Kikkawa Naoko 吉川直子

… Alternative Names

Researcher Number	50400924
Other IDs
Affiliation (Current)	2022: 千葉大学, 大学院医学研究院, 特任講師
Affiliation (based on the past Project Information) *help	2022: 千葉大学, 大学院医学研究院, 特任講師 2020: 千葉大学, 大学院医学研究院, 特任講師 2019: 千葉大学, 医学部附属病院, 助教 2016 – 2018: 千葉大学, 医学部附属病院, 医員 2017: 千葉大学, 医学部附属病院, その他 2014 – 2015: 千葉大学, 医学部附属病院, 特任助教 2011 – 2013: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator マイクロRNA / 頭頸部扁平上皮癌 / マイクロＲＮＡ / 頭頸部癌 / がん抑制遺伝子 / 癌抑制遺伝子 / (1)頭頸部癌 / (2)マイクロRNA / 下咽頭癌 / miR-504 … More Except Principal Investigator 頭頸部扁平上皮癌 / 癌抑制型マイクロRNA / 癌遺伝子 / マイクロRNA / MET / 細胞外マトリックス Less

頭頸部扁平上皮癌・スーパーエンハンサー解析に基づく抗癌剤耐性機構の解明Principal Investigator
- Principal Investigator
  
  吉川直子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
機能性RNAを起点とした治療抵抗性頭頸部扁平上皮癌のドラッグリポジション戦略Principal Investigator
- Principal Investigator
  
  吉川直子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
Identification of activated molecular pathways involved in treatment-resistant head and neck squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KIKKAWA NAOKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Elucidation of the extracellular matrix signal mechanism controled by tumor suppressor microRNAs in head and neck cancer
- Principal Investigator
  
  Ichiro Fukumoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
  Chiba University
Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysisPrincipal Investigator
- Principal Investigator
  
  KIKKAWA Naoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Identification of hypo-pharyngeal and esophageal squamous cell carcinoma molecular pathways based on microRNA expression signaturePrincipal Investigator
- Principal Investigator
  
  KIKKAWA Naoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Toxic epidermal necrolysis associated with nivolumab treatment for head and neck cancer2020
- Author(s)
  Koshizuka K, Sakurai D, Sunagane M, Mita Y, Hamasaki S, Suzuki T, Kikkawa N, Nakano M, Hanazawa T.
- Journal Title
  
  Clin Case Rep.
  
  Volume: 9 Pages: 848-852
- DOI
  10.1002/ccr3.3695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09863
[Journal Article] Regulation of KIF2A by Antitumor miR-451a Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma2019
- Author(s)
  Uchida Akifumi、Seki Naohiko、Mizuno Keiko、Yamada Yasutaka、Misono Shunsuke、Sanada Hiroki、Kikkawa Naoko、Kumamoto Tomohiro、Suetsugu Takayuki、Inoue Hiromasa
- Journal Title
  
  Cancers
  
  Volume: 11 Pages: 258-258
- DOI
  10.3390/cancers11020258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-18K09338
[Journal Article] Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma2019
- Author(s)
  Uchida Akifumi、Seki Naohiko、Mizuno Keiko、Misono Shunsuke、Yamada Yasutaka、Kikkawa Naoko、Sanada Hiroki、Kumamoto Tomohiro、Suetsugu Takayuki、Inoue Hiromasa
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 420-432
- DOI
  10.1111/cas.13853
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-18K09338
[Journal Article] Inhibition of integrin beta1-mediated oncogenic signalling by the antitumor microRNA-29 family in head and neck squamous cell carcinoma.2018
- Author(s)
  Koshizuka Keiichi、Kikkawa Naoko、Hanazawa Toyoyuki、Yamada Yasutaka、Okato Atsushi、Arai Takayuki、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 3663-3676
- DOI
  10.18632/oncotarget.23194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-17K16893, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K20229
[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017
- Author(s)
  Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Matsushita R, Mataki H, Mizuno K, Okamoto Y, Seki N.
- Journal Title
  
  J Hum Genet.
  
