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HATTORI Takayuki  服部 隆行

ORCIDConnect your ORCID iD *help
Researcher Number 50377751
Other IDs
Affiliation (based on the past Project Information) *help 2014 – 2018: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官
2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 主任研究官
2006: 浜松医科大学, COE研究員
2006: 浜松医科大学, 医学部, 研究員
2005 – 2006: Hamamatsu University School of Medicine, Department of Biochemistry 1, Post-doctorial Fellow, 医学部, COE研究員
Review Section/Research Field
Principal Investigator
Drug development chemistry / Functional biochemistry
Except Principal Investigator
General medical chemistry / Biological pharmacy / Functional biochemistry
Keywords
Principal Investigator
タンパク質分解 / Ras / プロテアソーム阻害薬 / アポトーシス阻害タンパク質 / 逆行輸送 / ゴルジ体 / 小胞輸送 / CD77 synthase / CD77 / 耐性 … More / 小胞輸送阻害 / プロテアソーム / アポトーシス / THP1細胞 / 志賀毒素 / 癌分子標的治療 / プロテインノックダウン / 分子標的治療 / 癌 / p27^<Kipl> / 細胞癌化 / 細胞周期 / CDK阻害蛋白質 / p27^<Kip1> / 蛋白質分解 / ユビキチンリガーゼ … More
Except Principal Investigator
プロテアソーム / ユビキチン / 細胞周期 / Cell cycle / RB / 蛋白質 / Hisタグ / タンパク質 / BCR-ABL / アンドロゲン受容体 / エストロゲン受容体 / SNIPER / プロテインノックダウン / タンパク質分解 / Degradation / Proteasome / Ubiquitin / p27kip1 / p27<kip1> / 分解 / p27^<Kip1> / ubiquitin / Mdm2 / 癌化 / RBタンパク質 / p27 / サイクリン Less
  • Research Projects

    (8 results)
  • Research Products

    (67 results)
  • Co-Researchers

    (11 People)
  •  Manipulation of cellular function by forced ubiquitylation

    • Principal Investigator
      NAITO MIKIHIKO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Mechanism of Shiga toxin-induced cell death and development of therapeutic agentPrincipal Investigator

    • Principal Investigator
      HATTORI TAKAYUKI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences
  •  Development of novel molecular target drug for activated Ras protein by the specific protein degradation systemPrincipal Investigator

    • Principal Investigator
      HATTORI TAKAYUKI
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences
  •  Development of novel antitumor drugs targeting activated Ras by protein knockdownPrincipal Investigator

    • Principal Investigator
      HATTORI Takayuki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences
  •  個体レベルでの細胞周期のリアルタイムイメージングの試み

    • Principal Investigator
      KITAGAWA Masatoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Hamamatsu University School of Medicine
  •  CDK阻害蛋白質p27^<Kip1>の新規ユビキチンリガーゼの細胞癌化への関与Principal Investigator

    • Principal Investigator
      服部 隆行
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Hamamatsu University School of Medicine
  •  Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.

    • Principal Investigator
      UCHIDA Chiharu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Hamamatsu University School of Medicine
  •  Regulation of tumor suppressor RB pathway via ubiquitin system.

    • Principal Investigator
      KITAGAWA Masatoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Hamamatsu University School of Medicine

All 2019 2018 2017 2016 2015 2013 2012 2011 2006

All Journal Article Presentation Book

  • [Book] Estrogen Receptors Methods and Protocols2016

    • Author(s)
      1.Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M
    • Total Pages
      576
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Book] 細胞周期集中マスター「第6章 ユビキチンシステムによる細胞周期制御」2006

    • Author(s)
      服部 隆行
    • Total Pages
      154
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17770110
  • [Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019

    • Author(s)
      Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 203-209

    • DOI

      10.1248/cpb.c18-00567

    • NAID

      130007607114

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 165-172

    • DOI

      10.1248/cpb.c18-00703

    • NAID

      130007606378

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase2018

    • Author(s)
      Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13549-13549

    • DOI

      10.1038/s41598-018-31913-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018

    • Author(s)
      K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
    • Journal Title

      J Med Chem.

      Volume: 61 Issue: 2 Pages: 576-582

    • DOI

      10.1021/acs.jmedchem.7b00413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
  • [Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation2018

    • Author(s)
      Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 18 Pages: 6776-6790

    • DOI

      10.1074/jbc.ra117.001091

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017

    • Author(s)
      Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 8 Issue: 10 Pages: 1042-1047

    • DOI

      10.1021/acsmedchemlett.7b00247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017

    • Author(s)
      Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 61 Issue: 2 Pages: 543-575

    • DOI

      10.1021/acs.jmedchem.7b00168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017

    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol pharmacol

      Volume: 91 Issue: 3 Pages: 159-166

    • DOI

      10.1124/mol.116.105569

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017

    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 18 Pages: 4478-4481

    • DOI

      10.1016/j.bmcl.2017.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017

    • Author(s)
      Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 8 Pages: 1657-1666

