KEZUKA Yuichiro 毛塚雄一郎

Researcher Number	50397163
Affiliation *help	2009 – 2018 : Iwate Medical University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Functional basic dentistry Except Principal Investigator Morphological basic dentistry / Living organism molecular science / Structural biochemistry
Keywords	Principal Investigator 酵素 / 口腔生化学 / 歯周病 / 硫化水素産生 / 立体構造 / 硫化水素 / 化合物スクリーニング / 薬学 / Fusobacterium / 反応中間体 … More Except Principal Investigator 短鎖脂肪酸 / 歯周病 / キチナーゼ / 歯学 / 糖鎖 / X線溶液散乱 / X線結晶構造解析 / 生物物理 / 酵素反応 / タンパク質 / 酪酸 / 分子動力学計算 / メタボロトーム / 溶液散乱 / モデリング / 抗真菌活性 / 口腔細菌 / X線構造解析 / 蛋白質 / Porphyromonas gingivalis / 代謝 / 分子認識 Less

Development of diagnosis and trial of control for periondontitis using metabrotome of oral bacteriaOngoing
- Principal Investigator
  
  吉田康夫
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
歯周病原細菌による有臭有毒物質産生を抑制する化合物の探索と改良Principal InvestigatorOngoing
- Principal Investigator
  
  毛塚雄一郎
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Elucidation and control of effect of short chain fatty acids on periodontopathogens
- Principal Investigator
  
  Yoshida Yasuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
Screening of novel inhibitors to hydrogen sulfide-producing enzymes -based on enzyme structures and reaction mechanisms- that can prevent oral malodorPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Approaches for elucidation of structure-function relationships of modular chitinases using a novel modeling method
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Iwate Medical University
Establishment of m olecular and structural basis of hydrogen sulfide-producing mechanism in Fusobacteriu mPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Iwate Medical University
Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodorPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis.2016
- Author(s)
  1. Yoshida, Y., Sato, M., Kezuka, Y., Hasegawa, Y., Nagano, K., Takebe, J. and Yoshimura, F.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume : 596 Pages : 138-148
- DOI
  10.1016/j.abb.2016.03.014
- Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462897, KAKENHI-PROJECT-25861752, KAKENHI-PROJECT-26462804
[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle X-ray scattering2013
- Author(s)
  Yuichiro Kezuka
- Journal Title
  
  Photon Factory Activity Rep. Part B
  
  Volume : 30 Pages : 270-270
- Data Source
  KAKENHI-PROJECT-24510302
[Journal Article] Crystal structures of βC-S lyase from Streptococcus anginosus in complex with its reaction intermediates2013
- Author(s)
  Yuichiro Kezuka
- Journal Title
  
  Photon Factory Activity Report
  
  Volume : 30 Pages : 275-275
- Data Source
  KAKENHI-PROJECT-25462897
[Journal Article] Structural insights into catalysis by βC-S lyase from2012
- Author(s)
  Kezuka Y,Yoshida Y, Nonaka T
- Journal Title
  
  treptococcus anginosus
  
  Volume : 80 Pages : 2447-58
- DOI
  10.1002/prot.24129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592721, KAKENHI-PROJECT-23792130
[Journal Article] Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from2012
- Author(s)
  Kezuka Y, Abe N, Yoshida Y, Nonaka
- Journal Title
  
  Acta Crystallogr. F
  
  Volume : 68 Pages : 1507-10
- DOI
  10.1107/S1744309112042546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592721, KAKENHI-PROJECT-23792130
[Journal Article] Identification and enzymatic analysis of a novel protein associated with production of hydrogen sulfide and L-serine from L-cysteine in2011
- Author(s)
  Yoshida, Y., Suwabe, K., Nagano, K., Kezuka, Y., Kato, H. and Yoshimura, F
- Journal Title
  
  Fusobacterium nucleatum subsp. nucleatum ATCC 25586
  
  Volume : Microbiology 15 Pages : 2164-2171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792130
[Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in Fusobacterium nucleatum subsp.nucleatum ATCC 255862010
- Author(s)
  Yoshida, Y.
- Journal Title
  
  Microbiology
  
  Volume : 156 Pages : 2260-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine2010
- Author(s)
  Yoshida, Y., Ito S., Kamo, M., Kezuka, Y., Tamura, H., Kunimatsu, K., Kato, H.
- Journal Title
  
