KEZUKA Yuichiro 毛塚雄一郎

Researcher Number	50397163
Other IDs
Affiliation (Current)	2022: 岩手医科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2009 – 2019: Iwate Medical University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Functional basic dentistry / Basic Section 57080:Social dentistry-related Except Principal Investigator Morphological basic dentistry / Structural biochemistry / Living organism molecular science
Keywords	Principal Investigator 酵素 / 歯周病 / 口腔生化学 / 硫化水素 / 口臭 / 立体構造 / 硫化水素産生 / 化合物スクリーニング / 細菌 / 薬学 … More / Fusobacterium / 硫化水素産生酵素 / 反応中間体 / 揮発性硫化物 / 短鎖脂肪酸 / 阻害剤 / X線結晶構造解析 / Porphyromonas gingivalis / 酵素構造 / 酪酸 / メチルメルカプタン … More Except Principal Investigator キチナーゼ / 短鎖脂肪酸 / 歯周病 / Porphyromonas gingivalis / 歯学 / 代謝 / タンパク質 / X線構造解析 / 蛋白質 / X線結晶構造解析 / X線溶液散乱 / 分子動力学計算 / 酵素反応 / 糖鎖 / 分子認識 / 生物物理 / 抗真菌活性 / モデリング / 溶液散乱 / 酪酸 / ATP / 口腔細菌 / メタボロトーム Less

新規作用機序－揮発性硫化物産生酵素阻害－に基づく口臭予防薬の開発Principal Investigator
- Principal Investigator
  
  毛塚雄一郎
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Iwate Medical University
Development of diagnosis and trial of control for periondontitis using metabrotome of oral bacteria
- Principal Investigator
  
  Yoshida Yasuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
Searching and improvement of the compounds that prevent production of odorous and toxic substances produced by periodontal pathogensPrincipal Investigator
- Principal Investigator
  
  Kezuka Yuichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Elucidation and control of effect of short chain fatty acids on periodontopathogens
- Principal Investigator
  
  Yoshida Yasuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Aichi Gakuin University
Screening of novel inhibitors to hydrogen sulfide-producing enzymes -based on enzyme structures and reaction mechanisms- that can prevent oral malodorPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Approaches for elucidation of structure-function relationships of modular chitinases using a novel modeling method
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Iwate Medical University
Establishment of m olecular and structural basis of hydrogen sulfide-producing mechanism in Fusobacteriu mPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University
Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Iwate Medical University
Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodorPrincipal Investigator
- Principal Investigator
  
  KEZUKA Yuichiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Iwate Medical University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Structure of a phosphotransacetylase from Porphyromonas gingivalis,a keystone pathogen of periodontitis2019
- Author(s)
  Kezuka Y, Yoshida Y, Nonaka
- Journal Title
  
  Photon Factory Activity Rep.Part B
  
  Volume: 36 Pages: 89-89
- Data Source
  KAKENHI-PROJECT-17K11634
[Journal Article] Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis2019
- Author(s)
  Yoshida Yasuo、Sato Mitsunari、Nonaka Takamasa、Hasegawa Yoshiaki、Kezuka Yuichiro
- Journal Title
  
  J. Oral Microbiol.
  
  Volume: 11 Pages: 1588086-1588086
- DOI
  10.1080/20002297.2019.1588086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11485, KAKENHI-PROJECT-17K11634, KAKENHI-PROJECT-19K10469
[Journal Article] Structure of an acetate kinase from Porphyromonas gingivalis,a keystone pathogen of periodontitis2019
- Author(s)
  Kezuka Y, Yoshida Y, Nonaka
- Journal Title
  
  Photon Factory Activity Rep.Part B
  
  Volume: 36 Pages: 90-90
- Data Source
  KAKENHI-PROJECT-17K11634
[Journal Article] Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis2019
- Author(s)
  Y. Yoshida, M. Sato, T. NonakaY, Y. Hasegawa, and Kezuka
- Journal Title
  
