FUJIOKA Hitomi 藤岡仁美

Researcher Number	50410064
Other IDs
Affiliation (Current)	2022: 聖マリアンナ医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2011 – 2021: 聖マリアンナ医科大学, 医学部, 講師 2010: 聖マリアンナ医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Neuroscience in general / Environmental physiology (including Physical medicine and Nutritional physiology) / Integrated Nutrition Science / Basic / Social brain science
Keywords	Principal Investigator ストレス / GnRH / LH / ミクログリア / マクロファージ / IL-1β / 終板脈絡器官 / 中枢性性腺機能低下 / macrophage / LPS … More / 機能性視床下部性性腺機能低下 / 視床下部性性腺機能低下 / 神経内分泌 / 生植生理学 / Kisspeptin / 機能性視床下部生性腺機能低下 … More Except Principal Investigator ミクログリア / ストレス / 海馬 / シナプス / 高次機能 / 学習 / GnRHニューロン / シクロオキシゲナーゼ / プロスタグランジン / GnRH / COX-1 / ゴナドトロピン放出ホルモン / HPA axis / 生殖 / 遺伝子改変マウス / 視床下部-下垂体-副腎軸 / 性周期異常 / 性差 / 環境 / 学習機能 / AMPA受容体サブユニット / 記憶 / 性周期 / AMPA/NMDA比 / LTP / occlusion / 粉餌 / シェファー / CA1 / CA3 / パッチクランプ法 / 学習課題 / 栄養状況 / ラット / マイクログリア / 恐怖条件づけ / AAV / Cre Lox P / CX3CR1 / CD68 / Cre / DIO / ｄTA / DREADD / dTA / 受動回避 / CX3CR / ミノマイシン / 養育環境 / 強化 / 神経科学 / グリア / 可塑性 Less

視床下部性性腺機能抑制における視索前野領域ミクログリアの役割の証明Principal Investigator
- Principal Investigator
  
  藤岡仁美
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  St. Marianna University School of Medicine
Studies of physiological role of microglia on hippocampus-dependent learning
- Principal Investigator
  
  明間立雄
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic / Social brain science
- Research Institution
  St. Marianna University School of Medicine
Hypothalamic hypogonadism: Elucidation of the mechanisms controlling GnRH neural activity via Toll-like receptor 4Principal Investigator
- Principal Investigator
  
  Fujioka Hitomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  St. Marianna University School of Medicine
Molecular mechanism for the sex difference in learning ability by feeding environment
- Principal Investigator
  
  Funabashi Toshiya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  St. Marianna University School of Medicine
Role of microglia in functional hypothalamic hypogonadismPrincipal Investigator
- Principal Investigator
  
  Fujioka Hitomi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  St. Marianna University School of Medicine
慢性ストレスによる生殖機能抑制
- Principal Investigator
  
  千田大
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Saitama Medical University
  Research Institute, International Medical Center of Japan
Novel physiological function of microglia: Possible involvement of microglia in the regulation of GnRH neural function
- Principal Investigator
  
  AKEMA Tatsuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  St. Marianna University School of Medicine

All 2022 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] QUICK生理学・解剖学2022
- Author(s)
  松尾　理　編集、舩橋利也、藤岡仁美　分担執筆
- Total Pages
  437
- Publisher
  羊土社
- ISBN
  9784758121187
- Data Source
  KAKENHI-PROJECT-17K01980
[Book] 生理学2022
- Author(s)
  岡田隆夫　編集、舩橋利也、藤岡仁美　分担執筆
- Total Pages
  368
- Publisher
  メジカルビュー社
- ISBN
  9784758317917
- Data Source
  KAKENHI-PROJECT-17K01980
[Book] Gonadotropin Releasing Hormone (GnRH): Production, Structure and Function2013
- Author(s)
  藤岡　仁美
- Publisher
  Nova Scientific Press, Inc
- Data Source
  KAKENHI-PROJECT-22500298
[Book] Morphological evidence for involvement of microglia in the regulation of GnRH neurons. In: Sills ES (ed)
- Author(s)
  Fujioka H, Funabashi T, Akema T.
- Publisher
  Gonadotropin Releasing Hormone (GnRH): Production, Structure and Function. Nova Scientific Press, Inc (New York), 2013.
- Data Source
  KAKENHI-PROJECT-22500298
[Journal Article] Short-term fasting decreases excitatory synaptic inputs to ventromedial tuberoinfundibular dopaminergic neurons and attenuates their activity in male mice2018
- Author(s)
  Kubota T, Fukushima A, Hagiwara H, Kamiya Y, Furuta M, Miyazaki T, Fujioka H, Fujiwara SE, Funabashi T, Akema T.
- Journal Title
  
