YAMAZAKI Tomohiko 山崎智彦

Researcher Number	50419264
Other IDs
Affiliation *help	2016 – 2018 : 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 2017 : 国立研究開発法人物質・材料研究機構, その他部局等, その他 2016 – 2017 : 国立研究開発法人物質・材料研究機構, その他部局等, その他研究員 2016 – 2017 : 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点ナノメディシングループ, 主幹研究員 2015 : 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 … More
Review Section/Research Field	Principal Investigator Biofunction/Bioprocess / Biofunction/Bioprocess / Basic Section 27040:Biofunction and bioprocess engineering-related Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Bio-related chemistry / Composite materials/Surface and interface engineering
Keywords	Principal Investigator トール様受容体9 / アジュバンド / トール様受容体 / 免疫活性化 / CpG ODN / トール様受容体9 (TLR9) / DNA結合 / ソルターゼ / 合成オリゴデオキシリボヌクレオチド / 末梢血単核細胞 … More Except Principal Investigator 生体情報・計測 / バイオテクノロジー / 細胞内計測 / 生物・生体工学 / 表面・界面物性 / 糖化関連疾病 / 蛋白質 / 生体分子 / 生体材料 / 細胞・組織 / タンパク質 / 構造・機能材料 / 表面・界面特性 / 複合材料・物性 / 酵素 Less

Regulation of the immunostimulatory activity of CpG ODNs by G-quadruplex formationPrincipal InvestigatorOngoing
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  National Institute for Materials Science
Development of intracellular multi-monitoring system and its application for analysis of glycation effect on tumor cellsOngoing
- Principal Investigator
  
  三上あかね
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo University of Technology
植物・微生物由来ヘミンからの免疫活性化ヘムポリマーの合成Principal InvestigatorOngoing
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Development of polymer-modified calcium phosphate coating with self-healing ability for biodegradable Mg alloysOngoing
- Principal Investigator
  
  廣本祥子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Composite materials/Surface and interface engineering
- Research Institution
  National Institute for Materials Science
Elucidation of molecular mechanism of novel iron-sulfur flavoprotein cytochrome dehydrogenaseOngoing
- Principal Investigator
  
  早出広司
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo University of Agriculture and Technology
ヘミン誘導体から構成される免疫活性化剤の開発Principal InvestigatorOngoing
- Principal Investigator
  
  山崎智彦
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Identification of the single-stranded DNA recognition site on human TLR9Principal Investigator
- Principal Investigator
  
  YAMAZAKI TOMOHIKO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science
Construction of self-assembled protein-based microsphere having molecular recognition ability.Principal Investigator
- Principal Investigator
  
  YAMAZAKI Tomohiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  National Institute for Materials Science

All 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] An Fe-S cluster in the conserved Cys-rich region in the catalytic subunit of FAD-dependentdehydrogenase complexes2016
- Author(s)
  Masaki Shiota, Tomohiko Yamazaki, Keiichi Yoshimatsu, Katsuhiro Kojima, Wakako Tsugawa, Stefano Ferri, Koji Sode
- Journal Title
  
  Bioelectrochemistry
  
  Volume : 112 Pages : 178-183
- DOI
  10.1016/j.bioelechem.2016.01.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04175
[Journal Article] Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines2013
- Author(s)
  H. Zhang, S. Chen, C. Zhi, T. Yamazaki, N. Hanagata
- Journal Title
  
  Int. J. Nanomed
  
  Volume : 8 Pages : 1783-1793
- DOI
  10.2147/IJN.S43251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24760655
[Journal Article] Recognition of CpG oligodeoxynucleotides by human Toll-like receptor 9 and subsequent cytokine induction2013
- Author(s)
  S. Suwarti, T. Yamazaki, S. Chechetka, N. Hanagata
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 430 Issue : 4 Pages : 1234-1239
- Publisher
  Elsevier
- DOI
  10.1016/j.bbrc.2012.12.068
- Year and Date
  2013-01-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22560777, KAKENHI-PROJECT-24760655
[Journal Article] Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles2012
- Author(s)
  K. Yoshimatsu, T. Yamazaki, I. Chronakis, L. Ye
- Journal Title
  
  Journal of Applied Polymer Science
  
  Volume : 124 Pages : 1249-1255
- DOI
  10.1002/app.35150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22760615
[Journal Article] Protein engineering approaches for constructing novel glucose sensing elements2010
- Author(s)
  T. Yamazaki and A. Sakaguchi
- Journal Title
  
