NISHIYAMA Atsuya 西山敦哉

Researcher Number	50378840
Other IDs	https://orcid.org/0000-0002-8416-3776
Affiliation (Current)	2021: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2021: 東京大学, 医科学研究所, 准教授 2016 – 2017: 東京大学, 医科学研究所, 講師 2012 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 講師 2011: 名古屋市立大学, 大学院・医学研究科, 講師
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Complex systems / Genetics/Chromosome dynamics / Basic Section 43010:Molecular biology-related Except Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator DNAメチル化 / DNA複製 / ユビキチン化 / ユビキチン / UHRF1 / DNMT1 / Dnmt1 / Uhrf1 / クロマチン / ヒストン … More Except Principal Investigator DNA維持メチル化 / 構造生物学 / DNA複製 / UHRF1 / DNMT1 / DNAメチル化 / ユビキチン / エピジェネティクス / ユビキチン化 Less

5-aza-dCTPによる新たなDNA維持メチル化制御機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
ケモテクノロジーで探るDNAメチル化部位特異的なユビキチンシグナル機能とその制御Principal InvestigatorOngoing
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
DNAメチル化を介したゲノム安定性制御の分子メカニズムPrincipal InvestigatorOngoing
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
複製因子の翻訳後修飾が制御する新しいDNAメチル化継承機構の構造基盤Ongoing
- Principal Investigator
  
  有田恭平
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Molecular basis of maintenance DNA methylationPrincipal Investigator
- Principal Investigator
  
  Nishiyama Atsuya
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  The University of Tokyo
DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Nagoya City University
不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Atsuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University
ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University

All 2020 2019 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] エピジェネティクスキーワード事典2013
- Author(s)
  西山敦哉, 山口留奈, 中西真
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24790290
[Journal Article] DNA維持メチル化機構を制御するユビキチンシグナル2020
- Author(s)
  西山敦哉
- Journal Title
  
  FARUAW
  
  Volume: 56 (1) Issue: 1 Pages: 36-40
- DOI
  10.14894/faruawpsj.56.1_36
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PUBLICLY-19H05285, KAKENHI-PROJECT-19H03153
[Journal Article] Enhanced processivity of Dnmt1 by mono-ubiquitinated histone H32020
- Author(s)
  Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R. G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake
- Journal Title
  
  Genes to Cells
  
  Volume: 25 Pages: 22-32
- DOI
  10.1111/gtc.12732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-19K17878, KAKENHI-PLANNED-15H05973, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H04048, KAKENHI-PROJECT-18K15211
[Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.2020
- Author(s)
  A. Nishiyama, C. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi
- Journal Title
  
  Nature communications
  
  Volume: 11 Pages: 1222-1222
- DOI
  10.1038/s41467-020-15006-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K07963, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-19H05285, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-19J22030
[Journal Article] Structure of the Dnmtl Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.2017
- Author(s)
  Ishiyama, S., Nishiyama, A., Saeki, Y., Moritsugu, K., Morimoto, D., Yamaguchi, L., Arai, N., Matsumura, R., Kawakami, T., Mishima, Y., Hojo, H., Shimamura. S., Ishikawa, F., Tajima, S., Tanaka, K., Ariyoshi, M., Shirakawa, M., Ikeguchi, M., Kidera, A., Suetake, I., Arita, K., and Nakanishi, M.
- Journal Title
  
  Mol. Cell
  
  Volume: 68 Pages: 350-360
- DOI
  10.1016/j.molcel.2017.09.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14418, KAKENHI-PROJECT-16K14714, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04780, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-15K18520, KAKENHI-PROJECT-26000014
[Journal Article] Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation2017
- Author(s)
  Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M
- Journal Title
  
  SCIENTIFIC REPORTS
  
  Volume: 7 Pages: 1-12
- DOI
  10.1038/s41598-017-00136-5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PUBLICLY-15H01462, KAKENHI-PROJECT-16H04739, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-14J07515, KAKENHI-PROJECT-26650002, KAKENHI-PROJECT-15K06942, KAKENHI-PROJECT-16K15238, KAKENHI-PROJECT-16K07099, KAKENHI-PROJECT-16K15239, KAKENHI-PLANNED-25116004, KAKENHI-PUBLICLY-16H01319, KAKENHI-PROJECT-26250027
[Journal Article] The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.2016
- Author(s)
  Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 470 (3) Pages: 741-7
- DOI
  10.1016/j.bbrc.2016.01.029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027
[Journal Article] Regulation of maintenance DNA methylation via histone ubiquitylation.2016
- Author(s)
  Nishiyama A, Yamaguchi L, Nakanishi M.
- Journal Title
  
  J Biochem.
  