  Fusobacterium nucleatum subsp. nucleatum ATCC 25586. Microbiology 156
  
  Pages : 2260-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Journal Article] Crystallization and preliminary X-ray analysis of βGS lyases from two streptococci2009
- Author(s)
  Kezuka, Y.
- Journal Title
  
  Acta Crystallographica Section F 65
  
  Pages : 874-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Journal Article] Crystallization and preliminary X-ray analysis of βC-S lyases from two oral streptococci.2009
- Author(s)
  Kezuka, Y., Yoshida, Y., Nonaka, T.
- Journal Title
  
  Acta Crystallogr. F 65
  
  Pages : 874-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Phosphotransacetylase and acetate kinase for ATP biosynthesis are essential in Porphyromonas gingivalis2017
- Author(s)
  吉田康夫、佐藤満成、毛塚雄一郎、長谷川義明、永野恵司、吉村文信
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 高硫化水素産生口腔細菌由来cysteine (hydroxyl) lyaseの立体構造と反応機構2017
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  2016年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 133.Phosphotransacetylase and acetate kinase for ATP biosynthesis are essential in Porphyromonas gingivalis2017
- Author(s)
  Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城、仙台）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] Porphyromonas gingivalisにおけるATP産生に関与するphosphotransacetylaseおよびacetate kinaseの酵素学的解析2016
- Author(s)
  吉田康夫、佐藤満成、毛塚雄一郎、長谷川義明、永野恵司、吉村文信
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Porphyromonas gingivalisの酪酸産生に関与するSuccinyl-CoA 還元酵素の構造機能解析2016
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Fusobacterium nucleatum由来硫化水素産生酵素の立体構造と反応機構2016
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  2015年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場（つくば市）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 128.Porphyromonas gingivalisの酪酸産生に関与するSuccinyl-CoA 還元酵素の構造機能解析2016
- Author(s)
  毛塚雄一郎, 吉田康夫
- Organizer
  第58回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌）
- Year and Date
  2016-08-23
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] Porphyromonas gingivalisにおけるATP産生に関与するphosphotransacetylaseおよびacetate kinaseの酵素学的解析2016
- Author(s)
  Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F
- Organizer
  第58回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌）
- Year and Date
  2016-08-23
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] グルタチオン S-トランスフェラーゼ及びヒスチジンタグを融合したタンパク質の発現と精製2015
- Author(s)
  藤原茂晃、福谷俊治、植田光彦、毛塚雄一郎、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2015
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌メチオニン γ-リアーゼの活性測定と結晶化の検討2015
- Author(s)
  鈴木喬介、佐藤裕也、近野平、遠藤彩姫、毛塚雄一郎、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2015
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2015
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24510302
[Presentation] 歯周病原細菌メチオニンγ-リアーゼの活性測定と結晶化の検討2014
- Author(s)
  鈴木喬介、佐藤裕也、近野平、遠藤彩姫、毛塚雄一郎、野中孝昌
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき明星大学（福島県いわき市）
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] Treponema denticolaメチオニンγ-リアーゼの酵素活性測定と結晶化の検討2014
- Author(s)
  佐藤裕也、毛塚雄一郎、野中孝昌
- Organizer
  日本生化学会東北支部第80回例会
- Place of Presentation
  アキタパークホテル（秋田県秋田市）
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2014
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第14回日本蛋白質科学会
- Place of Presentation
  横浜産貿ホールマリネリア（神奈川県横浜市）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2014
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第8回東北糖鎖研究会
- Place of Presentation
  岩手医科大学（岩手県紫波郡矢巾町）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24510302
[Presentation] Structure analysis of hydrogen sulfide-producing enzyme complexed with its reaction intermediates from a periodontal pathogen2013
- Author(s)
  Kezuka, Y., Yoshida, Y. and Nonaka, T
- Organizer
  Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Mini-Symposium -Molecular Bases for Medical and Pharmaceutical Sciences
- Place of Presentation
  Yahaba, Iwate
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2013
- Author(s)
  毛塚雄一郎
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館、鳥取市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-producing enzyme complexed with its reaction intermediates from a periodontal pathogen2013
- Author(s)
  Yuichiro KEZUKA
- Organizer
  Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Mini-Symposium -Molecular Bases for Medical and Pharmaceutical Sciences-
- Place of Presentation
  岩手医科大学、紫波郡矢巾町
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の結晶構造解析2013
- Author(s)
  毛塚雄一郎
- Organizer
  第1回物構研サイエンスフェスタ
- Place of Presentation
  エポカルつくば、つくば市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の結晶構造解析2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第1回物構研サイエンスフェスタ
- Place of Presentation
  つくば市
- Year and Date
  2013-03-14
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-produicing enzyme complexed with its reaction intermediates from a periodontal pathogen2012
- Author(s)
  Kezuka, Y., Yoshida, Y. and Nonaka, T
- Organizer
  A Joint Meeting of the Asian Crystallographic Association and Society of Crystallographers in Australia and New Zealand
- Place of Presentation
  Adelaide, Australia
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  野中孝昌、毛塚雄一郎、吉田康夫
- Organizer
  第6回岩手医科大学先端医療薬学研究センター講演会
- Place of Presentation
  紫波郡矢巾町
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第29回PFシンポジウム
- Place of Presentation
  つくば市
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  毛塚雄一郎
- Organizer
  第29回PFシンポジウム
- Place of Presentation
  エポカルつくば
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-produicing enzyme complexed with its reaction intermediates from a periodontal pathogen2012
- Author(s)
  Yuichiro KEZUKA
- Organizer
  A Joint Meeting of the Asian Crystallographic Association (AsCA) and Society of Crystallographers in Australia and New Zealand (SCANZ)
- Place of Presentation
  Adelaide Convention Centre, Adelaide, Australia
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造2012
- Author(s)
  毛塚雄一郎
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場、名古屋市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ反応中間体の結晶構造解析2010
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Structural insights into catalysis of βC-S lyase from Streptococcus anginosus2010
- Author(s)
  Yuichiro Kezuka
- Organizer
  The 10th Conference of the Asian Crystallographic Association
- Place of Presentation
  BEXCO(釜山、韓国)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ反応中間体の結晶構造解析2010
- Author(s)
  毛塚雄一郎
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Structural insights into catalysis of βC-S lyase from Streptococcus anginosus2010
- Author(s)
  Yuichiro Kezuka, Yasuo Yoshida, Takamasa Nonaka
- Organizer
  The 10th Conference of the Asian Crystallographic Association
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ/基質複合体の結晶構造解析:硫化水素産生能と反応機構2009
- Author(s)
  毛塚雄一郎
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本県)
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ/基質複合体の結晶構造解析:硫化水素産生能と反応機構2009
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Structure of hydrogen sulfide-producing enzyme from a periodontal pathogen
- Author(s)
  Yuichiro Kezuka
- Organizer
  23rd Congress and General Assembly of the International Union of Crystallography
- Place of Presentation
  モントリオール
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構
- Author(s)
  毛塚雄一郎
- Organizer
  第14回日本蛋白質科学会
- Place of Presentation
  横浜市、ワークピア横浜・横浜産貿ホールマリネリア
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構
- Author(s)
  毛塚雄一郎
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  鳥取市、とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25462897