  Volume: 62 Pages: 113-121
- DOI
  10.1038/jhg.2016.47
- NAID
  40021036343
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K11224
[Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-<i>miR</i>-150 as antitumor miRNAs2017
- Author(s)
  Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Pages: 30288-30304
- DOI
  10.18632/oncotarget.16327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-17K11375, KAKENHI-PROJECT-17K16893, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K20229
[Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017
- Author(s)
  Keiichi Koshizuka, Toyoyuki Hanazawa, Ichiro Fukumoto, Naoko Kikkawa, Yoshitaka Okamoto, Naohiko Seki.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 62 Pages: 3-13
- DOI
  10.1038/jhg.2016.105
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K10800
[Journal Article] Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer2017
- Author(s)
  Koshizuka Keiichi、Hanazawa Toyoyuki、Kikkawa Naoko、Arai Takayuki、Okato Atsushi、Kurozumi Akira、Kato Mayuko、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Pages: 1681-1692
- DOI
  10.1111/cas.13298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-17K11375, KAKENHI-PROJECT-17K16893, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K20229
[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma2016
- Author(s)
  Fukumoto I, Koshizuka K, Hanazawa T, Kikkawa N, Matsushita R, Kurozumi A, Kato M, Okato A, Okamoto Y, Seki N.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 49（3） Pages: 1119-1129
- DOI
  10.3892/ijo.2016.3602
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K11224
[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.2016
- Author(s)
  Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
- Journal Title
  
  J Hum Genet.
  
  Volume: 61(2) Pages: 109-118
- DOI
  10.1038/jhg.2015.120
- NAID
  40020742209
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596
[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways2015
- Author(s)
  Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  British Journal of Cancer
  
  Volume: 112 Pages: 891-900
- DOI
  10.1038/bjc.2015.19
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-26462596
[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014
- Author(s)
  Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol
  
  Volume: 44 Pages: 2085-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462676
[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.2014
- Author(s)
  Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, Yamamoto N, Goto Y, Nishikawa R, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume: 111 Pages: 386-394
- DOI
  10.1038/bjc.2014.293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528
[Journal Article] Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and necksquamous cell carcinoma2012
- Author(s)
  Kinoshita T, Hanazawa T, Nohata N,Kikkawa N, Enokida H, Yoshino H, Yamasaki T, Hidaka H, Nakagawa M, Okamoto Y, Seki N
- Journal Title
  
  Oncotarget
  
  Volume: 3(11) Pages: 1386-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Journal Article] Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinussquamous cell carcinoma2011
- Author(s)
  Nohata N, Hanazawa T, Kikkawa N, Sakurai D, Fujimura L, Chiyomaru T, Kawakami K, Yoshino H, Enokida H, Nakagawa M, Katayama A, Harabuchi Y, Okamoto Y, Seki N
- Journal Title
  
  Br J Cancer
  
  Volume: 105 Pages: 833-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Journal Article] (2010) miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)2010
- Author(s)
  Kikkawa N, Hanazawa T, Fujimura L, Nohata N, Suzuki H, Chazono H, Sakurai D,Horiguchi S, Okamoto Y, Seki N
- Journal Title
  
