IWATA Hisataka 岩田尚孝

Researcher Number	50385499
Other IDs
Affiliation (Current)	2025: 東京農業大学, 農学部, 教授
Affiliation (based on the past Project Information) *help	2025: 東京農業大学, 農学部, 教授 2013 – 2023: 東京農業大学, 農学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 42010:Animal production science-related / Animal production science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields Except Principal Investigator Integrative animal science
Keywords	Principal Investigator ミトコンドリア / 卵子 / 加齢 / テロメア長 / 胚 / 胚発生 / 顆粒層細胞 / 卵胞液 / 細胞外小胞 / DNAの脱メチル化 … More / 父親 / 細胞外核酸 / 多糖類 / Hippoシグナル / 多糖軟質ゲル / Hippo　signaling / Focal Adhesion / 卵子発育 / 胚盤胞 / アクチン重合 / 体外発育卵子 / 体外受精 / 培養基質 / 多糖ゲル / エピゲネティクス / 凍結 / ゲノム変異 / 細胞外DNA / ゲノムの変異 / 肥満 / オートファージ / 初期胞状卵胞卵子 / 発生 / SIRT1 … More Except Principal Investigator 受精卵 / One-carbon metabolism / ウシ / 着床前胚 / 初期胚 / ニュートリエピジェネティクス / エピジェネティクス / 老化 / 免疫 / 炎症 / 子宮 / 卵管 / 妊娠 / 加齢 Less

Factors in follicular fluid reducing epigenetic abnormalities in in vitro developed embryos.Principal Investigator
- Principal Investigator
  
  岩田尚孝
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Agriculture
Effect of increased paternal age on mitochondria of embryosPrincipal Investigator
- Principal Investigator
  
  岩田尚孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Agriculture
Development of polysaccharide gel culture system of in vitro embryo culture system.Principal Investigator
- Principal Investigator
  
  Iwata Hisataka
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Tokyo University of Agriculture
Age associated mitochondrial changes in oocytesPrincipal Investigator
- Principal Investigator
  
  IWATA Hisataka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Tokyo University of Agriculture
Molecular mechanism of pregnancy failure with aging: possible role of inflammasome
- Principal Investigator
  
  SHIRASUNA Koumei
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Tokyo University of Agriculture
Nutriepigenetics in mammalian preimplantation embryos
- Principal Investigator
  
  Ikeda Shuntaro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Kyoto University
Possible countermeasures against age-associated deteriorations of bovine oocytesPrincipal Investigator
- Principal Investigator
  
  IWATA Hisataka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Tokyo University of Agriculture

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Effect of paternal aging and vitrification on mitochondrial DNA copy number and telomere length of mouse blastocysts2024
- Author(s)
  Aburada N, Ito J, Inoue Y, Yamamoto T, Hayashi M, Teramoto N, Okada Y, Koshiishi Y, Shirasuna K, Iwata H.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 70 Issue: 2 Pages: 65-71
- DOI
  10.1262/jrd.2023-079
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05959
[Journal Article] Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos2023
- Author(s)
  Ito J, Kageyama M, Hara S, Sato T, Shirasuna K, Iwata H.
- Journal Title
  
  Mitochondrion
  
  Volume: 68 Pages: 105-113
- DOI
  10.1016/j.mito.2022.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05959
[Journal Article] Effects of a gel culture system made of polysaccharides (xanthan gum and locust bean gum) on in vitro bovine oocyte development and gene expression of the granulosa cells.2021
- Author(s)
  Sugimoto A, Inoue Y, Tanaka K, Sinozawa A, Shirasuna K, Iwata H.
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 88 Issue: 7 Pages: 516-524
- DOI
  10.1002/mrd.23518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22372
[Journal Article] Xanthan gum and locust bean gum substrate improves bovine embryo development.2020
- Author(s)
  Hara S, Aoki S, Nagata M, Shirasuna K, Noguchi T, Iwata H.
- Journal Title
  
  Reprod Domest Anim.
  
