TAKAKU Shizuka 高久静香

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高久静香タカクシズカ

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Researcher Number	50383013
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員 2005: 獨協医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 髄鞘形成 / 軸索変性・再生 / ミエリン形成 / リピドーム解析 / ドラッグリポジショニング / ミエリン構造 / 共培養 / シグナル伝達 / ドラッグ・リポジショニング / 抗がん剤 … More / 共培養系 / シュワン細胞 / ニューロン / 末梢神経障害 … More Except Principal Investigator 免疫 / シグナル伝達 / 神経科学 / 脂質 / 糖鎖 Less

Pathogenesis-based therapeutic approaches to chemotherapy-induced peripheral neuropathyPrincipal Investigator
- Principal Investigator
  
  TAKAKU Shizuka
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
1次感覚ニューロンにおけるb系列ガングリオシドの機能的役割
- Principal Investigator
  
  結城伸泰
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Dokkyo Medical University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy2023
- Author(s)
  Yako Hideji、Niimi Naoko、Takaku Shizuka、Sango Kazunori
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 14 Pages: 1208441-1208441
- DOI
  10.3389/fendo.2023.1208441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07027
[Journal Article] Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies2022
- Author(s)
  Sango Kazunori、Takaku Shizuka、Tsukamoto Masami、Niimi Naoko、Yako Hideji
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 950623-950623
- DOI
  10.3389/fcell.2022.950623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-20K07773
[Journal Article] RAGE activation in macrophages and development of experimental diabetic polyneuropathy2022
- Author(s)
  Osonoi Sho、Mizukami Hiroki、Takeuchi Yuki、Sugawa Hikari、Ogasawara Saori、Takaku Shizuka、Sasaki Takanori、Kudoh Kazuhiro、Ito Koichi、Sango Kazunori、Nagai Ryoji、Yamamoto Yasuhiko、Daimon Makoto、Yamamoto Hiroshi、Yagihashi Soroku
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 23
- DOI
  10.1172/jci.insight.160555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-20K07773
[Journal Article] Pretreatment with Zonisamide Mitigates Oxaliplatin-Induced Toxicity in Rat DRG Neurons and DRG Neuron-Schwann Cell Co-Cultures2022
- Author(s)
  Takaku Shizuka、Sango Kazunori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 9983-9983
- DOI
  10.3390/ijms23179983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-20K07773
[Journal Article] Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro2021
- Author(s)
  Takaku Shizuka、Tsukamoto Masami、Niimi Naoko、Yako Hideji、Sango Kazunori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 2971-2971
- DOI
  10.3390/ijms22062971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-20K16127, KAKENHI-PROJECT-20K07027
[Journal Article] Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems2021
- Author(s)
  Niimi Naoko、Yako Hideji、Takaku Shizuka、Chung Sookja K.、Sango Kazunori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 3 Pages: 1031-1031
- DOI
  10.3390/ijms22031031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-20K16127, KAKENHI-PROJECT-20K07027
[Journal Article] Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions2021
- Author(s)
  Yako Hideji、Niimi Naoko、Kato Ayako、Takaku Shizuka、Tatsumi Yasuaki、Nishito Yasumasa、Kato Koichi、Sango Kazunori
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 18910-18910
- DOI
  10.1038/s41598-021-98082-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16127, KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-20K07773, KAKENHI-PROJECT-21K06718
[Journal Article] Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway2020
- Author(s)
  Mizukami Hiroki、Osonoi Sho、Takaku Shizuka、Yamagishi Shin-Ichiro、Ogasawara Saori、Sango Kazunori、Chung Sookja、Yagihashi Soroku
- Journal Title
  
