal Investigator
  
  安井潔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
免疫逃避機構を付与したデザイナー細胞を用いた新規移植療法の開発Principal Investigator
- Principal Investigator
  
  安井潔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagasaki University
Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cells
- Principal Investigator
  
  Muraoka Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of effective T cell therapy by stealth technique and regulation of IRF expressionPrincipal Investigator
- Principal Investigator
  
  Yasui Kiyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Understanding the mechanism by which an interfeon-gamma-induced, mitochondria-localized novel protein inhibits virus infection
- Principal Investigator
  
  KUBO Yoshinao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
Post-translational histnoe modification and chromatin strucure
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Phosphorylation and ubiquitylation of H2A regulate chromatin structure and function
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University
Analysis of effect for DNA structure by phosphorylation of histone protein
- Principal Investigator
  
  NAKAGAWA Takeya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nagasaki University
Core histone modifications change the higher order of DNA structurec resulting in its biological output
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University

All 2023 2022 2021 2020 2019 2016 2015 2004 2003

All Journal Article Presentation

[Journal Article] T cell receptor gene‐modified allogeneic T cells with siRNA for endogenous T cell receptor induce efficient tumor regression without graft‐versus‐host disease2023
- Author(s)
  Satomi Okada, Daisuke Muraoka, Kiyoshi Yasui, Isao Tawara, Ayumi Kawamura, Sachiko Okamoto, Junichi Mineno, Naohiro Seo, Hiroshi Shiku, Susumu Eguchi, Hiroaki Ikeda
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 11 Pages: 4172-4183
- DOI
  10.1111/cas.15954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19532, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-19K23919, KAKENHI-PROJECT-21H02990
[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022
- Author(s)
  Dotsu Yosuke、Muraoka Daisuke、Ogo Naohisa、Sonoda Yudai、Yasui Kiyoshi、Yamaguchi Hiroyuki、Yagita Hideo、Mukae Hiroshi、Asai Akira、Ikeda Hiroaki
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 2 Pages: e003958-e003958
- DOI
  10.1136/jitc-2021-003958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-21H02990
[Journal Article] IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement2022
- Author(s)
  Kubo Yoshinao、Yasui Kiyoshi、Izumida Mai、Hayashi Hideki、Matsuyama Toshifumi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 14 Pages: 2240-2240
- DOI
  10.3390/cells11142240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-22K08581, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-18K16773
[Journal Article] 固形がんを標的としたCAR-T細胞療法2021
- Author(s)
  安井潔、池田裕明
- Journal Title
  
  BIO Clinica
  
  Volume: 11 Pages: 26-30
- Data Source
  KAKENHI-PROJECT-19K09048
[Journal Article] Nucleosome assembly protein 1 is a regulator of histone H1 acetylation2021
- Author(s)
  Yoneda Mitsuhiro、Yasui Kiyoshi、Nakagawa Takeya、Hattori Naoko、Ito Takashi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 6 Pages: 763-773
- DOI
  10.1093/jb/mvab098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-20K06489
[Journal Article] がん免疫における新規治療アプローチ　2)TCR-T細胞によるがん治療2020
- Author(s)
  安井潔、池田裕明
- Journal Title
  
  腫瘍内科
  
  Volume: 26 Pages: 71-78
- Data Source
  KAKENHI-PROJECT-19K09048
[Journal Article] Fragments of target cells are internalized into retroviral envelope protein-expressing cells during cell-cell fusion by endocytosis.2016
- Author(s)
  M. Izumida, H. Kamiyama, T. Suematsu, E. Honda, Y. Koizumi, K. Yasui, H. Hayashi, K. Ariyoshi, Y. Kubo
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 6 Pages: 1552-1552
- DOI
  10.3389/fmicb.2015.01552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08499
[Journal Article] Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-12016
- Author(s)
  Y. Kubo, M. Izumida, Y. Yashima, H. Yoshii-Kamiyama, Y. Tanaka, K. Yasui, H. Hayashi, T. Matsuyama
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 44 Pages: 71255-71273
- DOI
  10.18632/oncotarget.12104
- NAID
  120006847273
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08499
[Journal Article] Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.2004
- Author(s)
  Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., Ito, T.
- Journal Title
  
  Genes Dev 18
  
  Pages: 877-888
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Isfolavones stimulate estrogen receptor-mediated core histone acetylation2004
- Author(s)
  Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
- Journal Title
  
  Biochem Biophys Res Commun 317
  
  Pages: 259-264
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Isoflavones stimulate estrogen receptor-mediated core histone acetylation.2004
- Author(s)
  Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L, Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
- Journal Title
  
  Biochem Biophys Res Commun 317
  
  Pages: 259-264
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.2004
- Author(s)
  Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., Ito, T
- Journal Title
  
  Genes Dev 18
  
  Pages: 877-888
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] クロマチンの形成と再構築2003
- Author(s)
  安井潔, 伊藤敬
- Journal Title
  
  実験医学 21
  
  Pages: 1402-1407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Chromatin assembly and remodeling2003
- Author(s)
  Yasui, K., Ito, T.
- Journal Title
  
