Otani Tetsuhisa 大谷哲久

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OTANI Tetsuhisa 大谷哲久

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Researcher Number	50415105
Other IDs	https://orcid.org/0000-0002-2557-6722
Affiliation (Current)	2025: 東京都立大学, 理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 東京都立大学, 理学研究科, 准教授 2023: 東京都立大学, 東京都立大学, 准教授 2016 – 2023: 生理学研究所, 生体機能調節研究領域, 助教 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2014: 独立行政法人理化学研究所, 多細胞システム形成研究センター, 研究員 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 研究員 2012: 独立行政法人理化学研究所, 形態形成シグナル研究グループ, 研究員
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 44010:Cell biology-related / Biological Sciences Except Principal Investigator Transformative Research Areas, Section (III) / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Keywords	Principal Investigator 上皮バリア / 密着結合 / ミオシン / 接着結合 / 張力 / 上皮極性 / 上皮可塑性 / 傍細胞輸送 / ＪＡＭ / Ｃｌａｕｄｉｎ … More / メカノバイオロジー / 細胞間接着 / 集団的細胞移動 / JAM / Claudin / Afadin / Ａｆａｄｉｎ / ホメオスタシス / 細胞競合 / アクチン / 上皮管腔構造 / ZO-1 / 上皮細胞 / 細胞骨格 / リン酸化 / 細胞内シグナル伝達 / Spindle-F / 細胞伸長 / ショウジョウバエ / 細胞極性 / IKKε / 微小管 / 細胞内輸送 / 細胞質ダイニン … More Except Principal Investigator 細胞間接着 / 組織修復 / 生理活性ペプチド / メカニカルストレス / 上皮 / 細胞競合 / Hippo経路 / アクトミオシン / 細胞間接着誘導ペプチド / Afadin / 上皮細胞 / 着床 / 子宮 Less

上皮細胞が頂端面で力学的に”連結”する機構の解明
- Principal Investigator
  
  藤森俊彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  National Institute for Basic Biology
細胞間接着を起点とした細胞競合の分子機構とその生理的制御機構の解明
- Principal Investigator
  
  小田裕香子
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Modular organization of tight junctions and its roles in epithelial plasticityPrincipal Investigator
- Principal Investigator
  
  Otani Tetsuhisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  National Institute for Physiological Sciences
Role of cell competition in epithelial barrier homeostasisPrincipal Investigator
- Principal Investigator
  
  大谷哲久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Mechanisms of tension homeostasis and its role in epithelial morphogenesisPrincipal Investigator
- Principal Investigator
  
  Otani Tetsuhisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute for Physiological Sciences
細胞内物流の中継基地の機能とその成立機構の解明Principal Investigator
- Principal Investigator
  
  大谷哲久
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
Regulation of motor-cargo interaction in cytoplasmic dynein-dependent intracellular transportPrincipal Investigator
- Principal Investigator
  
  OTANI Tetsuhisa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex2024
- Author(s)
  Nguyen Thanh Phuong、Otani Tetsuhisa、Tsutsumi Motosuke、Kinoshita Noriyuki、Fujiwara Sachiko、Nemoto Tomomi、Fujimori Toshihiko、Furuse Mikio
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223 Issue: 5 Pages: 1-23
- DOI
  10.1083/jcb.202307104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06663, KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-20H05669, KAKENHI-PROJECT-21H02523
[Journal Article] Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis2023
- Author(s)
  H Koyama, H Okumura, AM Ito, K Nakamura, T Otani, K Kato, T Fujimori
- Journal Title
  
  PLoS Computational Biology
  
  Volume: 19 Issue: 8 Pages: 1-27
- DOI
  10.1371/journal.pcbi.1011306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PLANNED-22H05168
[Journal Article] Mechanism of interdigitation formation at apical boundary of MDCK cell2023
- Author(s)
  S Miyazaki, T Otani, K Sugihara, T Fujimori, M Furuse, T Miura
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 5 Pages: 1-21
- DOI
  10.1016/j.isci.2023.106594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02523
[Journal Article] ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions2022
- Author(s)
  Alexis J Haas, Ceniz Zihni, Susanne M Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S Balda, Karl Matter
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 23 Pages: 3775-3775
- DOI
  10.3390/cells11233775
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02523
[Journal Article] Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif2022
- Author(s)
  Sachiko Fujiwara, Thanh Phuong Nguyen, Kyoko Furuse, Yugo Fukazawa, Tetsuhisa Otani, Mikio Furuse
- Journal Title
  
  Ann N Y Acad Sci.
  
  Volume: 1516 Issue: 1 Pages: 85-94
- DOI
  10.1111/nyas.14881
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-21K15095
[Journal Article] Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes2022
- Author(s)
  Hanna M Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo
- Journal Title
  
  PLoS Biol.
  
