Yamamoto Takehiro 山本雄広

… Alternative Names

YAMAMOTO Takehiro 山本雄広

山本雄広ヤマモトタケヒロ

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Researcher Number	50383774
Other IDs	https://orcid.org/0000-0003-4974-9859
External Links
Affiliation (Current)	2024: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 2010 – 2013: 慶應義塾大学, 医学部, 助教 2007: Keio University, 医学部, 助教 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Living organism molecular science / Transformative Research Areas, Section (III) / Basic Section 43030:Functional biochemistry-related / Tumor biology and related fields / Functional biochemistry / Biological Sciences / Cell biology Except Principal Investigator Basic Section 43010:Molecular biology-related / Basic Section 59040:Nutrition science and health science-related / オミクス計測科学
Keywords	Principal Investigator 解糖系 / 翻訳後修飾 / メチル化 / 含硫アミノ酸 / 抗がん剤耐性 / アルギニンメチル化 / メチオニン代謝 / ミトコンドリア / 酸化ストレス / 中心炭素代謝 … More / ポリスルフィド / 化学治療抵抗性 / セリン合成経路 / 脂質代謝 / 脂肪酸合成 / セリン合成系 / 抗がん剤 / 細胞骨格 / 硫化水素 / 核移行 / PRMT1 / エネルギー代謝 / 含硫アミノ酸代謝 / Gfer / Drp1 / アポトーシス / ペントースリン酸回路 / 糖代謝 / 一酸化炭素 / HO-1 / CBS / メタボローム / 一酸化炭素(CO) … More Except Principal Investigator RNAプロセシング / 細胞内微細構造 / 翻訳制御 / mRNA / 卵母細胞 / ストレス / 代謝異常 / ERストレス / Nrf1 / 酸化ストレス / アミノ酸代謝 / Nrf1/2 / 代謝 / ポリアミン / 転写因子 / 老化 / エピジェネティクス / 質量分析イメージング / メタボロミクス Less

貧栄養性微小環境を勘案した悪性形質を支持する膵がん-間質間の硫黄代謝連携の理解Principal Investigator
- Principal Investigator
  
  山本雄広
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
セリン合成経路による悪性形質獲得のためのがん細胞代謝リプログラミング機構の解明Principal Investigator
- Principal Investigator
  
  山本雄広
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Keio University
Analysis of temporal and spatial control of mRNA translation that is mediated by subcellular structures and novel RNA processing
- Principal Investigator
  
  小谷友也
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Hokkaido University
Controlling the aging and metabolic process with anti-stress enzyme expression profiles through those controlling transcriptional factor, Nrf1
- Principal Investigator
  
  TSUJITA Tadayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saga University
Augmented glycolysis and its blanched pathway by microtubule-stabilizing reagent determine the chemosensitivity of breast cancer cell via the sulfur metabolism.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Takehiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Keio University
Nuclear-specific arginine methylation of glycolytic enzymes regulates energy metabolismPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takehiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
核－ミトコンドリア間コミュニケーションによる代謝相互作用の分子機構の解明Principal Investigator
- Principal Investigator
  
  山本雄広
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Analysis of epigenetic regulation by visualizing S-adenosylmethionine metabolism in cancer cells using imaging mass spectrometry.
- Principal Investigator
  
  Kubo Akiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  オミクス計測科学
- Research Institution
  Keio University
Modification of mitochondrial fission factor, DRP1 affects the biotransformation of glucose through sulfur-containing amino acid metabolism.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Takehiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Keio University
CO regulates directional biotransformation of glucose via protein arginine methylation.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Takehiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Keio University
CO-CBS系による細胞内メチレーション制御機構の分子基盤整備Principal Investigator
- Principal Investigator
  
