YAMAZAKI Tomohiko 山崎智彦

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YAMAZAKI TOMOHIKO 山崎智彦

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Researcher Number	50419264
Other IDs	https://orcid.org/0000-0003-2136-8042
Affiliation (Current)	2024: 国立研究開発法人物質・材料研究機構, 高分子・バイオ材料研究センター, 主幹研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人物質・材料研究機構, 高分子・バイオ材料研究センター, 主幹研究員 2016 – 2023: 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 2020: 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー代行主幹研究員 2020: 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー代行主幹研究員 2017: 国立研究開発法人物質・材料研究機構, その他部局等, その他 … More 2017: 国立研究開発法人物質・材料研究機構, その他部局等, その他研究員 2016: 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点ナノメディシングループ, 主幹研究員 2015: 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 2013: 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 2012: 独立行政法人物質・材料研究機構, その他部局等, 研究員 2011: 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 2010: 独立行政法人物質・材料研究機構, 生体材料センター, 主幹研究員 Less
Review Section/Research Field	Principal Investigator Biofunction/Bioprocess / Biofunction/Bioprocess / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 27040:Biofunction and bioprocess engineering-related Except Principal Investigator Basic Section 26030:Composite materials and interfaces-related / Basic Section 57030:Conservative dentistry-related / Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields / Composite materials/Surface and interface engineering / Biomedical engineering/Biomaterial science and engineering / Bio-related chemistry
Keywords	Principal Investigator 免疫活性化 / アジュバンド / アジュバント / CpG ODN / グアニン四重鎖構造 / トール様受容体９ / インターロイキン / インターフェロン / ヘモゾイン / トール様受容体9 … More / トール様受容体 / 疎水場 / 電気化学 / プロトポルフィリン / ナノプラスチック / DNA高次構造 / アイモチーフ / NFカッパ B / ワクチン / I型インターフェロン / Gカルテット構造 / 抗体産出 / 免疫細胞 / オリゴ / I型インターロイキン / CpGオリゴデオキシヌクレオチド / ポリマー / マラリア / 酵素合成 / ヘム / 末梢血単核細胞 / 相互作用 / インターフェロンγ / インフラマソーム / 末梢血単核球細胞 / イソプロピルアクリルアミド / ヘミン / DNA結合 / 合成オリゴデオキシリボヌクレオチド / オリゴデオキシヌクレオチド / トール様受容体9 (TLR9) / CpG ODNs / TLR9 / DNA結合部位 / アレルギー / 合成オリゴデオキシヌクレオチド / 分子認識ペプチド / ソルターゼ / 徐放制御 / マイクロ粒子 / ハイドロフォビン / 両親媒性蛋白質 / 酵素 / 分子認識 … More Except Principal Investigator 生体材料 / 腐食 / ポリマー / 自己修復 / 幹細胞 / 象牙芽細胞 / 体性幹細胞 / マクロファージ / 樹状細胞 / 象牙質・歯髄複合体 / 生体吸収性被膜 / XPS / インピーダンス / 炭酸含有率 / 水酸アパタイト / 炭酸アパタイト / 生体用マグネシウム / 骨置換 / 炭酸アパタイト被膜 / マグネシウム合金 / 深紫外長残光 / 長残光蛍光ナノ粒子 / 深紫外残光 / ナノ粒子 / 浸漬試験 / 細胞適合性 / アニオン性ポリマー / 非イオン性ポリマー / アパタイト被覆 / アパタイト被膜 / 耐傷性 / 水酸アパタイト被膜 / マグネシウム / 表面・界面物性 / リン酸カルシウム被膜 / 細胞・組織 / 複合材料・物性 / 表面・界面特性 / 構造・機能材料 / 生体内溶解性／生体吸収性 / 細胞接着 / ポリマー複合化 / リン酸カルシウム / 生体吸収性 / 生体内溶解性金属材料 / 糖化物 / 腫瘍細胞 / 細胞内糖化 / 糖化関連疾病 / 細胞内計測 / 生体情報・計測 / 蛋白質 / 疎水性領域 / 生体分子 / バイオテクノロジー / 生物・生体工学 / 酵素 / タンパク質 / 分子間電子伝達 / 分子内電子伝達 / ヘムｃ / グルコース脱水素酵素 / 電子伝達 / シトクロム / 鉄硫黄クラスタ / フラビン酵素 / バイオセンサ / バイオエレクトロニクス / 直接電子移動 Less