  Volume: 20 Issue: 4 Pages: e3001586-e3001586
- DOI
  10.1371/journal.pbio.3001586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05286, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02523
[Journal Article] JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells2022
- Author(s)
  Sonja Thölmann, Jochen Seebach, Tetsuhisa Otani, Luise Florin, Hans Schnittler, Volker Gerke, Mikio Furuse, Klaus Ebnet
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 2 Pages: 1-19
- DOI
  10.1007/s00018-022-04140-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02523, KAKENHI-PLANNED-21H05286
[Journal Article] Angulin-1 seals tricellular contacts independently of tricellulin and claudins2021
- Author(s)
  Sugawara Taichi、Furuse Kyoko、Otani Tetsuhisa、Wakayama Tomohiko、Furuse Mikio
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 9
- DOI
  10.1083/jcb.202005062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-20K21509, KAKENHI-PROJECT-21K15333, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-21H05286
[Journal Article] Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function2021
- Author(s)
  Saito Akira C.、Higashi Tomohito、Fukazawa Yugo、Otani Tetsuhisa、Tauchi Masashi、Higashi Atsuko Y.、Furuse Mikio、Chiba Hideki
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 32 Issue: 8 Pages: 722-738
- DOI
  10.1091/mbc.e20-07-0464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06223, KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-16H06276, KAKENHI-PUBLICLY-20H05058, KAKENHI-PROJECT-19H03323, KAKENHI-PROJECT-21H02523, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-21H05286
[Journal Article] Tight Junction Structure and Function Revisited2020
- Author(s)
  Otani Tetsuhisa、Furuse Mikio
- Journal Title
  
  Trends in Cell Biology
  
  Volume: 30 Issue: 10 Pages: 805-817
- DOI
  10.1016/j.tcb.2020.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-16H06276
[Journal Article] New perspective of the structure and function of tight junctions2020
- Author(s)
  大谷哲久，古瀬幹夫
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 5 Pages: 731-734
- DOI
  10.14952/SEIKAGAKU.2020.920731
- NAID
  40022394517
- ISSN
  0037-1017
- Year and Date
  2020-10-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K06234
[Journal Article] Angulin-1 seals tricellular contacts independently of tricellulin and claudins2020
- Author(s)
  Taichi Sugawara, Kyoko Furuse, Tetsuhisa Otani, Mikio Furuse
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 323378-323378
- DOI
  10.1101/2020.10.02.323378
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06234
[Journal Article] The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts2020
- Author(s)
  Yukako Oda, Taichi Sugawara, Yuko Fukata, Yasushi Izumi, Tetsuhisa Otani, Tomohito Higashi, Masaki Fukata, Mikio Furuse
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 13 Pages: 4289-4302
- DOI
  10.1074/jbc.ra119.010491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PUBLICLY-18H04873, KAKENHI-PUBLICLY-19H04974, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02437
[Journal Article] Physiological functions of junctional adhesion molecules (JAMs) in tight junctions2020
- Author(s)
  Hartmann Christian、Schwietzer Ysabel Alessa、Otani Tetsuhisa、Furuse Mikio、Ebnet Klaus
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1862 Issue: 9 Pages: 183299-183299
- DOI
  10.1016/j.bbamem.2020.183299
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-16H06276
[Journal Article] Effective physical properties of cell-cell interaction explain basic structural units of three-dimensional morphogenesis2019
- Author(s)
  Hiroshi Koyama, Hisashi Okumura, Atsushi M Ito, Tetsuhisa Otani, Kazuyuki Nakamura, Kagayaki Kato, Toshihiko Fujimori
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 812198-812198
- DOI
  10.1101/812198
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06234
[Journal Article] Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, Shinsaku Tokuda, Kei Sugihara, Taichi Sugawara, Kyoko Furuse, Takashi Miura, Klaus Ebnet, Mikio Furuse
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 218 Issue: 10 Pages: 3372-3396
- DOI
  10.1083/jcb.201812157
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-16H06276
[Journal Article] The plus‐tip tracking and microtubule stabilizing activities of Javelin‐like regulate microtubule organization and cell polarity2019
- Author(s)
  Raju Baskar, Anna Bahkrat, Tetsuhisa Otani, Housei Wada, Geula Davidov, Himanshu Pandey, Larisa Gheber, Raz Zarivach, Shigeo Hayashi, Uri Abdu
- Journal Title
  
