NISHIYAMA Atsuya 西山敦哉

Researcher Number	50378840
Other IDs	https://orcid.org/0000-0002-8416-3776
Affiliation (Current)	2025: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 医科学研究所, 准教授 2018 – 2022: 東京大学, 医科学研究所, 准教授 2016 – 2017: 東京大学, 医科学研究所, 講師 2012 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 講師 2011: 名古屋市立大学, 大学院・医学研究科, 講師
Review Section/Research Field	Principal Investigator Complex systems / Biological Sciences / General medical chemistry / Basic Section 43050:Genome biology-related / Basic Section 43010:Molecular biology-related / Genetics/Chromosome dynamics Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (III)
Keywords	Principal Investigator DNAメチル化 / ユビキチン / DNA複製 / DNMT1 / UHRF1 / ユビキチン化 / ヒストン / クロマチン / Uhrf1 / Dnmt1 … More / USP7 / SUMO / 質量分析 / PAF15 / 脱ユビキチン化 / PCNA / CDCA7 / DNAメチル化阻害剤 / タンパク質ーDNA架橋 / 架橋修復 / ラギング鎖 / LIG3 / HPF1 / PARP1 / ゲノム安定性 / LIG1 / ADPリボシル化 / 岡崎フラグメント / 5-aza-dC / 染色体 / 無細胞系 / ツメガエル卵 / 構造解析 / ヒストンH3 / Usp7 / DUB / Trim28 / 試験管内系 / 翻訳後修飾 / ツメガエル卵抽出液 … More Except Principal Investigator クライオ電子顕微鏡 / 構造生物学 / DNAメチル化 / 起動性DNAエレメント / DNAメチル化酵素 / 構造生命科学 / エピジェネティクス / ユビキチン / DNMT1 / DNA維持メチル化 / 分子動力学計算 / リン酸化 / LIG1 / UHRF1 / DNA複製 / クロマチン / ユビキチン化 / 複製因子 Less

Structural basis for activation and repression of motile DNA elements and Development of their control technology
- Principal Investigator
  
  有田恭平
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Yokohama City University
DNAメチル化酵素の包括的な理解に向けた構造生命科学研究とその応用
- Principal Investigator
  
  有田恭平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Molecular mechanism of DNA replication-uncoupled maintenance DNA methylationPrincipal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  The University of Tokyo
5-aza-dCTPによる新たなDNA維持メチル化制御機構の解明Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
ケモテクノロジーで探るDNAメチル化部位特異的なユビキチンシグナル機能とその制御Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Molecular Mechanisms for Regulation of Genomic Stability via DNA MethylationPrincipal Investigator
- Principal Investigator
  
  Nishiyama Atsuya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
Structural basis for DNA methylation maintenance regulated by replication factors.
- Principal Investigator
  
  Arita Kyohei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Molecular basis of maintenance DNA methylationPrincipal Investigator
- Principal Investigator
  
  Nishiyama Atsuya
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  The University of Tokyo
DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Nagoya City University
不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Atsuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University
ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] エピジェネティクスキーワード事典2013
- Author(s)
  西山敦哉, 山口留奈, 中西真
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24790290
[Journal Article] The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD52023
- Author(s)
  Miyashita Ryota、Nishiyama Atsuya、Qin Weihua、Chiba Yoshie、Kori Satomi、Kato Norie、Konishi Chieko、Kumamoto Soichiro、Kozuka-Hata Hiroko、Oyama Masaaki、Kawasoe Yoshitaka、Tsurimoto Toshiki、Takahashi Tatsuro S、Leonhardt Heinrich、Arita Kyohei、Nakanishi Makoto
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 79013-79013
- DOI
  10.7554/elife.79013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15036, KAKENHI-PLANNED-21H05280, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-20H03186, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-21H00272, KAKENHI-PUBLICLY-22H04697
[Journal Article] Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.2022
- Author(s)
  Hata K, Kobayashi N, Sugimura K, Qin W, Haxholli D, Chiba Y, Yoshimi S, Hayashi G, Onoda H, Ikegami T, Mulholland CB, Nishiyama A, Nakanishi M, Leonhardt H, Konuma T, Arita K
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 50 Issue: 21 Pages: 12527-12542
- DOI
  10.1093/nar/gkac1082
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-19H03153, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-21H00272, KAKENHI-PLANNED-19H05741
[Journal Article] Structural basis for activation of DNMT12022
- Author(s)
  Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez PA, Arita K
- Journal Title
  
  Nat Commun.
  