  Volume: 159 (1) Pages: 249-253
- DOI
  10.1093/jb/mvv113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Journal Article] Regulation of maintenance DNA methylation via histone ubiquitylation.2016
- Author(s)
  Haruta M, Shimada M, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 469 Pages: 9-15
- DOI
  10.1016/j.bbrc.2015.12.090
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08280, KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26860195
[Journal Article] Uhrf1-dependent ubiquitylation of histone H3 at lysine 23 couples maintenance DNA methylation and DNA replication.2014
- Author(s)
  Nishiyama, A
- Journal Title
  
  Nature.
  
  Volume: 502 Pages: 249-253
- DOI
  10.1038/nature12488
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23240124, KAKENHI-PROJECT-23249015, KAKENHI-PUBLICLY-24113711, KAKENHI-PROJECT-24659137, KAKENHI-PROJECT-24790290, KAKENHI-PUBLICLY-25131717, KAKENHI-PROJECT-25461659
[Journal Article] Xenopus leavis Ctc1-Stn1-Ten1 (xCST) Protein Complex is Involved in Priming DNA Synthesis on Single-stranded DNA Template in Xenopus Egg extract2012
- Author(s)
  Nakaoka, H.
- Journal Title
  
  The Journal ofBiological Chemistry
  
  Volume: 287 Pages: 619-627
- DOI
  10.1074/jbc.m111.263723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Journal Article] Essential role of Xenopus TRF2 in telomere end protection and replication2011
- Author(s)
  Muraki, K.
- Journal Title
  
