Naoe Yoshinori 直江吉則

… Alternative Names

NAOE Yoshinori 直江吉則

Less

Researcher Number	50392048
Other IDs
Affiliation (Current)	2022: 名古屋大学, 医学系研究科, 特任准教授 2022: 国立研究開発法人国立長寿医療研究センター, その他部局等, その他
Affiliation (based on the past Project Information) *help	2018 – 2022: 名古屋大学, 医学系研究科, 特任准教授 2017: 名古屋大学, 医学系研究科, 特任講師 2015: 国立研究開発法人国立長寿医療研究センター, 運動器疾患研究部, 流動研究員 2014: 独立行政法人国立長寿医療研究センター, 老化機構研究部, 流動研究員 2014: 国立長寿医療研究センター研究所, 研究員 … More 2014: 独立行政法人国立長寿医療センター, 老化機構研究部免疫研究室, 室長 2013: 独立行政法人国立長寿医療研究センター, 老化機構研究部, 室長 2011: 独立行政法人国立長寿医療研究センター, 研究所老化機構研究部免疫研究室, 室長 2011: 独立行政法人国立長寿医療研究センター, 老化機構研究部・免疫研修室, 室長 2010: 独立行政法人国立長寿医療研究センター, 老化機構研究部・免疫研究室, 室長 2009: National Institute for Longevity Sciences,NCGG, 老化機構研究部免疫研究室, 室長 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Surgery of the organs maintaining homeostasis and related fields / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Immunology / Laboratory animal science / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 細胞障害性T細胞 / T細胞 / 免疫学 / マイクロアレイ / ヘルパーT細胞 / ThPOK / CXXC5 / エピジェネティクス / Ｔ細胞 / Cxxc5 … More / iPS細胞 / 癌免疫 / 癌抗原 / iPS / T細胞レセプター / がん抗原 / 腫瘍溶解性ウイルス / 腸内細菌叢 / 抗腫瘍効果 / 免疫 / 癌 … More Except Principal Investigator ユビキチン / MHC class II / 樹状細胞 / 抗原提示 / CD86 / 寛容 / IgE / マクロファージ / 糖尿病 / 炎症 / トランスジェニックマウス / ノックアウトマウス / 脂肪組織 / 遺伝子発現 / 糖代謝 / 遺伝子組換えマウス / 核内タンパク質 / 慢性炎症 / ２型糖尿病 / 遺伝子組み換えマウス / 肥満 / ob/obマウス / 腫瘍溶解性ウイルス / 癌免疫 / C-REV / 腫瘍溶解性ウィルス / CAR-T cell / 膵癌 Less

固形癌に対するCAR-T、ウイルス療法の併用による新規免疫療法の開発
- Principal Investigator
  
  粕谷英樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Role of intestinal flora on the antitumor immunity of oncolytic virusesPrincipal Investigator
- Principal Investigator
  
  直江吉則
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nagoya University
癌を支える癌関連間葉系幹細胞の癌ワクチンへの標的化
- Principal Investigator
  
  松村繁
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya University
TCR sequencing of tumor infiltrating T cells using iPS cell technologyPrincipal Investigator
- Principal Investigator
  
  Naoe Yoshinori
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University
ThPOK represses CXXC5, which inhibits CD40L expression in cytotoxic T cells through epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  Naoe Yoshinori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Novel immune regulation through regulated MHC II ubiquitination
- Principal Investigator
  
  ISHIDO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Showa Pharmaceutical University
Modulatory effects of macrophage M-mod/USP2 on type2 diabetes
- Principal Investigator
  
  KITAMURA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Rakuno Gakuen University
  Nagoya City University
Identification of Runx transcriptional factors target genes in regulatory T cell.Principal Investigator
- Principal Investigator
  
  NAOE Yoshinori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology

All 2021 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 遺伝子医学MOOK 31号がん免疫療法 - What's now and what's next? 第2章の4の3) 腫瘍溶解性ウイルスHF10による再発乳がん多発結節症例, 切除不能進行膵がん症例に対する臨床研究2017
- Author(s)
  粕谷英樹, 直江吉則, 一ノ瀬亨, 廣岡芳樹, 後藤秀実, 田中舞紀
- Total Pages
  294
- Publisher
  (株)メディカルドゥ
- Data Source
  KAKENHI-PROJECT-17K19696
[Book] 免疫の辞典2012
- Author(s)
  直江吉則
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Oncolytic herpes simplex virus HF10 (canerpaturev, C-REV) promotes accumulation of CD8+PD-1- tumor-infiltrating T cells in PD-L1 enriched tumor microenvironment.2021
- Author(s)
  Eissa I.R., Mukoyama N., Abdelmoneim, M., Naoe, Y., Matsumura, S., Bustos-Villalobos I., Ichinose T., Miyajima N., Morimoto D., Tanaka M., Fujimoto, Y., Kodera Y., Kasuya H.
- Journal Title
  
