Nakano Kazuhisa 中野和久

… Alternative Names

中野和久ナカノカズヒサ

NAKANO Kazuhisa 中野和久

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Researcher Number	50406500
Affiliation (Current)	2022: 川崎医科大学, 医学部, 教授 2022: 産業医科大学, 医学部, 非常勤医師
Affiliation (based on the past Project Information) *help	2022: 川崎医科大学, 医学部, 教授 2016 – 2019: 産業医科大学, 医学部, 講師 2014 – 2015: 産業医科大学, 医学部, 助教 2008 – 2009: University of Occupational and Environmental Health, Japan, 医学部, 助教
Review Section/Research Field	Principal Investigator Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 関節リウマチ / エピジェネティクス / DNAメチル化 / 滑膜細胞 / 炎症性サイトカイン / サイトカイン / ドパミン / T細胞分化 / 樹状細胞 / DNA脱メチル化 … More / 滑膜 / エピゲノム / TET3 / 糖鎖修飾 / 内科 / 発現制御 Less

関節リウマチにおけるDNAメチル化ダイナミズムの解明とエピゲノム創薬に向けてPrincipal Investigator
- Principal Investigator
  
  中野和久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kawasaki Medical School
Drug discovery targeting Tet3 for refractory rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Nakano Kazuhisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  University of Occupational and Environmental Health, Japan
Dynamism of DNA methylation in Rheumatoid ArthritisPrincipal Investigator
- Principal Investigator
  
  Nakano Kazuhisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  University of Occupational and Environmental Health, Japan
The role of neurotransmitter in DC-T cell interaction and new strategy for treatment of RAPrincipal Investigator
- Principal Investigator
  
  NAKANO Kazuhisa
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2017 2016 2015 2014 2009

All Journal Article Presentation Patent

[Journal Article] 関節リウマチ滑膜におけるDNAメチル化とTET分子2017
- Author(s)
  中野和久、田中良哉
- Journal Title
  
  Keynote R・A
  
  Volume: 5 Pages: 9-13
- Data Source
  KAKENHI-PROJECT-26461479
[Journal Article] Dopamine released by Dendritic cells polarizes Th2 differentiation2009
- Author(s)
  Nakano K, Higashi, T., Takagi, R., Hashimoto, K., Tanaka, Y., Matsushita, S.
- Journal Title
  
  International Immunology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790704
[Journal Article] Dopamine released by dendritic cells polarizes Th2 differentiation2009
- Author(s)
  中野和久, et al.
- Journal Title
  
  International Immunology 21
  
  Pages: 645-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790704
[Journal Article] 樹状細胞-T細胞間における免疫修飾物質としてのドパミンの機能と関節リウマチの病態形成における役割2009
- Author(s)
  中野和久、松下祥、齋藤和義、山岡邦宏、田中良哉
- Journal Title
  
  日本臨床免疫学会会誌 32巻
  
  Pages: 1-6
- NAID
  10024961683
- Data Source
  KAKENHI-PROJECT-20790704
[Journal Article] Dopamine released by dendritic cells polarizes Th2 differentiation.2009
- Author(s)
  Nakano K, Higashi T, Takagi R, Hashimoto K, Tanaka Y, Matsushita S.
- Journal Title
  
  International Immunology 21巻
  
  Pages: 645-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790704
[Journal Article] 樹状細胞-T細胞間における免疫修飾物質としてのドパミンの機能と関節リウマチの病態形成における役割2009
- Author(s)
  中野和久, 他
- Journal Title
  
