Sekiya Motohiro 関谷元博

… Alternative Names

Researcher Number	50420245
Other IDs
Affiliation (Current)	2021: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 筑波大学, 医学医療系, 准教授 2017: 筑波大学, 医学医療系, 講師 2009 – 2010: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, Hospital, Research fellow 2006 – 2007: 東京大学, 医学部附属病院, 医員 2006: 東大, 医学部附属病院
Review Section/Research Field	Principal Investigator Metabolomics / Health science and related fields / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 代謝産物 / センサー / コレステロール / コレステロールエステル / マクロファージ / 泡沫化 / 水解 / エピゲノム / インスリン / 膵β細胞 … More Except Principal Investigator 肥満 / 中性脂肪 / 転写調節 / obesity / triglycerides / transcrintional regulation / 脂質 / 脂肪酸 / オルガネラ / 転写因子 / リピドミクス / 小胞体 / ミトコンドリア / 酵素 / ライブセルイメージング / 脂肪毒性 / 脂質代謝 / 脂肪酸伸長酵素 / オルガネラリピッドコード Less

新しく同定された代謝産物センサー分子の分子基盤解明と医療応用Principal InvestigatorOngoing
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Tsukuba
Molecular mechanism of organella homeostasis regulated by quantity and quality of lipidsOngoing
- Principal Investigator
  
  島野仁
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator
- Principal Investigator
  
  Sekiya Motohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  University of Tsukuba
マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
in vivo promoter analysis of lipogenic genes
- Principal Investigator
  
  YAHAGI Naoya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020
- Author(s)
  Satoh A, Han S, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, and Shimano H.
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 3 Pages: 100930-100930
- DOI
  10.1016/j.isci.2020.100930
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07095, KAKENHI-PROJECT-19K11713, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-19H00449, KAKENHI-PROJECT-18K19724
[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.2020
- Author(s)
  Ma Yang、Sekiya Motohiro、Kainoh Kenta、Matsuda Takaaki、Iwasaki Hitoshi、Osaki Yoshinori、Sugano Yoko、Suzuki Hiroaki、Takeuchi Yoshinori、Miyamoto Takafumi、Yahagi Naoya、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 523 Pages: 354-360
- DOI
  10.1016/j.bbrc.2019.12.070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-19K11713, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-18K19724
[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020
- Author(s)
  Matsuzaka T, Kuba M, Koyasu S, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
- Journal Title
  
  Hepatology
  
  Volume: - Pages: 1609-1625
- DOI
  10.1002/hep.30953
- Description
  in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-19K20175, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-16H06276
[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.2019
- Author(s)
  Murayama Yuki, Takafumi Miyamoto, et al.
- Journal Title
  
  FEBS Lett
  
  Volume: 593 Pages: 423-432
- DOI
  10.1002/1873-3468.13328
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17K12895, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H05060
[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.2019
- Author(s)
  Sharma Rahu, Takafumi Miyamoto, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Pages: 1-12
- DOI
  10.1038/s41598-019-41631-1
- NAID
  120006714297
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-18K19724, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.2018
- Author(s)
  Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 499 Pages: 239-245
- DOI
  10.1016/j.bbrc.2018.03.135
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16H03253, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811
[Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance2018
- Author(s)
  Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
- Journal Title
  
  Endocrinology
  
  Volume: 159(6) Pages: 2308-2323
- DOI
  10.1210/en.2017-03179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice.2018
- Author(s)
  Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 19 Pages: 2148-2148
- DOI
  10.3390/ijms19072148
- NAID
  120006531296
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811
[Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Biochem Biophys Res Commun 387
  
  Pages: 511-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Cell Metab 10(3)
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008
- Author(s)
  Sekiya M, et. al.
- Journal Title
  
  J Lipid Res (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis2008
- Author(s)
  Sekiya M, Osuga J, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yanagi N, et al.
- Journal Title
  
  J Lipid Res (in press)
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] A metabolite sensor CtBP2 integrates metabolic flux to orchestrate glucose and lipid homeostasis in liver2019
- Author(s)
  Motohiro Sekiya, Hitoshi Shimano, Gokhan Hotamisligil
- Organizer
  60th International Conference on the Bioscience of Lipids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 転写因子CREBHの未成熟型・成熟型による動脈硬化形成に対する二重支配の分子メカニズム2018
- Author(s)
  中川嘉、韓松伊、大石麻代、王雨農、関谷元博、松坂賢、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 代謝産物センサーによる新しい脂質・糖代謝制御システムの解明と医療応用2018
- Author(s)
  関谷元博、菅澤威仁、馬　洋、戒能賢太、関根七海、Gokhan Hotamisligil、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 新規に同定されたリパーゼNCEHはマクロファージの主要な中性コレステロールエステラーゼである2009
- Author(s)
  関谷元博
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] A Novel Lipase, Neutral Cholesterol Ester Hydrolase, is a major regulator of Neutral Cholesterol Ester Hydrolysis in Macrophages.2009
- Author(s)
  関谷元博
- Organizer
  第41回日本動脈硬化学会総会・学術集会
- Place of Presentation
  山口
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] 新規に同定されたマクロファージコレステロールエズテラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたコレステロールエステラーゼ(MCEH)は未同定であったマクロファージの中性コレステロールエステラーゼである2006
- Author(s)
  関谷元博, 他
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージに発現する新規コレステロールエステラーゼ(macrophage cholesteryl ester hydrolase, MCEH)ノックアウトマウスの解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第38回日本動脈硬化学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージにおいて新規に同定されたコレステロールエステラーゼ(MCEH)のin vivo解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第49回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979

1. YAHAGI Naoya (60420246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. OSUGA Jun-ichi (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. IIZUKA Yoko (40420244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 島野仁 (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. 松坂賢 (70400679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 韓松伊 (80729541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. 中川嘉 (80361351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. KUMAGAI Kae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 會田雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 武内謙憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
12. 小西守周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 宮本崇史

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
14. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 升田紫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekiya Motohiro 関谷 元博

関谷 元博 セキヤ モトヒロ

SEKIYA Motobiro 関谷 元博

Research Projects

Research Products

Co-Researchers

新しく同定された代謝産物センサー分子の分子基盤解明と医療応用Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of organella homeostasis regulated by quantity and quality of lipidsOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

in vivo promoter analysis of lipogenic genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020

Author(s)

Journal Title

DOI

Description

Data Source

[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice.2018

Sekiya Motohiro 関谷元博

関谷元博セキヤモトヒロ

SEKIYA Motobiro 関谷元博