OSHIUMI Hiroyuki 押海裕之

Researcher Number	50379103
Other IDs
External Links
Affiliation *help	2015 – 2018 : 熊本大学, 大学院生命科学研究部(医), 教授 2014 : 北海道大学, 人獣共通感染症リサーチセンター, 准教授 2014 : 北海道大学, 学内共同利用施設等, 准教授 2012 – 2013 : 北海道大学, 医学(系)研究科(研究院), 講師 2013 : 北海道大学, 大学院・大医学研究科, 講師 … More
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Molecular biology Except Principal Investigator Immunology / Biological Sciences
Keywords	Principal Investigator 自然免疫 / ウイルス / ユビキチン / インターフェロン / I型インターフェロン / RIG-I / C型肝炎 / 核酸 / 免疫 / 細胞周期 … More Except Principal Investigator Toll-like receptor / 自然免疫 / Toll-like-receptor / poliovirus / TICAM-1 / RNAウイルス / 樹状細胞 / 細胞性免疫 / インターフェロン / HCV / RNAアジュバント / IPS-1 Less

自然免疫を介した宿主とウイルスの新たな相互作用の解明Principal InvestigatorOngoing
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kumamoto University
自然免疫系の細胞質内核酸認識経路が自然炎症を引き起こす仕組みPrincipal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Novel molecular mechanisms of antiviral innate immune responsePrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
Molecular mechanisms of dendritic cell maturation in response to pattern sensing
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
自然免疫に於ける未知の微生物認識分子群の単離と炎症への繋がりの解明Principal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
In vivo role of novel innate immune factors during viral infectionPrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
Isolation and analysis of novel molecules that recognize viral infectionPrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
ウイルス感染のRNA応答
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
限られた時間内に相同組換えが終わる仕組みと、組換えの新たな展開Principal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Hokkaido University
  Osaka University
サイクリンが遺伝的組換えを制御し癌を抑制する仕組みPrincipal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Oligomerization in Health and Diseases.2013
- Author(s)
  Matsumoto, M., K. Funami, H. Oshiumi, and T. Seya
- Publisher
  Academic Press, ELSEVIER INC.
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
- Journal Title
  
  PLoS Pathog.
  
  Volume : 13 Issue : 1
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.ppat.1006162
- PMID
  28103322
- Year and Date
  2017-01-19
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014
[Journal Article] Extracellular vesicles deliver host and virus RNA and regulate innate immune response2017
- Author(s)
  Kouwaki T., Okamoto M., Tsukamoto H., Fukushima Y. and Oshiumi H.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume : 18
- DOI
  10.3390/ijms18030666
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430165, KAKENHI-PROJECT-15K08517
[Journal Article] Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection.2016
- Author(s)
  Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Takahiro Sanada, Naoki Yamamoto, Edin J. Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya and *Hiroyuki Oshiumi
- Journal Title
  
  Frontiers in Immunology
  
  Volume : 7 Pages : 335-335
- DOI
  10.3389/fimmu.2016.00335
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15K08517
[Journal Article] Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.2016
- Author(s)
  Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, Seya T.
- Journal Title
  
  Oncotarget
  
  Volume : 7 Pages : 68179-68193
- DOI
  10.18632/oncotarget.11907
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
[Journal Article] The dataset of proteins specifically interacted with activated TICAM-12016
- Author(s)
  Funami K, Matsumoto M, Oshiumi H, Obuse C, Seya T.
- Journal Title
  
  Data Brief
  
  Volume : 8 Pages : 697-699
- DOI
  10.1016/j.dib.2016.06.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.2016
- Author(s)
  Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  Oncoimmunology
  
  Volume : 8
- DOI
  10.1080/2162402X.2016.1188244
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J02429, KAKENHI-PROJECT-15K08517
[Journal Article] Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.2016
- Author(s)
  Kasamatsu, J., Deng, M., Matsumoto, M., Azuma, M., Funami, K., Shime, H., Kasahara, M., Oshiumi, H. and Seya, T.
- Journal Title
  
  BMC Immunol.
  