    • DOI

      10.1111/cas.13284

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.2017

    • Author(s)
      Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 5 Pages: 1032-1041

    • DOI

      10.1111/cas.13198

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
  • [Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).2017

    • Author(s)
      Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 11 Pages: 4556-4570

    • DOI

      10.1074/jbc.m116.768853

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
  • [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016

    • Author(s)
      Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 20 Pages: 4865-4869

    • DOI

      10.1016/j.bmcl.2016.09.041

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
  • [Journal Article] M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.2016

    • Author(s)
      Hattori T, Watanabe-Takahashi M, Shiina I, Ohashi Y, Dan S, Nishikawa K, Yamori T, Naito M.
    • Journal Title

      Genes Cells.

      Volume: 21(8) Issue: 8 Pages: 901-906

    • DOI

      10.1111/gtc.12386

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-15K08040
  • [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016

    • Author(s)
      Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
    • Journal Title

      Curr Cancer Drug Targets

      Volume: 16 Pages: 136-146

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Journal Article] A Helix-Stabilized Cell-Penetrating Peptide As An Intracellular-Delivery Tool2016

    • Author(s)
      Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
    • Journal Title

      Chembiochem

      Volume: 17 Issue: 2 Pages: 137-140

    • DOI

      10.1002/cbic.201500468

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
  • [Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016

    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol. Biol.

      Volume: 1366 Pages: 549-560

    • DOI

      10.1007/978-1-4939-3127-9_42

    • ISBN
      9781493931262, 9781493931279
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
  • [Journal Article] Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin2015

    • Author(s)
      Takayuki Hattori, Miho Watanabe-Takahashi, Nobumichi Ohoka, Takashi Hamabata, Koichi Furukawa, Kiyotaka Nishikawa, and Mikihiko Naito
    • Journal Title

      FEBS Open Bio

      Volume: 5 Issue: 1 Pages: 605-614

    • DOI

      10.1016/j.fob.2015.06.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-15H04696
  • [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2018

    • Author(s)
      Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018

    • Author(s)
      Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2018

    • Author(s)
      内藤幹彦、大岡伸通、柴田識人、服部隆行
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2018

    • Author(s)
      Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017

    • Author(s)
      大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第21回日本がん分子標的治療学会 学術集会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017

    • Author(s)
      柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017

    • Author(s)
      Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      EMBO conference Ubiquitin and SUMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 網羅的人工ユビキチン修飾システムの構築2016

    • Author(s)
      服部 隆行,正田 卓司,奥平 桂一郎,柴田 識人,大岡 伸通,伊藤 進,栗原 正明,内藤 幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] BCR-ABL の蛋白質分解誘導剤開発を指向した BCR-ABL 結合化合物の探索2016

    • Author(s)
      柴田 識人,大岡 伸通,服部 隆行,橋井 則貴,斎藤 臣雄,近藤 恭光,石井 明子,長田 裕之,内藤 幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発2016

    • Author(s)
      山下 博子,出水 庸介,加藤 巧馬,大岡 伸通,三澤 隆史,服部 隆行,田中 正一,内藤 幹彦,大庭 誠,栗原 正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] 志賀毒素耐性THP-1細胞の単離と解析2016

    • Author(s)
      服部 隆行,高橋 美帆,西川 喜代孝,内藤 幹彦
    • Organizer
      第20回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      富山県・富山市
    • Year and Date
      2016-11-10
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016

    • Author(s)
      Mikihiko Naito, Takayuki Hattori, Nobumichi Ohoka, Norihito Shibata, Takuji Shoda, Yosuke Demizu, Masaaki Kurihara
    • Organizer
      Tenth AACR/JCA Joint Conference
    • Place of Presentation
      ハワイ
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] Hisタグタンパク質分解誘導分子の開発2016

    • Author(s)
      沖津 航陽,服部 隆行,出水 庸介,三澤 隆史,正田 卓司,内藤 幹彦,栗原 正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016

    • Author(s)
      中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016

    • Author(s)
      大岡 伸通,伊東 昌宏,奥平 桂一郎,永井 克典,柴田 識人,服部 隆行,長 展生,内藤 幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016

    • Author(s)
      服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016

    • Author(s)
      三澤 隆史,山下 博子,加藤 巧馬,服部 隆行,大庭 誠,田中 正一,内藤 幹彦,出水 庸介,栗原 正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] 細胞内His タグタンパク質分解誘導剤の開発2016

    • Author(s)
      沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用2015

    • Author(s)
      山下 博子,出水 庸介,三澤 隆史,服部 隆行,大庭 誠,田中 正一,内藤 幹彦,栗原正明
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      東大阪市
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発2015

    • Author(s)
      山下 博子,出水 庸介,三澤 隆史,大庭 誠,田中 正一,服部 隆行,内藤 幹彦,栗原 正明
    • Organizer
      第31会日本DDS学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] プロテアソーム阻害による志賀毒素誘導性細胞死の抑制2015