  Volume: 55 Issue: 9 Pages: 1124-1131
- DOI
  10.1111/rda.13750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22372
[Journal Article] Cell-free DNA in medium is associated with the maturation ability of <i>in vitro</i> cultured oocytes2019
- Author(s)
  MUNAKATA Yasuhisa、SHIRASUNA Koumei、KUWAYAMA Takehito、IWATA Hisataka
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 65 Issue: 2 Pages: 171-175
- DOI
  10.1262/jrd.2018-123
- NAID
  130007630933
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J12261, KAKENHI-PROJECT-16K07996
[Journal Article] Xanthan gum and Locust bean gum gel supports <i>in vitro</i> development of porcine oocytes derived from early antral follicles2019
- Author(s)
  Yasuhisa Munakata, Ayaka Sugimoto, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 65 Issue: 6 Pages: 551-554
- DOI
  10.1262/jrd.2019-074
- NAID
  130007768754
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22372
[Journal Article] Addition of granulosa cells collected from differential follicle stages supports development of oocytes derived from porcine early antral follicles.2018
- Author(s)
  Ishiguro A, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Reprod Med Biol.
  
  Volume: 18 Issue: 1 Pages: 65-71
- DOI
  10.1002/rmb2.12248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] Follicular factors determining granulosa cell number and developmental competence of porcine oocytes2018
- Author(s)
  Munakata Yasuhisa、Ueda Manami、Kawahara-Miki Ryoka、Kansaku Kazuki、Itami Nobuhiko、Shirasuna Koumei、Kuwayama Takehito、Iwata Hisataka
- Journal Title
  
  Journal of Assisted Reproduction and Genetics
  
  Volume: 35 Issue: 10 Pages: 1809-1819
- DOI
  10.1007/s10815-018-1247-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18J12261, KAKENHI-PROJECT-16K07996
[Journal Article] Age-related changes in the bovine corpus luteum function and progesterone secretion2018
- Author(s)
  Hori Konomi、Matsuyama Shuichi、Nakamura Sho、Iwata Hisataka、Kuwayama Takehito、Miyamoto Akio、Shirasuna Koumei
- Journal Title
  
  Reproduction in Domestic Animals
  
  Volume: 54 Issue: 1 Pages: 23-30
- DOI
  10.1111/rda.13303
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21172, KAKENHI-PROJECT-15K07783
[Journal Article] Short-term heat stress induces mitochondrial degradation and biogenesis and enhances mitochondrial quality in porcine oocytes2018
- Author(s)
  Itami N, Shirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Journal of Thermal Biology
  
  Volume: 74 Pages: 256-263
- DOI
  10.1016/j.jtherbio.2018.04.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J07329, KAKENHI-PROJECT-16K07996
[Journal Article] Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells2018
- Author(s)
  Seno K, Tanikawa N, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  Am J Reprod Immunol
  