  Volume : 17 Pages : 9
- Publisher
  BioMed Central
- DOI
  10.1186/s12865-016-0147-y
- PMID
  info:pmid/27141827
- Year and Date
  2016-05-03
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04716, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704
[Journal Article] STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.2016
- Author(s)
  Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, Seya T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 478 Pages : 1764-1771
- DOI
  10.1016/j.bbrc.2016.09.021
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704, KAKENHI-ORGANIZER-25112001
[Journal Article] Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response2016
- Author(s)
  Oshiumi H, Kouwaki T, Seya T
- Journal Title
  
  Frontiers in Immunology
  
  Volume : 7 Pages : 200-200
- DOI
  10.3389/fimmu.2016.00200
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)2015
- Author(s)
  Masato Nakai , Hiroyuki Oshiumi , Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, and Naoya Sakamoto
- Journal Title
  
  Sensors
  
  Volume : 15 Pages : 27160-27173
- DOI
  10.3390/s151027160
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Links between recognition and degradation of cytoplasmic viral RNA in innate immune response2015
- Author(s)
  Hiroyuki Oshiumi, Edin J Mifsud, and Takuji Daito
- Journal Title
  
  Reviews in Medical Virology
  
  Volume : 26 Pages : 90-101
- DOI
  10.1002/rmv.1865
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-22015
- Author(s)
  Kenji Funami, Misako Matsumoto, Yoshiaki Enokizono, Noriko Ishii, Megumi Tatematsu, Hiroyuki Oshiumi, Fuyuhiko Inagaki and Tsukasa Seya
- Journal Title
  
  The Journal of Immunology
  
  Volume : 195 Pages : 4456-4465
- DOI
  10.4049/jimmunol.1402628
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] PolyI:C-induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo2015
- Author(s)
  Ryo Takemura, Hiromi Takaki, Seiji Okada, Hiroaki Shime, Takashi Akazawa, Hiroyuki Oshiumi, Misako Matsumoto, Takanori Teshima, and Tsukasa Seya
- Journal Title
  
  Cancer Immunology Research
  
  Volume : 3 Issue : 8 Pages : 902-914
- Publisher
  American Association for Cancer Research
- DOI
  10.1158/2326-6066.CIR-14-0219
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590500, KAKENHI-PROJECT-26860593
[Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepetocytes and bendritic Cells in Response to Hepatitis C Virus Infection.2015
- Author(s)
  Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T
- Journal Title
  
  Journal of immunology
  
  Volume : 194 Pages : 773-780
- DOI
  10.4049/jimmunol.1301459
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591515, KAKENHI-PROJECT-13J01978, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214
[Journal Article] RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response2015
- Author(s)
  Ken Takashima, Hiroyuki Oshiumi, Hiromi Takaki, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  Cell Reports
  
  Volume : 11 Pages : 192-200
- DOI
  10.1016/j.celrep.2015.03.027
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog2015
- Author(s)
  Haruko Sato, Hiroyuki Oshiumi, Hiromi Takaki, Hirokazu Hikono, and Tsukasa Seya
- Journal Title
  
  Microbiology and Immunology
  
  Volume : 59 Issue : 10 Pages : 633-640
- Publisher
  Wiley-Blackwell
- DOI
  10.1111/1348-0421.12322
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-26860593
[Journal Article] DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation2015
- Author(s)
  Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  Cell Reports
  
  Volume : 11 Issue : 8 Pages : 1193-1207
- Publisher
  Cell Press
- DOI
  10.1016/j.celrep.2015.04.047
- Year and Date
  2015-05-26
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model.2015
- Author(s)
  Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T
- Journal Title
  
  J Innate Immun.
  