  Volume: 13 (1) Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-022-34779-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06129, KAKENHI-PUBLICLY-21H05733, KAKENHI-PROJECT-19H03153, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-21H00272, KAKENHI-PROJECT-23K23828, KAKENHI-PLANNED-19H05741
[Journal Article] HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation2021
- Author(s)
  Kumamoto Soichiro、Nishiyama Atsuya、Chiba Yoshie、Miyashita Ryota、Konishi Chieko、Azuma Yoshiaki、Nakanishi Makoto
- Journal Title
  
  Nucleic Acids Research
  
  Volume: - Issue: 9 Pages: 5003-5016
- DOI
  10.1093/nar/gkab269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05285, KAKENHI-PUBLICLY-21H00272, KAKENHI-PROJECT-19H03153
[Journal Article] Navigating the DNA methylation landscape of cancer2021
- Author(s)
  Nishiyama Atsuya、Nakanishi Makoto
- Journal Title
  
  Trends in Genetics
  
  Volume: 37 Issue: 11 Pages: 1012-1027
- DOI
  10.1016/j.tig.2021.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H00272, KAKENHI-PROJECT-19H03153
[Journal Article] Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF12021
- Author(s)
  Kori Satomi、Shibahashi Yuki、Ekimoto Toru、Nishiyama Atsuya、Yoshimi Sae、Yamaguchi Kosuke、Nagatoishi Satoru、Ohta Masateru、Tsumoto Kouhei、Nakanishi Makoto、Defossez Pierre-Antoine、Ikeguchi Mitsunori、Arita Kyohei
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 52 Pages: 116500-116500
- DOI
  10.1016/j.bmc.2021.116500
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-18H05426, KAKENHI-PUBLICLY-21H00272, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-19J22030, KAKENHI-PROJECT-20H02531, KAKENHI-PLANNED-19H05741
[Journal Article] Enhanced processivity of Dnmt1 by monoubiquitinated histone H32020
- Author(s)
  Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R. G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake
- Journal Title
  
  Genes Cells
  
  Volume: 25 Issue: 1 Pages: 22-32
- DOI
  10.1111/gtc.12732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-19K17878, KAKENHI-PLANNED-15H05973, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H04048, KAKENHI-PROJECT-18K15211, KAKENHI-PLANNED-19H05740, KAKENHI-PLANNED-19H05741, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00981, KAKENHI-ORGANIZER-19H05739
[Journal Article] Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation2020
- Author(s)
  A. Nishiyama, C. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi
- Journal Title
  
  Nat. Commun.
  
  Volume: 11 Issue: 1 Pages: 1222-1222
- DOI
  10.1038/s41467-020-15006-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05316, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-19H05285, KAKENHI-PLANNED-19H05744, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H02392, KAKENHI-PROJECT-19H03153, KAKENHI-PROJECT-19J22030, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K07963, KAKENHI-ORGANIZER-19H05739
[Journal Article] DNA維持メチル化機構を制御するユビキチンシグナル2020
- Author(s)
  西山敦哉
- Journal Title
  
  Farumashia
  
  Volume: 56 Issue: 1 Pages: 36-40
- DOI
  10.14894/faruawpsj.56.1_36
- NAID
  130007779037
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PUBLICLY-19H05285, KAKENHI-PROJECT-19H03153
[Journal Article] Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.2017
- Author(s)
  Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M
- Journal Title
  
  Mol Cell
  
  Volume: 68 Issue: 2 Pages: 350-360
- DOI
  10.1016/j.molcel.2017.09.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14418, KAKENHI-PROJECT-16K14714, KAKENHI-PROJECT-16K18503, KAKENHI-PROJECT-26293018, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16H04780, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-15K05565, KAKENHI-PROJECT-15K18520, KAKENHI-PROJECT-26000014
[Journal Article] Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.2017
- Author(s)
  Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-017-00136-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PUBLICLY-15H01462, KAKENHI-PROJECT-16H04739, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-14J07515, KAKENHI-PROJECT-26650002, KAKENHI-PROJECT-15K06942, KAKENHI-PROJECT-16K15238, KAKENHI-PROJECT-16K07099, KAKENHI-PLANNED-25116004, KAKENHI-PUBLICLY-16H01319, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-16K15239, KAKENHI-PROJECT-17H01398
[Journal Article] The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.2016
- Author(s)
  Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 470 (3) Issue: 3 Pages: 741-747
- DOI
  10.1016/j.bbrc.2016.01.029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027
[Journal Article] Regulation of maintenance DNA methylation via histone ubiquitylation.2016
- Author(s)
  Nishiyama A, Yamaguchi L, Nakanishi M.
- Journal Title
  
  J Biochem.
  