  Jikkenigaku 21
  
  Pages: 1402-1407
- NAID
  110000013990
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Presentation] 治療標的抗原発現が不均一な腫瘍に対する効果的な細胞輸注療法を担うT細胞の特徴解析と機構解明2023
- Author(s)
  とう思拓、村岡大輔、中司交明、安井潔、原田直純、澤田晋一、秋吉一成、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08876
[Presentation] 腫瘍関連マクロファージ指向性CHPナノゲルの標的分子の探索2023
- Author(s)
  中司交明、村岡大輔、安井潔、原田直純、澤田晋一、秋吉一成、永安武、池田裕明
- Organizer
  第82回日本癌学会学術総会 (横浜)
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023
- Author(s)
  安井潔
- Organizer
  第27回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-22K08876
[Presentation] Exploring the molecules involving in the drug delivery targeted to tumor-associated macrophages by CHP nanogels2022
- Author(s)
  中司交明、村岡大輔、安井潔、原田直純、澤田晋一、秋吉一成、永安武、池田裕明
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03005
[Presentation] 腫瘍不均一性の克服に向けた"ステルス T 細胞"を用いたがん免疫療法の開発2022
- Author(s)
  安井潔
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K08876
[Presentation] フェロトーシス誘導剤を用いた腫瘍不均一性を克服するがん免疫療法の開発2021
- Author(s)
  江原大輔、山口小百合、安井潔、村岡大輔、室田浩之、池田裕明
- Organizer
  第25回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] 独自siRNAベクターによるMHC classⅠ発現抑制「ステルスT細胞」を用いたがん免疫療法の開発2021
- Author(s)
  安井　潔、Xiangyue Meng、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖　洋、江口　晋、池田裕明
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] 独自siRNAベクターによるMHC class I発現抑制「ステルスT細胞」を用いたがん免疫療法の開発2021
- Author(s)
  安井潔、MENG X、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖洋、江口晋、池田裕明
- Organizer
  第25回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] フェロトーシス現象を利用した腫瘍不均一性を克服するがん免疫療法2021
- Author(s)
  江原大輔、山口小百合、安井潔、村岡大輔、室田浩之、池田裕明
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] T細胞やNK細胞による拒絶反応、およびGVHDを回避しうる「ステルスT細胞」を用いたがん免疫療法の開発2020
- Author(s)
  安井潔、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖洋、江口晋、池田裕明
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] T細胞やNK細胞による拒絶反応、およびGVHDを回避しうる「ステルスT細胞」を用いたがん免疫療法の開発2020
- Author(s)
  安井　潔、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖　洋、江口　晋、池田裕明
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] 非自己Ｔ細胞の利用を可能にするステルスＴ細胞を用いたがん免疫療法の開発2019
- Author(s)
  安井潔、岡田怜美、松村尚美、古賀洋一、岡本幸子、峰野純一、村岡大輔、珠玖　洋、江口　晋、池田裕明
- Organizer
  がん免疫学会
- Data Source
  KAKENHI-PROJECT-19K09048
[Presentation] Role of a samll GTP-binding protein, Rab3a, in the formation of HIV-1 virion2016
- Author(s)
  Y.Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
- Organizer
  日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Placenta formation by human endogenous retrovirus is inhibited by interferons.2015
- Author(s)
  M. Izumida, Y. Kubo, H. Hayashi, K. Yasui, T. Matsuyama
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08499
[Presentation] Identification of a CD63 binding protein and its role in HIV replication2015
- Author(s)
  Y. Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08499

1. NAKAGAWA Takeya (50363502)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 池田裕明 (40374673)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
3. ITO Takashi (90306275)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 沖昌也 (60420626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NANABA Yasuaki (90444869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIZUSAKI Hirofumi (40467957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IKEHARA Tsuyoshi (90359951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KUBO Yoshinao (30273527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. Muraoka Daisuke (20608955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 浅井章良 (60381737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 金高賢悟 (10549570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YASUI Kiyoshi 安井 潔

Yasui Kiyoshi 安井 潔

安井 潔 ヤスイ キヨシ

Research Projects

Research Products

Co-Researchers

フェロトーシス誘導を用いて腫瘍不均一性を克服する固形癌に有効なCAR-T療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫逃避機構を付与したデザイナー細胞を用いた新規移植療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of effective T cell therapy by stealth technique and regulation of IRF expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanism by which an interfeon-gamma-induced, mitochondria-localized novel protein inhibits virus infection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Post-translational histnoe modification and chromatin strucure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phosphorylation and ubiquitylation of H2A regulate chromatin structure and function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of effect for DNA structure by phosphorylation of histone protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Core histone modifications change the higher order of DNA structurec resulting in its biological output

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] T cell receptor gene‐modified allogeneic T cells with siRNA for endogenous T cell receptor induce efficient tumor regression without graft‐versus‐host disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 固形がんを標的としたCAR-T細胞療法2021

Author(s)

Journal Title

Data Source

[Journal Article] Nucleosome assembly protein 1 is a regulator of histone H1 acetylation2021

YASUI Kiyoshi 安井潔

Yasui Kiyoshi 安井潔

安井潔ヤスイキヨシ

[Journal Article] がん免疫における新規治療アプローチ　2)TCR-T細胞によるがん治療2020