KOREKANE Hiroaki 是金宏昭

Researcher Number	50421912
Affiliation (based on the past Project Information) *help	2016: 独立行政法人理化学研究所, 疾患糖鎖研究チーム, 研究員 2014: 大阪大学, 産業科学研究所, 特任助教 2013: (独)理化学研究所, グローバル研究クラスタ理研-マックスプランク連携研究センターシステム糖鎖生物学研究グループ疾患糖鎖研究チーム, 研究員 2013: 独立行政法人理化学研究所, 疾患糖鎖研究チーム, 研究員
Review Section/Research Field	Principal Investigator Functional biochemistry Except Principal Investigator Pathological medical chemistry / Tumor biology
Keywords	Principal Investigator ピロホスファターゼ/ホスホジエステラーゼ / 糖ヌクレオチド / 糖転移酵素 / 糖鎖修飾 / がん化 / グライコーム Except Principal Investigator 糖鎖修飾 / 糖転移酵素 / 糖鎖 / 糖ヌクレオチド … More / 糖鎖サイクル / 糖鎖機能 / 細胞膜受容体 / グルコサミン転移酵素 / オルガネラ / シグナル / 細胞膜儒超帯 / シグナル伝達 / N-アセチルグルコサミン / グルコーストランスポーター / グルコースセンサー機能 / 膵臓β細胞 / 糖転移酵素発現調節 / 糖尿病 / 高脂肪食 / がん糖鎖 / シアリルTn抗原 / 転移 / 浸潤 / 低酸素 / sTn抗原 / がん転移 / がん微小環境 / 抗アポトーシス Less

糖転移酵素制御因子として同定したENPP3と糖ヌクレオチド代謝の生物学的意義Principal Investigator
- Principal Investigator
  
  是金宏昭
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironments
- Principal Investigator
  
  Ohtsubo Kazuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kumamoto University
Development of a novel antidiabetic drug based on the targeting of GnT-IVa glycosyltransferase
- Principal Investigator
  
  OHTSUBO KAZUAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
  Osaka University
Biological Regulation of GlcNAc cycle
- Principal Investigator
  
  TANIGUCHI Naoyuki
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
  Osaka University

All 2017 2016 2015 2014 2013 2012 2011 2010 2008 Other

All Journal Article Presentation Book

[Book] ENPP3-mediated Regulation of Glycan Biosynthesis. Glycoscience: Biology and Medicine. Endo, T., Seeberger, P.H., Hart, G.W., Wong, C.H., Taniguchi, N. (eds)2014
- Author(s)
  Korekane, H., Park, J.Y., and Taniguchi, N.
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26440051
[Book] Glycosylation in Cancer: Enzymatic basis for alterations in N-glycan branching. Glycoscience: Biology and Medicine. Endo, T., Seeberger, P.H., Hart, G.W., Wong, C.H., Taniguchi, N. (eds)2014
- Author(s)
  Korekane, H., and Taniguchi, N.
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26440051
[Book] Glycosyltransferases　Methods in Molecular Biology Volume 1022 20132013
- Author(s)
  Takamatsu S, Korekane H, Ohtsubo K, Oguri S, Park JY, Matsumoto A, Taniguchi N.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Book] Glycosyltransferases Methods in Molecular Biology Volume 10222013
- Author(s)
  Takamatsu S, Korekane H, Ohtsubo K, Oguri S, Park JY, Matsumoto A, Taniguchi N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models2017
- Author(s)
  Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 312
- DOI
  10.1152/ajplung.00151.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-16K09559, KAKENHI-PROJECT-16H04758
[Journal Article] Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb).2014
- Author(s)
  Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I, Taniguchi N
- Journal Title
  
  J Biol Chem.
  
  Volume: 288(39) Pages: 27912-27926
- DOI
  10.1074/jbc.m113.474304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23501303, KAKENHI-PROJECT-24659111, KAKENHI-PROJECT-25430122
[Journal Article] The absence of core fucose upregulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.2014
- Author(s)
  Kurimoto A, Kitazume S, Kizuka Y, Nakajima K, Oka R, Fujinawa R, Korekane H, Yamaguchi Y, Wada Y, Taniguchi N
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289(17) Pages: 11704-11714
- DOI
  10.1074/jbc.m113.502542
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-24790301, KAKENHI-PROJECT-26440051
[Journal Article] Precise structural analysis of O-linked oligosaccharides in human serum.2014
- Author(s)
  Yabu, M., Korekane, H., Miyamoto, Y.
- Journal Title
  