  Int. J. Cancer
  
  Volume: 1 Pages: 1-14
- DOI
  10.1002/ijc.33550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02691
[Journal Article] The Current Status and Future Prospects of Oncolytic Viruses Clinical Trials against Melanoma,Glioma,Pancreatic and Breast cancers.2018
- Author(s)
  Eissa Ibrahim、Bustos-Villalobos Itzel、Ichinose Toru、Matsumura Shigeru、Naoe Yoshinori、Miyajima Noriyuki、Morimoto Daishi、Mukoyama Nobuaki、Zhiwen Wu、Tanaka Maki、Hasegawa Hitoki、Sumigama Seiji、Aleksic Branko、Kodera Yasuhiro、Kasuya Hideki
- Journal Title
  
  Cancers
  
  Volume: 10 Pages: 1-22
- DOI
  10.3390/cancers10100356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15274, KAKENHI-PROJECT-16H05413, KAKENHI-PROJECT-18H02691, KAKENHI-PROJECT-17K19696, KAKENHI-PROJECT-17K16907
[Journal Article] A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer.2018
- Author(s)
  Hirooka Yoshiki、Kasuya Hideki、Ishikawa Takuya、Kawashima Hiroki、Ohno Eizaburo、Villalobos Itzel B.、Naoe Yoshinori、Ichinose Toru、Koyama Nobuto、Tanaka Maki、Kodera Yasuhiro、Goto Hidemi
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Pages: 596-596
- DOI
  10.1186/s12885-018-4453-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15274, KAKENHI-PROJECT-16H05413, KAKENHI-PROJECT-17K19696, KAKENHI-PROJECT-17K16907
[Journal Article] Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes2017
- Author(s)
  Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Pages: 1-14
- DOI
  10.1038/s41467-017-00768-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19696, KAKENHI-PUBLICLY-17H05805, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-15K08291, KAKENHI-PROJECT-16K15362, KAKENHI-PROJECT-15K08535
[Journal Article] Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.2017
- Author(s)
  Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H.
- Journal Title
  
  Front Oncol.
  
  Volume: 7 Pages: 147-147
- DOI
  10.3389/fonc.2017.00149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19696, KAKENHI-PROJECT-16H05413
[Journal Article] ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells2016
- Author(s)
  Tsuchiya Y, Naito T, Tenno M, Maruyama M, Koseki H, Taniuchi I, Naoe Y.
- Journal Title
  
  J Leukoc Biol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460401
[Journal Article] Proliferation-coupled osteoclast differentiation by RANKL: cell density as a determinant of osteoclast function2015
- Author(s)
  Motiur Rahman M, Takeshita S, Matsuoka K, Kaneko K, Naoe Y, Sakaue-Sawano A, Miyawaki A, Ikeda K.
- Journal Title
  
  Bone
  
  Volume: 81 Pages: 392-399
- DOI
  10.1016/j.bone.2015.08.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440095, KAKENHI-PROJECT-25460401, KAKENHI-PROJECT-26670182
[Journal Article] A novel Cd8-cis regulatory element that directs expression in CD44+CD62L+CD8+ T cells and in CD8aa+ dendritic cells.2015
- Author(s)
  Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W.
- Journal Title
  
  J. Leukoc. Biol.
  
  Volume: 97 Pages: 635-44
- DOI
  10.1189/jlb.1hi1113-597rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460401, KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26293109
[Journal Article] Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation2013
- Author(s)
  Kitamura et al.
- Journal Title
  
  FASEB J
  
  Volume: 27 Pages: 2940-2953
- DOI
  10.1096/fj.13-233528
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117723, KAKENHI-PROJECT-24500494, KAKENHI-PROJECT-24500495, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-25460261, KAKENHI-PROJECT-25460401
[Journal Article] Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue.2013
- Author(s)
  Kitamura H, Naoe Y, Kimura S, Miyamoto T, Okamoto S, Toda C, Shimamoto Y, Iwanaga T, Miyoshi I
- Journal Title
  
