NISHIYAMA Atsuya 西山敦哉

Researcher Number	50378840
Other IDs	https://orcid.org/0000-0002-8416-3776
Affiliation *help	2016 – 2018 : 東京大学, 医科学研究所, 講師 2012 – 2015 : 名古屋市立大学, 医学(系)研究科(研究院), 講師 2011 : 名古屋市立大学, 大学院・医学研究科, 講師
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Genetics/Chromosome dynamics Except Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator DNAメチル化 / ユビキチン / クロマチン / Dnmt1 / DNA複製 / Uhrf1 / ユビキチン化 / DNMT1 / ヒストン / UHRF1 … More Except Principal Investigator 構造生物学 / DNAメチル化 / DNA複製 Less

複製因子の翻訳後修飾が制御する新しいDNAメチル化継承機構の構造基盤Ongoing
- Principal Investigator
  
  有田恭平
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Molecular basis of maintenance DNA methylationPrincipal InvestigatorOngoing
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  The University of Tokyo
DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Nagoya City University
不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Atsuya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University
ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator
- Principal Investigator
  
  西山敦哉
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Nagoya City University

All 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] エピジェネティクスキーワード事典2013
- Author(s)
  西山敦哉, 山口留奈, 中西真
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24790290
[Journal Article] Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation2017
- Author(s)
  Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M
- Journal Title
  
  Sci Rep.
  
  Volume : 7 Pages : 1-12
- DOI
  10.1038/s41598-017-00136-5
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PUBLICLY-15H01462, KAKENHI-PROJECT-16H04739, KAKENHI-PROJECT-16H04818, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-14J07515, KAKENHI-PROJECT-26650002, KAKENHI-PROJECT-15K06942, KAKENHI-PROJECT-16K15238
[Journal Article] The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.2016
- Author(s)
  Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 470 (3) Pages : 741-747
- DOI
  10.1016/j.bbrc.2016.01.029
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027
[Journal Article] Regulation of maintenance DNA methylation via histone ubiquitylation.2016
- Author(s)
  Nishiyama A, Yamaguchi L, Nakanishi M.
- Journal Title
  
  J Biochem.
  
  Volume : 159 (1) Pages : 249-253
- DOI
  10.1093/jb/mvv113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Journal Article] Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication.2016
- Author(s)
  Haruta M, Shimada M, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 469 Pages : 960-966
- DOI
  10.1016/j.bbrc.2015.12.090
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08280, KAKENHI-PUBLICLY-15H01188, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26860195, KAKENHI-PROJECT-26460350
[Journal Article] Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.2013
- Author(s)
  Nishiyama, A
- Journal Title
  
  Nature.
  
  Volume : 502 Pages : 249-253
- DOI
  10.1038/nature12488
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PROJECT-23240124, KAKENHI-PROJECT-23249015, KAKENHI-PUBLICLY-24113711, KAKENHI-PROJECT-24659137, KAKENHI-PROJECT-24790290, KAKENHI-PUBLICLY-25131717, KAKENHI-PROJECT-25461659
[Journal Article] Xenopus laevis Ctc1-Stn1-Ten1 (xCST) complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract2012
- Author(s)
  Nakaoka, H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume : 287 Issue : 1 Pages : 619-627
- Publisher
  American Society for Biochemistry and Molecular Biology
- DOI
  10.1074/jbc.M111.263723
- PMID
  22086929
- Year and Date
  2012-01-02
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Journal Article] Essential roles of Xenopus TRF2 in telomere end protection and replication2011
- Author(s)
  Muraki, K.
- Journal Title
  