  Genes Cells
  
  Volume: 16 Pages: 728-739
- DOI
  10.1111/j.1365-2443.2011.01520.x
- NAID
  120005595847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Presentation] Molecular mechanism for multiple-monoubiquitination of replication factor PAF152019
- Author(s)
  柴野歩実, 松澤舜, 郡聡実, 西山敦哉, 中西真, 有田恭平
- Organizer
  第42回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] A unique mechanism for multi-monoubiquitination of histone H3 by UHRF12019
- Author(s)
  松澤舜, 若月誠, 柴野歩実, 郡聡実, 古川亜矢子, 西村善文, 西山敦哉, 中西真, 有田恭平
- Organizer
  第42回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] Molecular mechanism of Okazaki fragment ligation2019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] Structural basis for the regulation of DNA methylation maintenance by replication factors2019
- Author(s)
  郡聡実, 治面地智宏, 又野翔平, 松村るみゑ, 横山遥、西山敦哉、中西真、佐藤衛, Pierre Defossez, 有田恭平
- Organizer
  第13 回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] The LIG3/XRCC1 complex ensures Okazaki fragment ligation in the absence of LIG12019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] The LIG3/XRCC1 complex ensures Okazaki fragment ligation in the absence of LIG12019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] DNMT1のメチル化部位への局在を保証する２つの異なる分子機構2019
- Author(s)
  西山敦哉, Christopher B. Mulholland, Sebastian Bultmann, 郡聡実, 遠藤彬則, 千葉祥恵, 隈本宗一郎, 佐伯泰, 有田恭平, Heinrich Leonhardt, 中西真
- Organizer
  42nd MBSJ, Symposium ” Crosstalk between epigenome replication, genome stability, and chromatin organization ”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] DNMT1のメチル化部位への局在を保証する２つの異なる分子機構2019
- Author(s)
  西山敦哉, Christopher B. Mulholland, Sebastian Bultmann, 郡聡実, 遠藤彬則, 千葉祥恵, 隈本宗一郎, 佐伯泰, 有田恭平, Heinrich Leonhardt, 中西真
- Organizer
  42nd MBSJ, Symposium ” Crosstalk between epigenome replication, genome stability, and chromatin organization ”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] Molecular mechanism of Okazaki fragment ligation2019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNAメチル化維持制御機構の解明2019
- Author(s)
  西山　敦哉
- Organizer
  東京大学医科学研究所国際共同利用・共同研究拠点事業平成30年度若手研究者シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] Structural Study for Recognition of Ubiquitylated Histone H3 by DNA Methyltransferase2019
- Author(s)
  Arita Kyohei, Ishiyama Satoshi, Nishiyama, Atsuya, Defossez, Pierre-Antoine, Nakanishi, Makoto
- Organizer
  ECM32 32nd European Crystallographic Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] Uhrf1依存的なPAF15のユビキチン化を介した DNA維持メチル化制御2018
- Author(s)
  西山敦哉、千葉祥恵、隈本宗一郎、佐伯泰、郡聡美、川上徹、有田恭平、中西真
- Organizer
  第41回日本分子生物学会年会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] マルチプルモノユビキチン化ヒストンH3が制御するDNA維持メチル化の構造基盤2018
- Author(s)
  有田恭平, 石山怜, 西山敦哉, 中西真, 川上徹, 末武勲
- Organizer
  第91 日本生化学化大会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] UHRF1依存的なマルチプルモノユビキチン化を介した維持DNAメチル化制御2018
- Author(s)
  西山敦哉, 千葉祥恵, 隈本宗一郎, 佐伯泰, 郡聡実, 有田恭平, 川上徹, 中西真
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] DNAメチル化継承を制御するユビキチン・コード2017
- Author(s)
  西山敦哉、石山玲、佐伯泰、三島優一、川上徹、北條裕信、末武勲、有田恭平、中西真
- Organizer
  ConBio2017 [4AW13] ユビキチン・コード：細胞内の最も難解な暗号を読む
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県かずさ
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] PAF15 のユビキチン化を介した維持DNA メチル化制御2017
- Author(s)
  西山　敦哉、佐伯　泰、有田　恭平、中西　真
- Organizer
  第35回染色体ワークショップ・第16回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県 (かずさアカデミアホール）
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県（パシフィコ横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 脱ユビキチン化酵素USP7による維持DNAメチル化制御2016
- Author(s)
  西山敦哉、山口留奈、三崎紀展、有田恭平、佐伯泰、中西真
- Organizer
  第33回染色体ワークショップ
- Place of Presentation
  宮城県宮城郡松島町
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, and Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都
- Year and Date
  2014-02-05
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  三島
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉, 山口留奈, Jafar Sharif, 城村由和, 川村猛, 中西圭子, 島村真太郎, 有田恭平, 児玉龍彦, 石川冬木, 古関明彦, 中西真
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguhi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLS ポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈、西山敦哉、城村由和、島村真太郎、石川冬木、秋山昌広、真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLSポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈, 西山敦哉, 城村由和, 島村真太郎, 石川冬木, 秋山昌広, 真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguchi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉、山口留奈、城村由和、島村真太郎、石川冬木、川村猛、Sharif Jafar、古関明彦、中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] DNA複製時におけるUhrf1とDnmt1による維持メチル化制御機構2012
- Author(s)
  山口留奈、西山敦哉、島村真太郎、石川冬木、中西真
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  ホテルニュー水戸屋(宮城県)
- Year and Date
  2012-01-26
- Data Source
  KAKENHI-PROJECT-23890175
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉, 山口留奈, 城村由和, 島村真太郎, 石川冬木, 川村猛, Jafar Sharif, 古関明彦, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] 染色体恒常性制御におけるDNAメチル化維持機構の役割
- Author(s)
  西山敦哉
- Organizer
  第37回分子生物学会年会ワークショップ、細胞周期を通じた染色体恒常性制御のニューフロンティア
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] DNAメチル化維持とカップルしたヒストンH3ユビキチン化の制御機構
- Author(s)
  西山敦哉
- Organizer
  大阪大学蛋白研セミナー「染色体伝承の分子背景：複製から染色体分離まで」
- Place of Presentation
  大阪大学蛋白質研究所 (大阪府、吹田市）
- Year and Date
  2014-09-25 – 2014-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717

1. 有田恭平 (40549648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. SAEKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. Moritsugu Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. NAGAO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. UEDA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SHIMADA Midori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中西真

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中西圭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 高橋沙央里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 篠原美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 篠原彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 渡邉幹夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 大谷淳二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石川冬木

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 油谷浩幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 木寺詔記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 森本大智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 白川昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 北條裕信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 小布施力史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 城村由和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

NISHIYAMA Atsuya 西山 敦哉

Research Projects

Research Products

Co-Researchers

5-aza-dCTPによる新たなDNA維持メチル化制御機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

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ケモテクノロジーで探るDNAメチル化部位特異的なユビキチンシグナル機能とその制御Principal InvestigatorOngoing

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DNAメチル化を介したゲノム安定性制御の分子メカニズムPrincipal InvestigatorOngoing

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複製因子の翻訳後修飾が制御する新しいDNAメチル化継承機構の構造基盤Ongoing

Principal Investigator

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Molecular basis of maintenance DNA methylationPrincipal Investigator

Principal Investigator

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DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator

Principal Investigator

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不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator

Principal Investigator

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ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator

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[Book] エピジェネティクスキーワード事典2013

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[Journal Article] DNA維持メチル化機構を制御するユビキチンシグナル2020

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[Journal Article] Enhanced processivity of Dnmt1 by mono-ubiquitinated histone H32020

Author(s)

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[Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.2020

Author(s)

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[Journal Article] Structure of the Dnmtl Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.2017

NISHIYAMA Atsuya 西山敦哉