TSUBOCHI Hiroyoshi 坪地宏嘉

… Alternative Names

坪地宏嘉ツボチヒロヨシ

Less

Researcher Number	50406055
Affiliation (Current)	2022: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022: 自治医科大学, 医学部, 教授 2017 – 2020: 自治医科大学, 医学部, 教授 2014 – 2016: 自治医科大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Respiratory surgery Except Principal Investigator Human pathology / Basic Section 55040:Respiratory surgery-related / Respiratory organ internal medicine / Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 肺癌 / AMF / Akt / p27 / 非小細胞肺癌 / Skp2 / KPC / Pirh 2 / 予後 / AKT遺伝子 / 自立型細胞運動刺激因子 / 上皮成長因子受容体 / 自律型細胞運動刺激因子 … More Except Principal Investigator … More 肺癌 / microRNA / Akt / 遺伝子増幅 / p27 / MLPA / ubiquitin ligase / 遺伝子多型 / mTOR / 転写制御 / 肺癌手術 / 左房血栓 / 脳梗塞 / Ubiquitin ligase / 細胞周期制御因子 / Pirh2 / EZH2 / siRNA / マイクロRNA / 網羅的発現解析 / miR-4448 / 小細胞肺癌 / EMT / 網羅解析 / 転移 / 癌性胸膜炎 / EZH2発現 / マイクロRNA発現 / 非小細胞肺癌 / TFF-1 / 増殖抑制 / 浸潤抑制 / abortive cell cycle / TFF1-3 / 浸潤 / 乳癌 / FISH / ELISA / trefoil factor / 左肺上葉切除術 / 左房血流 / 過流 / 心原性脳梗塞 / 4DCT / 血流解析 / 左上葉切除術 / 術後合併症 / Trefoil factor / バイオマーカー / TFFファミリー / AKT / コンピューター　流体解析 / 左上葉切除 Less

Fluid dynamic risk measurement of LA thrombus after lung cancer surgery
- Principal Investigator
  
  遠藤俊輔
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Jichi Medical University
Analysis of aberrant Akt/mTOR signature for the precision medicine in lung carcinoma
- Principal Investigator
  
  土橋洋
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  International University of Health and Welfare
肺葉切除後の心原性脳梗塞の原因解明-肺静脈遮断に伴う左房内血流パターンの変化
- Principal Investigator
  
  遠藤俊輔
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Jichi Medical University
Dysregulation of AKT network and its application for precision medicine in lung cancer
- Principal Investigator
  
  土橋洋
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  International University of Health and Welfare
  Jichi Medical University
Analysis of AMF and its related proteins in lung cancerPrincipal Investigator
- Principal Investigator
  
  TSUBOCHI Hiroyoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Jichi Medical University
Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them
- Principal Investigator
  
  DOBASHI Yoh
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Jichi Medical University
Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysis
- Principal Investigator
  
  NOBUYUKI KOYAMA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jichi Medical University

All 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020
- Author(s)
  Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 13(8) Pages: 2201-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08727
[Journal Article] The length of the left superior pulmonary vein stump after left upper lobectomy depends on its position to the left atrial appendage.2020
- Author(s)
  Minegishi K, Tsubochi H, Maki M, Endo S.
- Journal Title
  
  J Thorac Dis
  
  Volume: 12(8) Pages: 4099-4104
- DOI
  10.21037/jtd-20-1170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08796
[Journal Article] Pulmonary Mucoepidermoid Carcinoma Arising in a Patient with Kartagener Syndrome: A Case Report.2020
- Author(s)
  Nagai Y, Koyama N, Iwai Y, Tsubochi H, Hiruta M, Mizushina Y, Koyama S, Ishikawa Y, Hagiwara K
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 20(1) Pages: 93-93
- DOI
  10.1186/s12890-020-1133-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-19H03446
[Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020
- Author(s)
  Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 13(8) Pages: 2201-2210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07378
[Journal Article] Screening of the copy number increase of AKT in lung carcinoma by Custom-Designed MLPA2019
- Author(s)
  K. Minegishi, Y. Dobashi, H. Tsubochi, R. Tokuda, K. Okudela, A. Ooi
- Journal Title
  
  Inter. J. Clin. Exp. Pathol.
  
  Volume: 12(9) Pages: 3344-56
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08727
[Journal Article] Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors2017
- Author(s)
  Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.
- Journal Title
  
  Can Sci.
  
  Volume: 107 Pages: 1527-1538
- DOI
  10.1111/cas.13013
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-26460438
[Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017
- Author(s)
  Dobashi Y, Tsubochi H, Minegishi K, Kitagawa M, Otani S, Ooi A.
- Journal Title
  
  Hum Pathol.
  