  The FEBS journal
  
  Volume: 286 Issue: 19 Pages: 3811-3830
- DOI
  10.1111/febs.14944
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-19H00996, KAKENHI-PROJECT-20K20460
[Journal Article] IKKε inhibits PKC to promote Fascin-dependent actin 2016bundling2016
- Author(s)
  Otani T, Ogura Y, Misaki K, Maeda T, Kimpara A, Yonemura S, Hayashi S
- Journal Title
  
  Development
  
  Volume: 143 Issue: 20 Pages: 3806-3816
- DOI
  10.1242/dev.138495
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01501, KAKENHI-PROJECT-15KT0086, KAKENHI-PROJECT-16K18544, KAKENHI-PROJECT-16K21629
[Journal Article] Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42.2014
- Author(s)
  Oda Y, Otani T, Ikenouchi J, Furuse M.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 127 Pages: 4201-12
- DOI
  10.1242/jcs.150607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657131, KAKENHI-PROJECT-24770197, KAKENHI-PROJECT-25711012, KAKENHI-PUBLICLY-26112713, KAKENHI-PROJECT-26291043
[Journal Article] Rab9 and retromer regulates retrograde trafficking of luminal protein required for epithelial tube length control2013
- Author(s)
  Bo Dong, Ken Kakihara, Tetsuhisa Otani, Housei Wada and Shigeo Hayashi
- Journal Title
  
  Nature Communications
  
  Volume: 4 Issue: 1 Pages: 1358-1358
- DOI
  10.1038/ncomms2347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770197, KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111007
[Journal Article] Drosophila oocyte polarity and cytoskeleton organization requires regulation of Ik2 activity by Spn-F and Javelin-like.2013
- Author(s)
  Amsalem S
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33:22 Issue: 22 Pages: 4371-4380
- DOI
  10.1128/mcb.00713-13
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-24770197
[Presentation] 細胞競合を介した上皮バリアの恒常性維持機構2023
- Author(s)
  大谷哲久
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] TJ membrane proteins regulate the mechanical resistance of the apical junctional complex2023
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, Mikio Furuse
- Organizer
  Gordon Research Conference "Cell Contact and Adhesion
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Competitive elimination of tight junction deficient cells regulate epithelial barrier homeostasis2022
- Author(s)
  Otani Tetsuhisa, Furuse Mikio
- Organizer
  The 74th Annual Meeting of the Japan Society for Cell Biology
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] 細胞間接着装置と上皮恒常性2022
- Author(s)
  大谷哲久
- Organizer
  第45回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Dissecting the roles of claudins and JAM-A in providing tight junction-dependent mechanical resistance2022
- Author(s)
  Nguyen Thanh Phuong , Otani Tetsuhisa, Furuse Mikio
- Organizer
  Cell Bio 2022 - An ASCB/EMBO meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] The roles of claudins and JAM-A in providing tight junction-dependent mechanical resistance2022
- Author(s)
  Nguyen Thanh Phuong , Otani Tetsuhisa, Furuse Mikio
- Organizer
  The 74th Annual Meeting of the Japan Society for Cell Biology
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Competitive elimination of tight junction deficient cells regulate epithelial barrier homeostasis2022
- Author(s)
  Otani Tetsuhisa, Furuse Mikio
- Organizer
  The 55th Annual Meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Competitive elimination of tight junction deficient cells regulate epithelial barrier homeostasis2021
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  4th International Tight Junction Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Competitive elimination of tight junction deficient cells regulate epithelial barrier homeostasis2021
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  The 51st NIPS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05286
[Presentation] Quest for claudin-independent occluding junctions in vivo2020
- Author(s)
  Tetsuhisa Otani
- Organizer
  53rd Annual meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Molecular organization of the macromolecule permeability barrier2020
- Author(s)
  Tetsuhisa Otani, Phuong Nguyen Thanh, Taichi Sugawara, Mikio Furuse
- Organizer
  The 72nd Annual Meeting of the Japanese Society for Cell Biology
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Tight Junction Structure and Function Revisited2020
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, Mikio Furuse
- Organizer
  MBSJ2020
- Invited
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Genetic dissection of the structural and functional organization of tight junctions.2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, and Mikio Furuse
- Organizer
  Gordon Research Conference on Cell Contact and Adhesion
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Genetic dissection of tight junctions.2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, and Mikio Furuse
- Organizer
  Joint Annual Meeting of 71st JSCB and 195h PSSJ
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Epithelial barrier homeostasis by cell competition.2019
- Author(s)
  Tetsuhisa Otani and Mikio Furuse
- Organizer
  52nd Annual meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] 上皮バリアと上皮極性形成における密着結合の役割2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第8回生理研・名大医合同シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] 上皮バリアと上皮極性形成における密着結合の役割2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第8回生理研・名大医合同シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  ASCB/EMBO 2018 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第70回日本細胞生物学会・第51回日本発生生物学会合同大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第70回日本細胞生物学会・第51回日本発生生物学会合同大会
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  ASCB/EMBO 2018 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Epithelial barrier homeostasis by cell competition.2017
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  The 3rd International Symposium on Cell Competition, Cell Competition and Cancer,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮バリアのホメオスタシスにおける細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第７回名古屋大学医学系研究科・生理学研究所　合同シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮バリアの恒常性の維持における細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第50回日本発生生物学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] Epithelial barrier homeostasis by cell competition.2017
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  The 3rd International Symposium on Cell Competition, Cell Competition and Cancer,
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮バリアの恒常性の維持における細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第50回日本発生生物学会大会
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮極性における密着結合の役割2017
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮バリアのホメオスタシスにおける細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第７回名古屋大学医学系研究科・生理学研究所　合同シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮極性における密着結合の役割2017
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮極性における密着結合の役割2016
- Author(s)
  大谷哲久、徳田深作、渡邊美香、古瀬幹夫
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] ZO-1 and ZO-2 are required for epithelial polarity in MDCK II cells2016
- Author(s)
  Tetsuhisa Otani
- Organizer
  International Conference Tight junctions and their proteins
- Place of Presentation
  ドイツ・ベルリン
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] IKKεによる局所シグナル伝達は細胞伸長過程における細胞極性維持に必要である2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第４７回日本発生生物学会
- Place of Presentation
  名古屋、日本
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第１１回日本ショウジョウバエ研究会
- Place of Presentation
  金沢、日本
- Year and Date
  2014-06-04
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] ショウジョウバエ剛毛細胞の伸長過程において細胞極性を維持する仕組み2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良、日本
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2013
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  The 23rd CDB Meeting, “Building multicellular systems from Cellular Cross-Talk”
- Place of Presentation
  RIKEN CDB, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Dynamic Organization of Paracrystalline Actin Bundles2012
- Author(s)
  Tetsuhisa Otani
- Organizer
  理研シンポジウム「細胞システムの動態と論理IV」
- Place of Presentation
  理化学研究所本所、埼玉県和光市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡、福岡県福岡市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  第１０回日本ショウジョウバエ研究会
- Place of Presentation
  東京慈恵会医科大学、東京都港区
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Dynamic Organization of Paracrystalline Actin Bundles by IKKε2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  神戸国際会議場・神戸商工会議所、兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Invited
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 2nd Asia-Pacific Drosophila Research Conference
- Place of Presentation
  ソウル大学（韓国）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Polarized transport and selective retention localizes the signaling center for bristle cell elongation.
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、Uri Abdu、林茂生
- Organizer
  56th Annual Drosophila Research Conference
- Place of Presentation
  シカゴ、米国
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKK antagonizes PKC-dependent inhibitory phosphorylation of Singed/Fascin to promote paracrystalline actin bundle assembly
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  The 46th Annual Meeting of the Japanese Society of Developmental Biologists
- Place of Presentation
  くにびきメッセ（島根県）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 65th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Cytoplasmic dynein-dependent localization of IKKepsilon to the distal tip is essential for Drosophila bristle cell elongation
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  ESF/EMBO coneference "Cell Polarity and membrane trafficking"
- Place of Presentation
  Pultusk, Poland
- Year and Date
  2014-05-11 – 2014-05-12
- Data Source
  KAKENHI-PROJECT-24770197