Development of a nanoplastic detection sensor utilizing DNA as molecular recognition elements.Principal Investigator
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  National Institute for Materials Science
Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages
- Principal Investigator
  
  大島勇人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Corrosion Control of Biodegradable Mg Alloys by Bone-Replacing Carbonate Apatite Coatings
- Principal Investigator
  
  廣本祥子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 26030:Composite materials and interfaces-related
- Research Institution
  National Institute for Materials Science
Construction of type I interferon-inducing oligodeoxynucleotide using i-motif DNA structuresPrincipal Investigator
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  National Institute for Materials Science
Synthesis and medical application of deep ultraviolet persistent nanophosphors
- Principal Investigator
  
  SUN Hong-tao
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
- Research Institution
  National Institute for Materials Science
Development of corrosion protection coatings of biomedical Mg alloys showing cell adhesion changing with time
- Principal Investigator
  
  HIROMOTO Sachiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 26030:Composite materials and interfaces-related
- Research Institution
  National Institute for Materials Science
synthesis of a hemin-containing copolymer as a novel immunostimulatorPrincipal Investigator
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Regulation of the immunostimulatory activity of CpG ODNs by G-quadruplex formationPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI Tomohiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  National Institute for Materials Science
Development of intracellular multi-monitoring system and its application for analysis of glycation effect on tumor cells
- Principal Investigator
  
  SAKAGUCHI-MIKAMI Akane
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo University of Technology
Elucidation of molecular mechanism of novel iron-sulfur flavoprotein cytochrome dehydrogenase
- Principal Investigator
  
  Sode Koji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo University of Agriculture and Technology
Development of polymer-modified calcium phosphate coating with self-healing ability for biodegradable Mg alloys
- Principal Investigator
  
  Hiromoto Sachiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Composite materials/Surface and interface engineering
- Research Institution
  National Institute for Materials Science
Development of a hemin-containing copolymer as a novel immunostimulatorPrincipal Investigator
- Principal Investigator
  
  YAMAZAKI TOMOHIKO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Identification of the single-stranded DNA recognition site on human TLR9Principal Investigator
- Principal Investigator
  
  YAMAZAKI TOMOHIKO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Construction of self-assembled protein-based microsphere having molecular recognition ability.Principal Investigator
- Principal Investigator
  
  YAMAZAKI Tomohiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] Water-Soluble Silicon Quantum Dots toward Fluorescence-Guided Photothermal Nanotherapy2022
- Author(s)
  Ozbilgin Irem Nur Gamze、Yamazaki Tomohiko、Watanabe Junpei、Sun Hong-Tao、Hanagata Nobutaka、Shirahata Naoto
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 17 Pages: 5188-5196
- DOI
  10.1021/acs.langmuir.1c02326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H01743, KAKENHI-PROJECT-21H01910, KAKENHI-PROJECT-21K18942
[Journal Article] G-quadruplex-based CpG oligodeoxynucleotide/DOTAP complex strongly stimulates immunity in CpG motif-specific and loop-length-dependent manners2022
- Author(s)
  Tu Anh Thi Tram、Hoshi Kazuaki、Shobo Miwako、Yamazaki Tomohiko
- Journal Title
  
  Nanomedicine: Nanotechnology, Biology and Medicine
  
  Volume: 40 Pages: 102508-102508
- DOI
  10.1016/j.nano.2021.102508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04858
[Journal Article] Structural analysis of guanine quadruplex-forming oligonucleotides and their application to oligonucleotide therapeutics2021
- Author(s)
  Yamazaki Tomohiko、TU Anh Ti Tram
- Journal Title
  
