GAO CONGXIAO 高叢笑

… Alternative Names

KOU Sousyou 高叢笑

高叢笑コウソウショウ

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Researcher Number	50379260
Affiliation (based on the past Project Information) *help	2016: 国立研究開発法人理化学研究所, 疾患糖鎖研究チーム, 客員研究員 2011 – 2013: 大阪大学, 産業科学研究所, 招へい教員 2008: 大阪大学, 医学糸研究科, 特任研究員 2005 – 2006: 大阪大学, 医学系研究科, 特任研究員
Review Section/Research Field	Principal Investigator Applied health science / Respiratory organ internal medicine / General surgery Except Principal Investigator General surgery
Keywords	Principal Investigator 酵素 / 発現制御 / 酸化ストレス / エピジェネティクス / 糖鎖 / 糖転移酵素 / alpha 1,6 fucose / alpah 1,6 fucose / Fut8ヘテロ欠損マウス / TGFβ … More / コアフコース / 喫煙暴露 / FUT8 / 慢性閉塞性肺疾患 / NKレセプター / α-Galエピトープ / NK細胞依存性細胞傷害 / 糖鎖構造解析 / ブタ内皮細胞 … More Except Principal Investigator 膜貫通型 / PI-anchor / 感染実験 / ブタC1-INH / H-D抗原 / サル補体価 / DAF(CD55) / 糖鎖構造解析 / 種特異性 / ブタfactor I / Lac Z assay / DAF重合分子 / 遺伝子導入 / PERV / レクチンブロット / α1,3GT-KO / GnT-III / DAF / ブタレトロウイルス / 糖鎖抗原 / 補体制御因子 / 遅延型拒絶反応 / 異種移植 Less

COPD感受因子である糖転移酵素Fut8の発現制御のエピジェネティクス解析Principal Investigator
- Principal Investigator
  
  高叢笑
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Institute of Physical and Chemical Research
The role of FUT8 in the development of chronic obstructive pulmonary diseasePrincipal Investigator
- Principal Investigator
  
  GAO CONGXIAO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Osaka University
Regulation of the delayed-type xenograft rejectlon and plg retrovIrus研究代表者
- Principal Investigator
  
  MIYAGAWA Shuji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
異種移植における糖鎖抗原とNK細胞Principal Investigator
- Principal Investigator
  
  高叢笑
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Osaka University

All 2017 2016 2013 2012 2011 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] Biological functions of branched N-glycans related to physiology and pathology of extracellular matrix.Extracellular Matrix: Pathobiology and Signaling2012
- Author(s)
  Gao C, Ohtsubo K, Gu J, and Taniguchi N
- Total Pages
  890
- Publisher
  DE GRUYTER
- Data Source
  KAKENHI-PROJECT-23591118
[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.2017
- Author(s)
  Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
- Journal Title
  
  American Journal of Physiology Lung Cellular and Molecular Physiology
  
  Volume: 312 Issue: 2 Pages: L268-L276
- DOI
  10.1152/ajplung.00151.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-16K09559, KAKENHI-PROJECT-16H04758
[Journal Article] N-glycans of growth factor receptors: their role in receptor function and disease implications.2016
- Author(s)
  Takahashi M, Hasegawa Y, Gao C, Kuroki Y, Taniguchi N.
- Journal Title
  
  Clinical Science
  
  Volume: 130 Issue: 20 Pages: 1781-1792
- DOI
  10.1042/cs20160273
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K19461
[Journal Article] Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells2013
- Author(s)
  Shirato K, Gao C, Ota F, Angata T, Shogomori H, Ohtsubo K, Yoshida K, Lepenies B, Taniguchi N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 435(3) Issue: 3 Pages: 460-465
- DOI
  10.1016/j.bbrc.2013.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24790593
[Journal Article] Sensitivity of heterozygous α1, 6- fucosyltransferase knock out mice to cigarette smoke-induced emphysema: implication of aberrant TGF-β signaling and MMP gene expression.2012
- Author(s)
  Gao C, Maeno T, Taniguchi N, et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591118
[Journal Article] Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema: IMPLICATION OF ABERRANT TRANSFORMING GROWTH FACTOR-β; SIGNALING AND MATRIX METALLOPROTEINASE GENE EXPRESSION.2012
- Author(s)
  Gao C, Maeno T, Ota F, Ueno M, Korekane H, Takamatsu S, Shirato K, Matsumoto A, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Betsuyaku T, Taniguchi N
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287(20) Issue: 20 Pages: 16699-16708
- DOI
  10.1074/jbc.m111.315333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24659111, KAKENHI-PROJECT-24790331, KAKENHI-PROJECT-24790593, KAKENHI-PLANNED-20117008
[Journal Article] α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).2012
- Author(s)
  Kamio K, Yoshida T, Gao C, Ishii T, Ota F, Motegi T, Kobayashi S, Fujinawa R, Ohtsubo K, Kitazume S, Angata T, Azuma A, Gemma A, Nishimura M, Betsuyaku T, Kida K, Taniguchi N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 424(1) Issue: 1 Pages: 112-117
- DOI
  10.1016/j.bbrc.2012.06.081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24790331
[Journal Article] The cross-species function of the pig C1 esterase inhibitor2006
- Author(s)
  C. Kobayashi, K. Matsunami, T Omori, K. Nakahata, S. Nakatsu, H. Xu, C. Gao, Y. Ihara, M. Fukuzawa, and S. Miyagawa
- Journal Title
  