1. 藤森俊彦 (80301274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 木下典行 (30300940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小田裕香子 (70452498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IKENOUCHI Junichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HIGASHI Tomohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 古瀬幹夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 林茂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 菅原太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otani Tetsuhisa 大谷 哲久

OTANI Tetsuhisa 大谷 哲久

Research Projects

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Co-Researchers

上皮細胞が頂端面で力学的に”連結”する機構の解明

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細胞間接着を起点とした細胞競合の分子機構とその生理的制御機構の解明

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Modular organization of tight junctions and its roles in epithelial plasticityPrincipal Investigator

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Role of cell competition in epithelial barrier homeostasisPrincipal Investigator

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Mechanisms of tension homeostasis and its role in epithelial morphogenesisPrincipal Investigator

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細胞内物流の中継基地の機能とその成立機構の解明Principal Investigator

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Regulation of motor-cargo interaction in cytoplasmic dynein-dependent intracellular transportPrincipal Investigator

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[Journal Article] Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex2024

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[Journal Article] Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis2023

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[Journal Article] Mechanism of interdigitation formation at apical boundary of MDCK cell2023

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[Journal Article] ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions2022

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[Journal Article] Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif2022

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[Journal Article] Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes2022

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[Journal Article] JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells2022

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Otani Tetsuhisa 大谷哲久

OTANI Tetsuhisa 大谷哲久