  Drug Delivery System
  
  Volume: 36 Issue: 5 Pages: 360-368
- DOI
  10.2745/dds.36.360
- NAID
  130008163742
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2021-11-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04858
[Journal Article] Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparal-lel Guanine-Quadruplex Structural Scaffold.2021
- Author(s)
  Safitri, F., Tu, A., Hoshi, K., Shobo, M., Zhao, D., Witarto, A., Sumarsono, S., Giri-Rachman, E., Tsukakoshi, K., Ikebukuro, K., and Yamazaki, T.
- Journal Title
  
  Sensors (Basel)
  
  Volume: 11(11) Issue: 11 Pages: 1617-1617
- DOI
  10.3390/biom11111617
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15694, KAKENHI-PROJECT-19KK0194, KAKENHI-PROJECT-18K04858
[Journal Article] Osteoclast and osteoblast responsive carbonate apatite coatings for biodegradable magnesium alloys2020
- Author(s)
  Hiromoto Sachiko、Itoh Sayaka、Noda Naomi、Yamazaki Tomohiko、Katayama Hideki、Akashi Takaya
- Journal Title
  
  Science and Technology of Advanced Materials
  
  Volume: 21 Issue: 1 Pages: 346-358
- DOI
  10.1080/14686996.2020.1761237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02449
[Journal Article] Monomeric G-Quadruplex-Based CpG Oligodeoxynucleotides as Potent Toll-Like Receptor 9 Agonists2020
- Author(s)
  Tu Anh Thi Tram、Hoshi Kazuaki、Ikebukuro Kazunori、Hanagata Nobutaka、Yamazaki Tomohiko
- Journal Title
  
  Biomacromolecules
  
  Volume: 21 Issue: 9 Pages: 3644-3657
- DOI
  10.1021/acs.biomac.0c00679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04858
[Journal Article] G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides2019
- Author(s)
  Hoshi, Kazuaki; Yamazaki, Tomohiko; Sugiyama, Yuuki; Tsukakoshi, Kaori; Tsugawa, Wakako; Sode, Koji; Ikebukuro, Kazunori
- Journal Title
  
  Nucleic acid therapeutics
  
  Volume: 29 (4) Issue: 4 Pages: 224-229
- DOI
  10.1089/nat.2018.0761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15694, KAKENHI-PROJECT-19KK0194, KAKENHI-PROJECT-18K04858
[Journal Article] Preparation, characterization, and evaluation of chitosan-based nanoparticles as CpG ODN carriers2019
- Author(s)
  Iswanti Febriana Catur、Nurulita Indah、Djauzi Samsuridjal、Sadikin Mohamad、Witarto Arief Budi、Yamazaki Tomohiko
- Journal Title
  
  Biotechnology & Biotechnological Equipment
  
  Volume: － Issue: 1 Pages: 1-7
- DOI
  10.1080/13102818.2019.1578690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04858
[Journal Article] Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production2018
- Author(s)
  Hoshi Kazuaki、Yamazaki Tomohiko、Yoshikawa Chiaki、Tsugawa Wakako、Ikebukuro Kazunori、Sode Koji
- Journal Title
  
  International Journal of Nanomedicine
  
  Volume: Volume 13 Pages: 4461-4472
- DOI
  10.2147/ijn.s166259
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0122, KAKENHI-PROJECT-15K06589
[Journal Article] Micromorphological effect of calcium phosphate coating on compatibility of magnesium alloy with osteoblast2017
- Author(s)
  S. Hiromoto, T. Yamazaki
- Journal Title
  
  SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
  
  Volume: 18 Issue: 1 Pages: 96-109
- DOI
  10.1080/14686996.2016.1266238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04511
[Journal Article] An Fe-S cluster in the conserved Cys-rich region in the catalytic subunit of FAD-dependentdehydrogenase complexes2016
- Author(s)
  Masaki Shiota, Tomohiko Yamazaki, Keiichi Yoshimatsu, Katsuhiro Kojima, Wakako Tsugawa, Stefano Ferri, Koji Sode
- Journal Title
  