  Volume: 79 Issue: 6
- DOI
  10.1111/aji.12826
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-16K11103, KAKENHI-PROJECT-26462498
[Journal Article] Mitochondrial dysfunction in cumulus-oocyte complexes increases cell-free mitochondrial DNA2018
- Author(s)
  Kansaku K, Munakata Y, Itami N, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 64 Issue: 3 Pages: 261-266
- DOI
  10.1262/jrd.2018-012
- NAID
  130007409988
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07996, KAKENHI-PROJECT-16J07329, KAKENHI-PROJECT-18J12261
[Journal Article] Non-esterified fatty acid-associated ability of follicular fluid to support porcine oocyte maturation and development.2018
- Author(s)
  Ogawa K, Itami N, Ueda M, Kansaku K, Shirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 17 Issue: 2 Pages: 155-163
- DOI
  10.1002/rmb2.12084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07996, KAKENHI-PROJECT-16J07329
[Journal Article] Resveratrol enhances the clearance of mitochondrial damage by vitrification and improves the development of vitrified-warmed bovine embryos.2018
- Author(s)
  Hara T, Kin A, Aoki S, Nakamura S, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 10 Pages: e0204571-e0204571
- DOI
  10.1371/journal.pone.0204571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes2018
- Author(s)
  Itami N, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 97 Issue: 5 Pages: 644-653
- DOI
  10.1093/biolre/ioy023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07996, KAKENHI-PROJECT-16J07329
[Journal Article] Maternal aging affects oocyte resilience to carbonyl cyanide-m-chlorophenylhydrazone -induced mitochondrial dysfunction in cows.2017
- Author(s)
  Kansaku K, Takeo S, Itami N, Kin A, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 11 Pages: e0188099-e0188099
- DOI
  10.1371/journal.pone.0188099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07996, KAKENHI-PROJECT-16J07329
[Journal Article] Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions2017
- Author(s)
  Ikeda S, Kawahara-Miki R, Iwata H, Sugimoto M, Kume S
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 3800-3800
- DOI
  10.1038/s41598-017-04003-1
- NAID
  120006463796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07779
[Journal Article] Differential effects of mitochondrial inhibitors on porcine granulosa cells and oocytes.2017
- Author(s)
  Kansaku K, Itami N, Kawahara-Miki R, Shirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Theriogenology
  
  Volume: 103 Pages: 98-103
- DOI
  10.1016/j.theriogenology.2017.07.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07996, KAKENHI-PROJECT-16J07329
[Journal Article] Effect of aging on telomere lengths in bovine oocytes and granulosa cells2017
- Author(s)
  Kin A, Kansaku K, Sumiya M, Itami N, Sirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Journal of Mammalian Ova Research
  
  Volume: 34
- NAID
  40021179880
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] Palmitic acid stimulates interleukin-8 via the TLR4/NF-kB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells.2017
- Author(s)
  Ohtsu A, Tanaka H, Seno K, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  Am J Reprod Immunol
  
  Volume: 印刷中 Issue: 6
- DOI
  10.1111/aji.12642
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07783
[Journal Article] Interferon tau regulates cytokine production and cellular function in human trophoblast cell line2017
- Author(s)
  Tanikawa N, Seno K, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  J Interferon & Cytokine Research
  
  Volume: 37 Issue: 10 Pages: 456-466
- DOI
  10.1089/jir.2017.0057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07783
[Journal Article] Age-associated mRNA expression changes in bovine endometrial cells in vitro2017
- Author(s)
  Tanikawa N, Ohtsu A, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  Reprod Biol Endocrinol
  
  Volume: 15 Issue: 1 Pages: 63-63
- DOI
  10.1186/s12958-017-0284-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07783
[Journal Article] Advanced glycation end products regulate interleukin-1β production in human placenta2017
- Author(s)
  Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 63 Issue: 4 Pages: 401-408
- DOI
  10.1262/jrd.2017-032
- NAID
  130005982808
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-26462498
[Journal Article] Polyacrylamide gel as a culture substrate improves in vitro oocyte growth from porcine early2017
- Author(s)
  Munakata Y, Kawahara-Miki R, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Mol Reprod Dev
  
  Volume: 84 Issue: 1 Pages: 44-54
- DOI
  10.1002/mrd.22758
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] Liver condition of Holstein cows affects mitochondrial function and fertilization ability of oocytes.2016
- Author(s)
  Tanaka H, Takeo S, Abe T, Kin A, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  J Reprod Dev
  
  Volume: 印刷中
- NAID
  130005157171
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Gene expression of granulosa cells and oocytes in various stages of follicle and in vitro grown oocytes and granulosa cell complexes.2016
- Author(s)
  Munakata Y, Kawahara-Miki R, Shiratsuki S, Tasaki H, Itami N, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  J Reprod Dev
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Low oxygen level increases proliferation and metabolic changes in bovine granulosa cells.2016
- Author(s)
  Shiratsuki S, Hara T, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 437 Pages: 75-85
- DOI
  10.1016/j.mce.2016.08.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] Palmitic acid induces interleukin-1beta secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.2016
- Author(s)
  Shirasuna K, Takano T, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
- Journal Title
  