  日本臨床免疫学会会誌 32
  
  Pages: 1-6
- NAID
  10024961683
- Data Source
  KAKENHI-PROJECT-20790704
[Patent] 関節炎の予防・治療剤、検査キット、並びに関節炎予防・治療薬のスクリーニング方法2015
- Inventor(s)
  中野和久
- Industrial Property Rights Holder
  学校法人産業医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-08-24
- Overseas
- Data Source
  KAKENHI-PROJECT-26461479
[Patent] 関節炎の予防・治療剤、検査キット、並びに関節炎予防・治療薬のスクリーニング方法2014
- Inventor(s)
  中野和久
- Industrial Property Rights Holder
  学校法人産業医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-174638
- Filing Date
  2014-08-28
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] The epigenetic induction of aggressive phenotype of fibroblast-like synovial cells (FLS) in rheumatoid arthritis (RA), the role of DNA demethylation enzyme TET32016
- Author(s)
  Kazuhisa Nakano, Akio Kawabe, Kei Sakata, Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka.
- Organizer
  第8回国際関節リウマチフォーラム
- Place of Presentation
  品川プリンスホテル（東京）
- Year and Date
  2016-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] 持続的炎症刺激による線維芽細胞様滑膜細胞(FLS)の表現型変化におけるDNA脱メチル化酵素TET3の役割とTET3阻害による関節炎制御2016
- Author(s)
  河邊明男、中野和久、山形薫、阪田圭、中山田真吾、田中良哉
- Organizer
  第44回日本臨床免疫学会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] 関節リウマチ滑膜細胞は炎症性サイトカイン誘導性のDNA脱メチル化酵素TET3を介して骨・軟骨破壊を促進する2016
- Author(s)
  河邊明男、中野和久、山形薫、阪田圭、中山田真吾、田中良哉
- Organizer
  第2回日本骨免疫学会
- Place of Presentation
  ホテルモントレ沖縄スパ＆リゾート（沖縄）
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] 持続的炎症刺激による滑膜細胞の表現型変化におけるDNA脱メチル化酵素TET3の役割とTET3阻害による関節炎制御2016
- Author(s)
  河邊明男、中野和久、山形薫、阪田圭、中山田真吾、田中良哉
- Organizer
  第60回日本リウマチ学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] 持続的炎症刺激による線維芽細胞様滑膜細胞(FLS)の表現型変化におけるDNA脱メチル化酵素TET3の役割とTET3阻害による関節炎制御2016
- Author(s)
  河邊明男、中野和久、山形薫、阪田圭、中山田真吾、田中良哉
- Organizer
  第37回日本炎症・再生医学会
- Place of Presentation
  みやこめっせ（京都）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] 炎症性サイトカインはリウマチ滑膜細胞にDNA脱メチル化酵素TET3依存性に骨・軟骨破壊を促進する2016
- Author(s)
  河邊明男、中野和久、山形薫、阪田圭、中山田真吾、田中良哉
- Organizer
  第34回日本骨代謝学会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] RA滑膜の慢性炎症はDNA脱メチル化酵素Tet3依存性に滑膜細胞に攻撃的表現型を付与する2015
- Author(s)
  中野和久、河邊明男、山形薫、中山田真吾、田中良哉
- Organizer
  第1回日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（沖縄県宮古島市）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] Alteration of DNA methylation by pro-inflammatory cytokines in Rheumatoid arthritis fibroblast-like synoviocytes2015
- Author(s)
  Kazuhisa Nakano, Akio Kawabe, Kaoru Yamagata, Shingo Nakayamada, and Yoshiya Tanaka
- Organizer
  第44回日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] TET3-mediated epigenetic alteration in Rheumatoid arthritis fibroblast-like synoviocytes2015
- Author(s)
  Kazuhisa Nakano, Kaoru Yamagata, Shingo Nakayamada, Akio Kawabe, and Yoshiya Tanaka
- Organizer
  第59回日本リウマチ学会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] TET3-mediated epigenetic alteration in Rheumatoid arthritis fibroblast-like synoviocytes2015
- Author(s)
  中野和久
- Organizer
  第５９回日本リウマチ学会
- Place of Presentation
  名古屋国際会議場(愛知県(名古屋市))
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] The Role Of TET3-Mediated DNA Demethylation By Pro-Inflammatory Cytokines In Rheumatoid Arthritis2014
- Author(s)
  Kazuhisa Nakano
- Organizer
  ACR /ARHP annual meeting 2014
- Place of Presentation
  Boston Convention & Exhibition Center(ボストン/米国)
- Year and Date
  2014-10-27
- Data Source
  KAKENHI-PROJECT-26461479
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis and plays a pivotal role in the pathogenesis of rheumatoid arthritis2009
- Author(s)
  Kazuhisa Nakano, Kunihiro Yamaoka, Kazuyoshi Saito, Sho Matsushita, Yoshiya Tanaka
- Organizer
  第37回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] 樹状細胞-T細胞相互作用におけるドパミンの役割とD1様受容体阻害による滑膜炎制御2009
- Author(s)
  中野和久
- Organizer
  第53回日本リウマチ学会
- Place of Presentation
  東京(グランドプリンスホテル新高輪)
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis in rheumatoid arthritis2009
- Author(s)
  Kazuhisa Nakano, Kunihiro Yamaoka, Kazuyoshi Saito, Yoshiya Tanaka
- Organizer
  第73回アメリカリウマチ学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis in rheumatoid arthritis2009
- Author(s)
  中野和久
- Organizer
  第73回アメリカリウマチ学会
- Place of Presentation
  フィラデルフィア、USA(Pennsylvania Convention Center)
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis and plays a pivotal role in the pathogenesis of rheumatoid arthritis2009
- Author(s)
  中野和久
- Organizer
  第37回日本臨床免疫学会
- Place of Presentation
  東京(東京ステーションコンファレンス)
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dopamine functions as a dendritic cells-mediated Th17-polarizing factor and plays a role for the pathogenesis of Rheumatoid Arthritis2009
- Author(s)
  Kazuhisa Nakano, Kazuyoshi Saito, Kunihiro Yamaoka, Sho Matsushita, Yoshiya Tanaka
- Organizer
  第9回国際炎症学会
- Place of Presentation
  東京
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic-cell-derived dopamine plays a pivotal role by inducing Th17-polarization in rheumatoid arthritis2009
- Author(s)
  Kazuhisa Nakano, Kazuyoshi Saito, Kunihiro Yamaoka, Sho Matsushita, Yoshiya Tanaka
- Organizer
  欧州リウマチ会議(EULAR)
- Place of Presentation
  コペンハーゲン
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic-cell-derived dopamine plays a pivotal role by inducing Th17-polarization in rheumatoid arthritis2009
- Author(s)
  中野和久
- Organizer
  欧州リウマチ会議(EULAR)
- Place of Presentation
  コペンハーゲン(Bella Center)
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis in rheumatoid arthritis2009
- Author(s)
  Kazuhisa Nakano, Kunihiro Yamaoka, Kazuyoshi Saito, Sho Matsushita, Yoshiya Tanaka
- Organizer
  第74回インターフェロン・サイトカイン学会
- Place of Presentation
  京都
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis in rheumatoid arthritis2009
- Author(s)
  中野和久
- Organizer
  第74回インターフェロン・サイトカイン学会
- Place of Presentation
  京都(日芝蘭会館)
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis2009
- Author(s)
  中野和久
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪(大阪国際会議場)
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] 樹状細胞-T細胞相互作用におけるドパミンの役割とD1様受容体阻害による滑膜炎制御2009
- Author(s)
  中野和久、齋藤和義、山岡邦宏、田中良哉
- Organizer
  第53回日本リウマチ学会
- Place of Presentation
  東京
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dendritic cell-derived dopamine induces IL-6-Th17 axis2009
- Author(s)
  Kazuhisa Nakano, Kunihiro Yamaoka, Kazuyoshi Saito, Sho Matsushita, Yoshiya Tanaka
- Organizer
  第39回日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790704
[Presentation] Dopamine functions as a dendritic cells-mediated Th17-polarizing factor and plays a role for the pathogenesis of Rheumatoid Arthritis2009
- Author(s)
  中野和久
- Organizer
  第9回国際炎症学会
- Place of Presentation
  東京(京王プラザホテル)
- Year and Date
  2009-07-08
- Data Source
  KAKENHI-PROJECT-20790704

