OTANI Tetsuhisa 大谷哲久

Researcher Number	50415105
Other IDs	https://orcid.org/0000-0002-2557-6722
Affiliation (Current)	2021: 生理学研究所, 生体機能調節研究領域, 助教
Affiliation (based on the past Project Information) *help	2016 – 2019: 生理学研究所, 生体機能調節研究領域, 助教 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2014: 独立行政法人理化学研究所, 多細胞システム形成研究センター, 研究員 2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 研究員 2012: 独立行政法人理化学研究所, 形態形成シグナル研究グループ, 研究員
Review Section/Research Field	Principal Investigator Cell biology / Biological Sciences / Basic Section 44010:Cell biology-related
Keywords	Principal Investigator 密着結合 / 上皮バリア / 上皮極性 / 張力 / 接着結合 / ミオシン / 細胞質ダイニン / 細胞内輸送 / 微小管 / IKKε … More

Modular organization of tight junctions and its roles in epithelial plasticityPrincipal InvestigatorOngoing
- Principal Investigator
  
  大谷哲久
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  National Institute for Physiological Sciences
Role of cell competition in epithelial barrier homeostasisPrincipal Investigator
- Principal Investigator
  
  大谷哲久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Physiological Sciences
Mechanisms of tension homeostasis and its role in epithelial morphogenesisPrincipal Investigator
- Principal Investigator
  
  Otani Tetsuhisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute for Physiological Sciences
細胞内物流の中継基地の機能とその成立機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  大谷哲久
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
Regulation of motor-cargo interaction in cytoplasmic dynein-dependent intracellular transportPrincipal Investigator
- Principal Investigator
  
  OTANI Tetsuhisa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts2020
- Author(s)
  Yukako Oda, Taichi Sugawara, Yuko Fukata, Yasushi Izumi, Tetsuhisa Otani, Tomohito Higashi, Masaki Fukata, Mikio Furuse
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 13 Pages: 4289-4302
- DOI
  10.1074/jbc.ra119.010491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PUBLICLY-18H04873, KAKENHI-PUBLICLY-19H04974, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-16H06276
[Journal Article] Effective physical properties of cell-cell interaction explain basic structural units of three-dimensional morphogenesis2019
- Author(s)
  Hiroshi Koyama, Hisashi Okumura, Atsushi M Ito, Tetsuhisa Otani, Kazuyuki Nakamura, Kagayaki Kato, Toshihiko Fujimori
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 812198-812198
- DOI
  10.1101/812198
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06234
[Journal Article] Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, Shinsaku Tokuda, Kei Sugihara, Taichi Sugawara, Kyoko Furuse, Takashi Miura, Klaus Ebnet, Mikio Furuse
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 218 Pages: 3372-3396
- DOI
  10.1083/jcb.201812157
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-18H02440, KAKENHI-PROJECT-16H06276
[Journal Article] The plus‐tip tracking and microtubule stabilizing activities of Javelin‐like regulate microtubule organization and cell polarity2019
- Author(s)
  Raju Baskar, Anna Bahkrat, Tetsuhisa Otani, Housei Wada, Geula Davidov, Himanshu Pandey, Larisa Gheber, Raz Zarivach, Shigeo Hayashi, Uri Abdu
- Journal Title
  
  The FEBS Journal
  
  Volume: 286 Pages: 3811-3830
- DOI
  10.1111/febs.14944
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234, KAKENHI-PROJECT-19H00996, KAKENHI-PROJECT-20K20460
[Journal Article] IKKε inhibits PKC to promote Fascin-dependent actin bundling.2016
- Author(s)
  Otani T, Ogura Y, Misaki K, Maeda T, Kimpara A, Yonemura S, Hayashi S
- Journal Title
  
  Development.
  