  Volume : 7 Pages : 47-58
- DOI
  10.1159/000365113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-26860593
[Journal Article] Myeloid-derived suppressor cell confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor model2014
- Author(s)
  Shime, H., A. Kojima, A. Maruyama, Y. Saito, H. Oshiumi, M. Matsumoto, and T. Seya.
- Journal Title
  
  Journal of Innate Immunity
  
  Volume : 6 Pages : 293-305
- DOI
  10.1159/000355126
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570
[Journal Article] Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models2014
- Author(s)
  Hiromi Takaki, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  The international Journal of Biochemistry & Cell Biology
  
  Volume : 53 Pages : 329-333
- Publisher
  Elsevier
- DOI
  10.1016/j.biocel.2014.05.001
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-26860593
[Journal Article] MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells2014
- Author(s)
  Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T
- Journal Title
  
  Mol Immunol
  
  Volume : 57(2) Pages : 100-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models2014
- Author(s)
  Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  J Innate Immun
  
  Volume : 6 Pages : 293-305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection2014
- Author(s)
  Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T
- Journal Title
  
  J Immunol
  
  Volume : (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells.2014
- Author(s)
  Hiromi Takaki, et al.
- Journal Title
  
  Molecular Immunology
  
  Volume : 57 Issue : 2 Pages : 100-109
- Publisher
  Pergamon-elsevier science ltd
- DOI
  10.1016/j.molimm.2013.08.007
- PMID
  info:pmid/24096085
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PROJECT-26860593, KAKENHI-PROJECT-23590558
[Journal Article] INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.2014
- Author(s)
  Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T
- Journal Title
  
  J Immunol.
  
  Volume : 193 Pages : 5199-5207
- DOI
  10.4049/jimmunol.1400924
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24590570
[Journal Article] Multi-step regulation of interferon induction by hepatitis C virus.2013
- Author(s)
  Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
- Journal Title
  
  Arch. Immunol. Therap. Exp.
  
  Volume : 61(2) Pages : 127-138
- DOI
  10.1007/s00005-012-0214-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.2013
- Author(s)
  Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T,Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S.
- Journal Title
  
  J. Immunol.
  
  Volume : 190(2) Pages : 764-773
- DOI
  10.4049/jimmunol.1202173
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses2013
- Author(s)
  Oshiumi H, Miyashita M, Matsumoto M, Seya T
- Journal Title
  
  PLoS Pathog
  
  Volume : 9(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA2013
- Author(s)
  Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T
- Journal Title
  
  PLoS One
  
  Volume : 8(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model2013
- Author(s)
  Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  J Immunol
  
  Volume : 191(9) Pages : 4740-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Multi-step regulation of interferon induction by hepatitis C virus2013
- Author(s)
  Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T
- Journal Title
  
  Arch Immunol Ther Exp (Warsz)
  
  Volume : 61(2) Pages : 127-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA2013
- Author(s)
  Suzuki, T., H. Oshiumi, M. Miyashita, H. H. Aly, M. Matsumoto, and T. Seya.
- Journal Title
  
  PLos ONE
  
  Volume : 8 Issue : 12 Pages : e83639
- Publisher
  Public library science
- DOI
  10.1371/journal.pone.0083639
- PMID
  info:pmid/24349538
- Year and Date
  2013-12-09
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PUBLICLY-24117506
[Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.2013
- Author(s)
  Oshiumi H, Miyashita M, Matsumoto M, Seya T.
- Journal Title
  
  PLoS Pathog.
  
  Volume : 9 Issue : 8 Pages : e1003533
- Publisher
  Public library science
- DOI
  10.1371/journal.ppat.1003533
- PMID
  info:pmid/23950712
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214
[Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.2013
- Author(s)
  Hiromi Takaki, et al.
- Journal Title
  
  J Immunol.
  
  Volume : 191 Pages : 4740-4747
- DOI
  10.4049/jimmunol.1301744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-22790445, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570
[Journal Article] Riplet ubiquitin ligase plays a pivotal role in TRIM25-mediated RIG-I activation and is targeted by Hepatitis C Virus.2013
- Author(s)
  Oshiumi, H., M. Miyashita, M. Matsumoto, and T. Seya
- Journal Title
  
  PLoS Pathog.
  
  Volume : 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.2012
- Author(s)
  Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
- Journal Title
  
  Oncoimmunol.
  