  Transplant Proc 38(10)
  
  Pages: 3321-2
- Data Source
  KAKENHI-PROJECT-18390346
[Journal Article] A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression2006
- Author(s)
  Takeshi Omori, Toshirou Nishida, Hiroshi Komoda, Yuichi Fumimoto, Toshinori Ito, Yoshiki Sawa, Congxiao Gao, Shino Nakatsu, Ryota Shirakura, and Shuji Miyagawa
- Journal Title
  
  Xenotransplantation 13
  
  Pages: 455-464
- Data Source
  KAKENHI-PROJECT-18390346
[Journal Article] Bisecting GlcNAc mediates the binding of annexin V to Hsp472005
- Author(s)
  Gao, CX
- Journal Title
  
  Glycobiology 15
  
  Pages: 1067-1075
- Data Source
  KAKENHI-PROJECT-17790889
[Presentation] Lowered level of core fucosylation is a possible non-invasive predictive marker for chronic obstructive pulmonary disease (COPD)2013
- Author(s)
  Gao C, Kamio K, Ota F., Ishii T., Kida K., Taniguchi N.
- Organizer
  Glyco 22
- Place of Presentation
  中国大連
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] Lowered level of core fucosylation is a possible non-invasive predictive marker for chronic obstructive pulmonary disease (COPD)2013
- Author(s)
  Gao, C.
- Organizer
  22nd International Symposium on Glycoconjugates (GLYCO XXII)
- Place of Presentation
  Dailian China
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] alpha1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to smoke-induced emphysema in mice and a possible non-invasive predictive marker for human chronic obstructive pulmonary disease (COPD).2012
- Author(s)
  Gao C, Kamio K, Ota F, Ishii T, Kobayashi S, Kida K, Taniguchi N
- Organizer
  Joint Meeting of the Society for Glycobiology and American Society for Marix Biology
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] Sensitivity of heterozygous a1, 6-fucosyltransferase knock out mice to cigarette smoke-induced emphysema: Implication of aberrant TGF-b signaling and MMP gene expression.2012
- Author(s)
  Gao C, Maeno T, Ota F, Korekane H, Takamatsu S, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Taniguchi N
- Organizer
  GlycoT 2012
- Place of Presentation
  Hannover, Germany
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] Sensitivity of heterozygous a1, 6-fucosyltransferase knock out mice to cigarette smoke-induced emphysema : Implication of aberrant TGF-βsignaling and MMP gene expression2012
- Author(s)
  Gao, C.
- Organizer
  8th International Symposium on Glycosyltransferases
- Place of Presentation
  Hannover, Germany
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] Fut8遺伝子変異マウスにおける慢性閉塞性肺疾患早期発症の分子機構の解明2011
- Author(s)
  高　叢笑
- Organizer
  第84回に本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] Molecular mechanism of the high susceptibility of alpha 1,6 fucosyltransferase (Fut8) heterozygous knockout mice to cigarette smoke-induced emphysema2011
- Author(s)
  Gao, C.
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591118
[Presentation] 異種膵島移植の実現に向かって2008
- Author(s)
  宮川周士、山本亜紀、石丸藍子、徐恒傑、フルダウスサビエル、趙玉、福澤正洋、池田孔佑、松成ひとみ、長嶋比呂志、藤村達也、高萩陽一、村一ヒ博、重久保
- Organizer
  The XXII International Congress of Transplantation
- Place of Presentation
  Sydney
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] ラット小腸移植におけるケモカイン阻害剤TAK一779の検討2007
- Author(s)
  徐恒傑、井原欣幸、上原秀一郎、上野豪久、高間勇一、フルダウスサビエル、福澤正洋、宮川周士
- Organizer
  7th Congress of the Asian Society of Transplantation
- Place of Presentation
  Pataya, Thailand
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] ブタN-acetylglucosaminlyltransferase I(GnT-1)のDominant Negative 法による糖鎖抗原の改変2007
- Author(s)
  松浪勝義、高叢笑、中津志野、宮川周士、福澤正洋
- Organizer
  膵・膵島移植研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] DAF および GnT-IIIを同時発現するα1, 3ガラクトース転移酵素遺伝子ダブルノックアウトプタの作出2007
- Author(s)
  高萩陽一、藤村達也、長嶋比呂志、型ll周士、重久保、白倉良太、村上博
- Organizer
  日本小腸移植研究会
- Place of Presentation
  札幌
- Year and Date
  2007-03-10
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] DAFとGnT-IIIを発現するα1, 3ガラクトース転移酵素遺伝子ダブルノックアウト豚の誕生2007
- Author(s)
  高萩陽一、藤村達也、長嶋比呂志、宮川周士、重久保、白倉良太、村上博
- Organizer
  異種移植研究会
- Place of Presentation
  東京
- Year and Date
  2007-03-10
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] 異種移植の可能性について
- Author(s)
  周士、中津志野、徐恒傑、福澤正洋、重久保、村上博、藤村達也、高萩陽一、村上博
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] a1, 3ガラクトース転移酵素遺伝子ダブルノックアウトブタの体細胞クローニングによる複製生産
- Author(s)
  松成ひとみ、宮川周士、高萩陽一、藤村達也、重久保、村上博、中野和明、藤原主、池田孔佑、白倉良太、長lll島比呂志
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] ブタ Dol-P-Mannosidase の同定とknockdown 法によるブタ内在性レトロウイルス感染制御の試み
- Author(s)
  中津志野、高叢笑、近藤昭宏、中川孝俊、福澤正洋、宮川周士
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] Plasminogen activator inhibiyor type 2によるNK細胞制御の試み
- Author(s)
  徐恒傑、松浪勝義、趙玉、石丸藍子、フルダウスサビエル、高間勇一、上野豪久、福澤正洋、宮川周士
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] α1-3ガラクトース転移酵素遺伝子ノックアウト(α1-3GTKO)ブタの解析
- Author(s)
  中津志野、高叢笑、宮川周士、藤村達也、高萩陽一、重久保、村上博、白倉良太、長嶋比呂志
- Data Source
  KAKENHI-PROJECT-18390346
[Presentation] ブタ内在性レトロウイルス(PERV)上の遺伝子導入ヒト補体制御因子の発現方法の検討
- Author(s)
  大倉英司、宮川周士、中津志野、高叢笑、奥村明之進、澤芳樹、白倉良太
- Data Source
  KAKENHI-PROJECT-18390346