  山本雄広
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Keio University

[Book] 酸化ストレスの医学2014
- Author(s)
  末松　誠、山本雄広、梶村眞弓
- Total Pages
  8
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PUBLICLY-26117726
[Book] 酸化ストレスの医学2014
- Author(s)
  末松　誠、山本雄広、梶村眞弓
- Total Pages
  8
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24510304
[Book] 酸化ストレスの医学「COとシグナル伝達」(印刷中)2008
- Author(s)
  山本雄広、高野直治、足立健、梶村真弓、末松誠
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-18770178
[Journal Article] Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide.2023
- Author(s)
  Nakamura T, Honda S, Ito S, Mizoguchi T, Yamamoto T, Kasahara M, Kabe Y, Matsuo K, and Suematsu M
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06072
[Journal Article] CO がもたらす代謝変動と翻訳後修飾～アルギニンメチル化によるがん細胞の代謝制御2022
- Author(s)
  山本雄広　吉岡佑士郎、山本有紗、末松誠
- Journal Title
  
  月刊細胞
  
  Volume: 54 Pages: 134-137
- Data Source
  KAKENHI-PROJECT-21K06072
[Journal Article] Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes.2021
- Author(s)
  Takei N, Sato K, Takada Y, Iyyappan R, Susor A, Yamamoto T, and Kotani T.
- Journal Title
  
  Current Research in Cell Biology
  
  Volume: 2 Pages: 100009-100009
- DOI
  10.1016/j.crcbio.2021.100009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21H02398
[Journal Article] On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity2021
- Author(s)
  Honda Kazufumi、Hishiki Takako、Yamamoto Sohe、Naito Yoshiko、Matsuura Tomomi、Iwaisako Keiko、Masui Toshihiko、Sakuma Tomohiro、Matsubara Osamu、Huang Wilber、Ida Tomoaki、Akaike Takaaki、Masugi Yohei、Sakamoto Michiie、Kato Tomoyasu、Kabe Yasuaki、Suematsu Makoto
- Journal Title
  
  Redox Biology
  
  Volume: 41 Pages: 101926-101926
- DOI
  10.1016/j.redox.2021.101926
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07306, KAKENHI-PROJECT-20K21496, KAKENHI-PROJECT-19H03856, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-20K08996, KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-21K06937
[Journal Article] Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target.2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Naito Y, Hishiki T, Mori M, Suematsu M, Shiomi K, Hashimoto T, Nozaki T
- Journal Title
  
  Int J Parasitol Drugs Drug Resist.
  
  Volume: 8 Issue: 1 Pages: 125-136
- DOI
  10.1016/j.ijpddr.2018.02.004
- NAID
  120007134287
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-17K19614
[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018
- Author(s)
  Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1561-1561
- DOI
  10.1038/s41467-018-03899-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Biochemical, metabolomic, and genetic analyses of dephospho coenzyme A kinase involved in coenzyme A biosynthesis in the human enteric parasite Entamoeba histolytica.2018
- Author(s)
  Nurkanto A, Jeelani G, Yamamoto T, Hishiki T, Naito Y, Suematsu M, Hashimoto T, Nozaki T
- Journal Title
  
  Frontiers in Microbiology, section Infectious Diseases
  
  Volume: 9 Pages: 2902-2902
- DOI
  10.3389/fmicb.2018.02902
- NAID
  120007128082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K01937
[Journal Article] Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching2017
- Author(s)
  Miyazawa, H., Yamaguchi, Y., Sugiura, Y., Honda, K., Kondo, K., Matsuda, F., Yamamoto, T., Suematsu, M., and Miura, M
- Journal Title
  
  Development
  
  Volume: 144 Issue: 1 Pages: 63-73
- DOI
  10.1242/dev.138545
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-16H06385
[Journal Article] メチオニン代謝　-がん細胞における制御機構とその役割2017
- Author(s)
  山本雄広、伊藤真衣、大津　陽、末松　誠
- Journal Title
  
  実験医学増刊号
  
  Volume: 35 Pages: 52-59
- Data Source
  KAKENHI-PROJECT-15H04355
[Journal Article] メチオニン代謝に起因するメチル化修飾を介した、がん細胞のエネルギー代謝制御機構2016
- Author(s)
  山本雄広、末松　誠
- Journal Title
  
  生化学
  
  Volume: 88 Pages: 397-401
- Data Source
  KAKENHI-PROJECT-15H04355
[Journal Article] ガスシグナルを介した翻訳後修飾によるがん細胞の代謝制御2016
- Author(s)
  山本雄広、末松　誠
- Journal Title
  