  Volume : 1 Issue : 6 Pages : 917-923
- Publisher
  Landes Bioscience
- DOI
  10.4161/onci.21244
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PUBLICLY-24117702
[Journal Article] Cross-priming for anti-tumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+ dendritic cells.2012
- Author(s)
  Azuma M., T. Ebihara, H. Oshiumi, M. Matsumoto, and T. Seya.
- Journal Title
  
  Oncoimmunology
  
  Volume : 1 Pages : 581-592
- DOI
  10.4161/onci.19893
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PUBLICLY-24117702
[Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  H.Shime
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume : 109 Issue : 6 Pages : 2066-2071
- Publisher
  National Academy of Sciences
- DOI
  10.1073/pnas.1113099109
- Year and Date
  2012-02-07
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-21200079, KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21590326, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24659214
[Journal Article] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume : 109 Pages : 2066-2071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice2012
- Author(s)
  Abe, Y., K. Fujii, N. Nagata, O. Takeuchi, S. Akira, H. Oshiumi, M. Matsumoto, T. Seya, and S. Koike
- Journal Title
  
  J. Virol
  
  Volume : 86 Pages : 185-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.2012
- Author(s)
  Abe, Y., K.Fujii, N.Nagata, O.Takeuchi, S.Akira, H.Oshiumi, M.Matsumoto, T.Seya, S.Koike
- Journal Title
  
  J. Virol.
  
  Volume : 86 Pages : 185-194
- DOI
  10.1128/JVI.05245-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390116, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590554, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIGI2012
- Author(s)
  Oshiumi, H., M.Matsumoto, T.Seya
- Journal Title
  
  J.Biocbem.
  
  Volume : 151 Pages : 5-11
- DOI
  10.1093/jb/mvr111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] Antiviral responses induced by the TLR3 pathway2011
- Author(s)
  Matsumoto, M., H. Oshiumi, and T. Seya
- Journal Title
  
  Rev. Med. Virol
  
  Volume : 21 Pages : 67-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection2011
- Author(s)
  Oshiumi, H., M. Okamoto, K. Fujii, T. Kawanishi, M. Matsumoto, S. Koike, and T. Seya.
- Journal Title
  
  Journal of Immunology
  
  Volume : 187 Pages : 5320-5327
- DOI
  10.4049/jimmunol.1101503
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390116, KAKENHI-PROJECT-23390120
[Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with shizophrenia2011
- Author(s)
  Deng Xia, Takaki H, Wang Li, et.al.
- Journal Title
  
  American journal of Medical Genetics
  
  Volume : 48 Issue : 4 Pages : 497-504
- Publisher
  Elsevier
- DOI
  10.1016/j.molimm.2010.10.006
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J01368, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] Antiviral responses induced by the TLR3 pathway. (review)2011
- Author(s)
  Matsumoto, M., H. Oshiumi, and T. Seya.
- Journal Title
  
  Rev. Med. Virol.
  
  Volume : 21 Pages : 67-77
- DOI
  10.1002/rmv.680
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] Establishing mouse hepatoma cell lines permissive to human hepatitis C virus2011
- Author(s)
  Aly, H. H., H. Oshiumi, M. Matsumoto, K. Shimotohno, T. Wakita, and T. Seya
- Journal Title
  
  PLoS ONE
  
  Volume : 6 (6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The TLR3-TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection2011
- Author(s)
  Oshiumi, H., M. Okamoto, K. Fujii, T. Kawanishi, M. Matsumoto, S. Koike, and T. Seya
- Journal Title
  
  J. Immunol
  
  Volume : 187 Pages : 5320-5327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The SKI2-related helicase DDX60 is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling2011
- Author(s)
  Miyashita, M., H. Oshiumi, M. Matsumoto, and T. Seya
- Journal Title
  
  Molec. Cell. Biol
  
  Volume : 31 Pages : 3802-3819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] DDX60, a DHXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling2011
- Author(s)
  Miyashita, M., H.Oshiumi, M.Matsumoto, T.Seya
- Journal Title
  