1. OKABE Masaru (30089875)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. MIYAZAWA Takayuki (80282705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUMIMOTO Yuuiti (20397748)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. MIYAGAWA Shuji (90273648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. OHTSUBO Kazuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. KOREKANE Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 谷口直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

GAO CONGXIAO 高 叢笑

KOU Sousyou 高 叢笑

高 叢笑 コウ ソウショウ

Research Projects

Research Products

Co-Researchers

COPD感受因子である糖転移酵素Fut8の発現制御のエピジェネティクス解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of FUT8 in the development of chronic obstructive pulmonary diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the delayed-type xenograft rejectlon and plg retrovIrus研究代表者

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

異種移植における糖鎖抗原とNK細胞Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Biological functions of branched N-glycans related to physiology and pathology of extracellular matrix.Extracellular Matrix: Pathobiology and Signaling2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-glycans of growth factor receptors: their role in receptor function and disease implications.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sensitivity of heterozygous α1, 6- fucosyltransferase knock out mice to cigarette smoke-induced emphysema: implication of aberrant TGF-β signaling and MMP gene expression.2012

Author(s)

Journal Title

Data Source

[Journal Article] Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema: IMPLICATION OF ABERRANT TRANSFORMING GROWTH FACTOR-β; SIGNALING AND MATRIX METALLOPROTEINASE GENE EXPRESSION.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The cross-species function of the pig C1 esterase inhibitor2006

Author(s)

Journal Title

Data Source

[Journal Article] A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression2006

Author(s)

Journal Title

Data Source

[Journal Article] Bisecting GlcNAc mediates the binding of annexin V to Hsp472005

Author(s)

Journal Title

Data Source

[Presentation] Lowered level of core fucosylation is a possible non-invasive predictive marker for chronic obstructive pulmonary disease (COPD)2013

Author(s)

Organizer

Place of Presentation

GAO CONGXIAO 高叢笑

KOU Sousyou 高叢笑

高叢笑コウソウショウ