    • Author(s)
      服部 隆行,高橋 美帆,椎名 勇,大橋 愛美,旦 慎吾,西川 喜代孝,内藤 幹彦
    • Organizer
      第19回腸管出血性大腸菌感染症研究会
    • Place of Presentation
      東京都
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] 新規小胞輸送阻害薬を用いた志賀毒素のアポトーシス死誘導活性の抑制2015

    • Author(s)
      服部 隆行,高橋 美帆,椎名 勇,大橋 愛美,旦 慎吾,西川 喜代孝,内藤 幹彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] Development of his-tag fused protein degradation inducer based on a protein knockdown strategy2015

    • Author(s)
      Koyo Okitsu, Takayuki Hattori, Yosuke Demizu, Takashi Misawa, Takuji Shoda, Mikihiko Naito, Masaaki Kurihara
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚市
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability2015

    • Author(s)
      Hiroko Yamashita, Yosuke Demizu, Takashi Misawa, Takayuki Hattori, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚市
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡 伸通,柴田 識人,服部 隆行,内藤 幹彦
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] ユビキチン化誘導剤によって起こるユビキチン関連死の解明2015

    • Author(s)
      大岡 伸通,永井 克典,服部 隆行,柴田 識人,長 展生,内藤 幹彦
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡 伸通,服部 隆行,内藤 幹彦
    • Organizer
      日本がん分子標的治療学会第19回学術集会
    • Place of Presentation
      松山市
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15K08040
  • [Presentation] Distinct phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells2013

    • Author(s)
      Takayuki Hattori, Chiharu Uchida, Hirotaka Takahashi, Naoki Yamamoto, Mikihiko Naito, Yoichi Taya.
    • Organizer
      Ninth AACR/JCA Joint Conference
    • Place of Presentation
      Hawaii, U S A
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] 細胞膜透過性蛍光 NTA の設計・合 成2013

    • Author(s)
      加藤 雅士,正田 卓司,出水 庸介,井 上 英史,服部 隆行,内藤 幹彦,栗原 正 明
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] 細胞分化に伴うRBタンパク質のセリン612の特異異的リン酸化.2013

    • Author(s)
      服部 隆行,内田 千晴,高橋 宏隆,山 本 直樹,内藤 幹彦,田矢 洋一
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapidcell death in breast cancer cells2013

    • Author(s)
      Keiichiro Okuhira, Yosuke Demizu, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko Nishimaki-Mogami, Masaaki Kurihara, Haruhiro Okuda, Mikihiko Naito.
    • Organizer
      Ninth AACR/JCA Joint Conference
    • Place of Presentation
      Hawaii, U S A
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] 分化細胞におけるRB タンパク質のserine612 の部位特異的リン酸化2012

    • Author(s)
      服部隆行,田矢洋一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] Development of Hybrid Small Molecules That Induce IAP-Mediated Ubiquitylation and Proteasomal Degradation of Target Proteins in a Specific Manner2012

    • Author(s)
      Mikihiko Naito, Keiichiro Okuhira, Yosuke Demizu, Yukihiro Itoh, Minoru Ishikawa, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko Nishimaki-Mogami, Masaaki Kurihara, and Yuichi Hashimoto
    • Organizer
      Genetics and Chemistry Sharing a Language of Discovery
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] シガトキシンBサブユニットによる細胞死誘導機構2012

    • Author(s)
      服部 隆行,大岡 伸通,高橋 美帆,西 川 喜代孝,内藤 幹彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] Degradation of Estrogen Receptor Induced by a Small Hybrid Molecule SNIPER (ER)2012

    • Author(s)
      Keiichiro Okuhira, Yosuke Demizu, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko-Nishimaki Mogami, Masaaki Kurihara, Haruhiro Okuda, and Mikihiko Naito
    • Organizer
      The 16th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] プロテインノックダウン法によるエストロゲンレセプターの分解2012

    • Author(s)
      奥平 桂一郎,出水 庸介,大岡 伸通, 柴田 識人,服部 隆行,最上(西巻) 知 子,栗原 正明,奥田 晴宏,内藤 幹彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23890251
  • [Presentation] プロテインノックダウン法によるエストロゲン受容体の分解2011

    • Author(s)
      奥平 桂一郎,出水 庸介,大岡 伸通, 柴田 織人,服部 隆行,最上(西巻)知子,栗原 正明,奥田 晴宏,内藤 幹彦
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-23890251
  • 1.  KITAGAWA Masatoshi (50294971)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  UCHIDA Chiharu (60223567)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KITAGAWA Kyoko (20299605)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  ODA Toshiaki (90126805)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  NAITO MIKIHIKO (00198011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 28 results
  • 6.  DEMIZU YOSUKE
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  大岡 伸通
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  旦 慎吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  大橋 愛美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  栗原 正明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  奥平 桂一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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