  Volume: 159 (1) Issue: 1 Pages: 249-253
- DOI
  10.1093/jb/mvv113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Journal Article] Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication2016
- Author(s)
  Haruta M, Shimada M, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 469 Issue: 4 Pages: 960-966
- DOI
  10.1016/j.bbrc.2015.12.090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08280, KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26860195
[Journal Article] Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication2013
- Author(s)
  Nishiyama, A
- Journal Title
  
  Nature
  
  Volume: 502 Issue: 7470 Pages: 249-253
- DOI
  10.1038/nature12488
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23240124, KAKENHI-PROJECT-23249015, KAKENHI-PUBLICLY-24113711, KAKENHI-PROJECT-24659137, KAKENHI-PROJECT-24790290, KAKENHI-PUBLICLY-25131717, KAKENHI-PROJECT-25461659
[Journal Article] Xenopus laevis Ctc1-Stn1-Ten1 (xCST) complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract2012
- Author(s)
  Nakaoka, H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 287 Issue: 1 Pages: 619-627
- DOI
  10.1074/jbc.m111.263723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Journal Article] Essential roles of Xenopus TRF2 in telomere end protection and replication2011
- Author(s)
  Muraki, K.
- Journal Title
  
  Genes to Cells
  
  Volume: 16 Issue: 6 Pages: 728-739
- DOI
  10.1111/j.1365-2443.2011.01520.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Presentation] The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD52022
- Author(s)
  西山敦哉
- Organizer
  第15回エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] USP7とATAD5はUHRF1依存的なPAF15ユビキチンシグナルを制御する2022
- Author(s)
  西山敦哉宮下諒太千葉祥恵郡聡実加藤修衣河添好孝秦裕子尾山大明高橋達郎有田恭平中西真
- Organizer
  第45回分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNMT1-DNA架橋によって誘導されるSUMOシグナルとその制御機構2022
- Author(s)
  西山敦哉, 谷本翔汰, 千葉祥恵, 遠藤彬則, 佐伯泰, 中西真
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] DNAメチル化継承の分子機構2022
- Author(s)
  西山敦哉
- Organizer
  日本遺伝学会第94回大会シンポジウムA
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] USP7とATAD5はUHRF1依存的なPAF15ユビキチンシグナルを制御する2022
- Author(s)
  西山敦哉宮下諒太千葉祥恵郡聡実加藤修衣河添好孝秦裕子尾山大明高橋達郎有田恭平中西真
- Organizer
  第45回分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD52022
- Author(s)
  西山敦哉
- Organizer
  第15回エピジェネティクス研究会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] DNMT1-DNA架橋によって誘導されるSUMOシグナルとその制御機構2022
- Author(s)
  西山敦哉, 谷本翔汰, 千葉祥恵, 遠藤彬則, 佐伯泰, 中西真
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNAメチル化継承の分子機構2022
- Author(s)
  西山敦哉
- Organizer
  日本遺伝学会第94回大会シンポジウムA
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] 日本遺伝学会第93回大会2021
- Author(s)
  隈本宗一郎、西山敦哉、千葉祥恵、宮下諒太、小西知恵子、東義明、中西真
- Organizer
  DNAメチル化と岡崎フラグメント連結をリンクする分子機構
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] Molecular mechanism of DNMT1-DNA cross-link repair2021
- Author(s)
  Atsuya Nishiyama, Akinori Endoh, Yoshie Chiba, Chieko Konishi, Ayane Kaketani, Tomomi Nagatani, Yasushi, Saeki, Makoto Nakanishi
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNAメチル化と岡崎フラグメント連結をリンクする分子機構2021
- Author(s)
  隈本宗一郎、西山敦哉、千葉祥恵、宮下諒太、小西知恵子、東義明、中西真
- Organizer
  日本遺伝学会第93回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNAメチル化制御因子PAF15ユビキチン化の制御機構2021
- Author(s)
  宮下諒太, 西山敦哉, 秦裕子, 尾山大明, 千葉祥恵, 中西真
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] Molecular mechanism of DNMT1-DNA cross-link repair2021
- Author(s)
  Atsuya Nishiyama, Akinori Endoh, Yoshie Chiba, Chieko Konishi, Ayane Kaketani, Tomomi Nagatani, Yasushi, Saeki, Makoto Nakanishi
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] PAF15ユビキチン化の制御機構2021
- Author(s)
  宮下諒太, 西山敦哉, 秦裕子, 尾山大明, 千葉祥恵, 中西真
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00272
[Presentation] DNA複製に伴う岡崎フラグメント連結を保証する分子機構2020