  Adipocyte
  
  Volume: 2 Pages: 227-236
- DOI
  10.4161/adip.25608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500494, KAKENHI-PROJECT-24500495, KAKENHI-PROJECT-25460261, KAKENHI-PROJECT-25460401
[Journal Article] Transcriptional control of T-cell development2011
- Author(s)
  直江吉則
- Journal Title
  
  Int Immunol
  
  Volume: 23 Pages: 661-668
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Transcriptional control of T-cell development2011
- Author(s)
  Naito T、Tanaka H、Naoe Y and Taniuchi I
- Journal Title
  
  InternaInternaI Immunology
  
  Volume: 23 Pages: 661-668
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes.2010
- Author(s)
  直江吉則
- Journal Title
  
  Nature Immunology
  
  Volume: 11 Pages: 442-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes2010
- Author(s)
  Sakaguchi S、Hombauer M、Bilic I、Naoe Y、Schebesta A、Taniuchi I andEllmeier W
- Journal Title
  
  Nat Immunol
  
  Volume: 11 Pages: 442-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromatin is modulated by histone H3 serin 10 phosphorylation.2009
- Author(s)
  直江吉則
- Journal Title
  
  Molecular cell 33
  
  Pages: 450-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Runx proteins regulate FoxP3 expression2009
- Author(s)
  Bruno L、Mazzarella L、Hoogenkamp M、Hertweck A、Cobb BS、Sauer S、Hadjur S、Leleu M、Naoe Y、Telfer J、Bonifer C、Taniuchi I、Fisher AG and Merkenschlager M
- Journal Title
  
  J Exp Med
  
  Volume: 206 Pages: 2329-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Indispensable role of Runx1/Cbfβ complex for in vivo suppressive function for FoxP3^+ regulatory T cells.2009
- Author(s)
  直江吉則
- Journal Title
  
  Immunity 31
  
  Pages: 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Runx proteins regulate FoxP3 expression.2009
- Author(s)
  直江吉則
- Journal Title
  