  The LUNG
  
  Volume: 24 Pages: 80-86
- Data Source
  KAKENHI-PROJECT-15H04355
[Journal Article] Cystathionine beta-synthase and PGRMC1 as CO sensors.2016
- Author(s)
  Kabe Y, Yamamoto T, Kajimura M, Sugiura Y, Koike I, Ohmura M, Nakamura T, Tokumoto Y, Tsugawa H, Handa H, Kobayashi T, and Suematsu M.
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 99 Pages: 333-344
- DOI
  10.1016/j.freeradbiomed.2016.08.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-26560469, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-16K07066
[Journal Article] CO-CBS-H2 S Axis: From Vascular Mediator to Cancer Regulator.2016
- Author(s)
  Suematsu M, Nakamura T, Tokumoto Y, Yamamoto T, Kajimura M, Kabe Y.
- Journal Title
  
  Microcirculation
  
  Volume: 23 Pages: 183-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04355
[Journal Article] CO-CBS-H2 S Axis: From Vascular Mediator to Cancer Regulator.2016
- Author(s)
  Suematsu M, Nakamura T, Tokumoto Y, Yamamoto T, Kajimura M, Kabe Y.
- Journal Title
  
  Microcirculation
  
  Volume: 23 Issue: 3 Pages: 183-190
- DOI
  10.1111/micc.12253
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07011, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-26670673, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-16K07066
[Journal Article] nnate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity.2015
- Author(s)
  Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M.
- Journal Title
  
  J Immunol
  
  Volume: 195 Issue: 4 Pages: 1883-1890
- DOI
  10.4049/jimmunol.1402103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-23249030, KAKENHI-PROJECT-25250012, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-25430139
[Journal Article] メチオニン代謝の変動ががんの代謝を決める~アルギニンメチル化修飾によるがん細胞の糖代謝制御2014
- Author(s)
  山本雄広、高野直治、石渡恭子、末松　誠
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 78-85
- Data Source
  KAKENHI-PUBLICLY-26117726
[Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.2014
- Author(s)
  Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H and Suematsu M
- Journal Title
  
  Nitric Oxide
  
  Volume: pii: S1089-8603 Pages: 495-499
- DOI
  10.1016/j.niox.2014.11.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-25870717, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-25513008
[Journal Article] メチオニン代謝の変動ががんの代謝を決める~アルギニンメチル化修飾によるがん細胞の糖代謝制御2014
- Author(s)
  山本雄広、高野直治、石渡恭子、末松　誠
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 78-85
- Data Source
  KAKENHI-PROJECT-24510304
[Journal Article] Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.2014
- Author(s)
  Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, Takako Hishiki, and Makoto Suematsu.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 3480-3480
- DOI
  10.1038/ncomms4480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo.2013
- Author(s)
  Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 11 Issue: 9 Pages: 973-985
- DOI
  10.1158/1541-7786.mcr-12-0669-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310136, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Carbon monoxide : Impact on remethylation and transsulfuration metabolism and its pathophysiologic implications2012
- Author(s)
  Hishiki T, Yamamoto T, Morikawa T, Kubo A, Kajimura M and Suematsu M.
- Journal Title
  
  Journal of molecular medicine
  
  Volume: Vol.90, No.3 Pages: 245-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012
- Author(s)
  Mayumi Tamada, et al
- Journal Title
  
  Cancer Research
  
  Volume: 72 Issue: 6 Pages: 1438-1448
- DOI
  10.1158/0008-5472.can-11-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J55543, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-22710222, KAKENHI-PROJECT-23790376
[Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.2012
- Author(s)
  Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M, and Saya H.
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 1438-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510304
[Journal Article] ガス分子による代謝システム制御機構の系統的探索と医学応用2012
- Author(s)
  末松誠、山本雄広、菱木貴子、加部泰明、梶村眞弓
- Journal Title
  
  実験医学
  
  Volume: Vol.30 No.2(増刊) Pages: 90-97
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012
- Author(s)
  Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M, and Saya H
- Journal Title
  
