KIKKAWA Naoko 吉川直子

Researcher Number	50400924
Affiliation *help	2016 – 2018 : 千葉大学, 医学部附属病院, 医員 2014 – 2015 : 千葉大学, 医学部附属病院, 特任助教 2011 – 2013 : 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Otorhinolaryngology Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator マイクロRNA / マイクロＲＮＡ / がん抑制遺伝子 / 頭頸部扁平上皮癌 / 頭頸部癌 / 下咽頭癌 / ｍｉｃｒｏＲＮＡ / (2)マイクロRNA / miR-504 / (1)頭頸部癌 / CDK6 … More Except Principal Investigator … More

治療抵抗性頭頸部扁平上皮癌において活性化されている機能性RNA分子経路の探索Principal InvestigatorOngoing
- Principal Investigator
  
  吉川直子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
頭頸部癌転移抑制型マイクロRNAが制御する細胞外マトリックスシグナル機構の解明Ongoing
- Principal Investigator
  
  福本一郎
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysisPrincipal Investigator
- Principal Investigator
  
  KIKKAWA Naoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Identification of hypo-pharyngeal and esophageal squamous cell carcinoma molecular pathways based on microRNA expression signaturePrincipal Investigator
- Principal Investigator
  
  KIKKAWA Naoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2017 2016 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017
- Author(s)
  Keiichi Koshizuka, Toyoyuki Hanazawa, Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Hiroko Mataki, Keiko Mizuno, Yoshitaka Okamoto and Naohiko Sekii
- Journal Title
  
  Journal of Human Genetics
  
  Volume : 62(1) Pages : 113-121
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10800
[Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017
- Author(s)
  Keiichi Koshizuka, Toyoyuki Hanazawa, Ichiro Fukumoto, Naoko Kikkawa, Yoshitaka Okamoto, Naohiko Seki.
- Journal Title
  
  Journal of Human Genetics
  
  Volume : 62 Pages : 3-13
- DOI
  10.1038/jhg.2016.105
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K10800
[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017
- Author(s)
  Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Matsushita R, Mataki H, Mizuno K, Okamoto Y, Seki N.
- Journal Title
  
  J Hum Genet.
  
  Volume : 62 Pages : 113-121
- DOI
  10.1038/jhg.2016.47
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-16K11224, KAKENHI-PROJECT-15K10801, KAKENHI-PUBLICLY-24112702
[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma2016
- Author(s)
  ICHIRO FUKUMOTO, KEIICHI KOSHIZUKA, TOYOYUKI HANAZAWA, NAOKO KIKKAWA, RYOSUkE MATSUSHITA, AKIRA KUROZUMI, MAYUKO KATO, ATSUSHI OKATO, YOSHITAKA OKAMOTO and NAOHIKO SEKI
- Journal Title
  
  INTERNATIONAL JOURNAL OF ONCOLOGY
  
  Volume : 49 Pages : 1119-1129
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10800
[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma2016
- Author(s)
  Fukumoto I, Koshizuka K, Hanazawa T, Kikkawa N, Matsushita R, Kurozumi A, Kato M, Okato A, Okamoto Y, Seki N.
- Journal Title
  
  International Journal of Oncology
  
  Volume : 49（3） Pages : 1119-29
- DOI
  10.3892/ijo.2016.3602
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-16K11224
[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.2016
- Author(s)
  Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
- Journal Title
  
  Journal ｏｆHuman Genetics
  
  Volume : 61(2) Pages : 109-118
- DOI
  10.1038/jhg.2015.120
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-26462596
[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways2015
- Author(s)
  Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  British Journal of Cancer
  
  Volume : 112 Pages : 891-900
- DOI
  10.1038/bjc.2015.19
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528, KAKENHI-PROJECT-15K10800, KAKENHI-PROJECT-15K10801, KAKENHI-PROJECT-26462596
[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.2014
- Author(s)
  Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, Yamamoto N, Goto Y, Nishikawa R, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Br J Cancer
  
  Volume : 111 Pages : 386-394
- DOI
  10.1038/bjc.2014.293
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-25462676, KAKENHI-PROJECT-25861528
[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014
- Author(s)
  Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
- Journal Title
  
  Int J Oncol
  
  Volume : 44 Pages : 2085-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462676
[Journal Article] Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and necksquamous cell carcinoma2012
- Author(s)
  Kinoshita T, Hanazawa T, Nohata N,Kikkawa N, Enokida H, Yoshino H, Yamasaki T, Hidaka H, Nakagawa M, Okamoto Y, Seki N
- Journal Title
  
  Oncotarget
  
  Volume : 3(11) Pages : 1386-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Journal Article] Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinussquamous cell carcinoma2011
- Author(s)
  Nohata N, Hanazawa T, Kikkawa N, Sakurai D, Fujimura L, Chiyomaru T, Kawakami K, Yoshino H, Enokida H, Nakagawa M, Katayama A, Harabuchi Y, Okamoto Y, Seki N
- Journal Title
  