  Journal of experimental medicine 206
  
  Pages: 2329-2337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Journal Article] Indispensable role of Runx1/Cbfβcomplex for in vivo suppressive function for FoxP3+regulatory T cells2009
- Author(s)
  Kitoh A、Ono M、Naoe Y、Ohkura N、Yamaguchi T、Yaguchi H、Kitabayashi I、Tsukada T、Nomura T、Miyamachi Y、Taniuchi I and Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume: 16 Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Combination therapy of Cetuximab and CANERPATUREV suppresses human colorectal cancer growth2019
- Author(s)
  Shigeru Matsumura, Zhiwen Wu, Toru Ichinose, Yoshinori Naoe, Itzel Bustos Villalobos, Ibrahim Ragab Eissa, Suguru Yamada, Yasuhiro Kodera, Maki Tanaka, and Hideki Kasuya
- Organizer
  日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-18H02691
[Presentation] 大腸癌モデルにおけるセツキシマブとC-REVとの併用治療効果について2019
- Author(s)
  Shigeru Matsumura, Zhiwen Wu, Toru Ichinose, Yoshinori Naoe, Itzel Bustos Villalobos, Ibrahim Ragab Eissa, Suguru Yamada, Yasuhiro Kodera, Maki Tanaka, and Hideki Kasuya
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02691
[Presentation] Combination of cetuximab and oncolytic virus canepaturev synergistically inhibits human colorectal cancer growth2019
- Author(s)
  Shigeru Matsumura, Zhiwen Wu, Toru Ichinose, Yoshinori Naoe, Itzel Bustos Villalobos, Ibrahim Ragab Eissa, Suguru Yamada, Yasuhiro Kodera, Maki Tanaka, and Hideki Kasuya
- Organizer
  癌免疫学会
- Data Source
  KAKENHI-PROJECT-18H02691
[Presentation] STING is dispensable for low susceptibility to C-REV (HF10) in pancreatic cancer cell lines2018
- Author(s)
  Matsumura S, Morimoto D, Naoe Y, Ichinose T, Eissa IR, Tanaka M, Kodera Y, Kasuya H
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02691
[Presentation] The synergistic effect of the combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102018
- Author(s)
  Nobuaki Mukoyama, Ibrahim Eissa, Yoshinori Naoe, Toru Ichinose, Shigeru Matsumura, Itzel Bustos, Wu Zhiwen, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Yasushi Fujimoto, Michihiko Sone, Yasuhiro Kodera, Hideki Kasuya
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] STING is dispensable for low susceptibility to C-REV(HF10) in pancreatic cancer cell lines2018
- Author(s)
  Shigeru Matsumura, Daishi Morimoto, Yoshinori Naoe, Toru Ichinose, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya
- Organizer
  4th ONCOLYTIC VIROTHERAPY Summit
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Does the expression level of STING correlate with susceptibility to oncolytic virus HF10 in human pancreatic cell lines?2018
- Author(s)
  Daishi Morimoto, Yoshinori Naoe, Shigeru Matsumura, Toru Ichinose, Ibrahim Eissa, Itzel Bustos, Noriyuki Miyajima, Nobuaki Mukoyama, Wu Zhiwen, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Clinical trial using HF10 with Gemcitabine and Erlotinib for 9 patients of Unresectable pancreatic cancer2018
- Author(s)
  Hideki Kasuya, Yoshiki Hirooka, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Noriyuki Miyajima, Daishi Morimoto, Hidemi Goto, Maki Tanaka
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Final total Data of Clinical trial using HF10 with Gemcitabine and Erlotinib against Unresectable Pancreatic Cancer2018
- Author(s)
  Hideki Kasuya, Yoshiki Hirooka, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Noriyuki Miyajima, Daishi Morimoto, Hidemi Goto, Maki Tanaka
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Combination therapy of oncolytic HSV HF10 and immune checkpoint inhibitor2018
- Author(s)
  H Kasuya, Y Naoe, S Matsumura, I Bustos, T Ichinose, I Eissa, W Zhiwen, N Miyajima, D Morimoto, M Tanaka
- Organizer
  International Oncolytic Virus Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] The synergistic effect of the combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus Canerpaturev(C-REV)2018
- Author(s)
  Yoshinori Naoe, Nobuaki Mukoyama, Ibrahim Eissa, Toru Ichinose, Shigeru Matsumura, Itzel Bustos, Wu Zhiwen, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Yasushi Fujimoto, Michihiko Sone, Yasuhiro Kodera, Hideki Kasuya
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] STING is dispensable for low susceptibility to C-REV (HF10) in pancreatic cancer cell lines2018
- Author(s)
  Matsumura S, Morimoto D, Naoe Y, Ichinose T, Eissa IR, Tanaka M, Kodera Y, Kasuya H
- Organizer
  4th Annual Oncolytic virotherapy summit
- Data Source
  KAKENHI-PROJECT-18H02691
[Presentation] Involvement of cGAS and STING in sensitivity to oncolytic virus HF10 in breast cancer cell lines2018
- Author(s)
  Noriyuki Miyajima, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Daishi Morimoto, Maki Tanaka, Hideki Kasuya
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Systemic therapeutic potential of oncolytic herpes simplex virus HF10 adsorbed on antigen-specific lymphocytes2017
- Author(s)
  Ichinose T, Naoe Y, Nassr E. I. R, Luo C, Villalobos I. B, Zhiwen W, Mukoyama N, Miyajima N, Morimoto D, Yamada S, Fujii T, Sugimoto H, Tanaka M, Kodera Y, Kasuya H.,
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102017
- Author(s)
  森本　大士, 直江　吉則, 向山　宜明, 一ノ瀬　亨, Itzel Bustos Villalobos, 神田　光郎, 丹羽　由紀子, 岩田　直樹, 林　真路, 小林　大介, 田中　千恵, 中山　吾郎, 山田　豪, 杉本　博行, 小池　聖彦, 藤原　道隆, 田中　舞紀, 藤本　保志, 粕谷　英樹, 小寺　泰
- Organizer
  第28回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] ヒト膵癌異種移植モデルにおけるnab-Paclitaxel（nab-PTX）と腫瘍溶解性単純ヘルペスウイルスHF10 との併用療法2017
- Author(s)
