NAOE Yoshinori 直江吉則

Researcher Number	50392048
Affiliation *help	2018 : 名古屋大学, 医学系研究科, 特任准教授 2016 – 2017 : 名古屋大学, 医学系研究科, 特任講師 2016 – 2018 : 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 2015 : 国立研究開発法人国立長寿医療研究センター, 運動器疾患研究部, 流動研究員 2014 : 国立長寿医療研究センター研究所, 研究員 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Immunology / Laboratory animal science / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 細胞障害性T細胞 / 免疫学 / Cxxc5 / ヘルパーT細胞 / エピジェネティクス / iPS細胞 / がん抗原 / ThPOK / マイクロアレイ / CXXC5 / T細胞 / Ｔ細胞 / T細胞レセプター … More Except Principal Investigator … More

癌を支える癌関連間葉系幹細胞の癌ワクチンへの標的化Ongoing
- Principal Investigator
  
  松村繁
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya University
iPS細胞技術を用いた新規腫瘍浸潤T細胞のTCR塩基配列決定Principal InvestigatorOngoing
- Principal Investigator
  
  直江吉則
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Challenging Research (Exploratory)
- Research Field
  
  Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University
ThPOK represses CXXC5, which inhibits CD40L expression in cytotoxic T cells through epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  Naoe Yoshinori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Novel immune regulation through regulated MHC II ubiquitination
- Principal Investigator
  
  ISHIDO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Showa Pharmaceutical University
Modulatory effects of macrophage M-mod/USP2 on type2 diabetes
- Principal Investigator
  
  KITAMURA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Rakuno Gakuen University
  Nagoya City University
Identification of Runx transcriptional factors target genes in regulatory T cell.Principal Investigator
- Principal Investigator
  
  NAOE Yoshinori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology

All 2016 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 免疫の辞典2012
- Author(s)
  直江吉則
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells2016
- Author(s)
  Tsuchiya Y, Naito T, Tenno M, Maruyama M, Koseki H, Taniuchi I, Naoe Y.
- Journal Title
  
  J Leukoc Biol.
  
  Volume : 印刷中
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460401
[Journal Article] Proliferation-coupled osteoclast differentiation by RANKL: cell density as a determinant of osteoclast function2015
- Author(s)
  Motiur Rahman M, Takeshita S, Matsuoka K, Kaneko K, Naoe Y, Sakaue-Sawano A, Miyawaki A, Ikeda K.
- Journal Title
  
  Bone
  
  Volume : 81 Pages : 392-399
- DOI
  10.1016/j.bone.2015.08.008
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440095, KAKENHI-PROJECT-25460401, KAKENHI-PROJECT-26670182
[Journal Article] A novel Cd8-cis regulatory element that directs expression in CD44+CD62L+CD8+ T cells and in CD8aa+ dendritic cells.2015
- Author(s)
  Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W.
- Journal Title
  
  J. Leukoc. Biol
  
  Volume : 97 Pages : 635-644
- DOI
  10.1189/jlb.1HI1113-597RR
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460401, KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26293109
[Journal Article] Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue.2013
- Author(s)
  Kitamura H, Naoe Y, Kimura S, Miyamoto T, Okamoto S, Toda C, Shimamoto Y, Iwanaga T, Miyoshi I
- Journal Title
  
  Adipocyte
  
  Volume : 2 Pages : 227-236
- DOI
  10.4161/adip.25608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500494, KAKENHI-PROJECT-25460261, KAKENHI-PROJECT-25460401
[Journal Article] Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation2013
- Author(s)
  Kitamura et al.
- Journal Title
  
  FASEB Journal
  
  Volume : 27 Pages : 4940-4953
- DOI
  10.1096/fj.13-233528
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117723, KAKENHI-PROJECT-24500494, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-25460261, KAKENHI-PROJECT-25460401
[Journal Article] Transcriptional control of T-cell development2011
- Author(s)
  Naito T、Tanaka H、Naoe Y and Taniuchi I
- Journal Title
  
  InternaInternaI Immunology
  
  Volume : 23 Pages : 661-668
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Transcriptional control of T-cell development2011
- Author(s)
  直江吉則
- Journal Title
  
  Int Immunol
  
  Volume : 23 Pages : 661-668
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes.2010
- Author(s)
  直江吉則
- Journal Title
  
  Nature Immunology
  
  Volume : 11 Pages : 442-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes2010
- Author(s)
  Sakaguchi S、Hombauer M、Bilic I、Naoe Y、Schebesta A、Taniuchi I andEllmeier W
- Journal Title
  
  Nat Immunol
  
  Volume : 11 Pages : 442-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Indispensable role of Runx1/Cbfβ complex for in vivo suppressive function for FoxP3^+ regulatory T cells.2009
- Author(s)
  直江吉則
- Journal Title
  
  Immunity 31
  
  Pages : 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Runx proteins regulate FoxP3 expression.2009
- Author(s)
  直江吉則
- Journal Title
  
  Journal of experimental medicine 206
  
  Pages : 2329-2337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromatin is modulated by histone H3 serin 10 phosphorylation.2009
- Author(s)
  直江吉則
- Journal Title
  
  Molecular cell 33
  
  Pages : 450-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Indispensable role of Runx1/Cbfβcomplex for in vivo suppressive function for FoxP3+regulatory T cells2009
- Author(s)
  Kitoh A、Ono M、Naoe Y、Ohkura N、Yamaguchi T、Yaguchi H、Kitabayashi I、Tsukada T、Nomura T、Miyamachi Y、Taniuchi I and Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume : 16 Pages : 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Runx proteins regulate FoxP3 expression2009
- Author(s)
  Bruno L、Mazzarella L、Hoogenkamp M、Hertweck A、Cobb BS、Sauer S、Hadjur S、Leleu M、Naoe Y、Telfer J、Bonifer C、Taniuchi I、Fisher AG and Merkenschlager M
- Journal Title
  