  J Reprod Immunol
  
  Volume: 116 Pages: 104-112
- DOI
  10.1016/j.jri.2016.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01395, KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-15K09146
[Journal Article] AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration.2016
- Author(s)
  Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
- Journal Title
  
  Am J Reprod Immunol
  
  Volume: 75 Issue: 5 Pages: 557-568
- DOI
  10.1111/aji.12506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-15K07783
[Journal Article] Relationship between the number of cells surrounding oocytes and energy states of oocytes.2016
- Author(s)
  Munakata Y, Ichinose T, Ogawa K, Itami N, Tasaki H, Shirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Theriogenology
  
  Volume: 86 Issue: 7 Pages: 1789-1798
- DOI
  10.1016/j.theriogenology.2016.05.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J07329, KAKENHI-PROJECT-16K07996
[Journal Article] Promotion of glucose utilization by insulin enhances granulosa cell proliferation and developmental competence of porcine oocyte grown in vitro.2016
- Author(s)
  Itami N, Munakata Y, Shirasuna K, Kuwayama T, Iwata H
- Journal Title
  
  Zygote
  
  Volume: 13 Issue: 1 Pages: 1-10
- DOI
  10.1017/s0967199416000356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J07329, KAKENHI-PROJECT-16K07996
[Journal Article] Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during post-ovulatory phase.2016
- Author(s)
  Tanaka H, Ohtsu A, Shiratsuki S, Kawahara-Miki R, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  Mol Reprod Dev
  
  Volume: 83 Issue: 9 Pages: 815-826
- DOI
  10.1002/mrd.22693
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07783
[Journal Article] Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality.2016
- Author(s)
  Takeo S, Kimura K, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Reproduction, Fertility and Development
  
  Volume: 印刷中 Issue: 4 Pages: 759-759
- DOI
  10.1071/rd15228
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J08274, KAKENHI-PROJECT-25450400
[Journal Article] Addition of granulosa cell mass to the culture medium of oocytes derived from early antral follicles increases oocyte growth, ATP content, and acetylation of H4K12.2016
- Author(s)
  Sugiyama M, Sumiya M, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Zygote
  
  Volume: 25 Issue: 6 Pages: 248-256
- DOI
  10.1017/s0967199416000198
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07996
[Journal Article] 卵子の老化とミトコンドリア2016
- Author(s)
  岩田　尚孝
- Journal Title
  
  Hormone Frontier in Gynecology
  
  Volume: 23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Effect of 5-aminoimidazole-4-carboxamide-ribonucleoside on the mitochondrial function and developmental ability of bovine oocytes2015
- Author(s)
  S Takeo, T Abe, K Shirasuna, T Kuwayama, H Iwata
- Journal Title
  
  Theriogenology
  
  Volume: 83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] The effect of high glucose concentration on the quality of oocytes derived from different growth stages of follicles2015
- Author(s)
  H Tasaki, Y Munakata, S Arai, S Murakami, T Kuwayama, H Iwata
- Journal Title
  
  Journal of Mannmalian Ova Reserch
  
  Volume: 32
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] 加齢と妊娠成立機構：免疫機能の重要性2015
- Author(s)
  白砂　孔明, 岩田　尚孝
- Journal Title
  
  日本胚移植学雑誌 (Japanese Journal of Embryo Transfer)
  
  Volume: 37 Pages: 133-137
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07783
[Journal Article] Relationship between　mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes.2015
- Author(s)
  Sato D, Itami N, Tasaki H, Takeo S, Kuwayama T, Iwata H.
- Journal Title
  
