Horio Takeshi 堀尾武史

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HORIO Takeshi 堀尾武史

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Researcher Number	50393228
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2025: 大阪公立大学, 大学院医学研究科, 客員教授 2013 – 2015: 川崎医科大学, 医学部, 教授 2007: National Cardiovascular Center Research Institute, Division of Hypertension and Nephrology, Department of Medicine, Medical doctor 2007: 国立循環器病センター研究所, 内科・高血圧腎臓部門, 医員 2007: National Cardiovascular Center Research Institute, 内科・高血圧腎臓部門, 医師 2006: 国立循環器病センター(研究所), 内科高血圧腎臓部門, 医員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Circulatory organs internal medicine / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine
Keywords	Principal Investigator Neovascularization / Natriuretic peptides / Atherosclerosis / 平滑筋細胞 / 血管新生 / ナトリウム利尿ペプチド / 動脈硬化 / 腎機能 / 左室拡張能 / 左室肥大 … More / レニン・アンジオテンシン系 / 降圧薬 / レニン・アンジオテンシン系阻害薬 / 慢性腎臓病 / 縦断研究 / 高血圧 / 心房細動 … More Except Principal Investigator 致死性不整脈 / 心臓交感神経 / 心筋梗塞 / グレリン / カルシニューリン / RGS4 / 心肥大 / GC-A / BNP / ANP / 心臓病態学 Less

循環器疾患における運動誘発性低酸素血症と運動機能、心機能改善に関する研究Principal Investigator
- Principal Investigator
  
  堀尾武史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka Metropolitan University
Primary prevention of atrial fibrillation in hypertensive patientsPrincipal Investigator
- Principal Investigator
  
  HORIO Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kawasaki Medical School
Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.
- Principal Investigator
  
  TOKUDOME Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Antiatherosclerotic therapy using cell differentiation-promoting effect of biologically active peptidesPrincipal Investigator
- Principal Investigator
  
  HORIO Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

All 2015 2014 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] 高血圧性心不全とナトリウム利尿ホルモン2008
- Author(s)
  堀尾武史
- Journal Title
  
  血圧 15
  
  Pages: 161-164
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Ghrelin Suppresses Cardiac Sympathetic Activity and Prevents Early Left Ventricular Remodeling in Rats With Myocardial Infarction.2008
- Author(s)
  Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K
- Journal Title
  
  Am J Physiol Heart Circ Physiol 294(1)
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2008
- Author(s)
  Schwenke DO, Tokudome T, Shirai M, Horio T, Kishimoto I, Klagg P, Kangawa K
- Journal Title
  
  Endocrinology 149
  
  Pages: 5127-5176
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008
- Author(s)
  Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K
- Journal Title
  
  Endocrinology 149(1)
  
  Pages: 237-44
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] 高血圧性心不全-病態と診断・治療の現状高血圧性心不全とナトリウム利尿ホルモン2008
- Author(s)
  堀尾武史
- Journal Title
  
  血圧 15
  
  Pages: 161-4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Hypertensive heart failure and natriuretic peptides.2008
- Author(s)
  Takeshi Horio, et. al.
- Journal Title
  
  J Blood Press 15
  
  Pages: 161-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008
- Author(s)
  Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K,Kangawa K
- Journal Title
  
  Circulation 117
  
  Pages: 2329-2339
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Cardioprotective effects of natriuretic peptides.2007
- Author(s)
  Tokudome T, Kishimoto I, Horio T, kangawa K.
- Journal Title
  
  Nippon Rinsho 65(Suppl 4)
  
  Pages: 165-169
- NAID
  40015438296
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] 心不全の発症進展機序サイトカイン2006
- Author(s)
  堀尾武史
- Journal Title
  
  日本臨床 64(5)
  
  Pages: 843-7
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Progress in therapy of chronic heart failure. Involvement of cytokines in the initiation and development of heart failure.2006
- Author(s)
  Takeshi Horio
- Journal Title
  
  Nihon Rinsho 64
  
  Pages: 843-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Evaluation of target organ damage in hypertension. MMP/TIMP ratio.2006
- Author(s)
  Takeshi Horio, et. al.
- Journal Title
  
  Nihon Rinsho 64(Suppl 6)
  
  Pages: 171-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] 高血圧(下巻)-最新の研究動向- 臓器障害の進展予測検査 MMP/TIMP比2006
- Author(s)
  堀尾武史, 他
- Journal Title
  
  日本臨床 64(増刊号6)
  
  Pages: 171-5
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] 臓器障害の進展予測検査 MMP/TIMP比2006
- Author(s)
  堀尾武史ら
- Journal Title
  
  日本臨床 64(増刊号6)
  
  Pages: 171-5
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] 慢性心不全治療の進歩-成因と臨床研究-心不全の発症進展機序サイトカイン2006
- Author(s)
  堀尾武史
- Journal Title
  
  日本臨床 64
  
  Pages: 843-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons.
- Author(s)
  Kishimoto I, Tokudome T, Horio T, Soeki T, Chusho H, Nakao K, Kangawa K
- Journal Title
  
  J Neuroendocrinol 20(11)
  