  Br J Cancer
  
  Volume: 103 Pages: 877-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 当科における高齢者の局所進行頭頸部癌に対するセツキシマブ併用放射線治療の臨床的検討2019
- Author(s)
  吉川直子
- Organizer
  第120回日本耳鼻咽喉科学会
- Data Source
  KAKENHI-PROJECT-19K09863
[Presentation] 姑息照射とS1内服にて制御良好な高齢者局所進行下咽頭癌の一症例2019
- Author(s)
  吉川直子
- Organizer
  第43回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-19K09863
[Presentation] 次世代シークエンサーを用いた頭頸部扁平上皮癌・マイクロＲＮＡ発現プロファイルに基づく新規癌抑制型マイクロＲＮＡの探索2017
- Author(s)
  吉川直子　越塚慶一　花澤豊行　福本一郎　岡本美孝　関直彦
- Organizer
  第41回頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-16K11224
[Presentation] 当科における頭頸部癌に対するセツキシマブ併用放射線治療の臨床的検討2017
- Author(s)
  吉川直子　國井直樹　鈴木猛司　山崎一樹　米倉修二　茶薗英明　櫻井大樹　花澤豊行　岡本美孝
- Organizer
  第79回耳鼻咽喉科臨床学会
- Data Source
  KAKENHI-PROJECT-16K11224
[Presentation] 下咽頭癌における癌抑制型ｍｉｃｒｏＲＮＡ－５０４の機能解析と標的分子の探索2014
- Author(s)
  吉川直子　花澤豊行　木下崇　福本一郎　岡本美孝
- Organizer
  第115回　日本耳鼻咽喉科学会総会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県福岡市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25462676
[Presentation] 下咽頭癌においてｍｉＲ－５０４はＣＤＫ６の制御を介して細胞増殖を抑制する2014
- Author(s)
  吉川直子　花澤豊行　木下崇　福本一郎　岡本美孝　関直彦
- Organizer
  第38回　日本頭頸部癌学会
- Place of Presentation
  東京ファッションタウンビル（東京都江東区）
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-25462676
[Presentation] 関直彦癌抑制型microRNA-375が制御する頭頸部扁平上皮癌の新規分子ネットワークの解明2012
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、木下崇、鈴木誉、茶薗英明、櫻井大樹、岡本美孝
- Organizer
  第36回日本頭頸部癌学会学術講演会
- Place of Presentation
  日島根県民会館島根
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 癌抑制型microRNA-375が制御する頭頸部扁平上皮癌の新規分子ネットワークの解明2012
- Author(s)
  吉川直子
- Organizer
  第36回　日本頭頸部癌学会学術講演会
- Place of Presentation
  島根県民会館　島根
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] Yoshitaka Okamoto, Naohiko SekiTumor suppressive microRNA-375 regulates molecular targets in head and neck squamous cell carcinoma2012
- Author(s)
  Naoko Kikkawa, Takashi Kinosita, NijiroNohata, Toyoyuki Hanazawa, Hirofumi Yosino, Hedeki Enokida, Masayuki Nakagawa
- Organizer
  第71回日本癌学会
- Place of Presentation
  ロイトン札幌札幌
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] Tumor suppressive microRNA-375 regulates molecular targets in head and neck squamous cell carcinoma2012
- Author(s)
  Naoko　Kikkawa
- Organizer
  第71回　日本癌学会
- Place of Presentation
  ロイトン札幌　札幌
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 岡本美孝下咽頭癌における癌抑制マイクロRNAの探索2011
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、鈴木誉、茶薗英明、櫻井大樹、堀口茂俊
- Organizer
  第112回日本耳鼻咽喉科学会
- Place of Presentation
  国立京都国際会館京都
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 関直彦頭頸部扁平上皮癌におけるmicroRNA-1の癌抑制機能と新規分子ネットワークの解明2011
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、ムラディルムラリフ、鈴木誉、茶薗英明、櫻井大樹、佐々木慶太、岡本美孝
- Organizer
  第35回日本頭頸部癌学会
- Place of Presentation
  ウインクあいち名古屋
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-1の癌抑制機能と新規分子ネットワークの解明
- Author(s)
  吉川直子
- Organizer
  第35回　日本頭頸部癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 下咽頭癌における癌抑制マイクロRNAの探索
- Author(s)
  吉川直子
- Organizer
  第112回　日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791876

1. SEKI Naohiko (50345013)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. HANAZAWA Toyoyuki (90272327)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. Ichiro Fukumoto (70748764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 岡本美孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
5. 木下崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 越塚慶一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 堅田浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kikkawa Naoko 吉川 直子

吉川 直子 キッカワ ナオコ

KIKKAWA Naoko 吉川 直子

Research Projects

Research Products

Co-Researchers

頭頸部扁平上皮癌・スーパーエンハンサー解析に基づく抗癌剤耐性機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

機能性RNAを起点とした治療抵抗性頭頸部扁平上皮癌のドラッグリポジション戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of activated molecular pathways involved in treatment-resistant head and neck squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the extracellular matrix signal mechanism controled by tumor suppressor microRNAs in head and neck cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hypo-pharyngeal and esophageal squamous cell carcinoma molecular pathways based on microRNA expression signaturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Toxic epidermal necrolysis associated with nivolumab treatment for head and neck cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of KIF2A by Antitumor miR-451a Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of integrin beta1-mediated oncogenic signalling by the antitumor microRNA-29 family in head and neck squamous cell carcinoma.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-<i>miR</i>-150 as antitumor miRNAs2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer2017

Author(s)

Kikkawa Naoko 吉川直子

吉川直子キッカワナオコ

KIKKAWA Naoko 吉川直子

[Presentation] 当科における頭頸部癌に対するセツキシマブ併用放射線治療の臨床的検討2017