  Volume: 143 Pages: 3806-3816
- DOI
  10.1242/dev.138495
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01501, KAKENHI-PROJECT-15KT0086, KAKENHI-PROJECT-16K18544, KAKENHI-PROJECT-16K21629
[Journal Article] Tricellulin regulates junctional tension of epithelial cells at tricellular contacts via Cdc422014
- Author(s)
  Oda Y, Otani T, Ikenouchi J, Furuse M.
- Journal Title
  
  J Cell Sci
  
  Volume: 127 Pages: 4201-12
- DOI
  10.1242/jcs.150607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24657131, KAKENHI-PROJECT-24770197, KAKENHI-PROJECT-25711012, KAKENHI-PUBLICLY-26112713, KAKENHI-PROJECT-26291043
[Journal Article] Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.2013
- Author(s)
  Bo Dong, Ken Kakihara, Tetsuhisa Otani, Housei Wada and Shigeo Hayashi
- Journal Title
  
  Nature Communications
  
  Volume: 4 Pages: 1-12
- DOI
  10.1038/ncomms2347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770197, KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111007
[Journal Article] Drosophila oocyte polarity and cytoskeleton organization requires regulation of Ik2 activity by Spn-F and Javelin-like.2013
- Author(s)
  Amsalem S
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 33:22 Pages: 4371-4380
- DOI
  10.1128/mcb.00713-13
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-24770197
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Genetic dissection of the structural and functional organization of tight junctions.2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, and Mikio Furuse
- Organizer
  Gordon Research Conference on Cell Contact and Adhesion
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Genetic dissection of tight junctions.2019
- Author(s)
  Tetsuhisa Otani, Thanh Phuong Nguyen, and Mikio Furuse
- Organizer
  Joint Annual Meeting of 71st JSCB and 195h PSSJ
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Epithelial barrier homeostasis by cell competition.2019
- Author(s)
  Tetsuhisa Otani and Mikio Furuse
- Organizer
  52nd Annual meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] 上皮バリアと上皮極性形成における密着結合の役割2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第8回生理研・名大医合同シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] 上皮バリアと上皮極性形成における密着結合の役割2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第8回生理研・名大医合同シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  ASCB/EMBO 2018 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第70回日本細胞生物学会・第51回日本発生生物学会合同大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第70回日本細胞生物学会・第51回日本発生生物学会合同大会
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2018
- Author(s)
  Tetsuhisa Otani, Shinsaku Tokuda, Mikio Furuse
- Organizer
  ASCB/EMBO 2018 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06234
[Presentation] Epithelial barrier homeostasis by cell competition.2017
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  The 3rd International Symposium on Cell Competition, Cell Competition and Cancer,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮バリアのホメオスタシスにおける細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第７回名古屋大学医学系研究科・生理学研究所　合同シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮バリアの恒常性の維持における細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第50回日本発生生物学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] Epithelial barrier homeostasis by cell competition.2017
- Author(s)
  Tetsuhisa Otani, Mikio Furuse
- Organizer
  The 3rd International Symposium on Cell Competition, Cell Competition and Cancer,
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮バリアの恒常性の維持における細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第50回日本発生生物学会大会
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮極性における密着結合の役割2017
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮バリアのホメオスタシスにおける細胞競合の役割2017
- Author(s)
  大谷哲久、古瀬幹夫
- Organizer
  第７回名古屋大学医学系研究科・生理学研究所　合同シンポジウム
- Data Source
  KAKENHI-PUBLICLY-17H05627
[Presentation] 上皮極性における密着結合の役割2017
- Author(s)
  大谷哲久、徳田深作、古瀬幹夫
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] 上皮極性における密着結合の役割2016
- Author(s)
  大谷哲久、徳田深作、渡邊美香、古瀬幹夫
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] ZO-1 and ZO-2 are required for epithelial polarity in MDCK II cells2016
- Author(s)
  Tetsuhisa Otani
- Organizer
  International Conference Tight junctions and their proteins
- Place of Presentation
  ドイツ・ベルリン
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18544
[Presentation] IKKεによる局所シグナル伝達は細胞伸長過程における細胞極性維持に必要である2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第４７回日本発生生物学会
- Place of Presentation
  名古屋、日本
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第１１回日本ショウジョウバエ研究会
- Place of Presentation
  金沢、日本
- Year and Date
  2014-06-04
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] ショウジョウバエ剛毛細胞の伸長過程において細胞極性を維持する仕組み2014