  Pages: 1213-1223
- Data Source
  KAKENHI-PROJECT-19790548
[Presentation] 高血圧心と心房細動発症およびその予防：有効なアップストリーム療法はあるのか2015
- Author(s)
  堀尾武史、秋山真樹、岩嶋義雄、吉原史樹、中村敏子、河野雄平
- Organizer
  第38回日本高血圧学会総会（シンポジウム）
- Place of Presentation
  愛媛県県民文化会館（松山）
- Year and Date
  2015-10-11
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] 日本人高血圧患者におけるレニン・アンジオテンシン系阻害薬の心房細動新規発症抑制効果：propensity score matching法を用いた検討2015
- Author(s)
  堀尾武史、秋山真樹、岩嶋義雄、吉原史樹、中村敏子、河野雄平
- Organizer
  第38回日本高血圧学会総会
- Place of Presentation
  愛媛県県民文化会館（松山）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] Risk Factors and Protective Agents for New-Onset Atrial Fibrillation in Hypertensive Patients2015
- Author(s)
  堀尾武史、秋山真樹、岩嶋義雄、吉原史樹、中村敏子、河野雄平
- Organizer
  第79回日本循環器学会学術集会（シンポジウム）
- Place of Presentation
  リーガロイヤルホテル大阪（大阪）
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] プライマリーケア医師の心房細動治療に対する意識調査2014
- Author(s)
  秋山真樹、堀尾武史
- Organizer
  第62回日本心臓病学会学術集会
- Place of Presentation
  仙台市民会館（宮城県・仙台市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] 発作性心房細動の有病を心エコー図法で指摘できるか―心機能良好でE/A高値の高齢者は高率に発作性心房細動を認める―2014
- Author(s)
  秋山真樹、鼠尾晋太郎、井口朋和、西村　哲、堀尾武史
- Organizer
  第25回日本心エコー図学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県・金沢市）
- Year and Date
  2014-04-17
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] C型ナトリウム利尿ペプチド(CNP):心臓における役割2008
- Author(s)
  堀尾武史
- Organizer
  第37回日本心脈管作動物質学会(シンポジウム)
- Place of Presentation
  仙台国際センター
- Year and Date
  2008-02-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] C型ナトリウム利尿ペプチド(CNP) : 心臓における役割2008
- Author(s)
  堀尾武史
- Organizer
  第37回日本心脈管作動物質学会(シンポジウム)
- Place of Presentation
  仙台(仙台国際センター)
- Year and Date
  2008-02-02
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Plasma adrenomedullin and atherosclerotic disease : usefulness as a predictor of future cardiovascular events.2007
- Author(s)
  Takeshi Horio
- Organizer
  39th Annual Scientific Meeting of the Japanese Atherosclerotic Society
- Place of Presentation
  Osaka
- Year and Date
  2007-07-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Plasma adrenomedullin and atherosclerotic disease:usefulness as a predictor of future cardiovascular events2007
- Author(s)
  堀尾武史, 他
- Organizer
  第39回日本動脈硬化学会総会(シンポジウム)
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-07-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] 真の“スーパーノーマル”（若年者と同様の心機能を有する高齢者）はあり得るのか　－心エコー図法で“スーパーノーマル”パターンを呈する被験者について、その基礎心疾患を解明する－
- Author(s)
  秋山真樹、堀尾武史、西村哲、坂口海雲
- Organizer
  第4回川崎医科大学学術集会
- Place of Presentation
  川崎医科大学（岡山県倉敷市）
- Data Source
  KAKENHI-PROJECT-25461079
[Presentation] 高血圧症における心房細動発症の予知と予防に関する研究
- Author(s)
  堀尾武史、秋山真樹、西村哲
- Organizer
  第4回川崎医科大学学術集会
- Place of Presentation
  川崎医科大学（岡山県倉敷市）
- Data Source
  KAKENHI-PROJECT-25461079

1. TOKUDOME Takeshi (00443474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. KISHIMOTO Ichiro (80312221)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. KANGAWA Kenji (00112417)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. AKIYAMA Maki (90309592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

Horio Takeshi 堀尾 武史

HORIO Takeshi 堀尾 武史

Research Projects

Research Products

Co-Researchers

循環器疾患における運動誘発性低酸素血症と運動機能、心機能改善に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Primary prevention of atrial fibrillation in hypertensive patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antiatherosclerotic therapy using cell differentiation-promoting effect of biologically active peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 高血圧性心不全とナトリウム利尿ホルモン2008

Author(s)

Journal Title

Data Source

[Journal Article] Ghrelin Suppresses Cardiac Sympathetic Activity and Prevents Early Left Ventricular Remodeling in Rats With Myocardial Infarction.2008

Author(s)

Journal Title

Data Source

[Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2008

Author(s)

Journal Title

Data Source

[Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008

Author(s)

Journal Title

Data Source

[Journal Article] 高血圧性心不全-病態と診断・治療の現状 高血圧性心不全とナトリウム利尿ホルモン2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hypertensive heart failure and natriuretic peptides.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008

Author(s)

Journal Title

Data Source

[Journal Article] Cardioprotective effects of natriuretic peptides.2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 心不全の発症進展機序 サイトカイン2006

Author(s)

Journal Title

Data Source

[Journal Article] Progress in therapy of chronic heart failure. Involvement of cytokines in the initiation and development of heart failure.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Evaluation of target organ damage in hypertension. MMP/TIMP ratio.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] 高血圧(下巻)-最新の研究動向- 臓器障害の進展予測検査 MMP/TIMP比2006

Author(s)

Horio Takeshi 堀尾武史

HORIO Takeshi 堀尾武史

[Journal Article] 高血圧性心不全-病態と診断・治療の現状高血圧性心不全とナトリウム利尿ホルモン2008

[Journal Article] 心不全の発症進展機序サイトカイン2006

[Journal Article] 慢性心不全治療の進歩-成因と臨床研究-心不全の発症進展機序サイトカイン2006