  Cancer Research
  
  Volume: Vol.72 Pages: 1438-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] ガス分子による代謝システム制御機構の系統的探索と医学応用2012
- Author(s)
  末松誠、山本雄広、菱木貴子、加部泰明、梶村眞弓
- Journal Title
  
  実験医学(増刊)
  
  Volume: 30 Pages: 90-97
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Carbon monoxide : Impact on remethylation and transsulfuration metabolism and its pathophysiologic implications2012
- Author(s)
  Hishiki T, Yamamoto T, Morikawa T, Kubo A, Kajimura M, Suematsu M
- Journal Title
  
  Journal of molecular medicine
  
  Volume: 90 Issue: 3 Pages: 245-254
- DOI
  10.1007/s00109-012-0875-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222, KAKENHI-PROJECT-24510304
[Journal Article] Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase.2011
- Author(s)
  Yamamoto T, et al.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 48 Pages: 96-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] ガス分子を介した代謝システム制御機構:酸素とグルコースが紡ぐ複雑系2011
- Author(s)
  末松誠、菱木貴子、久保亜紀子、大村光代、梶村眞弓、加部泰明、高野直治、山本雄広
- Journal Title
  
  細胞工学
  
  Volume: Vol.30, No.1 Pages: 10-19
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase2011
- Author(s)
  Yamamoto T, Takano N, Ishiwata K, and Suematsu M
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: Vol.48 Pages: 96-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Interactions of Multiple Gas-Transducing Systems : Hallmarks and Uncertainties of CO, NO, and H_2S Gas Biology2010
- Author(s)
  Kajimura M, Fukuda R, Bateman RM, Yamamoto T, and Suematsu M
- Journal Title
  
  Antioxidants & Redox Signaling
  
  Volume: Vol.13, No.2 Pages: 157-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Assessing a shift of glucose biotransformation by LC-MS/MS-based metabolome analysis in carbon monoxide-exposed cells2010
- Author(s)
  Takano N, Yamamoto T, Adachi T, and Suematsu M
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: Vol.662 Pages: 101-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Assessing a shift of glucose biotransformation by LC-MS/MS-based metabolome analysis in carbon monoxide-exposed cells.2010
- Author(s)
  Takano N, Yamamoto T, et al.
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 662 Pages: 101-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine .BETA.-synthase2010
- Author(s)
  Yamamoto T, Takano N, Ishiwata K, Suematsu M
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 48 Issue: 1 Pages: 96-100
- DOI
  10.3164/jcbn.11-011FR
- NAID
  130004879240
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710222
[Journal Article] Myeloperoxidase is a key regulator of oxidative stress-mediated apoptosis in myeloid leukemic cells.2007
- Author(s)
  Nakazato, T, Sagawa, M., Yamato, K., Xian, M., Yamamoto. T.Suema tsu M., Ikeda, Y. and Kizaki, M.
- Journal Title
  
  Clinical Cancer Research 13
  
  Pages: 5436-5445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770178
[Journal Article] Gaseous neuromodulator-related genes expressed in the brain of honeybee Apis mellifera.2007
- Author(s)
  Watanabe, T., Kikuchi, M., Hatakeyama, D., Shiga, T., Yamamoto T., Aonuma, H., Takahata, M., Suzuki, N., Ito, E.
- Journal Title
  
  Developmental Neurobiology 67
  
  Pages: 456-473
- Data Source
  KAKENHI-PROJECT-18770178
[Journal Article] Gaseous neuromodulator-related genes expressed in the brain of honeybee Apis mellifera.2007
- Author(s)
  Watanabe, T, Kikuchi, M., Hatakeyma, D., Shiga, T, Yamamoto, T., A onuma, H., Takahata, M., Suzuki, N.and Ito, E.
- Journal Title
  
  Developmental Neurobiology 67
  
  Pages: 456-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18770178
[Journal Article] メタボローム解析技術による新しい代謝制卸機構の系統的探索 : ガスバイオロジーの推進と医学への応用2006
- Author(s)
  末松誠, 菱木貴子, 岩渕拓也, 山本雄広, 行武良哲, 塚田孝祐
- Journal Title
  