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良、日本
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2013
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  The 23rd CDB Meeting, “Building multicellular systems from Cellular Cross-Talk”
- Place of Presentation
  RIKEN CDB, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Dynamic Organization of Paracrystalline Actin Bundles2012
- Author(s)
  Tetsuhisa Otani
- Organizer
  理研シンポジウム「細胞システムの動態と論理IV」
- Place of Presentation
  理化学研究所本所、埼玉県和光市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡、福岡県福岡市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKKepsilon promotes paracrystalline actin bundle assembly by protecting Singed/Fascin from PKC-dependent inhibitory phosphorylation2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  第１０回日本ショウジョウバエ研究会
- Place of Presentation
  東京慈恵会医科大学、東京都港区
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Dynamic Organization of Paracrystalline Actin Bundles by IKKε2012
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  神戸国際会議場・神戸商工会議所、兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Invited
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 2nd Asia-Pacific Drosophila Research Conference
- Place of Presentation
  ソウル大学（韓国）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Polarized transport and selective retention localizes the signaling center for bristle cell elongation.
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、Uri Abdu、林茂生
- Organizer
  56th Annual Drosophila Research Conference
- Place of Presentation
  シカゴ、米国
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] IKK antagonizes PKC-dependent inhibitory phosphorylation of Singed/Fascin to promote paracrystalline actin bundle assembly
- Author(s)
  Tetsuhisa Otani, Takuya Maeda, Kazuyo Misaki, Shigenobu Yonemura, and Shigeo Hayashi
- Organizer
  The 46th Annual Meeting of the Japanese Society of Developmental Biologists
- Place of Presentation
  くにびきメッセ（島根県）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] A self-sustaining signaling center controls cell elongation
- Author(s)
  Tetsuhisa Otani, Kenzi Oshima, Akiyo Kimpara, Michiko Takeda, Shigeo Hayashi
- Organizer
  The 65th Annual Meeting of the Japan Society for Cell Biology
- Place of Presentation
  ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-24770197
[Presentation] Cytoplasmic dynein-dependent localization of IKKepsilon to the distal tip is essential for Drosophila bristle cell elongation
- Author(s)
  大谷哲久、大島健司、金原明代、武田美智子、林茂生
- Organizer
  ESF/EMBO coneference "Cell Polarity and membrane trafficking"
- Place of Presentation
  Pultusk, Poland
- Year and Date
  2014-05-11 – 2014-05-12
- Data Source
  KAKENHI-PROJECT-24770197

1. 古瀬幹夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 林茂生

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 米村重信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小椋陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 池ノ内順一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 深田優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 深田正紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTANI Tetsuhisa 大谷 哲久

Research Projects

Research Products

Co-Researchers

Modular organization of tight junctions and its roles in epithelial plasticityPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of cell competition in epithelial barrier homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of tension homeostasis and its role in epithelial morphogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内物流の中継基地の機能とその成立機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of motor-cargo interaction in cytoplasmic dynein-dependent intracellular transportPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effective physical properties of cell-cell interaction explain basic structural units of three-dimensional morphogenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The plus‐tip tracking and microtubule stabilizing activities of Javelin‐like regulate microtubule organization and cell polarity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IKKε inhibits PKC to promote Fascin-dependent actin bundling.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tricellulin regulates junctional tension of epithelial cells at tricellular contacts via Cdc422014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drosophila oocyte polarity and cytoskeleton organization requires regulation of Ik2 activity by Spn-F and Javelin-like.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019

Author(s)

Organizer

Data Source

[Presentation] ZO family proteins regulate epithelial polarity independent of tight junction strand assembly.2019

Author(s)

OTANI Tetsuhisa 大谷哲久