  PLoS One
  
  Volume: 18 Issue: 4 Pages: e94488-e94488
- DOI
  10.1371/journal.pone.0094488
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from2015
- Author(s)
  M Sugiyama, R Kawahara-Miki, H Kawana, K Shirasuna, T Kuwayama, H Iwata
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 61
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Effects of reaggregated of granulosa cells and oocytes derived from early antral follicles on the properties of oocytes grown in vitro2015
- Author(s)
  A Oi, H Tasaki, Y Munakata, K Shirasuna, T Kuwayama, H Iwata
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 61
- NAID
  130005077742
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Mitochondrial biogenesis and degradation are induced by CCCP treatment of porcine oocytes.2015
- Author(s)
  Itami N, Shiratsuki S, Shirasuna K, Kuwayama T, Iwata H.
- Journal Title
  
  Reproduction.
  
  Volume: 150 Issue: 2 Pages: 97-104
- DOI
  10.1530/rep-15-0037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Resveratrol improves the quality of pig oocytes derived from early antral follicles through SIRT1 activation2015
- Author(s)
  N Itami, K Shirasuna, T Kuwayama, H Iwata
- Journal Title
  
  Theriogenology
  
  Volume: 83 Issue: 8 Pages: 1360-1367
- DOI
  10.1016/j.theriogenology.2015.01.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes2014
- Author(s)
  Takeo S, Sato D, Kimura K, Monji Y, Kuwayama T, Kawahara-Miki R, Iwata H
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 60 Issue: 2 Pages: 92-99
- DOI
  10.1262/jrd.2013-102
- NAID
  130003381865
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Maternal liver damage delays meiotic resumption in bovine oocytes through impairment of signalling cascades originated from low p38MAPK activity in cumulus cells.2014
- Author(s)
  Tanaka H, Takeo S, Monji Y, Kuwayama T, Iwata H.
- Journal Title
  
  Reprod Domest Anim
  
  Volume: 49 Issue: 1 Pages: 101-108
- DOI
  10.1111/rda.12235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Age-associated changes in bovine oocytes and granulosa cell complexes collected from early antral follicles.2014
- Author(s)
  N Itami, R Kawahara-Miki, H Kawana, M Endo, T Kuwayama, H Iwata
- Journal Title
  
  Journal of Assisted Reproduction and Genetics
  
  Volume: 31 Issue: 8 Pages: 1079-1088
- DOI
  10.1007/s10815-014-0251-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450400
[Journal Article] Brilliant cresyl blue staining negatively affects mitochondrial functions in porcine oocytes.2013
- Author(s)
  Santos EC, Sato D, Lucia T, Iwata H.
- Journal Title
  
