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TSUBOCHI Hiroyoshi  坪地 宏嘉

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… Alternative Names

坪地 宏嘉  ツボチ ヒロヨシ

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Researcher Number 50406055
Affiliation (Current) 2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2023: 自治医科大学, 医学部, 教授
2014 – 2016: 自治医科大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 55040:Respiratory surgery-related / Respiratory surgery
Except Principal Investigator
Basic Section 55040:Respiratory surgery-related / Human pathology / Basic Section 49020:Human pathology-related / Respiratory organ internal medicine
Keywords
Principal Investigator
肺癌 / 化学発光ライブイメージング / 可視化 / 微小転移モデル / 自律型細胞運動刺激因子 / 上皮成長因子受容体 / 自立型細胞運動刺激因子 / AKT遺伝子 / 予後 / Pirh 2 … More / KPC / Skp2 / 非小細胞肺癌 / p27 / Akt / AMF … More
Except Principal Investigator
肺癌 / microRNA / 脳梗塞 / 肺癌手術 / 4DCT / 左房内血栓 / 肺葉切除 / 心原性脳梗塞 / 左房血栓 / スーパーコンピューター / 左房 / ELISA / 転写制御 / abortive cell cycle / 浸潤能 / アポトーシス / バイオマーカー / 増殖抑制 / mTOR / 転移 / 遺伝子多型 / ubiquitin ligase / MLPA / p27 / 遺伝子増幅 / Akt / 左上葉切除 / コンピューター 流体解析 / 流体シミュレーション / CFD解析 / 4Dflow MRI / 左房流体力学 / 肺切除術 / 画像編集 / AI / 数理流体解析 / 4DMRI / AKT / Trefoil factor / TFFファミリー / SASP因子 / 細胞老化因子 / Forkhead box O / trefoil factor-1 / 術後合併症 / 左上葉切除術 / 血流解析 / 4DCT / 過流 / 左房血流 / 左肺上葉切除術 / 散逸係数 / 流体解析 / 旋回流 / 数理的流体解析 / 散逸エネルギー / 衝突流 / 数値流体力学 / 肺葉切除術 / trefoil factor / FISH / 乳癌 / 浸潤抑制 / TFF-1 / 蛍光免疫染色 / TFF1-3 / 浸潤 / 遊走 / Trefoil factor-1 / 非小細胞肺癌 / マイクロRNA発現 / EZH2発現 / 癌性胸膜炎 / 網羅解析 / EMT / 小細胞肺癌 / miR-4448 / 網羅的発現解析 / マイクロRNA / siRNA / EZH2 / Pirh2 / 細胞周期制御因子 / Ubiquitin ligase Less
  • Research Projects

    (8 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (23 People)
  •  生体内で可視化できる肺癌の超微小転移モデルの確立Principal Investigator

    • Principal Investigator
      坪地 宏嘉
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jichi Medical University
  •  Fluid dynamic risk measurement of LA thrombus after lung cancer surgery

    • Principal Investigator
      遠藤 俊輔
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jichi Medical University
  •  Analysis of aberrant Akt/mTOR signature for the precision medicine in lung carcinoma

    • Principal Investigator
      土橋 洋
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      International University of Health and Welfare
  •  Fluid dynamic change in left atrium after pulmonary lobectomy

    • Principal Investigator
      Endo Shunsuke
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jichi Medical University
  •  Dysregulation of AKT network and its application for precision medicine in lung cancer

    • Principal Investigator
      Dobashi Yoh
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      International University of Health and Welfare
      Jichi Medical University
  •  Analysis of AMF and its related proteins in lung cancerPrincipal Investigator

    • Principal Investigator
      TSUBOCHI Hiroyoshi
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Jichi Medical University
  •  Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them

    • Principal Investigator
      DOBASHI Yoh
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Jichi Medical University
  •  Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysis

    • Principal Investigator
      NOBUYUKI KOYAMA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University

All 2023 2021 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Retrograde S(9+)10 Segmentectomy without Interlobar Fissurelectomy.2023

    • Author(s)
      Negishi N, Tsubochi H, Endo S. et al.
    • Journal Title

      Kyobu Geka

      Volume: 76(1) Pages: 20-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07378
  • [Journal Article] Diagnostic utility of trefoil factor families for the early detection of lung cancer and their correlation with tissue expression2023

    • Author(s)
      Minegishi Kentaro, Dobashi Yoh, Koyama Teruhide, Ishibashi Yuko, Furuya Miki, Tsubochi Hiroyoshi, Ohmoto Yasukazu, Yasuda Tomohiko, Nomura Sachiyo.
    • Journal Title