  Glycobiology
  
  Volume: 24(6) Pages: 542-553
- DOI
  10.1093/glycob/cwu022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430151, KAKENHI-PROJECT-26440051
[Journal Article] Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III.2014
- Author(s)
  2.Shinya Hanashima, Hiroaki Korekane, Naoyuki Taniguchi, Yoshiki Yamaguchi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Pages: 4533-4537
- DOI
  10.1016/j.bmcl.2014.07.074
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24710257, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-26440051
[Journal Article] The chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes2014
- Author(s)
  Okuda H, Tatsumi K, Morita S, Shibukawa Y, Korekane H, Horii-Hayashi N, Wada Y, Taniguchi N, Wanaka A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Pages: 2620-2631
- DOI
  10.1074/jbc.m113.504787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390081, KAKENHI-PROJECT-23500416, KAKENHI-PROJECT-23590221, KAKENHI-PROJECT-24591618, KAKENHI-PROJECT-24592141, KAKENHI-PROJECT-24593106, KAKENHI-PROJECT-25870634, KAKENHI-PROJECT-26293039, KAKENHI-PROJECT-26440051
[Journal Article] N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells.2013
- Author(s)
  Ohtsubo K, Takamatsu S, Gao C, Korekane H, Kurosawa TM, Taniguchi N
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 434(2) Pages: 346-351
- DOI
  10.1016/j.bbrc.2013.03.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23790363
[Journal Article] Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.2013
- Author(s)
  Kanekiyo K, Inamori K, Kitazume S, Sato K, Maeda J, Higuchi M, Kizuka Y, Korekane H, Matsuo I, Honke K, Taniguchi N
- Journal Title
  
  J Neurosci.
  
  Volume: 33(24) Pages: 10037-10047
- DOI
  10.1523/jneurosci.3137-12.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25430122, KAKENHI-PROJECT-25670166
[Journal Article] Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases.2012
- Author(s)
  Angata T, Fujinawa R, Kurimoto A, Nakajima K, Kato M, Takamatsu S, Korekane H, Gao CX, Ohtsubo K, Kitazume S, Taniguchi N.
- Journal Title
  
  Ann. NY Acad. Sci.
  
  Volume: 1253(1) Pages: 159-169
- DOI
  10.1111/j.1749-6632.2012.06469.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Sensitivity of heterozygous alpha1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema : implication of aberrant transforming growth factor-beta signaling and matrix metalloproteinase gene expression2012
- Author(s)
  Gao C, Maeno T, Ota F, Ueno M, Korekane H, Takamatsu S, Shirato K, Matsumoto A, Kobayashi S, Yoshida K, Kitazume S, Ohtsubo K, Betsuyaku T, Taniguchi N
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287(20) Pages: 16699-16708
- DOI
  10.1074/jbc.m111.315333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PROJECT-23591118, KAKENHI-PROJECT-24659111, KAKENHI-PROJECT-24790331, KAKENHI-PROJECT-24790593, KAKENHI-PLANNED-20117008
[Journal Article] N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells2011
- Author(s)
  Korekane H., et al, 他9名
- Journal Title
  
  Glycoconj J
  
  Volume: 28 Pages: 183-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle.(総説)2011
- Author(s)
  Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N.
- Journal Title
  
  J.Clin.Biochem.Nutr. 48(1)
  
  Pages: 20-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, alpha2,6-sialylated blood group type 2H (ST2H) antigen2010
- Author(s)
  Korekane H., et al.(他7名)
- Journal Title
  
  J.Biochem.
  
  Volume: 148 Pages: 359-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Journal Article] Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate alpha2, 6-sialylated blood group type 2H (ST2H) antigen.2010
- Author(s)
  Korekane H, Matsumoto A, Ota F, Hasegawa T, Misonou Y, Shida K, Miyamoto Y, Taniguchi N.
- Journal Title
  
  J.Biochem. 148(3)
  