  Zygote
  
  Volume: 20 Issue: 3 Pages: 1-8
- DOI
  10.1017/s0967199413000610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 異なる時期に採取したウシ精液に由来する胚のミトコンドリア数とテロメア長の関係性2023
- Author(s)
  伊藤洵, 沖村匡史, 岩田尚孝
- Organizer
  第６８回日本生殖医学会
- Data Source
  KAKENHI-PROJECT-22K05959
[Presentation] ウシ精子のテロメア長が胚のテロメア長とミトコンドリア数に及ぼす影響2023
- Author(s)
  髙橋司宰　青木漱吾　岩田尚孝
- Organizer
  第 7 回日本胚移植技術研究会
- Data Source
  KAKENHI-PROJECT-22K05959
[Presentation] レスベラトロールの飲水投与は父親の加齢に起因する胚中テロメア長の短縮を抑制する2023
- Author(s)
  寺元能子, 岡田悠里, 伊藤洵, 油田奈緒, 林正宗, 岩田尚孝
- Organizer
  第６８回日本生殖医学会
- Data Source
  KAKENHI-PROJECT-22K05959
[Presentation] 増粘多糖類で作成したゲル基質を体外成熟に用いるとウシ胚発生が有意に改善する2021
- Author(s)
  原駿介，井上裕貴，田中啓介，野口龍生，白砂孔明，岩田尚孝
- Organizer
  第114回　日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-19K22372
[Presentation] 多糖類で作成した基質が、ウシ初期胞状卵胞卵子の体外発育に及ぼす影響2021
- Author(s)
  杉本彩嘉，井上裕貴，田中啓介，岩田尚孝
- Organizer
  第114回　日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-19K22372
[Presentation] キサンタンガムを基質に用いたブタ未熟卵子の体外発育2019
- Author(s)
  杉本　彩嘉,　岩田　尚孝
- Organizer
  第64回　日本生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K22372
[Presentation] 卵子発育を支えるマイクロRNA2019
- Author(s)
  岩田　尚孝
- Organizer
  第19回日本生殖工学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07996
[Presentation] キサンタンガムを基質に用いたウシ体外受精胚の培養2019
- Author(s)
  永田美樹,　岩田尚孝
- Organizer
  第64回　日本生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K22372
[Presentation] ウシ末梢血多核球と単核球におけるIFNT応答性と作用の比較検討2018
- Author(s)
  鬼沢優里，江口空，舟島なつみ，作本亮介，坂上信忠，岩田尚孝，桑山岳人，白砂孔明
- Organizer
  第110回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] 加齢がウシ卵管上皮細胞の細胞老化や加齢性炎症に及ぼす影響2018
- Author(s)
  中村悠稀,　市川遥翔，水野佳穂，岩田尚孝，桑山岳人，白砂孔明
- Organizer
  第110回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] ウシ脾臓細胞におけるインターフェロンτの免疫細胞分化誘導の可能性の検討2018
- Author(s)
  江口空，鬼沢優里，舟島なつみ，宗像祥久，作本亮介，坂上信忠，岩田尚孝，桑山岳人，白砂孔明
- Organizer
  第110回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] Telomere lengths in oocytes and granulosa cells derived from aged cows　Kin A, Kansaku K2017
- Author(s)
  Kin A, Kansaku K, Ueno Y, Shirasuna K, Kuwayama T, Iwata H
- Organizer
  4ｔｈ World congress of reproductive biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07996
[Presentation] Aged-associated increases in mitochondrial DNA mutation in bovine oocytes2017
- Author(s)
  Kin A, Kansaku K, Kawahara-Miki R, Shirasuna K, Kuwayama T, Iwata H
- Organizer
  The 11th Congress of the Pacific Society for Reproductive Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07996
[Presentation] Inflammation, interferon signaling, and cell cycle-related genes are changed with aging in bovine endometrial cells.2017
- Author(s)
  Tanikawa N, Ohtsu A, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Miyamoto A Shirasuna K
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] Effect of aging on the corpus luteum function in beef and dairy cows.2017
- Author(s)
  Hori K, Matsuyama S, Nakamura S, Naito A, Matsushita M, Arihara W, Kawahara H, Iwata H, Kuwayama T, Miyamoto A Shirasuna K
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] Inflammatory-related factors are activated depending on aging in bovine oviduct epithelial cells.2017
- Author(s)
  Shirasuna K, Tanaka H, Ohtsu A, Nakamura Y, Kawahara-Miki R, Iwata H, Kuwayama T
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] Granulosa cell number and oocyte growth2017
- Author(s)
  Iwata Hisataka
- Organizer
  4ｔｈ World congress of reproductive biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07996
[Presentation] パルミチン酸はウシ卵管上皮細胞の炎症応答を惹起する2016
- Author(s)
  大津彩華, 田中葉月，白築章吾，岩田尚孝，桑山岳人，白砂孔明
- Organizer
  第109回日本繁殖生物学会
- Place of Presentation
  麻布大学（神奈川県　相模原市）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] ウシの加齢に伴う黄体機能の変化についての検討2016
- Author(s)
  堀このみ, 内藤あおば，松下麻友美，大津彩華，岩田尚孝，桑山岳人，宮本明夫，白砂孔明
- Organizer
  第109回日本繁殖生物学会
- Place of Presentation
  麻布大学（神奈川県　相模原市）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] ヒト絨毛細胞株(Sw71)においてパルミチン酸はNLRP3インフラマソームを活性化する2016
- Author(s)
  妹尾琴実、鷹野弘樹、大津彩華、大口昭英、唐澤直義、高橋将文、岩田尚孝、桑山岳人、白砂孔明
- Organizer
  第31回日本生殖免疫学会
- Place of Presentation
  神戸国際会議場（兵庫県　神戸市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] 軽度の低酸素環境がヒト栄養膜細胞株の炎症応答やオートファジーに及ぼす影響2016