  Indonesian Nanoletter
  
  Volume : 3 Pages : 44-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] 構造制御による免疫活性化CpG ODNの機能向上2017
- Author(s)
  山崎智彦
- Organizer
  つくば医工連携フォーラム 2017
- Place of Presentation
  千現地区、物質・材料研究機構, つくば
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Improved immunostimulatory activity of phosphodiester CpG oligodeoxynucleotides by G-quadruplex formation2016
- Author(s)
  山崎智彦、花方信孝
- Organizer
  International Symposium on Nanomedicine
- Place of Presentation
  つくば中央、産業技術総合研究所、つくば
- Year and Date
  2016-11-24
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] 免疫活性化DNAナノ構造体2016
- Author(s)
  星和明、山崎智彦
- Organizer
  つくば医工連携フォーラム2016
- Place of Presentation
  産業技術総合研究所つくばセンター、つくば市
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] DNA structure control immunostimulatory effect of CpG ODN2016
- Author(s)
  K. Hoshi, K. Sode, W. Tsugawa, K. Ikebukuro, N. Hanagata, Tomohiko Yamazaki
- Organizer
  MANA International Symposium 2016
- Place of Presentation
  つくば国際会議場、つくば市
- Year and Date
  2016-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] CpGオリゴヌクレオチドの免疫活性能に対するポリグアノシンの影響2015
- Author(s)
  山崎智彦、花方信孝
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル、鹿児島市
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Recognition of CpG olygodeoxynucleotides by human Toll-like receptor 92015
- Author(s)
  T. YAMAZAKI, S. SUWARTI, N. HANAGATA
- Organizer
  Toll 2015
- Place of Presentation
  Palacio de Congresos de Mabella, Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06589
[Presentation] Immunostimulation effect of G-rich CpG oligonucleotide2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  International Symposium on Smart Biomaterials
- Place of Presentation
  NIMS, Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシン配列付加によるCpG ODNの免疫活性化能の向上2014
- Author(s)
  杉山雄紀, 早出広司, 津川　若子, 池袋一典, 花方信孝, 山崎智彦
- Organizer
  分子・物質合成プラットフォーム平成25年度シンポジウム
- Place of Presentation
  つくば国際会議場、つくば市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] G-quadruplex structure extend the immunostimulatory effect of CpG oligodeoxynucleotides2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  MANA International Symposium 2014
- Place of Presentation
  Epocal Tsukuba, Tsukuba, Japan
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシンを有する免疫活性化オリゴヌクレオチドの開発2014
- Author(s)
  杉山雄紀, 早出広司, 津川　若子, 池袋一典, 花方信孝, 山崎智彦
- Organizer
  つくば医工連携フォーラム2014
- Place of Presentation
  産総研　共同講堂、つくば市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Immunostimulation effect of G-rich CpG oligonucleotide2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  International Symposium on Smart Biomaterials
- Place of Presentation
  NIMS(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシン配列付加によるCpG ODNの免疫活性化能の向上2014
- Author(s)
  杉山雄紀,早出広司,津川若子,池袋一典,花方信孝,山崎智彦
- Organizer
  分子・物質合成プラットフォーム平成25年度シンポジウム
- Place of Presentation
  つくば国際会議場(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] G-quadruplex structure extend the immunostimulatory effect of CpG oligodeoxynucleotides2014
- Author(s)
  T. Yamazaki, Y Sugiyama, K Sode, W Tsugawa, K Ikebukuro, N. Hanagata
- Organizer
  MANA International Symposium 2014
- Place of Presentation
  つくば国際会議場(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] オリゴグアノシンを有する免疫活性化オリゴヌクレオチドの開発2014
- Author(s)
  杉山雄紀,早出広司,津川若子,池袋一典,花方信孝,山崎智彦
- Organizer
  つくば医工連携フォーラム2014
- Place of Presentation
  産業技術総合研究所(つくば市茨城県)
- Year and Date
  2014-01-28
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 天然型免疫活性化CpGオリゴデオキシヌクレオチドの開発2013
- Author(s)
  山崎智彦, 花方信孝
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学、名古屋市
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 天然型免疫活性化CpGオリゴデオキシヌクレオチドの開発2013
- Author(s)
  山崎智彦,花方信孝
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学(名古屋市愛知県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2012
- Author(s)
  山崎智彦, 辰巳公平, 大橋一夫, 谷口彰良, 岡野光夫
- Organizer
  第21回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京女子医科大学(東京都)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Natural CpG ODNs-induced human TLR9 specific immunostimulation2012
- Author(s)
  Suwarti Suwarti, Tomohiko Yamazaki and Nobutaka Hanagata
- Organizer
  Homeostatic Inflammation Symposium
- Place of Presentation
  一橋記念講堂（東京都）
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Natural CpG ODNs-induced human TLR9 specific immunostimulation2012
- Author(s)
  S. Suwarti, T. Yamazaki, and N. Hanagata
- Organizer
  Homeostatic Inflammation Symposium
- Place of Presentation
  一橋記念講堂(東京都)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Characterization of interleukin-6 induction by natural CpG oligodeoxynuxleotide2012
- Author(s)
  Chechetka Svetlana, Tomohiko Yamazaki and Nobutaka Hanagata
- Organizer
  第６回ナノバイオメディカル学会大会
- Place of Presentation
  産業技術総合研究所（つくば市　茨城県）
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] Characterization of interleukin-6 induction by natural CpG oligodeoxynuxleotide2012
- Author(s)
  C. Svetlana, T. Yamazaki and N. Hanagata
- Organizer
  第6回ナノバイオメディカル学会大会
- Place of Presentation
  産業技術総合研究所(つくば市茨城県)
- Data Source
  KAKENHI-PROJECT-24760655
[Presentation] 遺伝性肝疾患治療を目指した肝臓細胞への遺伝子導入2012
- Author(s)
  山崎智彦,辰巳公平,大橋一夫,谷口彰良,岡野光夫
- Organizer
  第21回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京(日本)
- Year and Date
  2012-01-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] 遺伝子銃を用いた肝臓細胞への遺伝子導入2011
- Author(s)
  山崎智彦, 辰巳公平, 吉松啓一, Wang Dan, 大橋一夫, 谷口彰良, 岡野光夫
- Organizer
  第33回日本バイオマテリアル学会大会
- Place of Presentation
  京都テルサ(京都府)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Identification of Hydroxyapatite-Binding Peptides2011
- Author(s)
  T. Yamazaki, N. Hanagata
- Organizer
  Joint Conference of The Fifth International Conference on the Science and Technology for Advanced Ceramics(STAC-5) and The 2nd International Conference
- Place of Presentation
  横浜(日本)
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2011
- Author(s)
  山崎智彦, 坂口あかね, 早出広司, 谷口彰良, 花方信孝
- Organizer
  日中バイオテクノロジー先端フォーラム2011
- Place of Presentation
  東京海洋大学(東京都)(招待講演)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Identification of Hydroxyapatite-Binding Peptides2011
- Author(s)
  山崎智彦, 花方信孝
- Organizer
  STAC5-AMDI2
- Place of Presentation
  メルパルク横浜(神奈川県)
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Novel CpG phosphodiester oligodeoxynucleotides as human toll-like receptor 9 agonists2011
- Author(s)
  山崎智彦, 孟文君, 花方信孝
- Organizer
  Infection & Immunity
- Place of Presentation
  Suzhou Dushu Lake Conference Center(蘇州,中国)
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] 遺伝子銃を用いた肝臓細胞への遺伝子導入2011
- Author(s)
  山崎智彦,辰巳公平,吉松啓一, Wang Dan,大橋一夫,谷口彰良,岡野光夫
- Organizer
  第33回日本バイオマテリアル学会大会
- Place of Presentation
  京都(日本)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Novel CpG phosphodiester oligodeoxynucleotides as human toll-like receptor 9 agonists2011
- Author(s)
  T. Yamazaki, W. Meng, N. Hanagata
- Organizer
  Infection & Immunity
- Place of Presentation
  Suzhou(中国)
- Year and Date
  2011-09-11
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Engineered transcriptional regulators for intracellular sensing and gene regulation2011
- Author(s)
  T. Yamazaki, A. Mikami, K. Sode, A. Taniguchi, N. Hanagata
- Organizer
  Japan-China International Forum of Advanced Research on Biotechnology 2011
- Place of Presentation
  東京(日本)
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Screening of Hydroxyapatite-Binding Peptides using Phage Display Library2010
- Author(s)
  山崎智彦、西田有紀、谷口彰良、生駒俊之
- Organizer
  Fourth International Conference on Fourth International Conferen
- Place of Presentation
  メルパルクホール,横浜
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-22760615
[Presentation] Screening of Hydroxyapatite-Binding Peptides using Phage Display Library2010
- Author(s)
  T. Yamazaki, Y. Nisida, A. Taniguchi, T. Ikoma
- Organizer
  Fourth International Conference on Science and Technology of Advanced Ceramics
- Place of Presentation
  横浜(日本)
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-22760615