- Author(s)
  西山敦哉, 隈本宗一郎, 千葉祥恵, 中西真
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] DNA複製に伴う岡崎フラグメント連結を保証する分子機構2020
- Author(s)
  西山敦哉, 隈本宗一郎, 千葉祥恵, 中西真
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] Molecular mechanism for multiple-monoubiquitination of replication factor PAF152019
- Author(s)
  柴野歩実, 松澤舜, 郡聡実, 西山敦哉, 中西真, 有田恭平
- Organizer
  第42回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] A unique mechanism for multi-monoubiquitination of histone H3 by UHRF12019
- Author(s)
  松澤舜, 若月誠, 柴野歩実, 郡聡実, 古川亜矢子, 西村善文, 西山敦哉, 中西真, 有田恭平
- Organizer
  第42回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] Molecular mechanism of Okazaki fragment ligation2019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] Structural basis for the regulation of DNA methylation maintenance by replication factors2019
- Author(s)
  郡聡実, 治面地智宏, 又野翔平, 松村るみゑ, 横山遥、西山敦哉、中西真、佐藤衛, Pierre Defossez, 有田恭平
- Organizer
  第13 回エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] The LIG3/XRCC1 complex ensures Okazaki fragment ligation in the absence of LIG12019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] The LIG3/XRCC1 complex ensures Okazaki fragment ligation in the absence of LIG12019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] DNMT1のメチル化部位への局在を保証する２つの異なる分子機構2019
- Author(s)
  西山敦哉, Christopher B. Mulholland, Sebastian Bultmann, 郡聡実, 遠藤彬則, 千葉祥恵, 隈本宗一郎, 佐伯泰, 有田恭平, Heinrich Leonhardt, 中西真
- Organizer
  42nd MBSJ, Symposium ” Crosstalk between epigenome replication, genome stability, and chromatin organization ”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05285
[Presentation] DNMT1のメチル化部位への局在を保証する２つの異なる分子機構2019
- Author(s)
  西山敦哉, Christopher B. Mulholland, Sebastian Bultmann, 郡聡実, 遠藤彬則, 千葉祥恵, 隈本宗一郎, 佐伯泰, 有田恭平, Heinrich Leonhardt, 中西真
- Organizer
  42nd MBSJ, Symposium ” Crosstalk between epigenome replication, genome stability, and chromatin organization ”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] Molecular mechanism of Okazaki fragment ligation2019
- Author(s)
  隈本　宗一郎、西山　敦哉、千葉　祥恵、中西　真
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03153
[Presentation] DNAメチル化維持制御機構の解明2019
- Author(s)
  西山　敦哉
- Organizer
  東京大学医科学研究所国際共同利用・共同研究拠点事業平成30年度若手研究者シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] Structural Study for Recognition of Ubiquitylated Histone H3 by DNA Methyltransferase2019
- Author(s)
  Arita Kyohei, Ishiyama Satoshi, Nishiyama, Atsuya, Defossez, Pierre-Antoine, Nakanishi, Makoto
- Organizer
  ECM32 32nd European Crystallographic Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] Uhrf1依存的なPAF15のユビキチン化を介した DNA維持メチル化制御2018
- Author(s)
  西山敦哉、千葉祥恵、隈本宗一郎、佐伯泰、郡聡美、川上徹、有田恭平、中西真
- Organizer
  第41回日本分子生物学会年会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] マルチプルモノユビキチン化ヒストンH3が制御するDNA維持メチル化の構造基盤2018
- Author(s)
  有田恭平, 石山怜, 西山敦哉, 中西真, 川上徹, 末武勲
- Organizer
  第91 日本生化学化大会
- Data Source
  KAKENHI-PROJECT-18H02392
[Presentation] UHRF1依存的なマルチプルモノユビキチン化を介した維持DNAメチル化制御2018
- Author(s)
  西山敦哉, 千葉祥恵, 隈本宗一郎, 佐伯泰, 郡聡実, 有田恭平, 川上徹, 中西真
- Organizer
  第91回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] DNAメチル化継承を制御するユビキチン・コード2017
- Author(s)
  西山敦哉、石山玲、佐伯泰、三島優一、川上徹、北條裕信、末武勲、有田恭平、中西真
- Organizer
  ConBio2017 [4AW13] ユビキチン・コード：細胞内の最も難解な暗号を読む
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県かずさ
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] PAF15 のユビキチン化を介した維持DNA メチル化制御2017
- Author(s)
  西山　敦哉、佐伯　泰、有田　恭平、中西　真
- Organizer
  第35回染色体ワークショップ・第16回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県 (かずさアカデミアホール）
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県（パシフィコ横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 脱ユビキチン化酵素USP7による維持DNAメチル化制御2016
- Author(s)
  西山敦哉、山口留奈、三崎紀展、有田恭平、佐伯泰、中西真
- Organizer
  第33回染色体ワークショップ
- Place of Presentation
  宮城県宮城郡松島町