- Author(s)
  白砂孔明，島村成美，後藤千尋，妹尾琴実，大口昭英，岩田尚孝，桑山岳人
- Organizer
  第24回日本胎盤学会
- Place of Presentation
  アバローム紀ノ國（和歌山県　和歌山市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] ウシ卵管上皮細胞における年齢依存性変化2016
- Author(s)
  田中葉月,大津彩華，白築章吾，岩田尚孝，桑山岳人，白砂孔明
- Organizer
  第109回日本繁殖生物学会
- Place of Presentation
  麻布大学（神奈川県　相模原市）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] AGEおよびHMGB1はヒト絨毛膜細胞株（Sw71）において炎症反応を惹起する2015
- Author(s)
  妹尾琴実，白砂孔明，島村成美，白築章吾，大口昭英，岩田尚孝，桑山岳人．
- Organizer
  第23回日本胎盤学会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-15K07783
[Presentation] 加齢ウシ由来卵子のミトコンドリアについて2015
- Author(s)
  岩田　尚孝
- Organizer
  日本生殖医学会
- Place of Presentation
  パシヒィコ横浜
- Year and Date
  2015-04-27
- Invited
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] Supplementation of culture medium with resveratrol increases developmental rate to the blastocyst stage concomitant with increase in ATP content and decrease in lipid content.2015
- Author(s)
  Abe T, Kobayashi A, Shirasuna K, Kuwayama T, Iwata H.
- Organizer
  Ovarian Club 6
- Place of Presentation
  Barcelona
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 卵子老化に関わる因子と老化素子の可能性2015
- Author(s)
  岩田　尚孝
- Organizer
  日本受精着床学会　32回
- Place of Presentation
  東京
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] Maternal aging affects mitochondrial turnover in bovine oocytes2015
- Author(s)
  Takeo S, Abe T, Shirasuna K, Kuwayama T, Iwata H.
- Organizer
  Ovarian Club 6
- Place of Presentation
  Barcelona
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] Low oxygen tension changes the metabolism and proliferative activity of bovine granulosa cells.2015
- Author(s)
  Shiratsuki S, Shirasuna K, Kuwayama T, Iwata H.
- Organizer
  Ovarian Club 6
- Place of Presentation
  Barcelona
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] レスベラトロールが加齢ウシ初期胞状卵胞卵子に及ぼす影響2014
- Author(s)
  川名宏典　白砂孔明　桑山岳人　岩田尚孝
- Organizer
  日本繁殖生物学学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-21
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] レスベラトロールは卵子内のミトコンドリアをSIRT1を介して更新し卵子の質を改善する2014
- Author(s)
  田崎秀尚、大井綾乃、門司恭典、桑山岳人、岩田尚孝
- Organizer
  日本畜産学会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 加齢がウシの卵子のヒストンH4K12のアセチル化状態、活性酸素量と体外受精率に及ぼす影響2013
- Author(s)
  竹尾駿、後藤大也、橋本周、森本義晴、岩田尚孝
- Organizer
  第54回日本卵子学会
- Place of Presentation
  学術総合センター
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] ブタ初期胞状卵胞由来卵子の体外発育における顆粒層細胞の交換の影響2013
- Author(s)
  大井綾野、田崎秀尚、桑山岳人、門司恭典、岩田尚孝
- Organizer
  106回日本繁殖生物学会大会
- Place of Presentation
  東京農工大学農学部府中キャンパス
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 卵子－顆粒層細胞複合体の再構成がブタ初期胞状卵胞由来卵子の体外発育に及ぼす影響2013
- Author(s)
  大井綾乃、田崎秀尚、門司恭典、桑山岳人、岩田尚孝
- Organizer
  36回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド　神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] N-アセチル-L-システインが加齢ウシ初期胞状卵胞由来卵子の体外発育能力に及ぼす影響2013
- Author(s)
  矢口沙耶、川名宏典、松本美保、細川貴代美、松井望、門司恭典、桑山岳人、岩田尚孝
- Organizer
  106回日本繁殖生物学会大会
- Place of Presentation
  東京農工大学農学部府中キャンパス
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] ブタ卵巣の保存が卵子中のミトコンドリアDNAコピー数に及ぼす影響2013
- Author(s)
  佐藤大地、木下尚也、羽場久美子、向田幸司、村山智紀、鵜沢美穂　鈴木由紀子、門司恭典、桑山岳人、岩田尚孝
- Organizer
  第54回日本卵子学会
- Place of Presentation
  学術総合センター
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 培養皿の底の形状はウシ職胞状卵胞由来卵子の体外での腔形成に影響する2013
- Author(s)
  川名宏典、松本美保、矢口沙耶、細川貴代美、松井望、門司恭典、桑山岳人、岩田尚孝
- Organizer
  106回日本繁殖生物学会大会
- Place of Presentation
  東京農工大学農学部府中キャンパス
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] BCB staining negatively affects mitochondrial functions in porcien oocytes2013
- Author(s)
  D Sato, ECS Santos H Iwata
- Organizer
  The 9th Conference of the Pacific Rim Society for Fertility and Sterility
- Place of Presentation
  Kobe International Confernce Center
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] 卵子老化に関わる因子と老化素子の可能性
- Author(s)
  岩田　尚孝
- Organizer
  日本受精着床学会
- Place of Presentation
  東京ハイアットリージェンシー
- Year and Date
  2014-07-31 – 2014-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-25450400
[Presentation] レスベラトロール添加がブタ初期胞状卵胞卵子の体外発育に及ぼす影響
- Author(s)
  伊丹暢彦　白砂孔明　桑山岳人　岩田尚孝
- Organizer
  日本繁殖生物学学会
- Place of Presentation
  帯広畜産大学
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25450400