  Volume: 66 Pages: 67-68
- DOI
  10.1016/j.humpath.2017.05.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-26460438
[Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017
- Author(s)
  Dobashi. Y., Tsubochi, H. Minegishi, K., Kitagawa, M., Otani, S. and Ooi, A.
- Journal Title
  
  Hum Pathol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460438
[Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma2017
- Author(s)
  Goto A, Dobashi Y, Tsubochi H, Maeda D, Ooi A
- Journal Title
  
  Hum Pathol.
  
  Volume: 印刷中 Pages: 1-10
- DOI
  10.1016/j.humpath.2016.04.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438
[Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma2016
- Author(s)
  Goto. A., Dobashi. Y., Tsubochi, H. and Ooi, A.
- Journal Title
  
  Human Pathology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460438
[Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.2015
- Author(s)
  Dobashi Y, Tsubochi H, Matsubara H, Inoue J, Inazawa J, Endo S, Ooi A
- Journal Title
  
  Cancer Science
  
  Volume: - Pages: 772-781
- DOI
  10.1111/cas.12669
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22134002, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25460452
[Journal Article] Solitary fibrous tumor of the thymus with variegated epithelial components.2014
- Author(s)
  Tsubochi, H., Endo, T., Sogabe, M., Endo, S., Morinaga, S. and Dobashi, Y.
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 7 Pages: 7477-84
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460438
[Presentation] ４DCTを用いた左房の血流解析　肺葉切除後の左房血栓形成のメカニズムの解明2019
- Author(s)
  遠藤俊輔、柴野智毅、峯岸健太郎、山本真一、坪地宏嘉
- Organizer
  第72回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08796
[Presentation] 左心耳と肺静脈入口部の関係による分類と左肺上葉切除後の左上肺静脈長の検討2019
- Author(s)
  峯岸健太郎、山名輝、小森健次朗、大野慧介、坪地宏嘉、遠藤俊輔
- Organizer
  第72回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08796
[Presentation] 小細胞肺癌切除34症例の臨床的検討2014
- Author(s)
  渡辺恭孝、小山信之、岩井悠希、白石守、川村留美、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
- Organizer
  第55回日本肺癌学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-26461195
[Presentation] Significance of Akt activation and AKT gene increases in bone and soft tissue tumors.2014
- Author(s)
  土橋　洋、坪地宏嘉、井上純、大井　章史.
- Organizer
  第 73回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26460438
[Presentation] 小細胞肺癌切除34症例の臨床的検討2014
- Author(s)
  渡辺恭孝、小山信之、岩井悠希、白石守、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26461195

1. DOBASHI Yoh (90231456)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. ENDOU Shunsuke (10245037)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. 北川雅敏 (50294971)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. 後藤明輝 (90317090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. 大谷智仁 (40778990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OOI Akishi (50160411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. SUGIMURA Haruhiko (00196742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUBARA Hirochika (00374166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. NOBUYUKI KOYAMA (30353460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. ISHIKAWA Yuichi (80222975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 遠藤哲哉 (50528601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 丹羽康則 (20406060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小形幸代 (10448847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 野村幸世 (70301819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 和田成生 (70240546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 真鍋徳子 (70463742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WATANABE Yasutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 仁木利郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 井上純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 稲澤譲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUBOCHI Hiroyoshi 坪地 宏嘉

坪地 宏嘉 ツボチ ヒロヨシ

Research Projects

Research Products

Co-Researchers

Fluid dynamic risk measurement of LA thrombus after lung cancer surgery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of aberrant Akt/mTOR signature for the precision medicine in lung carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺葉切除後の心原性脳梗塞の原因解明-肺静脈遮断に伴う左房内血流パターンの変化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dysregulation of AKT network and its application for precision medicine in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of AMF and its related proteins in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

Author(s)

Journal Title

Data Source

[Journal Article] The length of the left superior pulmonary vein stump after left upper lobectomy depends on its position to the left atrial appendage.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pulmonary Mucoepidermoid Carcinoma Arising in a Patient with Kartagener Syndrome: A Case Report.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

Author(s)

Journal Title

Data Source

[Journal Article] Screening of the copy number increase of AKT in lung carcinoma by Custom-Designed MLPA2019

Author(s)

Journal Title

Data Source

[Journal Article] Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017

TSUBOCHI Hiroyoshi 坪地宏嘉

坪地宏嘉ツボチヒロヨシ

[Presentation] ４DCTを用いた左房の血流解析　肺葉切除後の左房血栓形成のメカニズムの解明2019