  Genes to Cells
  
  Volume : 16 Issue : 6 Pages : 728-739
- Publisher
  wiley
- DOI
  10.1111/j.1365-2443.2011.01520.x
- PMID
  21554499
- Year and Date
  2011-05-09
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220012, KAKENHI-PROJECT-23657005, KAKENHI-PROJECT-23890175
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県 (かずさアカデミアホール）
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] 片鎖メチル化結合蛋白質UHRF1によるPCNAのユビキチン化2017
- Author(s)
  西山敦哉、山口留奈、三崎紀展、佐伯泰、中西真
- Organizer
  第34回染色体ワークショップ/第15回核ダイナミクス研究会
- Place of Presentation
  千葉県かずさ
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] 脱ユビキチン化酵素USP7による維持DNAメチル化制御2016
- Author(s)
  西山敦哉、山口留奈、三崎紀展、有田恭平、佐伯泰、中西真
- Organizer
  第33回染色体ワークショップ
- Place of Presentation
  宮城県宮城郡松島町
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県（パシフィコ横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-16H04818
[Presentation] ユビキチン修飾系によるDNAメチル化維持経路の制御2016
- Author(s)
  西山　敦哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01188
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, and Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都
- Year and Date
  2014-02-05
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Regulation of DNA methylation-coupled histone H3 ubiquitylation2014
- Author(s)
  Atsuya Nishiyama, Luna Yamaguchi, Makoto Nakanishi
- Organizer
  Replication, repair and transcription; coupling mechanisms and chromatin dynamics for genome integrity
- Place of Presentation
  京都大学時計台記念館（京都府）
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  三島
- Year and Date
  2013-10-18
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉, 山口留奈, Jafar Sharif, 城村由和, 川村猛, 中西圭子, 島村真太郎, 有田恭平, 児玉龍彦, 石川冬木, 古関明彦, 中西真
- Organizer
  第36回分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-06
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化とDNA維持メチル化制御2013
- Author(s)
  西山敦哉
- Organizer
  平成25年度遺伝研研究会「クロマチンによる遺伝情報のエピジェネティック制御機構」
- Place of Presentation
  国立遺伝学研究所（静岡県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] Uhrf1依存的なヒストンH3のユビキチン化を介したDNA維持メチル化制御機構2013
- Author(s)
  西山敦哉、山口留奈、Jafar Sharif, 城村由和、川村猛、中西圭子、島村真太郎、有田恭平、児玉龍彦、石川冬木、古関明彦、中西真
- Organizer
  第36回分子生物学会年会ワークショップ「タンパク質翻訳後修飾を介した超分子複合体形成とゲノム機能制御」
- Place of Presentation
  神戸国際会議場（兵庫県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉、山口留奈、城村由和、島村真太郎、石川冬木、川村猛、Sharif Jafar、古関明彦、中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLS ポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈、西山敦哉、城村由和、島村真太郎、石川冬木、秋山昌広、真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguhi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1-mediated histone H3 ubiquitylation couples DNA methylation with DNA replication2012
- Author(s)
  Nishiyama A, Yamaguchi L, Johmura Y, Shimamura S, Ishikawa F, Sharif J, Koseki H, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, Nakanishi M
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji Yumebutai（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Implication of TLS in maintaining genome integrity under defective maintenance DNA methylation through Uhrf1-dependent PCNA ubiquitylation2012
- Author(s)
  Yamaguchi L, Nishiyama A, Johmura Y, Shimamura S, Ishikawa F, Hanaoka F, and Nakanishi M
- Organizer
  The 8^<th> 3R Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] ヒストンH3のユビキチン化を介したDNA維持メチル化の監視機構2012
- Author(s)
  西山敦哉, 山口留奈, 城村由和, 島村真太郎, 石川冬木, 川村猛, Jafar Sharif, 古関明彦, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] Uhrf1依存的なPCNAのモノユビキチン化を介したTLSポリメラーゼとDNA維持メチル化の関わり2012
- Author(s)
  山口留奈, 西山敦哉, 城村由和, 島村真太郎, 石川冬木, 秋山昌広, 真木寿治, 中西真
- Organizer
  第35回分子生物学会年会
- Place of Presentation
  博多
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24790290
[Presentation] DNA複製時におけるUhrf1とDnmt1による維持メチル化制御機構2012
- Author(s)
  山口留奈、西山敦哉、島村真太郎、石川冬木、中西真
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  ホテルニュー水戸屋(宮城県)
- Year and Date
  2012-01-26
- Data Source
  KAKENHI-PROJECT-23890175
[Presentation] DNAメチル化維持とカップルしたヒストンH3ユビキチン化の制御機構
- Author(s)
  西山敦哉
- Organizer
  大阪大学蛋白研セミナー「染色体伝承の分子背景：複製から染色体分離まで」
- Place of Presentation
  大阪大学蛋白質研究所 (大阪府、吹田市）
- Year and Date
  2014-09-25 – 2014-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717
[Presentation] 染色体恒常性制御におけるDNAメチル化維持機構の役割
- Author(s)
  西山敦哉
- Organizer
  第37回分子生物学会年会ワークショップ、細胞周期を通じた染色体恒常性制御のニューフロンティア
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-25131717

1. 有田恭平 (40549648)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
2. ISHIKAWA Fuyuki

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
3. NAKANISHI Makoto

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
4. 古関明彦

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
5. 中西圭子

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
6. 島田緑

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. 城村由和

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
8. 金井恵理

# of Collaborated Projects : 0results

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9. 的場聖明

# of Collaborated Projects : 0results

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10. 金井雅史

# of Collaborated Projects : 0results

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11. 長尾恒治

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12. 小布施力史

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

NISHIYAMA Atsuya 西山 敦哉

Research Projects

Research Products

Co-Researchers

複製因子の翻訳後修飾が制御する新しいDNAメチル化継承機構の構造基盤Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of maintenance DNA methylationPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNAメチル化を制御するユビキチンシグナルとその機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

不完全なDNAメチル化に伴うクロマチンタンパク質のユビキチン化とその役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of DNA replication machinery in maintenance of DNA methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ツメガエル卵抽出液を用いたDNAメチル化制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] エピジェネティクスキーワード事典2013

Author(s)

Publisher

Data Source

[Journal Article] Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of maintenance DNA methylation via histone ubiquitylation.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Xenopus laevis Ctc1-Stn1-Ten1 (xCST) complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract2012

Author(s)

Journal Title

Publisher

DOI

PMID

Year and Date

Data Source

[Journal Article] Essential roles of Xenopus TRF2 in telomere end protection and replication2011

Author(s)

Journal Title

NISHIYAMA Atsuya 西山敦哉