Sekiya Motohiro 関谷元博

… Alternative Names

関谷元博セキヤモトヒロ

SEKIYA Motobiro 関谷元博

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Researcher Number	50420245
Other IDs
Affiliation (Current)	2022: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2022: 筑波大学, 医学医療系, 准教授 2018 – 2020: 筑波大学, 医学医療系, 准教授 2017: 筑波大学, 医学医療系, 講師 2009 – 2010: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, Hospital, Research fellow 2006 – 2007: 東京大学, 医学部附属病院, 医員 2006: 東大, 医学部附属病院
Review Section/Research Field	Principal Investigator Metabolomics / Health science and related fields / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Metabolomics
Keywords	Principal Investigator 代謝産物 / センサー / コレステロール / コレステロールエステル / マクロファージ / 泡沫化 / 水解 / エピゲノム / インスリン / 膵β細胞 … More / 発現制御 / 内科 / 糖尿病 / 脂質 / ゲノム / 脂肪酸 / ジヌクレオチド / 小分子化合物 … More Except Principal Investigator 脂質代謝 / 肥満 / 中性脂肪 / 転写調節 / obesity / triglycerides / transcrintional regulation / 多価不飽和脂肪酸 / 小胞体 / ミトコンドリア / 脂質 / 脂肪酸 / オルガネラ / 転写因子 / リピドミクス / 酵素 / ライブセルイメージング / 脂肪毒性 / 脂肪酸伸長酵素 / オルガネラリピッドコード Less

Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application
- Principal Investigator
  
  島野仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
新しく同定された代謝産物センサー分子の分子基盤解明と医療応用Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Tsukuba
Molecular mechanism of organella homeostasis regulated by quantity and quality of lipids
- Principal Investigator
  
  SHIMANO HITOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator
- Principal Investigator
  
  Sekiya Motohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  University of Tsukuba
マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
in vivo promoter analysis of lipogenic genes
- Principal Investigator
  
  YAHAGI Naoya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion2020
- Author(s)
  Sekiya Motohiro、Matsuda Takaaki、Yamamoto Yuki、Furuta Yasuhisa、Ohyama Mariko、Murayama Yuki、Sugano Yoko、Ohsaki Yoshinori、Iwasaki Hitoshi、Yahagi Naoya、Yatoh Shigeru、Suzuki Hiroaki、Shimano Hitoshi
- Journal Title
  
  BMC Medical Genetics
  
  Volume: 21 Pages: 91-91
- DOI
  10.1186/s12881-020-01031-z
- NAID
  120007147873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21611, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051
[Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020
- Author(s)
  Satoh A, Han S, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, and Shimano H.
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 3 Pages: 100930-100930
- DOI
  10.1016/j.isci.2020.100930
- NAID
  120006891020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07095, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-19H00449, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-19K11737, KAKENHI-ORGANIZER-17H06391
[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020
- Author(s)
  Matsuzaka T, Kuba M, Koyasu S, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
- Journal Title
  
  Hepatology
  
  Volume: 71 Pages: 1609-1625
- DOI
  10.1002/hep.30953
- NAID
  120007132717
- Description
  in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-20K21611, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18K06206
[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.2020
- Author(s)
  Ma Yang、Sekiya Motohiro、Kainoh Kenta、Matsuda Takaaki、Iwasaki Hitoshi、Osaki Yoshinori、Sugano Yoko、Suzuki Hiroaki、Takeuchi Yoshinori、Miyamoto Takafumi、Yahagi Naoya、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 523 Pages: 354-360
- DOI
  10.1016/j.bbrc.2019.12.070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-18K06206
[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.2019
- Author(s)
  Murayama Yuki, Takafumi Miyamoto, et al.
- Journal Title
  
  FEBS Lett
  
  Volume: 593 Pages: 423-432
- DOI
  10.1002/1873-3468.13328
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17K12895, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-17K00846
[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.2019
- Author(s)
  Sharma Rahu, Takafumi Miyamoto, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Pages: 1-12
- DOI
  10.1038/s41598-019-41631-1
- NAID
  120007133465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-18K19724, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.2018
- Author(s)
  Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 499 Pages: 239-245
- DOI
  10.1016/j.bbrc.2018.03.135
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16H03253, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811
[Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance2018
- Author(s)
  Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
- Journal Title
  
  Endocrinology
  
  Volume: 159(6) Pages: 2308-2323
- DOI
  10.1210/en.2017-03179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice.2018
- Author(s)
  Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 19 Pages: 2148-2148
- DOI
  10.3390/ijms19072148
- NAID
  120007133834
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811
[Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Biochem Biophys Res Commun 387
  
  Pages: 511-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Cell Metab 10(3)
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008
- Author(s)
  Sekiya M, et. al.
- Journal Title
  
  J Lipid Res (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis2008
- Author(s)
  Sekiya M, Osuga J, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yanagi N, et al.
- Journal Title
  