  J. Oral Microbio
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11634
[Journal Article] Structural insights into the catalytic mechanism of cysteine (hydroxyl) lyase from the hydrogen sulfide-producing oral pathogen, Fusobacterium nucleatum2018
- Author(s)
  Kezuka Yuichiro、Ishida Tetsuo、Yoshida Yasuo、Nonaka Takamasa
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Pages: 733-748
- DOI
  10.1042/bcj20170838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11485
[Journal Article] Physical and thermodynamic characterization of the rice gibberellin receptor/gibberellin/DELLA protein complex2018
- Author(s)
  Xiang Hongyu、Okamura Hideyasu、Kezuka Yuichiro、Katoh Etsuko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 17719-17719
- DOI
  10.1038/s41598-018-35765-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11485
[Journal Article] Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis.2016
- Author(s)
  1. Yoshida, Y., Sato, M., Kezuka, Y., Hasegawa, Y., Nagano, K., Takebe, J. and Yoshimura, F.
- Journal Title
  
  Arch Biochim Biophys
  
  Volume: 596 Pages: 138-148
- DOI
  10.1016/j.abb.2016.03.014
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462897, KAKENHI-PROJECT-25463012, KAKENHI-PROJECT-25861752, KAKENHI-PROJECT-26462804
[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle X-ray scattering2013
- Author(s)
  Yuichiro Kezuka
- Journal Title
  
  Photon Factory Activity Rep. Part B
  
  Volume: 30 Pages: 270-270
- Data Source
  KAKENHI-PROJECT-24510302
[Journal Article] Crystal structures of βC-S lyase from Streptococcus anginosus in complex with its reaction intermediates2013
- Author(s)
  Yuichiro Kezuka
- Journal Title
  
  Photon Factory Activity Report
  
  Volume: 30 Pages: 275-275
- Data Source
  KAKENHI-PROJECT-25462897
[Journal Article] Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from2012
- Author(s)
  Kezuka Y, Abe N, Yoshida Y, Nonaka
- Journal Title
  
  Fusobacterium nucleatum. Acta Crystallogr
  
  Volume: 68 Pages: 1507-10
- DOI
  10.1107/s1744309112042546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592721, KAKENHI-PROJECT-23792130
[Journal Article] Structural insights into catalysis by βC-S lyase from2012
- Author(s)
  Kezuka Y,Yoshida Y, Nonaka T
- Journal Title
  
  treptococcus anginosus
  
  Volume: 80 Pages: 2447-2458
- DOI
  10.1002/prot.24129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592721, KAKENHI-PROJECT-23792130
[Journal Article] Identification and enzymatic analysis of a novel protein associated with production of hydrogen sulfide and L-serine from L-cysteine in2011
- Author(s)
  Yoshida, Y., Suwabe, K., Nagano, K., Kezuka, Y., Kato, H. and Yoshimura, F
- Journal Title
  
  Fusobacterium nucleatum subsp. nucleatum ATCC 25586
  
  Volume: Microbiology 15 Pages: 2164-2171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792130
[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle2010
- Author(s)
  Kezuka, Y., Kojima, M., Mizuno, R., Suzuki, K., Watanabe, T. & Nonaka, T
- Journal Title
  
  X-ray scattering Proteins
  
  Volume: 78 Pages: 2295-2305
- Data Source
  KAKENHI-PROJECT-21570119
[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray cry stallography and small-angle X-ray scattering2010
- Author(s)
  Kezuka, Y.
- Journal Title
  
  Proteins : Structure, Function, and Bioinformatics
  
  Volume: 78 Pages: 2295-2305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570119
[Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine2010
- Author(s)
  Yoshida, Y., Ito S., Kamo, M., Kezuka, Y., Tamura, H., Kunimatsu, K., Kato, H.
- Journal Title
  
  Fusobacterium nucleatum subsp. nucleatum ATCC 25586. Microbiology 156
  
  Pages: 2260-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Journal Article] Crystallization and preliminary X-ray analysis of βGS lyases from two streptococci2009
- Author(s)
  Kezuka, Y.
- Journal Title
  
  Acta Crystallographica Section F 65
  
  Pages: 874-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Journal Article] Crystallization and preliminary X-ray analysis of βC-S lyases from two oral streptococci.2009
- Author(s)
  Kezuka, Y., Yoshida, Y., Nonaka, T.
- Journal Title
  