  森本大士, 直江吉則, 一ノ瀬亨, Bustos Itzel, 神田光郎, 丹羽由紀子, 岩田直樹, 林真路, 小林大介, 田中千恵, 山田豪, 中山吾郎, 杉本博行, 小池聖彦, 藤原道隆, 藤井努, 田中舞紀, 粕谷英樹, 小寺泰弘
- Organizer
  第117 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] COMBINATION THERAPY AGAINST HUMAN COLORECTAL CANCER WITH THE EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR CETUXIMAB AND ONCOLYTIC HERPES SIMPLEX VIRUS HF102017
- Author(s)
  呉智聞, 一ノ瀬亨, 駱晨虹, 直江吉則, ヴィラロボスイッツェル・バストス, 山田豪, 杉本博行, 宮嶋則行, 森本大士, 向山宣昭, 西川洋子, 小出悠介, 小寺泰弘, 田中舞紀, 粕谷英樹
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] 腫瘍溶解性単純ヘルペスウイルスHF10と免疫チェックポイント阻害剤の併用2017
- Author(s)
  森本　大士, 直江　吉則, 向山　宜明, 宮嶋　則行, Ibrahim Ragab Eissa, 一ノ瀬　亨, Itzel Bustos-Villalobos, 山田　豪, 田中　舞紀, 藤本　保志, 小寺　泰弘, 粕谷　英樹
- Organizer
  第51回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102017
- Author(s)
  Mukoyama N, Naoe Y, Ichinose T, Nassr E. I. R, Luo C, Villalobos I. B, Zhiwen W, Miyajima N, Morimoto D, Tanaka M, Fujimoto Y, Sone M, Kodera Y, Kasuya H.
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] HF10 ウイルス療法におけるin situ vaccination効果についての検討2017
- Author(s)
  粕谷英樹, 直江吉則, Bustos Itzel, 一ノ瀬亨, 森本大士, 向山宣昭, 呉智聞, 藤井努, 小寺泰弘, 田中舞紀
- Organizer
  第117 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Combination therapy against human pancreatic cancer with oncolytic herpes virus HF10 and abraxane2017
- Author(s)
  Wu Z, Ichinose T, Luo C, Naoe Y, Villalobos I. B, Yamada S, Fujii T, Sugimoto H, Miyajima N, Morimoto D, Mukoyama N, Nishikawa Y, Koide U, Kuwahara T, Kodera Y, Tanaka M, Kasuya H.
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] ヒト大腸がんモデルにおけるセツキシマブとの併用による腫瘍溶解性ウイルスHF10 の抗腫瘍効果2017
- Author(s)
  呉智聞, 一ノ瀬亨, 駱晨虹, 直江吉則, イッツェル・ブストス・ビジャロボス, 山田豪, 藤井努, 杉本博行, 森本大士, 向山宣昭, 小寺泰弘, 田中舞紀, 粕谷英樹
- Organizer
  第117 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Clinical trial data using HF10, oncolytic herpes simplex virus2017
- Author(s)
  Kasuya H, Ichinose T, Naoe Y, Villalobos I. B, Nassr E. I. R, Luo C, Zhiwen W, Mukoyama N, Miyajima N, Morimoto D, Hirooka Y, Goto H, Tanaka M.
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] Combination therapy of oncolytic herpes virus and anti-angiogenesis agent (bevacizumab) against human gastric cancer xenograft2017
- Author(s)
  H. Kasuya, G. Tan, C. Luo, T. Ichinose, I. Bustos, Y. Naoe
- Organizer
  EACR-AACR-SIC Special Conference 2017
- Data Source
  KAKENHI-PROJECT-17K19696
[Presentation] マクロファージ分子M-modによる肥満症・糖尿病の制御2013
- Author(s)
  北村　浩、木村俊介、嶋本良則、岡部　潤、宮本智美、直江吉則、岡本士毅、戸田知得、Assam El-Osta、三好一郎
- Organizer
  第１５６回日本獣医学会学術集会
- Place of Presentation
  岐阜大学（岐阜県）
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] Cxxc5, ThPOK target gene, suppresses CD4+ helper T cell functions during CD8+cytotoxic T differentiation2013
- Author(s)
  直江吉則、内藤拓、天野麻理、丸山光生、古関明彦、谷内一郎
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460401
[Presentation] Possible involvement of a novel macrophage molecule in pathogenesis of type 2 diabetes2012
- Author(s)
  Hiroshi Kitamura, Shunsuke Kimura, Tomomi Miyamoto, Masatoshi Ito, Yoshinori Shimamoto, Jun Okabe, Yoshinori Naoe, Koji Hase, Osamu Ohara, Ichiro Miyoshi
- Organizer
  The 4th EMBO meeting
- Place of Presentation
  アクロポリス国際会議場（ニース、フランス）
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] ヘルパーT細胞分化過程における特異的な選択的スプライシングの検出2011
- Author(s)
  直江吉則
- Organizer
  第21回Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] 老化関連因子Zizimin2/Dock11の獲得免疫系における機能解析2011
- Author(s)
  直江吉則
- Organizer
  第34回日本基礎老化学会年会
- Place of Presentation
  東京
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Functional analysis of an age-related novel GEF、Zizimin2/Dock11 in immunosenescence2011
- Author(s)
  Naoe Y
- Organizer
  Ninth Asia/Oceania Regional Congress of Gerontology and Geriatrics
- Place of Presentation
  Melbourne、Australia
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] 加齢に伴う免疫低下メカニズムの解析2011
- Author(s)
  直江吉則
- Organizer
  第11回日本抗加齢医学会総会
- Place of Presentation
  京都
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Operationg with a fake ID at the border : Lineage switch of mucosal CD4T cells2010
- Author(s)
  Naoe Y
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Molecular mechanisms of functional decline in the immunosenescence2010
- Author(s)
  Naoe Y
- Organizer
  Asian Aging Core for Longevity Research and Education 2010 Jeju Conference
- Place of Presentation
  Jeju、Korea
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] 免疫老化関連因子Zizimin2/Dock11のin vivoにおける機能解析2010
- Author(s)
  直江吉則
- Organizer
  第33回日本基礎老化学会
- Place of Presentation
  名古屋
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] The zinc finger protein MAZR is part of the transcription factor network that regulates CD4/CD8 cell fate decision of DP thymocytes2010
- Author(s)
  Naoe Y
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe、Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] Analysis of zizimin2 function in mouse dendritic cells2009
- Author(s)
  Naoe Y
- Organizer
  第32回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21590348
[Presentation] マクロファージのUSP2による２型糖尿病制御の可能性
- Author(s)
  北村　浩、木村俊介、宮本智美、岡部潤、嶋本良則、直江吉則、三好一郎
- Organizer
  日本実験動物学会
- Place of Presentation
  札幌コンベンションセンター(北海道）
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-24500494
[Presentation] マクロファージのUSP2-新たな糖尿病制御分子-
- Author(s)
  北村浩、木村俊介、岡部潤、宮本智美、嶋本良則、直江吉則、戸田知得、岡本士毅、三好一郎
- Organizer
  日本獣医学会
- Place of Presentation
  北海道大学（北海道）
- Year and Date
  2014-09-09 – 2014-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-24500494