1. SHIRASUNA Koumei (20552780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
2. Ikeda Shuntaro (50447893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Sugimoto Miki (20243074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Kume Shinichi (90355454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 桑山岳人 (40215124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
6. 中村翔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 高橋将文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大口昭英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IWATA Hisataka 岩田 尚孝

Research Projects

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Co-Researchers

Factors in follicular fluid reducing epigenetic abnormalities in in vitro developed embryos.Principal Investigator

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Effect of increased paternal age on mitochondria of embryosPrincipal Investigator

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Development of polysaccharide gel culture system of in vitro embryo culture system.Principal Investigator

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Age associated mitochondrial changes in oocytesPrincipal Investigator

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Molecular mechanism of pregnancy failure with aging: possible role of inflammasome

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Nutriepigenetics in mammalian preimplantation embryos

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Possible countermeasures against age-associated deteriorations of bovine oocytesPrincipal Investigator

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[Journal Article] Effect of paternal aging and vitrification on mitochondrial DNA copy number and telomere length of mouse blastocysts2024

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[Journal Article] Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos2023

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[Journal Article] Effects of a gel culture system made of polysaccharides (xanthan gum and locust bean gum) on in vitro bovine oocyte development and gene expression of the granulosa cells.2021

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[Journal Article] Xanthan gum and locust bean gum substrate improves bovine embryo development.2020

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[Journal Article] Cell-free DNA in medium is associated with the maturation ability of <i>in vitro</i> cultured oocytes2019

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[Journal Article] Xanthan gum and Locust bean gum gel supports <i>in vitro</i> development of porcine oocytes derived from early antral follicles2019

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IWATA Hisataka 岩田尚孝