  Mol.Cell Biol
  
  Volume : 31 Issue : 18 Pages : 3802-3819
- Publisher
  American Society for Microbiology
- DOI
  10.1128/MCB.01368-10
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558
[Journal Article] Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV)2011
- Author(s)
  Aly, H.H., H.Oshiumi, H.Shime, M.Matsumoto, T.Wakita, K.Shimotohno, T.Seya
- Journal Title
  
  Plos ONE
  
  Volume : 6 Issue : 6 Pages : e21284
- Publisher
  Public Library of Science
- DOI
  10.1371/journal.pone.0021284
- Year and Date
  2011-06-22
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-23659407
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection2010
- Author(s)
  Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, Seya T
- Journal Title
  
  Cell Host Microbe
  
  Volume : 8 Issue : 6 Pages : 496-509
- Publisher
  Cell press
- DOI
  10.1016/j.chom.2010.11.008
- PMID
  info:pmid/21147464
- Year and Date
  2010-12-16
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21687018, KAKENHI-PROJECT-22790450
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune response to RNA virus infection2010
- Author(s)
  押海裕之
- Journal Title
  
  Cell Host & Microbe
  
  Volume : 8 Pages : 496-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction2010
- Author(s)
  押海裕之
- Journal Title
  
  Plos One
  
  Volume : 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] DEAD BOX3(DDX3) helicases binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology
  
  Volume : 40 Pages : 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] DEAD BOX3(DDX3) helicases binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology
  
  Volume : 40 Pages : 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune response to RNA virus infection2010
- Author(s)
  押海裕之
- Journal Title
  
  Cell Host & Microbe
  
  Volume : 8 Pages : 496-509
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction2010
- Author(s)
  押海裕之
- Journal Title
  
  Plos One
  
  Volume : 5
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] DEAD/H BOX 3(DDX3)helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.2010
- Author(s)
  笹井美和、立松恵、押海裕之、以下4名省略
- Journal Title
  
  Molecular Immunology 47巻
  
  Pages : 1283-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential.2010
- Author(s)
  押海裕之以下3名省略
- Journal Title
  
  European Journal of Immunology 40巻
  
  Pages : 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Pan-vertebrate Toll-like receptors during evolution(review)2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  Curr. Genomics 9
  
  Pages : 488-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Riplet/RNF135, a RING-finger protein, ubiquitinates RIG-I to promote interferon-β induction during the early phase of viral infection2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages : 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Regulator of Complement Activation (RCA) gene cluster in Xenopus tropicalis2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  Immunogenetics (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-β induction during the Early Phase of Viral Infection2009
- Author(s)
  Hiroyuki Oshiumi
- Journal Title
  
  Journal of Biological Chemisitry 284
  
  Pages : 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Asp-Glu-Ala-Asp/His (DEAD/H) BOX 3 (DDX3) helicase assembles in the IFN-β promoter stimulator-1 (IPS-1) pathway to enhance IFN-β induction2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  PloS Pathol (submitted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2009
- Author(s)
  押海裕之, 他12名省略(13人中3番目)
- Journal Title
  
  Plos Genetics 6巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Mitofusin 2 inhibits mitochondrial antiviral signaling.2009
- Author(s)
  安川開、押海裕之、以下6名省略
- Journal Title
  
  Science Signaling 2巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.2009
- Author(s)
  高木宏美、押海裕之以下4名省略
- Journal Title
  
  European Journal of Immunology 39巻
  
  Pages : 3469-3476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-b induction during the Early Phase of Viral Infection.2009
- Author(s)
  押海裕之、以下3名省略
- Journal Title
  
  JBC 284巻
  
  Pages : 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Regulator of complement activation (RCA) gene cluster in Xenopus tropicails.2009
- Author(s)
  押海裕之、以下3名省略
- Journal Title
  
  Immunogenetics 61巻
  
  Pages : 371-384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.2008
- Author(s)
  松尾綾、押海裕之、以下6名省略
- Journal Title
  