  Bioelectrochemistry
  
  Volume: 112 Pages: 178-183
- DOI
  10.1016/j.bioelechem.2016.01.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04175
[Journal Article] Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines2013
- Author(s)
  H. Zhang, S. Chen, C. Zhi, T. Yamazaki, N. Hanagata
- Journal Title
  
  Int. J. Nanomed
  
  Volume: 8 Pages: 1783-1793
- DOI
  10.2147/ijn.s43251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24760655
[Journal Article] Recognition of CpG oligodeoxynucleotides by human Toll-like receptor 9 and subsequent cytokine induction2013
- Author(s)
  S. Suwarti, T. Yamazaki, S. Chechetka, N. Hanagata
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 430 Issue: 4 Pages: 1234-1239
- DOI
  10.1016/j.bbrc.2012.12.068
- NAID
  120005228348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22560777, KAKENHI-PROJECT-24760655
[Journal Article] Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles2012
- Author(s)
  K. Yoshimatsu, T. Yamazaki, I. Chronakis, L. Ye
- Journal Title
  
  Journal of Applied Polymer Science
  
  Volume: 124 Issue: 2 Pages: 1249-1255
- DOI
  10.1002/app.35150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22760615
[Journal Article] Protein engineering approaches for constructing novel glucose sensing elements2010
- Author(s)
  T. Yamazaki and A. Sakaguchi
- Journal Title
  
