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OHSHIMA Shigetoshi  大嶋 重敏

ORCIDConnect your ORCID iD *help
Researcher Number 50375268
Affiliation (based on the past Project Information) *help 2007 – 2013: Akita Univ., 1^<st> Dept. of Medicine, Assistant Professor
2007: Akita University, School of Medicine, assistant professor
2006: 秋田大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Metabolomics
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
NASH / Pten遺伝子 / therapeutic agent / inflammation / steatosis / reactive oxygen speies / Pten gene / ミトコンドリア / Pten遺伝 / 治療薬 … More / 炎症 / 脂肪肝 / 酸化ストレス / Obマウス / マウス / Ob / ob/obマウス / 遺伝子治療 / 肥満 / PTEN … More
Except Principal Investigator
class I PI3-kinase / autolysosome / autophagosome / PTEN / イノシトールリン脂質 / 脂肪性肝炎 / Atg conjugation / Pten gene / autophagy / 発癌 / 線維化 / 炎症 / Atg複合体 / Pten遺伝子 / オートファジー / N-acetyleisteine / antioxidant / hepatic caricinogenesis / oxidative stress / steatohepatitis / N-アセチルシステイン / 抗酸化剤 / 肝発癌 / 酸化ストレス / クローン病 / 潰瘍性大腸炎 / マウスモデル / 炎症性腸疾患 / Pten / INPP4B / PPARγ / Akt2 / 肝癌 / 肝腫瘍性病変 / 肝臓学 Less
  • Research Projects

    (6 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (5 People)
  •  炎症性腸疾患の発症に関わる腸上皮細胞におけるイノシトールリン脂質代謝異常の解明

    • Principal Investigator
      堀江 泰夫
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Elucidation of the phosphatidylinositol metabolism to control steatohepatitis and hepatocellular carcinoma

    • Principal Investigator
      HORIE Yasuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Study for therapeutic effect of hepatocyte specific Pten deficiency on severe obesity.Principal Investigator

    • Principal Investigator
      OHSHIMA Shigetoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Akita University
  •  Role of lipid and oxidative stress on carcinogenesis in the digestive system

    • Principal Investigator
      WATANABE Sumio
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Autophagy is involved in inflammation, fibrosis, and carcinogenesis-A study using mice model

    • Principal Investigator
      HORIE Yasuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  The study of NASH mechanism-in terms of reactive oxygen species and mitochondrial function-Principal Investigator

    • Principal Investigator
      OHSHIMA Shigetoshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University

All 2011 2007 2006 Other

All Journal Article Presentation

  • [Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma lessons fromhepatocyte-specific phosphatase and tensin homolog(PTEN)-deficient mice2007

    • Author(s)
      Watanabe S, Horie Y, Kataoka E, Sato W, Dohmen T, Ohshima S, Goto T, Suzuki A.
    • Journal Title

      J.Gastroenterol.Hepatol. 22(Suppl1)

    • Data Source
      KAKENHI-PROJECT-18390213
  • [Journal Article] Nonalcoholie steatohepatitis and hepatoellular careinoma : lessons from hepatoeyte-speeific phosphatase and tensin homolog (PTEN)-defieiet mice.2007

    • Author(s)
      Wattanabe S, Horio Y. Kataoka E, Sato W, Dohmon T. Ohshima S. Goto T. Suzuki A.
    • Journal Title

      J. Gastroenterol. Hepatol. 22(Suppl1)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390213
  • [Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma : lessons from hepatoeyte-specific phosphatase and tensin homolog (PTEN)-defient mice.2007

    • Author(s)
      Watanabe S. Horie Y. Kataoka E. Sato W. Dohmon T. Ohshima S. Goto T. Suzuki A.
    • Journal Title

      J. Gastroenterol. Hepatol 22 (Suppl 1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390213
  • [Journal Article] Hepatic gene ezpression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge2006

    • Author(s)
      Sato W, Horie Y, Kataoka E, Ohshima S, Dohmen T, Iizuka M, Sasaki J, Sasaki M, Hamada K, Kishimoto H, Suzuki A, Watanabe S
    • Journal Title

      HEPATOLOGY RESEARCH 34

      Pages: 256-265

    • Data Source
      KAKENHI-PROJECT-18390213
  • [Presentation] 肝細胞特異的Pten欠損によるレプチン欠損ob/obマウスの肥満の改善2011

    • Author(s)
      大嶋重敏,堀江泰夫,後藤隆,三浦光一,澁谷友美,佐藤亘,道免孝洋,姉崎有美子,山田育弘,鎌田健太郎,鈴木聡,大西洋英
    • Organizer
      肝臓病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-20591041
  • [Presentation] Hepatocyte-specific Pten deficiency improves obesity in the leptin-deficient ob/ob mouse.2011

    • Author(s)
      Shigetoshi Ohshima, Yasuo Horie, Takashi Goto, Kouichi Miura, Akira Suzuki, Hirohide Ohnishi
    • Organizer
      DDW2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-10
    • Data Source
      KAKENHI-PROJECT-20591041
  • [Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using patocyte-specific Pten deficient mice2007

    • Author(s)
      Shigetoshi Ohshima, Yasuo HorieTakahiro Domen, et. al.
    • Organizer
      Liver disease society.(EASL)
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590714
  • [Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using hepatocyte-specific Pten deficient mice-2007

    • Author(s)
      Shigetoshi, Ohshima, Yasuo, Horie, Takahiro, Domen, et. al
    • Organizer
      ヨーロッパ肝臓病学会(EASL)
    • Place of Presentation
      スペイン,バルセロナ
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590714
  • [Presentation] Eicosapentaenoic acid improve steatohepatitis in newly established mice Model of nonalcoholic steatohepatitis2007

    • Author(s)
      Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima et.al
    • Organizer
      ヨーロッパ肝臓病学会(EASL)
    • Place of Presentation
      スペイン,バルセロナ
    • Year and Date
      2007-04-17
    • Data Source
      KAKENHI-PROJECT-18590714
  • [Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討2007

    • Author(s)
      堀江泰夫, 大嶋重敏, 渡辺純夫
    • Organizer
      JDDW2007
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-20
    • Data Source
      KAKENHI-PROJECT-18590714
  • [Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討

    • Author(s)
      堀江 泰夫、大嶋 重敏、渡辺 純夫
    • Data Source
      KAKENHI-PROJECT-18390213
  • 1.  HORIE Yasuo (30282164)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 2.  WATANABE Sumio (20138225)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  OHNISHI Hirohide (00313023)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SASAKI Takehiko (50333365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  IKEJIMA Kenichi (20317382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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