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TSUBOCHI Hiroyoshi  坪地 宏嘉

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… Alternative Names

坪地 宏嘉  ツボチ ヒロヨシ

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Researcher Number 50406055
Affiliation (Current) 2022: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2022: 自治医科大学, 医学部, 教授
2017 – 2020: 自治医科大学, 医学部, 教授
2014 – 2016: 自治医科大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Respiratory surgery
Except Principal Investigator
Human pathology / Basic Section 55040:Respiratory surgery-related / Respiratory organ internal medicine / Basic Section 49020:Human pathology-related
Keywords
Principal Investigator
肺癌 / AMF / Akt / p27 / 非小細胞肺癌 / Skp2 / KPC / Pirh 2 / 予後 / AKT遺伝子 / 自立型細胞運動刺激因子 / 上皮成長因子受容体 / 自律型細胞運動刺激因子 … More
Except Principal Investigator
… More 肺癌 / microRNA / Akt / 遺伝子増幅 / p27 / MLPA / ubiquitin ligase / 遺伝子多型 / mTOR / 転写制御 / 肺癌手術 / 左房血栓 / 脳梗塞 / Ubiquitin ligase / 細胞周期制御因子 / Pirh2 / EZH2 / siRNA / マイクロRNA / 網羅的発現解析 / miR-4448 / 小細胞肺癌 / EMT / 網羅解析 / 転移 / 癌性胸膜炎 / EZH2発現 / マイクロRNA発現 / 非小細胞肺癌 / TFF-1 / 増殖抑制 / 浸潤抑制 / abortive cell cycle / TFF1-3 / 浸潤 / 乳癌 / FISH / ELISA / trefoil factor / 左肺上葉切除術 / 左房血流 / 過流 / 心原性脳梗塞 / 4DCT / 血流解析 / 左上葉切除術 / 術後合併症 / Trefoil factor / バイオマーカー / TFFファミリー / AKT / コンピューター 流体解析 / 左上葉切除 Less
  • Research Projects

    (7 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (21 People)
  •  Fluid dynamic risk measurement of LA thrombus after lung cancer surgery

    • Principal Investigator
      遠藤 俊輔
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jichi Medical University
  •  Analysis of aberrant Akt/mTOR signature for the precision medicine in lung carcinoma

    • Principal Investigator
      土橋 洋
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      International University of Health and Welfare
  •  肺葉切除後の心原性脳梗塞の原因解明-肺静脈遮断に伴う左房内血流パターンの変化

    • Principal Investigator
      遠藤 俊輔
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Jichi Medical University
  •  Dysregulation of AKT network and its application for precision medicine in lung cancer

    • Principal Investigator
      土橋 洋
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      International University of Health and Welfare
      Jichi Medical University
  •  Analysis of AMF and its related proteins in lung cancerPrincipal Investigator

    • Principal Investigator
      TSUBOCHI Hiroyoshi
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory surgery
    • Research Institution
      Jichi Medical University
  •  Involvement of Akt/mTOR in lung cancer and design of novel therapy targeting them

    • Principal Investigator
      DOBASHI Yoh
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Jichi Medical University
  •  Identification of a factor determining invasion and metastasis in non-small cell lung cancer and its therapeutic application based on comprehensive microRNA analysis

    • Principal Investigator
      NOBUYUKI KOYAMA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Jichi Medical University

All 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

    • Author(s)
      Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 13(8) Pages: 2201-10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Journal Article] The length of the left superior pulmonary vein stump after left upper lobectomy depends on its position to the left atrial appendage.2020

    • Author(s)
      Minegishi K, Tsubochi H, Maki M, Endo S.
    • Journal Title

      J Thorac Dis

      Volume: 12(8) Pages: 4099-4104

    • DOI

      10.21037/jtd-20-1170

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Journal Article] Pulmonary Mucoepidermoid Carcinoma Arising in a Patient with Kartagener Syndrome: A Case Report.2020

    • Author(s)
      Nagai Y, Koyama N, Iwai Y, Tsubochi H, Hiruta M, Mizushina Y, Koyama S, Ishikawa Y, Hagiwara K
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 20(1) Pages: 93-93

    • DOI

      10.1186/s12890-020-1133-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-17K09671, KAKENHI-PROJECT-19H03446
  • [Journal Article] EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.2020

    • Author(s)
      Tsubochi H, Minegishi K, Goto A, Nakamura R, Matsubara D, Dobashi Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 13(8) Pages: 2201-2210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07378
  • [Journal Article] Screening of the copy number increase of AKT in lung carcinoma by Custom-Designed MLPA2019

    • Author(s)
      K. Minegishi, Y. Dobashi, H. Tsubochi, R. Tokuda, K. Okudela, A. Ooi
    • Journal Title

      Inter. J. Clin. Exp. Pathol.