  細胞工学 25・12
  
  Pages: 1427-1431
- Data Source
  KAKENHI-PROJECT-18770178
[Patent] MALDI 用試料調製方法及び試料調製装置2015
- Inventor(s)
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Holder
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-510153
- Filing Date
  2015-10-02
- Overseas
- Data Source
  KAKENHI-PROJECT-25513008
[Patent] MALDI 用試料調製方法及び試料調製装置2014
- Inventor(s)
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Holder
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-04
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] マウス初期発生における新規の母性mRNA転写後制御機構2022
- Author(s)
  高田裕貴, 山本雄広, 小谷友也
- Organizer
  日本発生生物学会第55回金沢大会
- Data Source
  KAKENHI-PROJECT-21H02398
[Presentation] 含硫化合物が支持するがん細胞の代謝特性獲得機構2022
- Author(s)
  山本雄広
- Organizer
  第94 回日本生化学会年大会
- Data Source
  KAKENHI-PROJECT-21K06072
[Presentation] マウス卵母細胞におけるTdrd3を介したEmi2 mRNAの時期特異的な翻訳制御2021
- Author(s)
  武井夏海, 佐藤圭祐, 高田裕貴, Iyyappan Rajan, Susor Andrej, 山本雄広, 小谷友也
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02398
[Presentation] マウス卵形成および胚発生における母性mRNAの3’非翻訳領域の短縮を介した新規翻訳制御機構2021
- Author(s)
  高田裕貴, 山本雄広, 小谷友也
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02398
[Presentation] マウス卵母細胞における顆粒形成と消失を介したEmi2 mRNAの翻訳抑制機構：RNA結合タンパク質の違いによる翻訳時期の制御2019
- Author(s)
  武井夏海、山本雄広、小谷友也
- Organizer
  第42回日本分子生物学会年大会
- Data Source
  KAKENHI-PROJECT-17K19614
[Presentation] アルギニンメチル化が制御するがん細胞のエネルギー代謝2019
- Author(s)
  山本雄広
- Organizer
  第92回日本生化学会年大会
- Data Source
  KAKENHI-PROJECT-17K19614
[Presentation] 極小発光タグHiBiTシステムを用いた中心代謝酵素の局在移行能アッセイ系の構築2019
- Author(s)
  山本雄広、折田巧、伊藤真衣、末松誠
- Organizer
  第42回日本分子生物学会年大会
- Data Source
  KAKENHI-PROJECT-17K19614
[Presentation] 翻訳後修飾を介した解糖系酵素PKM2の核移行メカニズムの解析2017
- Author(s)
  山本雄広、伊藤真衣、高野直治、石渡恭子、倉堀智一、末松　誠
- Organizer
  生命科学系合同学会ConBio2017
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] メチオニン代謝に起因するがん細胞の糖代謝制御機構2016
- Author(s)
  山本雄広
- Organizer
  第３２回臨床フリーラジカル会議
- Place of Presentation
  京都・けぶり河（京都府亀岡市）
- Year and Date
  2016-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] アルギニンメチル化酵素PRMT1の核移行メカニズムの解明2016
- Author(s)
  山本雄広、伊藤真衣、大津陽、長坂美咲、石渡恭子、高野直治、末松　誠
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] メチオニン代謝に起因するがん細胞の糖代謝制御機構2016
- Author(s)
  山本雄広
- Organizer
  第３２回臨床フリーラジカル会議
- Place of Presentation
  京都・けぶり河（京都府亀岡市）
- Year and Date
  2016-01-29
- Invited
- Data Source
  KAKENHI-PUBLICLY-26117726
[Presentation] アルギニンメチル化酵素PRMT1の細胞内局在機構の解明2016
- Author(s)
  山本雄広、伊藤真衣、大津陽、石渡恭子、高野直治、末松　誠
- Organizer
  第89回日本生化学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] アルギニンメチル化を介したがん細胞のエネルギー代謝制御機構2015
- Author(s)
  山本雄広
- Organizer
  東北大学医学部酸素医学コアセンター特別セミナー
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] アルギニンメチル化を介したマクロファージの解糖系制御機構の解明2015
- Author(s)
  山本雄広、伊藤真衣、石渡恭子、高野直治、内藤善子、菱木貴子、末松　誠
- Organizer
  BMB2015
- Place of Presentation
  ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-26117726
[Presentation] Carbon monoxide regulates directional biotransformation of glucose via protein arginine methylation2015
- Author(s)
  Yamamoto T, Takano N, Ishiwata K, Suematsu M
- Organizer
  10th World Congress for Microcirculation
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-09-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] アルギニンメチル化を介したマクロファージの解糖系制御機構の解明2015
- Author(s)
  山本雄広、伊藤真衣、石渡恭子、高野直治、内藤善子、菱木貴子、末松　誠
- Organizer
  BMB2015
- Place of Presentation
  ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] メチオニン代謝に起因するがん細胞の解糖系の制御機構2015
- Author(s)
  山本雄広、高野直治、石渡恭子、伊藤真衣、末松誠
- Organizer
  第３回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H04355
[Presentation] 担がん組織切片における過硫化グルタチオン蓄積の質量イメージングによる評価2015
- Author(s)
  久保亜紀子・大村光代・中西　豪・菱木貴子・山本雄広・末松　誠
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場　エポカルつくば（茨城県つくば市）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] Metabolic crosstalk between organelles during macrophage polarization2015