  Acta Crystallogr. F 65
  
  Pages: 874-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Searching for novel inhibitors to a hydrogen sulfide-producing enzyme from Fusobacteriumnucleatum.2019
- Author(s)
  Kezuka Y, Yoshida Y
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11634
[Presentation] Fusobacterium nucleatum硫化水素産生酵素阻害剤の探索2019
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10469
[Presentation] Porphyromonas gingivalisのATP合成に関与するphosphotransacetylase (Pta)およびacetate kinase (Ack)の遺伝学的および酵素学的解析2018
- Author(s)
  吉田康夫、毛塚雄一郎、長谷川義明
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Porphyromonas gingivalis のATP合成に関与するphosphotransacetylase (Pta)およびacetate kinase (Ack)の遺伝学的および酵素学的解析2018
- Author(s)
  Yasuo Yoshida, Yuichiro Kezuka, Yoshiaki Hasegawa
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17K11634
[Presentation] Porphyromonas gingivalisのATP産生に関与するphosphotransacetylaseおよびacetate kinaseの立体構造解析と生化学的解析2018
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 口腔細菌に由来する硫化水素産生酵素 cysteine (hydroxyl) lyaseの構造と反応機構2018
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  日本生化学会東北支部84回例会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 口腔細菌に由来する硫化水素産生酵素cysteine (hydroxyl) lyaseの構造と反応機構2018
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  日本生化学会東北支部第84回例会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Porphyromonas gingivalisのATP産生に関与するphosphotransacetylaseおよびacetate kinaseの立体構造解析と生化学的解析2018
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17K11634
[Presentation] Fusobacterium nucleatumにおける硫化水素産生機構の解明とその制御2017
- Author(s)
  毛塚雄一郎
- Organizer
  平成29年度歯科基礎医学会若手研究者助成コンペティション
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Phosphotransacetylase and acetate kinase for ATP biosynthesis are essential in Porphyromonas gingivalis.2017
- Author(s)
  Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F.
- Organizer
  第90回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K11634
[Presentation] メチオニンγ-リアーゼに対する化合物スクリーニングアッセイ系の構築2017
- Author(s)
  菊池彩子、野中孝昌、毛塚雄一郎
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Fusobacterium nucleatumに特有の硫化水素産生酵素Fn1055の立体構造と反応機構2017
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Phosphotransacetylase and acetate kinase for ATP biosynthesis are essential in Porphyromonas gingivalis2017
- Author(s)
  吉田康夫、佐藤満成、毛塚雄一郎、長谷川義明、永野恵司、吉村文信
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 硫化水素産生口腔細菌由来cysteine (hydroxyl) lyaseの構造および生化学的解析2017
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  2017年度酵素補酵素研究会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 高硫化水素産生口腔細菌由来cysteine (hydroxyl) lyaseの立体構造と反応機構2017
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  2016年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 硫化水素産生口腔細菌由来cysteine (hydroxyl) lyaseの構造および生化学的解析2017
- Author(s)
  毛塚雄一郎、石田哲夫、吉田康夫、野中孝昌
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] 133.Phosphotransacetylase and acetate kinase for ATP biosynthesis are essential in Porphyromonas gingivalis2017
- Author(s)
  Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城、仙台）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] Porphyromonas gingivalisにおけるATP産生に関与するphosphotransacetylaseおよびacetate kinaseの酵素学的解析2016
- Author(s)
  吉田康夫、佐藤満成、毛塚雄一郎、長谷川義明、永野恵司、吉村文信
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Porphyromonas gingivalisの酪酸産生に関与するSuccinyl-CoA 還元酵素の構造機能解析2016
- Author(s)
  毛塚雄一郎、吉田康夫
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-16K11485
[Presentation] Fusobacterium nucleatum由来硫化水素産生酵素の立体構造と反応機構2016
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  2015年度量子ビームサイエンスフェスタ
- Place of Presentation
  つくば国際会議場（つくば市）
- Year and Date
  2016-03-15
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 128.Porphyromonas gingivalisの酪酸産生に関与するSuccinyl-CoA 還元酵素の構造機能解析2016
- Author(s)
  毛塚雄一郎, 吉田康夫
- Organizer
  第58回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌）
- Year and Date
  2016-08-23
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] Porphyromonas gingivalisにおけるATP産生に関与するphosphotransacetylaseおよびacetate kinaseの酵素学的解析2016
- Author(s)
  Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F
- Organizer
  第58回歯科基礎医学会学術大会・総会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌）
- Year and Date
  2016-08-23
- Data Source
  KAKENHI-PROJECT-26462804
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2015
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2015
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] グルタチオン S-トランスフェラーゼ及びヒスチジンタグを融合したタンパク質の発現と精製2015
- Author(s)
  藤原茂晃、福谷俊治、植田光彦、毛塚雄一郎、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌メチオニン γ-リアーゼの活性測定と結晶化の検討2015
- Author(s)
  鈴木喬介、佐藤裕也、近野平、遠藤彩姫、毛塚雄一郎、野中孝昌
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2015
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第15回日本蛋白質科学会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24510302
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2014
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第14回日本蛋白質科学会
- Place of Presentation
  横浜産貿ホールマリネリア（神奈川県横浜市）
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌メチオニンγ-リアーゼの活性測定と結晶化の検討2014
- Author(s)
  鈴木喬介、佐藤裕也、近野平、遠藤彩姫、毛塚雄一郎、野中孝昌
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき明星大学（福島県いわき市）
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] Treponema denticolaメチオニンγ-リアーゼの酵素活性測定と結晶化の検討2014
- Author(s)
  佐藤裕也、毛塚雄一郎、野中孝昌
- Organizer
  日本生化学会東北支部第80回例会
- Place of Presentation
  アキタパークホテル（秋田県秋田市）
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] モジュラーキチナーゼの立体構造と抗真菌活性の相関解明への試み2014
- Author(s)
  毛塚雄一郎、関安孝、野中孝昌
- Organizer
  第8回東北糖鎖研究会
- Place of Presentation