  Indonesian Nanoletter
  
  Volume: 3 Pages: 44-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22760615
[Patent] 免疫刺激オリゴヌクレオチド2020
- Inventor(s)
  山崎智彦
- Industrial Property Rights Holder
  物質・材料研究機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-143071
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K04858
[Patent] 共重合体、免疫アジュバントおよび非ヒト動物を免疫する方法2018
- Inventor(s)
  山崎智彦、吉川千晶、星和明
- Industrial Property Rights Holder
  国立研究開発機構物質・材料研究機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-112204
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15K06589
[Patent] ヘム骨格を有するポリマーアジュバント2017
- Inventor(s)
  山崎智彦、吉川千晶、星和明
- Industrial Property Rights Holder
  国立研究開発法人物質・材料研究機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-171231
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] ε-Poly-L-Lysine / Guanine-Quadruplexes CpG Oligodeoxynucleotide Complexes for Vaccine Adjuvant Applications2022
- Author(s)
  ZHAO Dandan, TU Thi Tram Anh, YOSHIKAWA, Chiaki, YAMAZAKI, Tomohiko.
- Organizer
  つくば医工連携フォーラム2022, つくばバイオマテリアル医工学研究会
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] Bioabsorbable Carbonate Apatite Coating for Biodegradable Mg Alloy and Osteoclast and Osteoblast Response2022
- Author(s)
  S. Hiromoto, S. Itoh, N. Noda, T. Yamazaki, H. Katayama, T. Akashi
- Organizer
  Joint Symposium -Society For Biomaterials + The Japanese Society for Biomaterials. 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23066
[Presentation] ヘム含有ポリマーのワクチンアジュバントとしての商品化2021
- Author(s)
  山崎智彦
- Organizer
  「つくばイノベーション・エコシステムの構築（医療・先端技術シーズを用いた超スマート社会の創成事業）」成果報告会
- Data Source
  KAKENHI-PROJECT-17KK0122
[Presentation] グアニン四重鎖構造を用いたDNAアジュバントの開発2021
- Author(s)
  山崎智彦, TU Thi Tram Anh, 星和明, Safitri Fika Ayu, 塚越かおり, 池袋一典
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] Development of functional oligonucleotides forming G-quadruplex structure by using topological structure evaluation based on CD spectrum analysis combined with principal component analysis2021
- Author(s)
  塚越かおり, 鈴木仁子, 大山泰史, 佐藤星, TU Thi Tram Anh, 堀口靖夫, 永森浩司, 山崎智彦, 池袋一典.
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] 水溶性ヘムポリマーのアジュバント効果2020
- Author(s)
  4.山崎智彦, 星和明, ツチトラムアン, 吉川千晶, 菅井和久, 袴田陽二
- Organizer
  第15回ナノ・バイオメディカル学会年会
- Data Source
  KAKENHI-PROJECT-17KK0122
[Presentation] Tuning of the immunostimulatory effect of G-quadruplex based CpG Oligodeoxynucleotides2020
- Author(s)
  Anh Thi Tram TU, Kazuaki Hoshi, Kazunori Ikebukuro, Tomohiko Yamazaki
- Organizer
  MANA International Symposium 2020 jointly with ICYS
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] マラリア原虫のヘム結晶を模倣したワクチン効果を増強する高分子2020
- Author(s)
  山崎智彦
- Organizer
  SATテクノロジー・ショーケース
- Data Source
  KAKENHI-PROJECT-17KK0122
[Presentation] Bioabsorbable Carbonate Apatite Coating for Biodegradable Mg Implants and Osteoclast Response2020
- Author(s)
  S. Hiromoto, S. Itoh, N. Noda, T. Yamazaki, H. Katayama, T. Akashi
- Organizer
  11th World Biomaterials Congress, WBC2020 Virtual. 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02449
[Presentation] Forming Monomeric Guanine-Quadruplex Structure for enhancing CpG oligodeoxynucleotides-mediated immunostimulatory properties.2020
- Author(s)
  ツチトラムアン,星和明, 池袋一典, 山崎智彦
- Organizer
  第15回ナノ・バイオメディカル学会年会
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] 水溶性ヘム含有ポリマーの合成と免疫活性化能の検討2020
- Author(s)
  山崎智彦、星和明、ツチトラムアン、吉川千晶、津川若子、早出広司、池袋一典
- Organizer
  第13回次世代アジュバント研究会
- Data Source
  KAKENHI-PROJECT-17KK0122
[Presentation] Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotides by Forming Monomeric Guanine-Quadruplex Structure2020
- Author(s)
  Anh Thi Tram TU, Kazuaki Hoshi, Kazunori Ikebukuro, Nobutaka Hanagata, Tomohiko Yamazaki
- Organizer
  16th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] Osteoclast responsive carbonate apatite coatings of WE43 alloy toward entirely-bioabsorbable and corrosion-controlled Mg alloys2020
- Author(s)
  S. Hiromoto, S. Itoh, N. Noda, T. Yamazaki, H. Katayama, T. Akashi
- Organizer
  12th Biometal Virtual Workshop. 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02449
[Presentation] Gカルテット構造によるCpG ODNの免疫活性化能の向上2019
- Author(s)
  山崎智彦、星和明、ツチトラムアン、塚越かおり、津川若子、早出広司、池袋一典
- Organizer
  第71回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] 免疫活性化能を有するヘミン含有共重合体の開発2019
- Author(s)
  星和明、ツチトラムアン、吉川千晶、津川若子、早出広司、池袋一典、山崎智彦
- Organizer
  第41回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-17KK0122
[Presentation] Immunostimulatory properties of CpG ODNs forming G-quadruplex structure2019
- Author(s)
  Anh Thi Tram TU, Kazuaki Hoshi, Kazunori Ikebukuro, Tomohiko Yamazaki
- Organizer
  46th International Symposium on Nucleic Acids Chemistry
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] Development of novel immunostimulators, as potent vaccine adjuvants2019