  Pages: 359-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249018
[Presentation] 糖鎖を介した低酸素環境におけるがん細胞の生存・転移戦略2016
- Author(s)
  藤井柊作, 高宮里奈, 高松真二, 是金宏昭, 前田賢人, 田嶋彩香, 谷口直之, 大坪和明
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] Pharmacological targeting of ST6GalNAc-I for suppression of tumor metastasis2015
- Author(s)
  Shusaku Fujii, Rina Takamiya, Shinji Takamatsu, Hiroaki Korekane, Kento Maeda, Naoyuki Taniguchi, Kazuaki Ohtsubo
- Organizer
  第３４回　日本糖質学会　年会
- Place of Presentation
  東京（東京大学）
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] sTn抗原合成阻害によるがん転移抑制を目的とした新規抗がん剤の探索2015
- Author(s)
  藤井柊作、大坪和明、是金宏昭、斎藤臣雄
- Organizer
  BMB２０１５
- Place of Presentation
  神戸（神戸国際会議場）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26430118
[Presentation] 膵臓β細胞におけるN型糖鎖修飾によるGLUT2の膜ドメイン局在と機能制御2013
- Author(s)
  大坪和明、高松真二、高叢笑、是金宏昭、黒澤努、谷口直之
- Organizer
  日本糖質学会　年会
- Place of Presentation
  大阪　（大阪国際交流センター）
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] 膵臓β細胞におけるN型糖鎖修飾によるGLUT2の膜ドメイン局在と機能制御2013
- Author(s)
  大坪和明、高松真二、高叢笑、是金宏昭、谷口直之
- Organizer
  日本糖質学会年会
- Place of Presentation
  大阪(大阪国際交流センター)
- Year and Date
  2013-08-07
- Data Source
  KAKENHI-PROJECT-23790363
[Presentation] ST6Gal I acts on the Fuc□1-2Gal□1-4GlcNAc□1-3Gal□1-4Glc-R structure, forming a unique fucoganglioside □2, 6-sialylated blood group Hantigen structure2008
- Author(s)
  H. Korekane
- Organizer
  Annual Meeting of the Society for Glycobiology2008
- Place of Presentation
  Fort Worth, TX, USA
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-20249018
[Presentation] Identification of ectonucleotide pyrophosphatase/ phosphodiesterase 3 (ENPP3) as a new modifier of glycan biosynthesis.
- Author(s)
  Taniguchi, N., Korekane, H.*, Park J. Y., Matsumoto, A., Nakajima, K., Takamatsu, S., Ohtsubo, K., and Miyamoto, Y.
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego CA, USA
- Year and Date
  2014-04-26 – 2014-04-30
- Data Source
  KAKENHI-PROJECT-26440051
[Presentation] Sialyl-Tn antigen is a potential target for the development of metastasis specific anti-tumor drugs
- Author(s)
  Shusaku Fujii, Rina Takamiya, Shinji Takamatsu, Hiroaki Korekane, Naoyuki Taniguchi, Kazuaki Ohtsubo
- Organizer
  2014 Society for Glycobiology & JSCR JOINT MEETING
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2014-11-16 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26430118

1. NAKAJIMA Kazuki (10442998)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. OHTSUBO Kazuaki (30525457)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. TANIGUCHI Naoyuki (90002188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. MATSUMOTO Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. SHIRATO Ken

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. MATSUMOTO Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. BETSUYAKU Tomoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KIDA Kozui

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. OKUDA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HORII Noriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 宮本泰豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 川口しのぶ

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 高叢笑

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 花島慎弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 山口芳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 李秀栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 樋口真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 本家孝一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 渋川幸直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 和田芳直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 辰巳晃子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 和中明生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 森田晶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOREKANE Hiroaki 是金 宏昭

Research Projects

Research Products

Co-Researchers

糖転移酵素制御因子として同定したENPP3と糖ヌクレオチド代謝の生物学的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironments

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel antidiabetic drug based on the targeting of GnT-IVa glycosyltransferase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological Regulation of GlcNAc cycle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ENPP3-mediated Regulation of Glycan Biosynthesis. Glycoscience: Biology and Medicine. Endo, T., Seeberger, P.H., Hart, G.W., Wong, C.H., Taniguchi, N. (eds)2014

Author(s)

Publisher

Data Source

[Book] Glycosylation in Cancer: Enzymatic basis for alterations in N-glycan branching. Glycoscience: Biology and Medicine. Endo, T., Seeberger, P.H., Hart, G.W., Wong, C.H., Taniguchi, N. (eds)2014

Author(s)

Publisher

Data Source

[Book] Glycosyltransferases Methods in Molecular Biology Volume 1022 20132013

Author(s)

Publisher

Data Source

[Book] Glycosyltransferases Methods in Molecular Biology Volume 10222013

Author(s)

Publisher

Data Source

[Journal Article] A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb).2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The absence of core fucose upregulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precise structural analysis of O-linked oligosaccharides in human serum.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination.2013

KOREKANE Hiroaki 是金宏昭

[Book] Glycosyltransferases　Methods in Molecular Biology Volume 1022 20132013