1. 向井知之 (00454421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 守田吉孝 (50346441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nakano Kazuhisa 中野 和久

中野 和久 ナカノ カズヒサ

NAKANO Kazuhisa 中野 和久

Research Projects

Research Products

Co-Researchers

関節リウマチにおけるDNAメチル化ダイナミズムの解明とエピゲノム創薬に向けてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery targeting Tet3 for refractory rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamism of DNA methylation in Rheumatoid ArthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of neurotransmitter in DC-T cell interaction and new strategy for treatment of RAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 関節リウマチ滑膜におけるDNAメチル化とTET分子2017

Author(s)

Journal Title

Data Source

[Journal Article] Dopamine released by Dendritic cells polarizes Th2 differentiation2009

Author(s)

Journal Title

Data Source

[Journal Article] Dopamine released by dendritic cells polarizes Th2 differentiation2009

Author(s)

Journal Title

Data Source

[Journal Article] 樹状細胞-T細胞間における免疫修飾物質としてのドパミンの機能と関節リウマチの病態形成における役割2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Dopamine released by dendritic cells polarizes Th2 differentiation.2009

Author(s)

Journal Title

Data Source

[Journal Article] 樹状細胞-T細胞間における免疫修飾物質としてのドパミンの機能と関節リウマチの病態形成における役割2009

Author(s)

Journal Title

NAID

Data Source

[Patent] 関節炎の予防・治療剤、検査キット、並びに関節炎予防・治療薬のスクリーニング方法2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 関節炎の予防・治療剤、検査キット、並びに関節炎予防・治療薬のスクリーニング方法2014

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] The epigenetic induction of aggressive phenotype of fibroblast-like synovial cells (FLS) in rheumatoid arthritis (RA), the role of DNA demethylation enzyme TET32016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 持続的炎症刺激による線維芽細胞様滑膜細胞(FLS)の表現型変化におけるDNA脱メチル化酵素TET3の役割とTET3阻害による関節炎制御2016

Author(s)

Organizer

Place of Presentation

Year and Date

Nakano Kazuhisa 中野和久

中野和久ナカノカズヒサ

NAKANO Kazuhisa 中野和久