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Kakoi Hironori  栫 博則

ORCIDConnect your ORCID iD *help
… Alternative Names

栫 博則  カコイ ヒロノリ

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Researcher Number 50423728
Affiliation (based on the past Project Information) *help 2015 – 2022: 鹿児島大学, 医歯学域医学系, 助教
2013: 鹿児島大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Orthopaedic surgery
Except Principal Investigator
Basic Section 90140:Medical technology assessment-related
Keywords
Principal Investigator
軟骨細胞 / 軟骨細胞分化 / 骨芽細胞分化 / 内軟骨性骨化 / Stk38l / 脊椎後縦靭帯骨化症 / セリン・スレオニン・キナーゼ / 骨芽細胞 / 後縦靭帯骨化症 / STK38L … More / BMPシグナル / 軟骨細胞成熟 / 変形性関節症 / BMP / Smpd3 … More
Except Principal Investigator
塞栓術 / MRI / 運動器カテーテル塞栓 Less
  • Research Projects

    (3 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (13 People)
  •  Effect of Amide proton transfer imaging of arterial embolization for osteoarthritis

    • Principal Investigator
      Hayashi Sadao
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90140:Medical technology assessment-related
    • Research Institution
      Kagoshima University
  •  Functional analysis of STK38L, the OPLL-associated gene, and research of its target genes in endochondral ossification.Principal Investigator

    • Principal Investigator
      Kakoi Hironori
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kagoshima University
  •  Analysis on function of Smpd3 in chondrocyte maturation and hyaluronan synthesisPrincipal Investigator

    • Principal Investigator
      Kakoi Hironori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Kagoshima University

All 2014 2013

All Journal Article Presentation

  • [Journal Article] BMP signaling upregulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt signaling pathway as a negative feedback mechanism.2014

    • Author(s)
      Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 12 Pages: 8135-8150

    • DOI

      10.1074/jbc.m113.509331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592221, KAKENHI-PROJECT-23592222, KAKENHI-PROJECT-25462376
  • [Presentation] BMPシグナルにより誘導されるSmpd3はセラミド-Akt経路を介して軟骨細胞分化成熟を抑制する2014

    • Author(s)
      前田 真吾、栫 博則、篠原 直弘、松山 兼寛、今村 勝行、河村 一郎、横内 雅博、石堂康弘、小宮節郎
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都府医師会館, 京都市
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] BMP signaling induces sphingomyelin phosphodiesterase 3 to suppress chondrocyte maturation and expression of hyaluronan synthase 2 in ATDC5 chondrocytes2013

    • Author(s)
      Shingo Maeda, Hironori Kakoi, Kanehiro Matsuyama, Ichiro Kawamura, Katsuyuki Imamura, Naohiro Shinohara, Masahiro Yokouchi, Yasuhiro Ishidou, Setsuro Komiya
    • Organizer
      TGF-β meeting in Uppsala
    • Place of Presentation
      Uppsala University, Uppsala, Sweden
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] Smpd3/nSMase2 suppresses Akt signaling pathway to inhibit chondrogenic differentiation and expression of Has2 in ATDC5 cells2013

    • Author(s)
      Hironori Kakoi, Shingo Maeda, Ichiro Kawamura, Katsuyuki Imamura, Naohiro Shinohara, Masahiro Yokouchi, Yasuhiro Ishidou, Setsuro Komiya
    • Organizer
      国際骨代謝学会・日本骨代謝学会 第2回合同国際会議
    • Place of Presentation
      神戸国際会議場, 神戸市
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] Neutral Sphingomyelinase 2 Is Increased During BMP-induced Differentiation of ATDC5 Chondrocytes to Suppress the Maturation as a Negative Feedback Mechanism2013

    • Author(s)
      Shingo Maeda, Hironori Kakoi, Kanehiro Matsuyama, Katsuyuki Imamura, Ichiro Kawamura, Naohiro Shinohara, Masahiro Yokouchi, Yasuhiro Ishidou, Setsuro Komiya
    • Organizer
      The American Society for Bone and Mineral Rresearch 2013
    • Place of Presentation
      Baltimore Covention Center, Baltimore, USA
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] BMP-2シグナルはneutral sphingomyelinase 2の誘導によるAktシグナル経路の抑制を介して軟骨細胞分化成熟を制御する2013

    • Author(s)
      前田真吾、栫博則、松山金寛、河村一郎、今村勝行、篠原直弘、永野聡、瀬戸口啓夫、横内雅博、石堂康弘、小宮節郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場, 神戸市
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] Smpd3 prevents maturation and expression of hyaluronan synthase 2 in ATDC5 chondrocytes2013

    • Author(s)
      Kakoi H, Maeda S, Imamura K, Kawamura I, Ishidou Y, Yokouchi M, Komiya S
    • Organizer
      ESCEO13-IOF Rome 2013
    • Place of Presentation
      Rome Cavalieri, Rome, Italy
    • Data Source
      KAKENHI-PROJECT-25462376
  • [Presentation] Smpd3/nSMase2はセラミドを介したAktシグナル経路阻害によりATDC5軟骨細胞分化とヒアルロン酸合成酵素Has2の発現を抑制する2013

    • Author(s)
      栫博則、前田真吾、松山兼寛、今村勝行、河村一郎、篠原直弘、横内雅博、石堂康弘、小宮節郎
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ, 千葉市
    • Data Source
      KAKENHI-PROJECT-25462376
  • 1.  Maeda Shingo (60353463)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 2.  Komiya Setsuro (30178371)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 3.  Ishidou Yasuhiro (10300740)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 4.  Hayashi Sadao (10549918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  河村 一郎 (90535832)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  冨永 博之 (20750798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  吉浦 敬 (40322747)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  福倉 良彦 (50315412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  泉 俊彦 (70768762)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  海江田 英泰 (40894241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MATSUYAMA Kanehiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SHINOHARA Naohiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YAHIRO Yuhei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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