- Author(s)
  Tomohiko YAMAZAKI
- Organizer
  CSIRO-NIMS SYMPOSIUM
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] Improvement of the immunostimulatory effects of CpG ODNs by forming G-quadruplex structure2019
- Author(s)
  Kazuaki Hoshi, Anh Thi Tram TU, Kaori Tsukakoshi, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Tomohiko Yamazaki
- Organizer
  46th International Symposium on Nucleic Acids Chemistry
- Data Source
  KAKENHI-PROJECT-18K04858
[Presentation] 免疫活性化能を有するヘミン含有ポリマーの開発2018
- Author(s)
  星和明、津川若子、早出広司、池袋一典、山崎智彦
- Organizer
  第27回インテリジェント材料・システムシンポジウム
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] リン酸カルシウム被覆AZ31合金の劣化に及ぼす様々な細胞の影響2018
- Author(s)
  廣本祥子, 野田なほみ, 山崎智彦
- Organizer
  日本金属学会2018年春期（第162回）講演大会
- Data Source
  KAKENHI-PROJECT-16H04511
[Presentation] Development of novel immunostimulatory ligands of toll like receptor 9, as potent activators of the innate immune system2018
- Author(s)
  Tomohiko YAMAZAKI
- Organizer
  6th Annual Meeting of Hypoxia and Oxidative Stress Studies
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Development of novel immunostimulatory ligands of Toll-like receptor 9 as potent activators of the innate immune system2018
- Author(s)
  Tomohiko YAMAZAKI
- Organizer
  Second Interdisciplinary and Research Alumni Symposium iJaDe2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Development of a polymer based immunostimulatory ligand mimicking malarial hemozoin2018
- Author(s)
  Tomohiko YAMAZAKI
- Organizer
  CSIRO-NIMS symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Gカルテット構造形成によるCpG ODNの免疫活性能の向上2017
- Author(s)
  山崎智彦、星和明、杉山雄紀、塚越かおり、津川若子、早出広司、池袋一典
- Organizer
  第69回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] ヘミン含有免疫活性化剤の開発2017
- Author(s)
  星和明、山崎智彦、津川若子、早出広司
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] 構造制御による免疫活性化CpG ODNの機能向上2017
- Author(s)
  山崎智彦
- Organizer
  つくば医工連携フォーラム 2017
- Place of Presentation
  千現地区、物質・材料研究機構, つくば
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] 免疫活性化DNAナノ構造体2016
- Author(s)
  星和明、山崎智彦
- Organizer
  つくば医工連携フォーラム2016
- Place of Presentation
  産業技術総合研究所つくばセンター、つくば市
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Improved immunostimulatory activity of phosphodiester CpG oligodeoxynucleotides by G-quadruplex formation2016
- Author(s)
  山崎智彦、花方信孝
- Organizer
  International Symposium on Nanomedicine
- Place of Presentation
  つくば中央、産業技術総合研究所、つくば
- Year and Date
  2016-11-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] DNA structure control immunostimulatory effect of CpG ODN2016
- Author(s)
  K. Hoshi, K. Sode, W. Tsugawa, K. Ikebukuro, N. Hanagata, Tomohiko Yamazaki
- Organizer
  MANA International Symposium 2016
- Place of Presentation
  つくば国際会議場、つくば市
- Year and Date
  2016-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Recognition of CpG olygodeoxynucleotides by human Toll-like receptor 92015
- Author(s)
  T. YAMAZAKI, S. SUWARTI, N. HANAGATA
- Organizer
  Toll 2015
- Place of Presentation
  Palacio de Congresos de Mabella, Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] CpGオリゴヌクレオチドの免疫活性能に対するポリグアノシンの影響2015
- Author(s)
  山崎智彦、花方信孝
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル、鹿児島市
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] オリゴグアノシンを有する免疫活性化オリゴヌクレオチドの開発2014
- Author(s)
  杉山雄紀, 早出広司, 津川　若子, 池袋一典, 花方信孝, 山崎智彦
- Organizer
  つくば医工連携フォーラム2014
- Place of Presentation
  産総研　共同講堂、つくば市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] G-quadruplex structure extend the immunostimulatory effect of CpG oligodeoxynucleotides2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  MANA International Symposium 2014
- Place of Presentation
  Epocal Tsukuba, Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Immunostimulation effect of G-rich CpG oligonucleotide2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  International Symposium on Smart Biomaterials
- Place of Presentation
  NIMS(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] G-quadruplex structure extend the immunostimulatory effect of CpG oligodeoxynucleotides2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  MANA International Symposium 2014
- Place of Presentation
  つくば国際会議場(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシンを有する免疫活性化オリゴヌクレオチドの開発2014
- Author(s)
  杉山雄紀,早出広司,津川若子,池袋一典,花方信孝,山崎智彦
- Organizer
  つくば医工連携フォーラム2014
- Place of Presentation
  産業技術総合研究所(つくば市茨城県)
- Year and Date
  2014-01-28
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシン配列付加によるCpG ODNの免疫活性化能の向上2014
- Author(s)
  杉山雄紀,早出広司,津川若子,池袋一典,花方信孝,山崎智彦
- Organizer
  分子・物質合成プラットフォーム平成25年度シンポジウム
- Place of Presentation