      Oncology Letters

      Volume: 25 Issue: 4 Pages: 139-139

    • DOI

      10.3892/ol.2023.13725

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20KK0174, KAKENHI-PROJECT-22H04923, KAKENHI-ORGANIZER-22H05021
  • [Journal Article] Salvage Surgery Post Definitive Chemoradiotherapy and Durvalumab for Lung Cancer2021

    • Author(s)
      Minegishi K, Tsubochi H, Ohno K, Komori K, Ozeki M, Endo S
    • Journal Title

      Ann Thorac Surg

      Volume: 112 Issue: 1 Pages: e53-e55

    • DOI

      10.1016/j.athoracsur.2020.09.083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-20K07378
  • [Journal Article] Intrapulmonary solitary fibrous tumour2021

    • Author(s)
      Horikiri A, Tsubochi H, Mizukoshi N, Myobatake R, Sakurai H, Shibano T, Kanai Y, Yamamoto S.
    • Journal Title

      J Surg Case Rep

      Volume: 2021(2) Issue: 2

    • DOI

      10.1093/jscr/rjaa603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-20K07378
  • [Journal Article] TFF-1 Functions to suppress multiple phenotypes associated with Lung Cancer Progression2021

    • Author(s)
      Minegishi, K., Dobashi, Y., Tsubochi, H., Hagiwara, K., Ishibashi, Y., Nomura, S., Nakamura, R., Ohmoto, Y. and Endo, S.
    • Journal Title

      OncoTargets and Therapy

      Volume: 14 Pages: 4761-77

    • DOI

      10.2147/ott.s322697

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-19H03510, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20KK0174
  • [Journal Article] Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.2021

    • Author(s)
      Mizushina, Y., Ohyanagi, F., Shiihara, J., Nomura, M., Ohta, H., Oshiro, H., Tsubochi, H., Kusaka, G. and Yamaguchi, Y.
    • Journal Title

      Thorac Cancer

      Volume: 12 Issue: 16 Pages: 2279-2282

    • DOI

      10.1111/1759-7714.14068

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20K08364
  • [Journal Article] Can the Japanese National Clinical Database risk calculator predict long-term survival of patients who undergo palliative segmentectomy for primary lung cancer?2021

    • Author(s)
      Tsubochi H, Maki M, Minegishi K, Shibano T, Kanai Y, Otani S, Yamamoto S, Tetsuka K, Endo S
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: 69 Issue: 7 Pages: 1096-104

    • DOI

      10.1007/s11748-021-01585-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-20K07378
  • [Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

    • Author(s)
      Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 13(8) Pages: 2201-10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

    • Author(s)
      Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 13(8) Pages: 2201-2210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07378
  • [Journal Article] The length of the left superior pulmonary vein stump after left upper lobectomy depends on its position to the left atrial appendage.2020

    • Author(s)
      Minegishi K, Tsubochi H, Maki M, Endo S.
    • Journal Title

      J Thorac Dis

      Volume: 12(8) Issue: 8 Pages: 4099-4104

    • DOI

      10.21037/jtd-20-1170

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Journal Article] Pulmonary mucoepidermoid carcinoma arising in a patient with Kartagener syndrome.2020

    • Author(s)
      Nagai Y, Koyama N, Iwai Y, Tsubochi H, Hiruta M, Mizushina Y, Koyama S, Ishikawa Y, Hagiwara K
    • Journal Title

      BMC Pulm Med.

      Volume: 20(1) Issue: 1 Pages: 93-93

    • DOI

      10.1186/s12890-020-1133-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-19H03446
  • [Journal Article] Screening of the copy number increase of AKT in lung carcinoma by Custom-Designed MLPA2019

    • Author(s)
      K. Minegishi, Y. Dobashi, H. Tsubochi, R. Tokuda, K. Okudela, A. Ooi
    • Journal Title

      Inter. J. Clin. Exp. Pathol.

      Volume: 12(9) Pages: 3344-56

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas2017

    • Author(s)
      Dobashi Y, Tsubochi H, Minegishi K, Kitagawa M, Otani S, Ooi A.
    • Journal Title

      Human Pathology

      Volume: 66 Pages: 67-68

    • DOI

      10.1016/j.humpath.2017.05.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-26460438
  • [Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017

    • Author(s)
      Dobashi. Y., Tsubochi, H. Minegishi, K., Kitagawa, M., Otani, S. and Ooi, A.
    • Journal Title

      Hum Pathol.