  Journal of Immunology 181巻
  
  Pages : 347-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Regulator of complement activation (RCA)gene cluster in Xenopus tropi cails2008
- Author(s)
  Hiroyuki Oshiumi
- Journal Title
  
  Immunogenetics (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] Extracellular Vesicles Including Exosomes Regulates Innate Immune Responses to Hepatitis B Virus Infection2016
- Author(s)
  Hiroyuki Oshiumi, Takahisa Kouwaki, Yoshimi Fukushima, Masaaki Okamoto
- Organizer
  第１５回あわじしま感染症・免疫フォーラム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] B型肝炎ウイルスに対する自然免疫応答におけるエクソソームの役割2016
- Author(s)
  押海裕之
- Organizer
  第８１回日本インターフェロンサイトカイン学会学術集会
- Place of Presentation
  長崎大学（長崎）
- Invited
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] DDX60, a cytoplasmic RNA helicase, enhances RIG-I-dependent and –independent antiviral innate immune response2015
- Author(s)
  Hiroyuki Oshiumi
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] Hepatitis C virus degrades Riplet ubiquitin ligase to escape host innate immune response2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  International congress of immunology 2013
- Place of Presentation
  Milano Congressi ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Hepatitis C virus NS3-4A protease cleaves Riplet ubiquitin ligase to abrogate RIG-I-mediated type I interferon production2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Hepatitis C virus NS3-4A protease cleaves Riplet ubiquitin ligase to abrogate RIG-I-mediated type I interferon production2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Hepatitis C virus degrades Riplet ubiquitin ligase to escape host innate immune response2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  International congress of immunology 2013
- Place of Presentation
  Milano Congressi ミラノ（イタリア）
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Riplet ubiquitin ligase is essential for TRIM25-mediated RIG-I activation and is targeted by hepatitis c virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium
- Place of Presentation
  学術総合センター（東京）
- Year and Date
  2012-10-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] C型肝炎ウイルスが、Ripletユビキチンライゲースを分解しRIG-I依存的なI型インターフェロン産生を抑制するメカニズムの解明2012
- Author(s)
  押海裕之　松本美佐子　瀬谷司
- Organizer
  日本ウイルス学会
- Place of Presentation
  グランキューブ大阪（大阪）
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Riplet ubiquitin ligase plays essential role in RIG-I-mediated type I interferon productioin, and is targeted by hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場（兵庫）
- Year and Date
  2012-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Riplet ubiquitin ligase plays essential role in RIG-I-mediated type I interferon production, and is targeted by hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場（兵庫）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Riplet ubiquitin ligase is essential for TRIM25-mediated RIG-I activation and is targeted by Hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium
- Place of Presentation
  学術総合センター（東京）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] C型肝炎ウイルスが、Ripletユビキチンライゲースを分解しRIG-I依存的なI型インターフェロン産生を抑制するメカニズムの解明2012
- Author(s)
  押海裕之　松本美佐子　瀬谷司
- Organizer
  日本ウイルス学会
- Place of Presentation
  グランキューブ大阪（大阪）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] The ubiquitin ligase Riplet is essential for RIG-I dependent type I interferon production in response to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Riplet ubiquitin ligase is essential for RIG-I dependent type I interferon production2011
- Author(s)
  押海裕之
- Organizer
  Keystone Symposium
- Place of Presentation
  Santa Fe Community Convention center (アメリカ合衆国)
- Year and Date
  2011-02-15
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] The ubjquitin ligase Riplet is essential for RIG-I dependent type I interferon production in response to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] The ubiquitin ligase Riplet is essential for RIG-I dependent type I interferon production in responses to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Riplet ubiquitin ligase is essential for RIG-I dependent type I interferon production2011
- Author(s)
  押海裕之
- Organizer
  Keystone Symposium
- Place of Presentation
  Santa Fe Community Convention center(アメリカ合衆国)
- Year and Date
  2011-02-15
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] 細胞質内ウイルスRNA認識センサーRIG-Iをユビキチン化するRiplet分子のノックアウトマウス作成と機能解析2010
- Author(s)
  押海裕之
- Organizer
  インターフェロンサイトカイン学会
- Place of Presentation
  北九州国際会議場(福岡県)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] TICAM-1/TRIF, a TLR3 adaptor, is essential for protection against poliovirus infection.2010
- Author(s)
  押海裕之
- Organizer
  国際免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] 細胞質内ウイルスRNA認識センサーRIG-Iをユビキチン化するRiplet分子のノックアウトマウス作成と機能解析2010
- Author(s)
  押海裕之
- Organizer
  インターフェロンサイトカイン学会
- Place of Presentation
  北九州国際会議場(福岡県)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] TICAM-1/TRIF, a TLR3 adaptor, is essential for protection against poliovirus infection.2010
- Author(s)
  押海裕之
- Organizer
  国際免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] DDX3 RNA helicase associates with RIG-1 and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜国際会議場(神奈川県)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] DDX3 RNA helicase associates with RIG-I and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  大阪府
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  神奈川県
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  京都府
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  京都国立京都国際会館
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] Riplet: a novel RING finger protein that activates RIG-I2008
- Author(s)
  Hiroyuki Oshiumi et. al.
- Organizer
  Keystone symposium
- Place of Presentation
  Keyston Resort, Colorado USA
- Year and Date
  2008-02-26
- Data Source
  KAKENHI-PROJECT-18770152
[Presentation] ユビキチンによるウイルスRNA認識センサー RIG-Iの活性化制御機構
- Author(s)
  押海裕之
- Organizer
  第25回日本生体防御学会学術総会
- Place of Presentation
  東北大学　片平さくらホール　（仙台）
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-24590570