  J Exp Med
  
  Volume : 206 Pages : 2329-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] マクロファージ分子M-modによる肥満症・糖尿病の制御2013
- Author(s)
  北村　浩、木村俊介、嶋本良則、岡部　潤、宮本智美、直江吉則、岡本士毅、戸田知得、Assam El-Osta、三好一郎
- Organizer
  第１５６回日本獣医学会学術集会
- Place of Presentation
  岐阜大学（岐阜県）
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] Cxxc5, ThPOK target gene, suppresses CD4+ helper T cell functions during CD8+cytotoxic T differentiation2013
- Author(s)
  直江吉則、内藤拓、天野麻理、丸山光生、古関明彦、谷内一郎
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460401
[Presentation] Possible involvement of a novel macrophage molecule in pathogenesis of type 2 diabetes2012
- Author(s)
  Hiroshi Kitamura, Shunsuke Kimura, Tomomi Miyamoto, Masatoshi Ito, Yoshinori Shimamoto, Jun Okabe, Yoshinori Naoe, Koji Hase, Osamu Ohara, Ichiro Miyoshi
- Organizer
  The 4th EMBO meeting
- Place of Presentation
  アクロポリス国際会議場（ニース、フランス）
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] 加齢に伴う免疫低下メカニズムの解析2011
- Author(s)
  直江吉則
- Organizer
  第11回日本抗加齢医学会総会
- Place of Presentation
  京都
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Functional analysis of an age-related novel GEF、Zizimin2/Dock11 in immunosenescence2011
- Author(s)
  Naoe Y
- Organizer
  Ninth Asia/Oceania Regional Congress of Gerontology and Geriatrics
- Place of Presentation
  Melbourne、Australia
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] ヘルパーT細胞分化過程における特異的な選択的スプライシングの検出2011
- Author(s)
  直江吉則
- Organizer
  第21回Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] 老化関連因子Zizimin2/Dock11の獲得免疫系における機能解析2011
- Author(s)
  直江吉則
- Organizer
  第34回日本基礎老化学会年会
- Place of Presentation
  東京
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Operationg with a fake ID at the border : Lineage switch of mucosal CD4T cells2010
- Author(s)
  Naoe Y
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Molecular mechanisms of functional decline in the immunosenescence2010
- Author(s)
  Naoe Y
- Organizer
  Asian Aging Core for Longevity Research and Education 2010 Jeju Conference
- Place of Presentation
  Jeju、Korea
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] 免疫老化関連因子Zizimin2/Dock11のin vivoにおける機能解析2010
- Author(s)
  直江吉則
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] The zinc finger protein MAZR is part of the transcription factor network that regulates CD4/CD8 cell fate decision of DP thymocytes2010
- Author(s)
  Naoe Y
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Analysis of zizimin2 function in mouse dendritic cells2009
- Author(s)
  Naoe Y
- Organizer
  第32回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] マクロファージのUSP2-新たな糖尿病制御分子-
- Author(s)
  北村浩、木村俊介、岡部潤、宮本智美、嶋本良則、直江吉則、戸田知得、岡本士毅、三好一郎
- Organizer
  日本獣医学会
- Place of Presentation
  北海道大学（北海道）
- Year and Date
  2014-09-09 – 2014-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] マクロファージのUSP2による２型糖尿病制御の可能性
- Author(s)
  北村　浩、木村俊介、宮本智美、岡部潤、嶋本良則、直江吉則、三好一郎
- Organizer
  日本実験動物学会
- Place of Presentation
  札幌コンベンションセンター(北海道）
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-24500494

1. 粕谷英樹 (00402636)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
2. ISHIDO Satoshi (10273781)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. KITAMURA Hiroshi (80312403)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
4. MIYOSHI Ichiro (10183972)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
5. OKAMOTO Shiki (40342919)

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
6. TAKAHASI Eiki (40446521)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. IWANAGA Toshihiko (10160128)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. KIMURA Shunsuke (40444525)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
9. 松村繁 (60523511)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 一ノ瀬亨 (60778091)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. Taniuchi Ichiro

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 阪上朝子

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 竹下淳

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

NAOE Yoshinori 直江 吉則

Research Projects

Research Products

Co-Researchers

癌を支える癌関連間葉系幹細胞の癌ワクチンへの標的化Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPS細胞技術を用いた新規腫瘍浸潤T細胞のTCR塩基配列決定Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ThPOK represses CXXC5, which inhibits CD40L expression in cytotoxic T cells through epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel immune regulation through regulated MHC II ubiquitination

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulatory effects of macrophage M-mod/USP2 on type2 diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Runx transcriptional factors target genes in regulatory T cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 免疫の辞典2012

Author(s)

Publisher

Data Source

[Journal Article] ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells2016

Author(s)

Journal Title

Data Source

[Journal Article] Proliferation-coupled osteoclast differentiation by RANKL: cell density as a determinant of osteoclast function2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel Cd8-cis regulatory element that directs expression in CD44+CD62L+CD8+ T cells and in CD8aa+ dendritic cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional control of T-cell development2011

Author(s)

Journal Title

Data Source

[Journal Article] Transcriptional control of T-cell development2011

Author(s)

Journal Title

Data Source

[Journal Article] The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes.2010

Author(s)

Journal Title

Data Source

NAOE Yoshinori 直江吉則