  つくば国際会議場(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Immunostimulation effect of G-rich CpG oligonucleotide2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  International Symposium on Smart Biomaterials
- Place of Presentation
  NIMS, Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシン配列付加によるCpG ODNの免疫活性化能の向上2014
- Author(s)
  杉山雄紀, 早出広司, 津川　若子, 池袋一典, 花方信孝, 山崎智彦
- Organizer
  分子・物質合成プラットフォーム平成25年度シンポジウム
- Place of Presentation
  つくば国際会議場、つくば市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 天然型免疫活性化CpGオリゴデオキシヌクレオチドの開発2013
- Author(s)
  山崎智彦,花方信孝
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学(名古屋市愛知県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 天然型免疫活性化CpGオリゴデオキシヌクレオチドの開発2013
- Author(s)
  山崎智彦, 花方信孝
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学、名古屋市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Natural CpG ODNs-induced human TLR9 specific immunostimulation2012
- Author(s)
  Suwarti Suwarti, Tomohiko Yamazaki and Nobutaka Hanagata
- Organizer
  Homeostatic Inflammation Symposium
- Place of Presentation
  一橋記念講堂（東京都）
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Characterization of interleukin-6 induction by natural CpG oligodeoxynuxleotide2012
- Author(s)
  Chechetka Svetlana, Tomohiko Yamazaki and Nobutaka Hanagata
- Organizer
  第６回ナノバイオメディカル学会大会
- Place of Presentation
  産業技術総合研究所（つくば市　茨城県）
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Characterization of interleukin-6 induction by natural CpG oligodeoxynuxleotide2012
- Author(s)
  C. Svetlana, T. Yamazaki and N. Hanagata
- Organizer
  第6回ナノバイオメディカル学会大会
- Place of Presentation
  産業技術総合研究所(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2012
- Author(s)
  山崎智彦, 辰巳公平, 大橋一夫, 谷口彰良, 岡野光夫
- Organizer
  第21回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京女子医科大学(東京都)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Natural CpG ODNs-induced human TLR9 specific immunostimulation2012
- Author(s)
  S. Suwarti, T. Yamazaki, and N. Hanagata
- Organizer
  Homeostatic Inflammation Symposium
- Place of Presentation
  一橋記念講堂(東京都)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 遺伝性肝疾患治療を目指した肝臓細胞への遺伝子導入2012
- Author(s)
  山崎智彦,辰巳公平,大橋一夫,谷口彰良,岡野光夫
- Organizer
  第21回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京(日本)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2011
- Author(s)
  T. Yamazaki, A. Mikami, K. Sode, A. Taniguchi, N. Hanagata
- Organizer
  Japan-China International Forum of Advanced Research on Biotechnology 2011
- Place of Presentation
  東京(日本)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2011
- Author(s)
  山崎智彦, 坂口あかね, 早出広司, 谷口彰良, 花方信孝
- Organizer
  日中バイオテクノロジー先端フォーラム2011
- Place of Presentation
  東京海洋大学(東京都)(招待講演)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Novel CpG phosphodiester oligodeoxynucleotides as human toll-like receptor 9 agonists2011
- Author(s)
  山崎智彦, 孟文君, 花方信孝
- Organizer
  Infection & Immunity
- Place of Presentation
  Suzhou Dushu Lake Conference Center(蘇州,中国)
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Identification of Hydroxyapatite-Binding Peptides2011
- Author(s)
  T. Yamazaki, N. Hanagata
- Organizer
  Joint Conference of The Fifth International Conference on the Science and Technology for Advanced Ceramics(STAC-5) and The 2nd International Conference
- Place of Presentation
  横浜(日本)
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Identification of Hydroxyapatite-Binding Peptides2011
- Author(s)
  山崎智彦, 花方信孝
- Organizer
  STAC5-AMDI2
- Place of Presentation
  メルパルク横浜(神奈川県)
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] 遺伝子銃を用いた肝臓細胞への遺伝子導入2011
- Author(s)
  山崎智彦,辰巳公平,吉松啓一, Wang Dan,大橋一夫,谷口彰良,岡野光夫
- Organizer
  第33回日本バイオマテリアル学会大会
- Place of Presentation
  京都(日本)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Novel CpG phosphodiester oligodeoxynucleotides as human toll-like receptor 9 agonists2011
- Author(s)
  T. Yamazaki, W. Meng, N. Hanagata
- Organizer
  Infection & Immunity
- Place of Presentation
  Suzhou(中国)
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] 遺伝子銃を用いた肝臓細胞への遺伝子導入2011
- Author(s)
  山崎智彦, 辰巳公平, 吉松啓一, Wang Dan, 大橋一夫, 谷口彰良, 岡野光夫
- Organizer
  第33回日本バイオマテリアル学会大会
- Place of Presentation
  京都テルサ(京都府)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Screening of Hydroxyapatite-Binding Peptides using Phage Display Library2010
- Author(s)
  T. Yamazaki, Y. Nisida, A. Taniguchi, T. Ikoma
- Organizer
  Fourth International Conference on Science and Technology of Advanced Ceramics
- Place of Presentation
  横浜(日本)
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Screening of Hydroxyapatite-Binding Peptides using Phage Display Library2010
- Author(s)
  山崎智彦、西田有紀、谷口彰良、生駒俊之
- Organizer
  Fourth International Conference on Fourth International Conferen
- Place of Presentation
  メルパルクホール,横浜
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-22760615