  岩手医科大学（岩手県紫波郡矢巾町）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24510302
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市
- Year and Date
  2013-06-12
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-producing enzyme complexed with its reaction intermediates from a periodontal pathogen2013
- Author(s)
  Yuichiro KEZUKA
- Organizer
  Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Mini-Symposium -Molecular Bases for Medical and Pharmaceutical Sciences-
- Place of Presentation
  岩手医科大学、紫波郡矢巾町
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の結晶構造解析2013
- Author(s)
  毛塚雄一郎
- Organizer
  第1回物構研サイエンスフェスタ
- Place of Presentation
  エポカルつくば、つくば市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構2013
- Author(s)
  毛塚雄一郎
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  とりぎん文化会館、鳥取市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素の結晶構造解析2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第1回物構研サイエンスフェスタ
- Place of Presentation
  つくば市
- Year and Date
  2013-03-14
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-producing enzyme complexed with its reaction intermediates from a periodontal pathogen2013
- Author(s)
  Kezuka, Y., Yoshida, Y. and Nonaka, T
- Organizer
  Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) Mini-Symposium -Molecular Bases for Medical and Pharmaceutical Sciences
- Place of Presentation
  Yahaba, Iwate
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造2013
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2013-06-20
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  野中孝昌、毛塚雄一郎、吉田康夫
- Organizer
  第6回岩手医科大学先端医療薬学研究センター講演会
- Place of Presentation
  紫波郡矢巾町
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-produicing enzyme complexed with its reaction intermediates from a periodontal pathogen2012
- Author(s)
  Kezuka, Y., Yoshida, Y. and Nonaka, T
- Organizer
  A Joint Meeting of the Asian Crystallographic Association and Society of Crystallographers in Australia and New Zealand
- Place of Presentation
  Adelaide, Australia
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造2012
- Author(s)
  毛塚雄一郎
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場、名古屋市
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structure analysis of hydrogen sulfide-produicing enzyme complexed with its reaction intermediates from a periodontal pathogen2012
- Author(s)
  Yuichiro KEZUKA
- Organizer
  A Joint Meeting of the Asian Crystallographic Association (AsCA) and Society of Crystallographers in Australia and New Zealand (SCANZ)
- Place of Presentation
  Adelaide Convention Centre, Adelaide, Australia
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 天然変性領域を含むタンパク質構造アンサンブルの構築2012
- Author(s)
  関安孝、毛塚雄一郎、野中孝昌
- Organizer
  第6回岩手医科大学先端医療薬学研究センター講演会
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21570119
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第29回PFシンポジウム
- Place of Presentation
  つくば市
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] 歯周病原細菌由来硫化水素産生酵素-反応中間体の結晶構造解析2012
- Author(s)
  毛塚雄一郎
- Organizer
  第29回PFシンポジウム
- Place of Presentation
  エポカルつくば
- Data Source
  KAKENHI-PROJECT-23792130
[Presentation] Structural insights into catalysis of βC-S lyase from Streptococcus anginosus2010
- Author(s)
  Yuichiro Kezuka, Yasuo Yoshida, Takamasa Nonaka
- Organizer
  The 10th Conference of the Asian Crystallographic Association
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ反応中間体の結晶構造解析2010
- Author(s)
  毛塚雄一郎
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ反応中間体の結晶構造解析2010
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Structural insights into catalysis of βC-S lyase from Streptococcus anginosus2010
- Author(s)
  Yuichiro Kezuka
- Organizer
  The 10th Conference of the Asian Crystallographic Association
- Place of Presentation
  BEXCO(釜山、韓国)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 細菌キチナーゼキチン結合ドメインの結合特性の比較解析2010
- Author(s)
  植村迪夫、丸屋良輔、山田伸明、原政司、池上貴久、毛塚雄一郎、野中孝昌、鈴木一史、渡邉剛志
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京大学駒場キャンパス
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21570119
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ/基質複合体の結晶構造解析:硫化水素産生能と反応機構2009
- Author(s)
  毛塚雄一郎、吉田康夫、野中孝昌
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] 口腔レンサ球菌由来βC-Sリアーゼ/基質複合体の結晶構造解析:硫化水素産生能と反応機構2009
- Author(s)
  毛塚雄一郎
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本県)
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21791810
[Presentation] Structural studies of a bacterial modular chitinase belonging to glycoside hydrolase family 192009
- Author(s)
  Yuichiro Kezuka, Yoshikane Itoh, Jun Watanabe, Takeshi Watanabe, and Takamasa Nonaka
- Organizer
  JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21570119
[Presentation] ファミリー19キチナーゼ活性ドメインの局所構造と分解生成物2009
- Author(s)
  杉山真一、岡田真司、深溝慶、毛塚雄一郎、野中孝昌、鈴木一史、渡邉剛志
- Organizer
  第23回キチン・キトサンシンポジウム
- Place of Presentation
  佐賀大学本庄キャンパス
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21570119
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構
- Author(s)
  毛塚雄一郎
- Organizer
  第14回日本蛋白質科学会
- Place of Presentation
  横浜市、ワークピア横浜・横浜産貿ホールマリネリア
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] Structure of hydrogen sulfide-producing enzyme from a periodontal pathogen
- Author(s)
  Yuichiro Kezuka
- Organizer
  23rd Congress and General Assembly of the International Union of Crystallography
- Place of Presentation
  モントリオール
- Data Source
  KAKENHI-PROJECT-25462897
[Presentation] 歯周病原細菌由来硫化水素産生酵素の構造と反応機構
- Author(s)
  毛塚雄一郎
- Organizer
  第13回日本蛋白質科学会
- Place of Presentation
  鳥取市、とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25462897