  Br J Cancer
  
  Volume : 105 Pages : 833-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Journal Article] (2010) miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)2010
- Author(s)
  Kikkawa N, Hanazawa T, Fujimura L, Nohata N, Suzuki H, Chazono H, Sakurai D,Horiguchi S, Okamoto Y, Seki N
- Journal Title
  
  Br J Cancer
  
  Volume : 103 Pages : 877-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 下咽頭癌における癌抑制型ｍｉｃｒｏＲＮＡ－５０４の機能解析と標的分子の探索2014
- Author(s)
  吉川直子　花澤豊行　木下崇　福本一郎　岡本美孝
- Organizer
  第115回　日本耳鼻咽喉科学会総会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県福岡市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25462676
[Presentation] 下咽頭癌においてｍｉＲ－５０４はＣＤＫ６の制御を介して細胞増殖を抑制する2014
- Author(s)
  吉川直子　花澤豊行　木下崇　福本一郎　岡本美孝　関直彦
- Organizer
  第38回　日本頭頸部癌学会
- Place of Presentation
  東京ファッションタウンビル（東京都江東区）
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-25462676
[Presentation] 癌抑制型microRNA-375が制御する頭頸部扁平上皮癌の新規分子ネットワークの解明2012
- Author(s)
  吉川直子
- Organizer
  第36回　日本頭頸部癌学会学術講演会
- Place of Presentation
  島根県民会館　島根
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] Yoshitaka Okamoto, Naohiko SekiTumor suppressive microRNA-375 regulates molecular targets in head and neck squamous cell carcinoma2012
- Author(s)
  Naoko Kikkawa, Takashi Kinosita, NijiroNohata, Toyoyuki Hanazawa, Hirofumi Yosino, Hedeki Enokida, Masayuki Nakagawa
- Organizer
  第71回日本癌学会
- Place of Presentation
  ロイトン札幌札幌
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 関直彦癌抑制型microRNA-375が制御する頭頸部扁平上皮癌の新規分子ネットワークの解明2012
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、木下崇、鈴木誉、茶薗英明、櫻井大樹、岡本美孝
- Organizer
  第36回日本頭頸部癌学会学術講演会
- Place of Presentation
  日島根県民会館島根
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] Tumor suppressive microRNA-375 regulates molecular targets in head and neck squamous cell carcinoma2012
- Author(s)
  Naoko　Kikkawa
- Organizer
  第71回　日本癌学会
- Place of Presentation
  ロイトン札幌　札幌
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 関直彦頭頸部扁平上皮癌におけるmicroRNA-1の癌抑制機能と新規分子ネットワークの解明2011
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、ムラディルムラリフ、鈴木誉、茶薗英明、櫻井大樹、佐々木慶太、岡本美孝
- Organizer
  第35回日本頭頸部癌学会
- Place of Presentation
  ウインクあいち名古屋
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 岡本美孝下咽頭癌における癌抑制マイクロRNAの探索2011
- Author(s)
  吉川直子、花澤豊行、野畑二次郎、鈴木誉、茶薗英明、櫻井大樹、堀口茂俊
- Organizer
  第112回日本耳鼻咽喉科学会
- Place of Presentation
  国立京都国際会館京都
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 頭頸部扁平上皮癌におけるmicroRNA-1の癌抑制機能と新規分子ネットワークの解明
- Author(s)
  吉川直子
- Organizer
  第35回　日本頭頸部癌学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791876
[Presentation] 下咽頭癌における癌抑制マイクロRNAの探索
- Author(s)
  吉川直子
- Organizer
  第112回　日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791876

1. SEKI Naohiko (50345013)

# of Collaborated Projects : 3results

# of Collaborated Products : 10results
2. HANAZAWA Toyoyuki (90272327)

# of Collaborated Projects : 2results

# of Collaborated Products : 11results
3. 福本一郎 (70748764)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
4. 木下崇

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
5. 岡本美孝

# of Collaborated Projects : 0results

# of Collaborated Products : 4results
6. 田宮元

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KIKKAWA Naoko 吉川 直子

Research Projects

Research Products

Co-Researchers

治療抵抗性頭頸部扁平上皮癌において活性化されている機能性RNA分子経路の探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

頭頸部癌転移抑制型マイクロRNAが制御する細胞外マトリックスシグナル機構の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of hypo-pharyngeal and esophageal squamous cell carcinoma molecular pathways based on microRNA expression signaturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017

Author(s)

Journal Title

Data Source

[Journal Article] The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma2016

Author(s)

Journal Title

Data Source

[Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014

Author(s)

Journal Title

Data Source

[Journal Article] Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and necksquamous cell carcinoma2012

Author(s)

Journal Title

Data Source

[Journal Article] Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinussquamous cell carcinoma2011

Author(s)

Journal Title

Data Source

[Journal Article] (2010) miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC)2010

Author(s)

KIKKAWA Naoko 吉川直子