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Journal Article] Loss of YAP1 defines neuroendocrine differentiation of lung tumors.2016

    • Author(s)
      Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 10 Pages: 1527-1538

    • DOI

      10.1111/cas.13013

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-26460438
  • [Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma2016

    • Author(s)
      Goto. A., Dobashi. Y., Tsubochi, H. and Ooi, A.
    • Journal Title

      Human Pathology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma.2016

    • Author(s)
      Goto A, Dobashi Y, Tsubochi H, Maeda D, Ooi A
    • Journal Title

      Hum Pathol

      Volume: 印刷中 Pages: 1-10

    • DOI

      10.1016/j.humpath.2016.04.011

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438
  • [Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas2015

    • Author(s)
      Dobashi Y, Tsubochi H, Matsubara H, Inoue J, Inazawa J, Endo S, Ooi A
    • Journal Title

      Cancer Sci

      Volume: - Issue: 6 Pages: 772-781

    • DOI

      10.1111/cas.12669

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22134002, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25460452
  • [Journal Article] Solitary fibrous tumor of the thymus with variegated epithelial components.2014

    • Author(s)
      Tsubochi, H., Endo, T., Sogabe, M., Endo, S., Morinaga, S. and Dobashi, Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 7 Pages: 7477-84

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Presentation] 拡大管状肺葉切除の手技と成績2021

    • Author(s)
      坪地 宏嘉 、明畠 良太、櫻井 秀嵩、水越 奈津樹、堀切 映江、大関 雅樹、根岸 秀樹、 柴野 智毅、峯岸 健太郎、金井 義彦、大谷 真一、山本 真一、遠藤 俊輔
    • Organizer
      第38回日本呼吸器外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07378
  • [Presentation] 胸部悪性腫瘍手術における心嚢内での肺動脈確保2021

    • Author(s)
      坪地 宏嘉、滝 雄史、小林 哲哉、加藤 梓、大須賀 史枝、根岸 秀樹、峯岸 健太郎、柴野 智毅、金井 義彦、大谷 真一、山本 真一、遠藤 俊輔
    • Organizer
      第62回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Presentation] 胸部悪性腫瘍手術における心嚢内での肺動脈確保2021

    • Author(s)
      坪地 宏嘉、滝 雄史、小林 哲哉、加藤 梓、大須賀 史枝、根岸 秀樹、峯岸 健太郎、柴野 智毅、金井 義彦、大谷 真一、山本 真一、遠藤 俊輔
    • Organizer
      第62回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07378
  • [Presentation] 拡大管状肺葉切除の手技と成績2021

    • Author(s)
      坪地 宏嘉 、明畠 良太、櫻井 秀嵩、水越 奈津樹、堀切 映江、大関 雅樹、根岸 秀樹、 柴野 智毅、峯岸 健太郎、金井 義彦、大谷 真一、山本 真一、遠藤 俊輔
    • Organizer
      第38回日本呼吸器外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Presentation] 4DCTを用いた左房の血流解析 肺葉切除後の左房血栓形成のメカニズムの解明2019

    • Author(s)
      遠藤俊輔、柴野智毅、峯岸健太郎、山本真一、坪地宏嘉
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Presentation] 左心耳と肺静脈入口部の関係による分類と左肺上葉切除後の左上肺静脈長の検討2019

    • Author(s)
      峯岸健太郎、山名輝、小森健次朗、大野慧介、坪地宏嘉、遠藤俊輔
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Presentation] Significance of Akt activation and AKT gene increases in bone and soft tissue tumors.2014

    • Author(s)
      土橋 洋、坪地 宏嘉、井上 純、大井 章史.
    • Organizer
      第 73回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Presentation] 小細胞肺癌切除34症例の臨床的検討2014

    • Author(s)
      渡辺恭孝、小山信之、岩井悠希、白石守、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-26
    • Data Source
      KAKENHI-PROJECT-26461195
  • [Presentation] 小細胞肺癌切除34症例の臨床的検討2014

    • Author(s)
      渡辺恭孝、小山信之、岩井悠希、白石守、川村留美、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-11-16
    • Data Source
      KAKENHI-PROJECT-26461195
  • 1.  ENDOU Shunsuke (10245037)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 2.  DOBASHI Yoh (90231456)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 3.  北川 雅敏 (50294971)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  後藤 明輝 (90317090)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 5.  大谷 智仁 (40778990)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  OOI Akishi (50160411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  SUGIMURA Haruhiko (00196742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MATSUBARA Hirochika (00374166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NOBUYUKI KOYAMA (30353460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  ISHIKAWA Yuichi (80222975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  遠藤 哲哉 (50528601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  丹羽 康則 (20406060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  小形 幸代 (10448847)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  野村 幸世 (70301819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  和田 成生 (70240546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  真鍋 徳子 (70463742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  柴野 智毅 (10648900)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  小林 哲也 (40974499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  仁木 利郎 (90198424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  WATANABE Yasutaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 21.  MATSYBARA Daisuk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  井上 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  稲澤 譲治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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