  Brain Communications
  
  Volume: 2 Issue: 2 Pages: 1-18
- DOI
  10.1093/braincomms/fcaa168
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-20K07773
[Presentation] 高ガラクトース環境におけるシュワン細胞株IMS32の細胞障害メカニズムの解析2023
- Author(s)
  八子英司, 新見直子, 高久静香, 三五一憲
- Organizer
  第32回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] LPAによるシュワン細胞脱分化・脱髄様病変誘導は、新規LPA1受容体阻害剤により抑制される2023
- Author(s)
  高久静香, 松本倖政, 西川顕治, 阿賀康弘, 三五一憲
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] ガラクトース負荷で誘導されるシュワン細胞障害機序とAR阻害薬Ranirestat,Epalrestatの効果の検証2023
- Author(s)
  八子英司, 新見直子, 高久静香, 三五一憲
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Efficacy of Pyruvate and Benfotiamine against Mouse and Cell Culture Models of Diabetic Neuropathy2023
- Author(s)
  Kazunori Sango, Hideji Yako, Mari Suzuki, Naoko Niimi, Shizuka Takaku
- Organizer
  Neurodiab 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 株化DRGニューロンND7/23と株化シュワン細胞IFRS1共培養系によるミエリン形成誘2023
- Author(s)
  高久静香, 三五一憲
- Organizer
  第6回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] CO-CULTURE OF LINED DORSAL ROOT GANGLION NEURONS AND SCHWANN CELLS AS A USEFUL TOOL FOR THE STUDY OF DIABETIC NEUROPATHY2023
- Author(s)
  Shizuka Takaku, Kazunori Sango
- Organizer
  Neurodiab 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] ガラクトース負荷によるIMS32シュワン細胞の代謝異常と細胞障害メカニズムの解析2023
- Author(s)
  八子英司, 新見直子, 高久静香, 三五一憲
- Organizer
  第38回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Zonisamide alleviates oxaliplatin-induced DRG neuron death in vitro2022
- Author(s)
  三五一憲, 高久静香
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 末梢神経病変に対するゾニサミドやエクセナチドの有用性2022
- Author(s)
  高久静香, 三五一憲
- Organizer
  第95回日本生化学会大会シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Myelinating co-culture system with immortalized dorsal root ganglion neurons and Schwann cells as a beneficial tool for the study of peripheral sensory neuropathies.2022
- Author(s)
  Sango K, Takaku S
- Organizer
  第99回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] オキサリプラチンの末梢神経系細胞毒性に対するゾニサミドの緩和効果.2022
- Author(s)
  高久静香, 三五一憲
- Organizer
  第6回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Pyruvate starvation under hyperglycemic environments induces rapid neuronal and Schwann cell death.2021
- Author(s)
  Sango K, Yako H, Niimi N, Kato A, Takaku S, Kato K
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] オキサリプラチン誘発末梢神経障害に対するゾニサミドの緩和効果－初代培養および株化DRGニューロンを用いた作用機序の検討－2021
- Author(s)
  高久静香, 三五一憲
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 株化後根神経節ニューロンND7/23と株化シュワン細胞IFRS1の共培養系による髄鞘形成誘導の試み2021
- Author(s)
  三五一憲, 高久静香
- Organizer
  第94回日本生化学会大会,
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Zonisamide pre-treatment alleviates oxaliplatin-induced dorsal root ganglion neuron death in vitro.2021
- Author(s)
  Sango K, Takaku S
- Organizer
  50th Annual Meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 高グルコース・外因性ピルビン酸環境下で誘導されるシュワン細胞死と解糖系-TCA回路フラックス減少におけるPARP の関与2021
- Author(s)
  八子英司, 新見直子, 加藤文子, 高久静香, 加藤宏一,三五一憲
- Organizer
  第36回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 高グルコース・外因性ピルビン酸欠乏環境下での解糖系変動に対するHIF1aと2-オキソグルタル酸の検証2021
- Author(s)
  八子英司, 加藤文子，新見直子, 高久静香, 加藤宏一, 三五一憲
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] ニューロンとシュワン細胞の相互作用に着目した、ニューロパチーの病態解明へのアプローチ2021
- Author(s)
  三五一憲, 八子英司, 高久静香, 新見直子
- Organizer
  第40回鎮静薬・オピオイドペプチドシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Significance of exogenous pyruvate in cells under exposure to high glucose conditions.2021
- Author(s)
  Sango K, Yako H, Niimi N, Kato A, Takaku S, Kato K
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] GLP-1受容体作動薬exendin-4はIFRS1シュワン細胞の生存・遊走・髄鞘化を促進する2021
- Author(s)
  三五一憲, 高久静香, 塚本雅美, 新見直子, 八子英司
- Organizer
  第32回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Stimulating effects of exendin-4 on AKT phosphorylation, proliferation, migration, and myelination of Schwann cells2021
- Author(s)
  Sango K, Takaku S, Tsukamoto M, Niimi N, Yako H
- Organizer
  Neurodiab
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] Role of pyruvate in maintaining Schwann cell viability and energy production under high glucose conditions2021
- Author(s)
  Sango K, Yako H, Niimi N, Kato A, Takaku S, Kato K
- Organizer
  Peripheral Nerve Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] 抗がん剤オキサリプラチンで誘発された末梢神経障害に対するゾニサミドの保護作用─培養ニューロン・シュワン細胞を用いた解析─2020
- Author(s)
  高久静香, 三五一憲
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07027
[Presentation] オキサリプラチンの末梢神経障害に対するゾニサミドの保護作用─培養系を用いた検討─2020
- Author(s)
  三五一憲, 高久静香
- Organizer
  第31回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07027

1. 結城伸泰 (60285913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 小鷹昌明 (50322409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 船越慶 (50406188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三五一憲 (50291943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 30 results
5. 水上浩哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 八木橋操六

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 八子英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAKU Shizuka 高久 静香

高久 静香 タカク シズカ

Research Projects

Research Products

Co-Researchers

Pathogenesis-based therapeutic approaches to chemotherapy-induced peripheral neuropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

1次感覚ニューロンにおけるb系列ガングリオシドの機能的役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RAGE activation in macrophages and development of experimental diabetic polyneuropathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pretreatment with Zonisamide Mitigates Oxaliplatin-Induced Toxicity in Rat DRG Neurons and DRG Neuron-Schwann Cell Co-Cultures2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 高ガラクトース環境におけるシュワン細胞株IMS32の細胞障害メカニズムの解析2023

Author(s)

Organizer

Data Source

[Presentation] LPAによるシュワン細胞脱分化・脱髄様病変誘導は、新規LPA1受容体阻害剤により抑制される2023

Author(s)

Organizer

Data Source

[Presentation] ガラクトース負荷で誘導されるシュワン細胞障害機序とAR阻害薬Ranirestat,Epalrestatの効果の検証2023

Author(s)

Organizer

Data Source

[Presentation] Efficacy of Pyruvate and Benfotiamine against Mouse and Cell Culture Models of Diabetic Neuropathy2023

Author(s)

Organizer

Data Source

[Presentation] 株化DRGニューロンND7/23と株化シュワン細胞IFRS1共培養系によるミエリン形成誘2023

Author(s)

Organizer

Data Source

[Presentation] CO-CULTURE OF LINED DORSAL ROOT GANGLION NEURONS AND SCHWANN CELLS AS A USEFUL TOOL FOR THE STUDY OF DIABETIC NEUROPATHY2023

Author(s)

Organizer

TAKAKU Shizuka 高久静香

高久静香タカクシズカ