1. YOSHIDA Yasuo (10315096)

# of Collaborated Projects : 4results

# of Collaborated Products : 13results
2. NONAKA Takamasa (30242457)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
3. KOJIMA Masaki (90277252)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. SEKI Yasutaka (30377220)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
5. 吉村文信 (50001962)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
6. 石原裕一 (50261011)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 長谷川義明

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KEZUKA Yuichiro 毛塚 雄一郎

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Development of diagnosis and trial of control for periondontitis using metabrotome of oral bacteriaOngoing

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歯周病原細菌による有臭有毒物質産生を抑制する化合物の探索と改良Principal InvestigatorOngoing

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Elucidation and control of effect of short chain fatty acids on periodontopathogens

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Screening of novel inhibitors to hydrogen sulfide-producing enzymes -based on enzyme structures and reaction mechanisms- that can prevent oral malodorPrincipal Investigator

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Approaches for elucidation of structure-function relationships of modular chitinases using a novel modeling method

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Establishment of m olecular and structural basis of hydrogen sulfide-producing mechanism in Fusobacteriu mPrincipal Investigator

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Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation

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Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodorPrincipal Investigator

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[Journal Article] Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis.2016

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[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle X-ray scattering2013

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[Journal Article] Crystal structures of βC-S lyase from Streptococcus anginosus in complex with its reaction intermediates2013

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[Journal Article] Structural insights into catalysis by βC-S lyase from2012

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[Journal Article] Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from2012

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[Journal Article] Identification and enzymatic analysis of a novel protein associated with production of hydrogen sulfide and L-serine from L-cysteine in2011

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[Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine in Fusobacterium nucleatum subsp.nucleatum ATCC 255862010

KEZUKA Yuichiro 毛塚雄一郎