1. SEYA Tsukasa (10301805)

# of Collaborated Projects : 2results

# of Collaborated Products : 33results
2. MATSUMOTO Misako (30332456)

# of Collaborated Projects : 2results

# of Collaborated Products : 33results
3. SHIME Hiroaki (70372133)

# of Collaborated Projects : 1results

# of Collaborated Products : 8results
4. 海老原敬 (20374407)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. OKABE Masaru

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
6. NAGATA Noriyo

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. 徳永文稔

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. 柴田佑里

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. 井上純一郎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. 澤崎達也

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 高橋宏隆

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 岩井一宏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 中野裕康

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 井上聡

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. 佐伯泰

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 田中啓二

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 赤澤隆

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
18. 小原道法

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
19. 井上直和

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. 茶山一彰

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. 井原健二

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. 加藤健太郎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
23. 藤井健

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 小池智

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
25. 粟井博丈(塚本博丈)

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
26. 田原舞乃

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
27. 笠原正典

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
28. 田原秀晃

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
29. 井上徳光

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
30. 伊川正人

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
31. 脇田隆字

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

OSHIUMI Hiroyuki 押海 裕之

Research Projects

Research Products

Co-Researchers

自然免疫を介した宿主とウイルスの新たな相互作用の解明Principal InvestigatorOngoing

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自然免疫系の細胞質内核酸認識経路が自然炎症を引き起こす仕組みPrincipal Investigator

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Novel molecular mechanisms of antiviral innate immune responsePrincipal Investigator

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Molecular mechanisms of dendritic cell maturation in response to pattern sensing

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自然免疫に於ける未知の微生物認識分子群の単離と炎症への繋がりの解明Principal Investigator

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In vivo role of novel innate immune factors during viral infectionPrincipal Investigator

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Isolation and analysis of novel molecules that recognize viral infectionPrincipal Investigator

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ウイルス感染のRNA応答

Principal Investigator

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限られた時間内に相同組換えが終わる仕組みと、組換えの新たな展開Principal Investigator

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サイクリンが遺伝的組換えを制御し癌を抑制する仕組みPrincipal Investigator

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[Book] Oligomerization in Health and Diseases.2013

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[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017

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[Journal Article] Extracellular vesicles deliver host and virus RNA and regulate innate immune response2017

Author(s)

Journal Title

OSHIUMI Hiroyuki 押海裕之