1. 粕谷英樹 (00402636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
2. 松村繁 (60523511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. ISHIDO Satoshi (10273781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KITAMURA Hiroshi (80312403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. MIYOSHI Ichiro (10183972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. OKAMOTO Shiki (40342919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. TAKAHASI Eiki (40446521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IWANAGA Toshihiko (10160128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. KIMURA Shunsuke (40444525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 一ノ瀬亨 (60778091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. SAKAUE Asako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. KODERA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. BUSTOS itzel

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. EISSA ibrahim

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 竹下淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 谷内一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 稲葉俊哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 香城諭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. SEO WOOSEOK

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Naoe Yoshinori 直江 吉則

NAOE Yoshinori 直江 吉則

Research Projects

Research Products

Co-Researchers

固形癌に対するCAR-T、ウイルス療法の併用による新規免疫療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of intestinal flora on the antitumor immunity of oncolytic virusesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌を支える癌関連間葉系幹細胞の癌ワクチンへの標的化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TCR sequencing of tumor infiltrating T cells using iPS cell technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ThPOK represses CXXC5, which inhibits CD40L expression in cytotoxic T cells through epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel immune regulation through regulated MHC II ubiquitination

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulatory effects of macrophage M-mod/USP2 on type2 diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Runx transcriptional factors target genes in regulatory T cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子医学MOOK 31号 がん免疫療法 - What's now and what's next? 第2章の4の3) 腫瘍溶解性ウイルスHF10による再発乳がん多発結節症例, 切除不能進行膵がん症例に対する臨床研究2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 免疫の辞典2012

Author(s)

Publisher

Data Source

[Journal Article] Oncolytic herpes simplex virus HF10 (canerpaturev, C-REV) promotes accumulation of CD8+PD-1- tumor-infiltrating T cells in PD-L1 enriched tumor microenvironment.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Current Status and Future Prospects of Oncolytic Viruses Clinical Trials against Melanoma,Glioma,Pancreatic and Breast cancers.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes2017

Author(s)

Journal Title

Naoe Yoshinori 直江吉則

NAOE Yoshinori 直江吉則

[Book] 遺伝子医学MOOK 31号がん免疫療法 - What's now and what's next? 第2章の4の3) 腫瘍溶解性ウイルスHF10による再発乳がん多発結節症例, 切除不能進行膵がん症例に対する臨床研究2017