1. 廣本祥子 (00343880)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
2. 吉川千晶 (10447930)

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3. 三上あかね (70469782)

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4. 早出広司 (10187883)

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5. 吉田裕美 (10313305)

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6. 津川若子 (80376871)

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7. 池袋一典 (70251494)

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8. 花方信孝

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# of Collaborated Products : 1results

YAMAZAKI Tomohiko 山崎 智彦

Research Projects

Research Products

Co-Researchers

Regulation of the immunostimulatory activity of CpG ODNs by G-quadruplex formationPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of intracellular multi-monitoring system and its application for analysis of glycation effect on tumor cellsOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

植物・微生物由来ヘミンからの免疫活性化ヘムポリマーの合成Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of polymer-modified calcium phosphate coating with self-healing ability for biodegradable Mg alloysOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanism of novel iron-sulfur flavoprotein cytochrome dehydrogenaseOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘミン誘導体から構成される免疫活性化剤の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the single-stranded DNA recognition site on human TLR9Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of self-assembled protein-based microsphere having molecular recognition ability.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Fe-S cluster in the conserved Cys-rich region in the catalytic subunit of FAD-dependentdehydrogenase complexes2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recognition of CpG oligodeoxynucleotides by human Toll-like receptor 9 and subsequent cytokine induction2013

Author(s)

Journal Title

Publisher

DOI

Year and Date

Language

Data Source

[Journal Article] Influence of template/functional monomer/cross-linking monomer ratio on particle size and binding properties of molecularly imprinted nanoparticles2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein engineering approaches for constructing novel glucose sensing elements2010

Author(s)

Journal Title

Data Source

[Presentation] 構造制御による免疫活性化CpG ODNの機能向上2017

YAMAZAKI Tomohiko 山崎智彦