  Neuroscience Letters
  
  Volume: 10 (671) Pages: 70-75
- DOI
  10.1016/j.neulet.2018.02.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08531, KAKENHI-PROJECT-17K08577, KAKENHI-PROJECT-17K01980, KAKENHI-PROJECT-16K08998
[Journal Article] Prostaglandin E2 modulates presynaptic regulation of GnRH neurons via EP4 receptors in accordance with estrogen milieu.2017
- Author(s)
  Fujioka H, Funabashi T, Akema T
- Journal Title
  
  Neuroscience
  
  Volume: 360 Pages: 139-145
- DOI
  10.1016/j.neuroscience.2017.07.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01980, KAKENHI-PROJECT-17K08577, KAKENHI-PROJECT-16K20218
[Journal Article] Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.2015
- Author(s)
  Fukushima A, Hagiwara H, Fujioka H, Kimura F, Akema T, Funabashi T.
- Journal Title
  
  Front Neurosci
  
  Volume: 9 Pages: 1-8
- DOI
  10.3389/fnins.2015.00088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860162, KAKENHI-PROJECT-26460325, KAKENHI-PROJECT-26500017
[Journal Article] Immunohistochemical evidence for the relationship between microglia and GnRH neurons in the preoptic area of ovariectomized rats with and without steroid replacement2013
- Author(s)
  Fujioka H, Kakehashi C, Funabashi T, Akema T.
- Journal Title
  
  Endocrine Journal
  
  Volume: 60 Issue: 2 Pages: 191-196
- DOI
  10.1507/endocrj.ej12-0280
  10.1507/endocrj.EJ12-0280
- NAID
  10031156741
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500298
[Journal Article] Lipopolysaccharide acutely inhibits proliferation of neural precursor cells in the dentate gyrus in adult rats.2010
- Author(s)
  Fujioka H, Akema T.
- Journal Title
  
  Brain Research
  
  Volume: 1352 Pages: 35-42
- DOI
  10.1016/j.brainres.2010.07.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500298
[Journal Article] Lipopolysaccharide acutely inhibits proliferation of neural precursor cells in the dentate gyrus in adult rats2010
- Author(s)
  藤岡仁美
- Journal Title
  