- Author(s)
  Yamamoto T, Itoh M, Ishiwata K, Takano N, Suematsu M
- Organizer
  第4回マトリョーシカ型生物学研究会
- Place of Presentation
  筑波大学（茨城県つくば市）
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26117726
[Presentation] 解糖系酵素PFKFB3のメチル化修飾によるがん細胞の糖代謝制御2014
- Author(s)
  山本雄広、高野直治、石渡恭子、大村光代、長畑善子、松浦友美、久保亜希子、菱木貴子、末松誠
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] アルギニンメチル化修飾が制御するがん細胞の代謝2014
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-26117726
[Presentation] アルギニンメチル化修飾が制御するがん細胞の代謝2014
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] 解糖系酵素PFKFB3のメチル化修飾によるがん細胞の糖代謝制御2014
- Author(s)
  山本雄広、高野直治、石渡恭子、大村光代、長畑善子、松浦友美、久保亜希子、菱木貴子、末松誠
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PUBLICLY-26117726
[Presentation] 解糖系酵素PFKFB3のメチル化制御はがん細胞の酸化ストレス耐性獲得に重要である2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松　誠
- Organizer
  第86回　日本生化学会本大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] アルギニンメチル化酵素PRMT1の細胞内局在を反映した糖代謝酵素の核内メチル化機構2013
- Author(s)
  山本雄広、石渡恭子、高野直治、大村光代、菱木貴子、長畑善子、末松　誠
- Organizer
  第36回　日本分子生物学会本大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] Carbon monoxide regulates directional biotransformation of glucose via protein arginine methylation2012
- Author(s)
  Takehiro Yamamoto, Kyoko Ishiwata, Naoharu Takano, Makoto Suematsu
- Organizer
  第33回　内藤コンファレンス酸素生物学：酸素濃度に対する生物応答とその制御破綻による疾患」
- Place of Presentation
  ガトーキングダム、札幌市
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] 一酸化炭素（CO）を介したアルギニンメチル化制御による糖代謝リモデリング機構の解明2012
- Author(s)
  山本雄広、石渡恭子、高野直治、菱木貴子、長畑善子、末松　誠
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡国際会議場、福岡市
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] 一酸化炭素(CO)による糖代謝リモデリング機構の解析2011
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第11回日本NO学会
- Place of Presentation
  町田市、東京
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] 一酸化炭素(CO)を介したアルギニンメチル化による糖代謝リモデリング機構の解析2011
- Author(s)
  山本雄広、高野直治、石渡恭子、菱木貴子、長畑善子、末松誠
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] 一酸化炭素(CO)を介したアルギニンメチル化による糖代謝リモデリング機構の解析2011
- Author(s)
  山本雄広、高野直治、石渡恭子、菱木貴子、長畑善子、末松誠
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] 一酸化炭素(CO)による糖代謝リモデリング機構の解析2011
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第11回日本NO学会
- Place of Presentation
  昭和薬科大学(東京都)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] 一酸化炭素(CO)による糖代謝リモデリング機構の解析2010
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第83回日本生化学会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] 一酸化炭素(CO)による糖代謝リモデリング機構の解析2010
- Author(s)
  山本雄広、高野直治、石渡恭子、末松誠
- Organizer
  第83回日本生化学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22710222
[Presentation] CO regulates the glucose metabolism via protein methylation.2008
- Author(s)
  Yamamoto, T., Takano, N., Iwabuchi, T., Hishiki, T., Adachi, T., Suematsu, M.
- Organizer
  第33回日本微小循環学会
- Place of Presentation
  東京
- Year and Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-18770178
[Presentation] 一酸化炭素(CO)による細胞内メチル化制御機構の解析2007
- Author(s)
  山本雄広, 高野直治, 菱木貴子, 足立健, 末松誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18770178
[Presentation] Role of stress-inducible CO in regulation of protein methylation and metabolism2007
- Author(s)
  Yamamoto T, Takano N, Iwabuchi T, Adachi T, Suematsu M.
- Organizer
  Nobel Forum Symposium for Global COE Program "Gas biology in medicine"
- Place of Presentation
  ストックホルム
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-18770178
[Presentation] ミトコンドリアの形態変化による細胞内エネルギー代謝調節機構の解明
- Author(s)
  山本雄広
- Organizer
  第3回マトリョーシカ型生物学研究会
- Place of Presentation
  神戸市
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PROJECT-24510304
[Presentation] ミトコンドリアの形態変化による細胞内エネルギー代謝調節機構の解明
- Author(s)
  山本雄広
- Organizer
  第3回マトリョーシカ型生物学研究会
- Place of Presentation
  神戸市
- Year and Date
  2014-07-11 – 2014-07-13
- Data Source
  KAKENHI-PUBLICLY-26117726