  J Lipid Res (in press)
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020
- Author(s)
  松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博, 中川嘉, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 腸肝転写因子CREBHはSREBPの活性を制御し、動脈硬化発症を抑制する(会議録)2020
- Author(s)
  中川嘉, 王雨農, 韓松伊, 水之江雄平, 荒木雅弥, 関谷元博, 松坂賢, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 亜急性甲状腺炎発症後バセドウ病が明らかになった2症例2020
- Author(s)
  菅野洋子, 中島里佳子, 大山真理子, 村山友樹, 大崎芳典, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 患側と考えられた副腎摘出後も改善が無く治療に苦慮した副腎髄質過形成の一例2020
- Author(s)
  古田泰久, 大崎芳典, 山本由季, 大山真理子, 村山友樹, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 笹野公伸, 竹越一博, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] メタボリックシンドロームの病態形成に重要と考えられる代謝産物センサー分子CtBP2の活性化化合物の探索2020
- Author(s)
  戒能賢太, 関谷元博, 松田高明, 馬洋, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020
- Author(s)
  松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博, 中川嘉, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 栄養環境センシングと制御(の分子基盤)　代謝産物センサー分子CtBP2を中心とした新しい代謝制御システムの同定2020
- Author(s)
  関谷元博, 戒能賢太, 馬洋, 松田高明, Gokhan Hotamisligil, 島野仁
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 成人後の治療自己中断中に糖尿病を契機に指摘された、POUF1/PIT-1遺伝子異常によると考えられる複合型下垂体機能低下症の一例2020
- Author(s)
  新田葉月, 村山友樹, 中島里佳子, 大山真理子, 大崎芳典, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 機械学習を用いた原発性アルドステロン症病型診断の試み2020
- Author(s)
  鈴木浩明(筑波大学医学医療系内分泌代謝・糖尿病内科), 松田えりか, 松田高明, 古田泰久, 村山友樹, 戒能賢太, 大崎芳典, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 中年期2型糖尿病者の認知機能低下の特徴と、におい、バランスとの関連2020
- Author(s)
  緑川学, 鈴木浩明, 鈴木康裕, 椿拓海, 田邉裕基, 山内一由, 佐藤泰之, 根本清貴, 菅野洋子, 岩崎仁, 関谷元博, 矢藤繁, 矢作直也, 羽田康司, 新井哲明, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] グルココルチコイドによるGR-Bmal/Clock複合体を介した時計遺伝子Nr1d1の抑制性転写制御機構2020
- Author(s)
  村山友樹, 矢作直也, 武内謙憲, 會田雄一, 何敏煕, Mehrazad Saber Zahra, 志鎌明人, 升田紫, 泉田欣彦, 宮本崇史, 関谷元博, 中川嘉, 松坂賢, 大崎芳典, 菅野洋子, 岩崎仁, 鈴木浩明, 川上康, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 脂肪酸伸長酵素Elovl6による神経新生の制御機構解明2020
- Author(s)
  大野博, 松坂賢, 本村香織, 志村拓哉, 宮本崇史, 関谷元博, 中川嘉, 島野
- Organizer
  日本臨床分子医学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 学際研究で切り拓く脂質とアミノ酸のメタボダイナミズム　脂肪酸の量と質とセンシングの視点からみた脂質多様性とメタボダイナミズム2020
- Author(s)
  島野仁, 松坂賢, 関谷元博, 宮本崇史
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] A metabolite sensor CtBP2 integrates metabolic flux to orchestrate glucose and lipid homeostasis in liver2019
- Author(s)
  Motohiro Sekiya, Hitoshi Shimano, Gokhan Hotamisligil
- Organizer
  60th International Conference on the Bioscience of Lipids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 転写因子CREBHの未成熟型・成熟型による動脈硬化形成に対する二重支配の分子メカニズム2018
- Author(s)
  中川嘉、韓松伊、大石麻代、王雨農、関谷元博、松坂賢、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 代謝産物センサーによる新しい脂質・糖代謝制御システムの解明と医療応用2018
- Author(s)
  関谷元博、菅澤威仁、馬　洋、戒能賢太、関根七海、Gokhan Hotamisligil、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 新規に同定されたリパーゼNCEHはマクロファージの主要な中性コレステロールエステラーゼである2009
- Author(s)
  関谷元博
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] A Novel Lipase, Neutral Cholesterol Ester Hydrolase, is a major regulator of Neutral Cholesterol Ester Hydrolysis in Macrophages.2009
- Author(s)
  関谷元博
- Organizer
  第41回日本動脈硬化学会総会・学術集会
- Place of Presentation
  山口
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] 新規に同定されたマクロファージコレステロールエズテラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたコレステロールエステラーゼ(MCEH)は未同定であったマクロファージの中性コレステロールエステラーゼである2006
- Author(s)
  関谷元博, 他
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージに発現する新規コレステロールエステラーゼ(macrophage cholesteryl ester hydrolase, MCEH)ノックアウトマウスの解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第38回日本動脈硬化学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージにおいて新規に同定されたコレステロールエステラーゼ(MCEH)のin vivo解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第49回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979

1. SHIMANO HITOSHI (20251241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. 松坂賢 (70400679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. YAHAGI Naoya (60420246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. OSUGA Jun-ichi (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IIZUKA Yoko (40420244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 韓松伊 (80729541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. 中川嘉 (80361351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
8. 大野博 (20847909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮本崇史 (50740346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. KUMAGAI Kae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. IZUMIDA Yoshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 會田雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
14. 武内謙憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
15. 小西守周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岩崎仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 升田紫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekiya Motohiro 関谷 元博

関谷 元博 セキヤ モトヒロ

SEKIYA Motobiro 関谷 元博

Research Projects

Research Products

Co-Researchers

Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application

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新しく同定された代謝産物センサー分子の分子基盤解明と医療応用Principal Investigator

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Molecular mechanism of organella homeostasis regulated by quantity and quality of lipids

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unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator

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マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator

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脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator

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in vivo promoter analysis of lipogenic genes

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[Journal Article] Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion2020

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[Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020

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[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020

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[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.2020

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[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex.2019

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[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.2019

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Sekiya Motohiro 関谷元博

関谷元博セキヤモトヒロ

SEKIYA Motobiro 関谷元博