  Brain Research
  
  Volume: 1352 Pages: 35-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] Involvement of kiss-1 neurons in the suppression of LH surge by LPS and amelioration of this suppression by minocycline pretreatment in ovarian steroid-primed ovariectomized rats2019
- Author(s)
  Hitomi FUJIOKA, Atsushi, FUKUSHIMA, Toshiya FUNABASHI, Tatsuo AKEMA
- Organizer
  第42回神経科学大会
- Data Source
  KAKENHI-PROJECT-17K01980
[Presentation] LPS急性ストレスによるGnRHサージ発生機構の活動抑制とミノサイクリン前投与による抑制解除へのkiss1ニューロンの関与（口頭発表，一般） 2018/10/272018
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  第45回日本神経内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01980
[Presentation] LPS急性ストレスによるGnRHサージ発生機構の活動抑制とミノサイクリン前投与による抑制解除へのkiss1ニューロンの関与2018
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  日本神経内分泌学会
- Data Source
  KAKENHI-PROJECT-16K20218
[Presentation] 雌ラットにおけるプロスタグランジンE2のGnRHニューロン微小EPSCへの影響2017
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松、静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K20218
[Presentation] 雌ラットにおけるプロスタグランジンE2のGnRHニューロン微小EPSCへの影響2017
- Author(s)
  藤岡仁美、明間立雄、舩橋利也
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松コングレスセンター（静岡県浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] リポポリサッカライドによるLHサージ状分泌抑制に関与する終板脈絡器官のIL-1β産生細胞の特徴2016
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] リポポリサッカライドによるLHサージ状分泌抑制に関与する終板脈絡器官のIL-1β産生細胞の特徴2016
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-16K20218
[Presentation] Minocycline did not affect the suppression by lipopolysaccharide of pulsatile luteinizing hormone secretion in ovariectomized rats.2016
- Author(s)
  Hitomi Fujioka, Atsushi Fukushima, Toshiya Funabashi, Tatsuo Akema
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] Characteristics of interleukin 1β producing cells involved in suppression of luteinizing hormone surge by LPS in the organum vasculosum of the lamina terminalis in ovarian steroid-primed ovariectomized rats2016
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26861345
[Presentation] Minocycline did not affect the suppression by lipopolysaccharide of pulsatile luteinizing hormone secretion in ovariectomized rats2016
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26861345
[Presentation] プロスタグランジンE2のGnRHニューロンminiature EPSCへの影響2015
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会合同学術集会
- Place of Presentation
  仙台市戦災復興記念館（宮城県・仙台）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26861345
[Presentation] プロスタグランジンE2のGnRHニューロンminiature EPSCへの影響2015
- Author(s)
  藤岡仁美, 舩橋利也, 明間立雄
- Organizer
  第42回日本神経内分泌学会
- Place of Presentation
  仙台市戦災復興記念館（宮城県仙台市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] GnRHニューロンの制御におけるミクログリアの関与(Possible involvement of microglia in regulation of GnRH neural functions)2013
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  第90回日本生理学会大会(学会連携シンポジウム)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] Possible involvement of microglia in regulation of GnRH neural functions.2013
- Author(s)
  藤岡　仁美
- Organizer
  第90回　日本生理学会（学会提携シンポジウム）
- Place of Presentation
  タワーホール船堀（東京l）
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラットGnRHニューロン周囲のシクロオキシゲナーゼ-1の細胞局在と性ステロイドの影響2012
- Author(s)
  藤岡仁美
- Organizer
  日本生理学会
- Place of Presentation
  信州大学(長野県)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラットGnRHニューロン周囲のシクロオキシゲナーゼ-1の細胞局在と性ステロイドの影響(Cellular localization of cyclooxygenase-1 and ovarian steroid effects on its expression in the vicinity of gonadotropin-releasing hormone neurons in the preoptic area of female rats)2012
- Author(s)
  藤岡仁美、掛橋千彰、舩橋利也、明間立雄
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラット・マウス・モルモットの視索前野におけるシクロオキシゲナーゼ-1の分布と細胞局在の検討(Distribution and cellular localization of cyclooxygenase-1 in the preoptic area of normal female rats, mice and guinea pigs)2011
- Author(s)
  藤岡仁美、掛橋千彰、明間立雄
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラット・マウス・モルモットの視索前野におけるシクロオキシゲナーゼ-1の分布と細胞局在の検討2011
- Author(s)
  藤岡仁美
- Organizer
  日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラット・マウス・モルモットの視索前野におけるシクロオキシゲナーゼ-1の細胞局在とGnRHニューロンとの解剖学的関係2011
- Author(s)
  藤岡仁美
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜(震災のため誌上開催)
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 雌ラット・マウス・モルモットの視索前野におけるシクロオキシゲナーゼ"1の細胞局在とGnRHニューロンとの解剖学的関係(Cellular localization of cyclooxygenase-1 and its anatomical relationship to gonadotropin-releasing hormone neurons in the preoptic area of normal female rats, mice and guinea pigs)2011
- Author(s)
  藤岡仁美、掛橋千彰、明間立雄
- Organizer
  第88回日本生理学会大会、第116回日本解剖学会全国学術集会C合同大会
- Place of Presentation
  東日本大震災により誌上開催
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 成体ラット海馬歯状回における神経新生に対する細菌性内毒素の急性効果(Proliferation of neural precursor cells in the dentate gyrus is acutely inhibited by lipopolysaccharide in adult rats.)2010
- Author(s)
  藤岡仁美、明間立雄
- Organizer
  第33回日本神経科学大会、第53回日本神経化学会大会および第20回日本神経回路学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22500298
[Presentation] 急性ストレスによるLH分泌抑制へのミクログリアの関与
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第41回日本神経内分泌学会学術集会
- Place of Presentation
  都道府県会館（東京都・千代田区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26861345
[Presentation] 絶食時に視床下部のミクログリアがPDGFR-aを介して摂食調節に関与する仮説
- Author(s)
  福島篤、萩原裕子、藤岡仁美、舩橋利也、明間立雄
- Organizer
  第41回日本神経内分泌学会学術集会
- Place of Presentation
  都道府県会館（東京）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] エストロゲンの細胞膜エストロゲン受容体GPERを介した摂食調節機構に関する研究
- Author(s)
  Atsushi Fukushima, Toshiya Funabashi, Miyako Furuta, Hiomi Fujioka, Yuuji Ogura, Tatsuo Akema
- Organizer
  第32回内分泌代謝学サマーセミナー
- Place of Presentation
  富士レークホテル（山梨）
- Year and Date
  2014-07-10 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] Effects of prostaglandin E2 on miniature EPSCs of gonadotropin-releasing hormone neurons
- Author(s)
  藤岡仁美、舩橋利也、明間立雄
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26861345
[Presentation] 急性ストレスによるLH分泌抑制へのミクログリアの関与
- Author(s)
  藤岡仁美, 福島篤, 舩橋利也, 明間立雄
- Organizer
  第41回日本神経内分泌学会学術集会
- Place of Presentation
  都道府県会館（東京）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26500017
[Presentation] IL-1β produced by Microglia/macrophage in the organum vasculosum of the lamina terminalis is involved in the suppression by lipopolysaccharide of steroid-induced luteinizing hormone surge in ovariectomized rats.
- Author(s)
  藤岡仁美、福島篤、舩橋利也、明間立雄
- Organizer
  第120回日本解剖学会・第92回日本生理学会合同大会
- Place of Presentation
  神戸国際会議場・展示場（兵庫県・神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26861345