1. Kubo Akiko (50455573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. TSUJITA Tadayuki (20622046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 水沼正樹 (10343295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小谷友也 (70419852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. GODA Nobuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. YAMAGUCHI Yoshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐谷秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 菱木貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 南嶋洋司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Takehiro 山本 雄広

YAMAMOTO Takehiro 山本 雄広

山本 雄広 ヤマモト タケヒロ

Research Projects

Research Products

Co-Researchers

貧栄養性微小環境を勘案した悪性形質を支持する膵がん-間質間の硫黄代謝連携の理解Principal Investigator

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セリン合成経路による悪性形質獲得のためのがん細胞代謝リプログラミング機構の解明Principal Investigator

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Analysis of temporal and spatial control of mRNA translation that is mediated by subcellular structures and novel RNA processing

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Controlling the aging and metabolic process with anti-stress enzyme expression profiles through those controlling transcriptional factor, Nrf1

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Augmented glycolysis and its blanched pathway by microtubule-stabilizing reagent determine the chemosensitivity of breast cancer cell via the sulfur metabolism.Principal Investigator

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Nuclear-specific arginine methylation of glycolytic enzymes regulates energy metabolismPrincipal Investigator

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核－ミトコンドリア間コミュニケーションによる代謝相互作用の分子機構の解明Principal Investigator

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Analysis of epigenetic regulation by visualizing S-adenosylmethionine metabolism in cancer cells using imaging mass spectrometry.

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Modification of mitochondrial fission factor, DRP1 affects the biotransformation of glucose through sulfur-containing amino acid metabolism.Principal Investigator

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CO regulates directional biotransformation of glucose via protein arginine methylation.Principal Investigator

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CO-CBS系による細胞内メチレーション制御機構の分子基盤整備Principal Investigator

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[Book] 酸化ストレスの医学2014

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[Book] 酸化ストレスの医学2014

Author(s)

Total Pages

Yamamoto Takehiro 山本雄広

YAMAMOTO Takehiro 山本雄広

山本雄広ヤマモトタケヒロ

[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018

[Journal Article] メチオニン代謝　-がん細胞における制御機構とその役割2017