1. Hiromoto Sachiko (00343880)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. 池袋一典 (70251494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. Sode Koji (10187883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SAKAGUCHI-MIKAMI Akane (70469782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUN Hong-tao (30571822)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 吉川千晶 (10447930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉田裕美 (10313305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 津川若子 (80376871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 光延由希子 (70814268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大島勇人 (70251824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. QuispeSalcedo Angela (20966866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 常木雅之 (40714944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 依田浩子 (60293213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HANAGATA Nobutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 塚越かおり

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

YAMAZAKI Tomohiko 山崎 智彦

YAMAZAKI TOMOHIKO 山崎 智彦

Research Projects

Research Products

Co-Researchers

Development of a nanoplastic detection sensor utilizing DNA as molecular recognition elements.Principal Investigator

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Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages

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Corrosion Control of Biodegradable Mg Alloys by Bone-Replacing Carbonate Apatite Coatings

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Construction of type I interferon-inducing oligodeoxynucleotide using i-motif DNA structuresPrincipal Investigator

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Synthesis and medical application of deep ultraviolet persistent nanophosphors

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Development of corrosion protection coatings of biomedical Mg alloys showing cell adhesion changing with time

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synthesis of a hemin-containing copolymer as a novel immunostimulatorPrincipal Investigator

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Regulation of the immunostimulatory activity of CpG ODNs by G-quadruplex formationPrincipal Investigator

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Development of intracellular multi-monitoring system and its application for analysis of glycation effect on tumor cells

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Elucidation of molecular mechanism of novel iron-sulfur flavoprotein cytochrome dehydrogenase

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Development of polymer-modified calcium phosphate coating with self-healing ability for biodegradable Mg alloys

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Development of a hemin-containing copolymer as a novel immunostimulatorPrincipal Investigator

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Identification of the single-stranded DNA recognition site on human TLR9Principal Investigator

Principal Investigator

Project Period (FY)

YAMAZAKI Tomohiko 山崎智彦

YAMAZAKI TOMOHIKO 山崎智彦