1. AKEMA Tatsuo (60128585)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. Funabashi Toshiya (70229102)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. 萩原裕子 (90468207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. KAKEHASHI Chiaki (80535683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 千田大 (90312842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 長谷都 (20450611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUKUSHIMA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 船橋利也

# of Collaborated Projects: 0 results

# of Collaborated Products: 20 results

FUJIOKA Hitomi 藤岡 仁美

Research Projects

Research Products

Co-Researchers

視床下部性性腺機能抑制における視索前野領域ミクログリアの役割の証明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies of physiological role of microglia on hippocampus-dependent learning

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hypothalamic hypogonadism: Elucidation of the mechanisms controlling GnRH neural activity via Toll-like receptor 4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism for the sex difference in learning ability by feeding environment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of microglia in functional hypothalamic hypogonadismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

慢性ストレスによる生殖機能抑制

Principal Investigator

Project Period (FY)

Research Category

Research Field

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Novel physiological function of microglia: Possible involvement of microglia in the regulation of GnRH neural function

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[Book] QUICK生理学・解剖学2022

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[Book] 生理学2022

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[Book] Gonadotropin Releasing Hormone (GnRH): Production, Structure and Function2013

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[Book] Morphological evidence for involvement of microglia in the regulation of GnRH neurons. In: Sills ES (ed)

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[Journal Article] Short-term fasting decreases excitatory synaptic inputs to ventromedial tuberoinfundibular dopaminergic neurons and attenuates their activity in male mice2018

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[Journal Article] Prostaglandin E2 modulates presynaptic regulation of GnRH neurons via EP4 receptors in accordance with estrogen milieu.2017

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[Journal Article] Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.2015

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FUJIOKA Hitomi 藤岡仁美

[Presentation] LPS急性ストレスによるGnRHサージ発生機構の活動抑制とミノサイクリン前投与による抑制解除へのkiss1ニューロンの関与（口頭発表，一般） 2018/10/272018