1. YOSHIDA Yasuo (10315096)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
2. NONAKA Takamasa (30242457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. KOJIMA Masaki (90277252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SEKI Yasutaka (30377220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 吉村文信 (50001962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 石原裕一 (50261011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITO Shuntaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HASEGAWA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 武部純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KEZUKA Yuichiro 毛塚 雄一郎

Research Projects

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新規作用機序－揮発性硫化物産生酵素阻害－に基づく口臭予防薬の開発Principal Investigator

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Development of diagnosis and trial of control for periondontitis using metabrotome of oral bacteria

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Searching and improvement of the compounds that prevent production of odorous and toxic substances produced by periodontal pathogensPrincipal Investigator

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Elucidation and control of effect of short chain fatty acids on periodontopathogens

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Screening of novel inhibitors to hydrogen sulfide-producing enzymes -based on enzyme structures and reaction mechanisms- that can prevent oral malodorPrincipal Investigator

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Approaches for elucidation of structure-function relationships of modular chitinases using a novel modeling method

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Establishment of m olecular and structural basis of hydrogen sulfide-producing mechanism in Fusobacteriu mPrincipal Investigator

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Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation

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Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodorPrincipal Investigator

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[Journal Article] Structure of a phosphotransacetylase from Porphyromonas gingivalis,a keystone pathogen of periodontitis2019

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[Journal Article] Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis2019

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[Journal Article] Structure of an acetate kinase from Porphyromonas gingivalis,a keystone pathogen of periodontitis2019

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[Journal Article] Characterization of the phosphotransacetylase-acetate kinase pathway for ATP production in Porphyromonas gingivalis2019

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[Journal Article] Structural insights into the catalytic mechanism of cysteine (hydroxyl) lyase from the hydrogen sulfide-producing oral pathogen, Fusobacterium nucleatum2018

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KEZUKA Yuichiro 毛塚雄一郎