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, and Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都
- Year and Date
  2014-02-05
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  三島
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉, 山口留奈, Jafar Sharif, 城村由和, 川村猛, 中西圭子, 島村真太郎, 有田恭平, 児玉龍彦, 石川冬木, 古関明彦, 中西真
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguhi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLS ポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈、西山敦哉、城村由和、島村真太郎、石川冬木、秋山昌広、真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLSポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈, 西山敦哉, 城村由和, 島村真太郎, 石川冬木, 秋山昌広, 真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguchi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉、山口留奈、城村由和、島村真太郎、石川冬木、川村猛、Sharif Jafar、古関明彦、中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] DNA複製時におけるUhrf1とDnmt1による維持メチル化制御機構2012
- Author(s)
  山口留奈、西山敦哉、島村真太郎、石川冬木、中西真
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  ホテルニュー水戸屋(宮城県)
- Year and Date
  2012-01-26
- Data Source
  KAKENHI-PROJECT-23890175
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉, 山口留奈, 城村由和, 島村真太郎, 石川冬木, 川村猛, Jafar Sharif, 古関明彦, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] 染色体恒常性制御におけるDNAメチル化維持機構の役割
- Author(s)
  西山敦哉
- Organizer
  第37回分子生物学会年会ワークショップ、細胞周期を通じた染色体恒常性制御のニューフロンティア
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] DNAメチル化維持とカップルしたヒストンH3ユビキチン化の制御機構
- Author(s)
  西山敦哉
- Organizer
  大阪大学蛋白研セミナー「染色体伝承の分子背景：複製から染色体分離まで」
- Place of Presentation
  大阪大学蛋白質研究所 (大阪府、吹田市）
- Year and Date
  2014-09-25 – 2014-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717

1. Arita Kyohei (40549648)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. SHIMADA Midori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 川上徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 池上貴久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 河添好孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SHARIF JAFAR

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中西真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NISHIYAMA Atsuya 西山 敦哉

Research Projects

Research Products

Co-Researchers

Structural basis for activation and repression of motile DNA elements and Development of their control technology

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DNAメチル化酵素の包括的な理解に向けた構造生命科学研究とその応用

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Molecular mechanism of DNA replication-uncoupled maintenance DNA methylationPrincipal Investigator

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5-aza-dCTPによる新たなDNA維持メチル化制御機構の解明Principal Investigator

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ケモテクノロジーで探るDNAメチル化部位特異的なユビキチンシグナル機能とその制御Principal Investigator

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Molecular Mechanisms for Regulation of Genomic Stability via DNA MethylationPrincipal Investigator

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Structural basis for DNA methylation maintenance regulated by replication factors.

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Molecular basis of maintenance DNA methylationPrincipal Investigator

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DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator

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不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator

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The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator

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ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator

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[Book] エピジェネティクスキーワード事典2013

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Data Source

NISHIYAMA Atsuya 西山敦哉