      Volume: 12(9) Pages: 3344-56

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08727
  • [Journal Article] Loss of YAP1 Defines Neuroendocrine Differentiation of Lung Tumors2017

    • Author(s)
      Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.
    • Journal Title

      Can Sci.

      Volume: 107 Pages: 1527-1538

    • DOI

      10.1111/cas.13013

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-26460438
  • [Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017

    • Author(s)
      Dobashi Y, Tsubochi H, Minegishi K, Kitagawa M, Otani S, Ooi A.
    • Journal Title

      Hum Pathol.

      Volume: 66 Pages: 67-68

    • DOI

      10.1016/j.humpath.2017.05.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-26460438
  • [Journal Article] Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.2017

    • Author(s)
      Dobashi. Y., Tsubochi, H. Minegishi, K., Kitagawa, M., Otani, S. and Ooi, A.
    • Journal Title

      Hum Pathol.

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma2017

    • Author(s)
      Goto A, Dobashi Y, Tsubochi H, Maeda D, Ooi A
    • Journal Title

      Hum Pathol.

      Volume: 印刷中 Pages: 1-10

    • DOI

      10.1016/j.humpath.2016.04.011

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438
  • [Journal Article] MicroRNAs associated with increased AKT gene number in human lung carcinoma2016

    • Author(s)
      Goto. A., Dobashi. Y., Tsubochi, H. and Ooi, A.
    • Journal Title

      Human Pathology

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas.2015

    • Author(s)
      Dobashi Y, Tsubochi H, Matsubara H, Inoue J, Inazawa J, Endo S, Ooi A
    • Journal Title

      Cancer Science

      Volume: - Pages: 772-781

    • DOI

      10.1111/cas.12669

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22134002, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-15K10270, KAKENHI-PROJECT-26460438, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25460452
  • [Journal Article] Solitary fibrous tumor of the thymus with variegated epithelial components.2014

    • Author(s)
      Tsubochi, H., Endo, T., Sogabe, M., Endo, S., Morinaga, S. and Dobashi, Y.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 7 Pages: 7477-84

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Presentation] 4DCTを用いた左房の血流解析 肺葉切除後の左房血栓形成のメカニズムの解明2019

    • Author(s)
      遠藤俊輔、柴野智毅、峯岸健太郎、山本真一、坪地宏嘉
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Presentation] 左心耳と肺静脈入口部の関係による分類と左肺上葉切除後の左上肺静脈長の検討2019

    • Author(s)
      峯岸健太郎、山名輝、小森健次朗、大野慧介、坪地宏嘉、遠藤俊輔
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-18K08796
  • [Presentation] 小細胞肺癌切除34症例の臨床的検討2014

    • Author(s)
      渡辺恭孝、小山信之、岩井悠希、白石守、川村留美、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-11-16
    • Data Source
      KAKENHI-PROJECT-26461195
  • [Presentation] Significance of Akt activation and AKT gene increases in bone and soft tissue tumors.2014

    • Author(s)
      土橋 洋、坪地 宏嘉、井上 純、大井 章史.
    • Organizer
      第 73回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-26460438
  • [Presentation] 小細胞肺癌切除34症例の臨床的検討2014

    • Author(s)
      渡辺恭孝、小山信之、岩井悠希、白石守、三輪千尋、坪地宏嘉、遠藤俊輔、小山信一郎
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-26
    • Data Source
      KAKENHI-PROJECT-26461195
  • 1.  DOBASHI Yoh (90231456)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 2.  ENDOU Shunsuke (10245037)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 3.  北川 雅敏 (50294971)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  後藤 明輝 (90317090)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 5.  大谷 智仁 (40778990)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  OOI Akishi (50160411)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  SUGIMURA Haruhiko (00196742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MATSUBARA Hirochika (00374166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  NOBUYUKI KOYAMA (30353460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  ISHIKAWA Yuichi (80222975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  遠藤 哲哉 (50528601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  丹羽 康則 (20406060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  小形 幸代 (10448847)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  野村 幸世 (70301819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  和田 成生 (70240546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  真鍋 徳子 (70463742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  WATANABE Yasutaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  MATSYBARA Daisuk
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  仁木 利郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  井上 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  稲澤 譲治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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