Yokota Kenichi 横田健一

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Kenichi Yokota 横田健一

YOKOTA Kenichi 横田健一

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Researcher Number	50424156
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 聖マリアンナ医科大学, 医学部, 准教授 2021 – 2023: 慶應義塾大学, 医学部(信濃町), 講師(非常勤) 2017 – 2019: 慶應義塾大学, 医学部(信濃町), 助教 2014 – 2015: 慶應義塾大学, 医学部, 助教 2013: 慶應義塾大学, 医学部, 共同研究員 … More 2012: 慶應義塾大学, 医学部, 助教 2011: 慶應義塾大学, 医学部, 特任研究員 2008 – 2009: The University of Tokyo, 分子細胞生物学研究所, 特任研究員 2007: Keio University, 医学部, 助教 2006: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator MR / アルドステロン / 高血圧 / 転写 / ミネラルコルチコイド受容体 / エピゲノム / ミネラルコルチコイド / CASZ1 / 原発性アルドステロン症 / 概日リズム / 転写因子 / ユビキチン / SUMO1

Elucidation of the role of a disease susceptibility SNP in CASZ1 in the development of hypertension and primary aldosteronism.Principal Investigator
- Principal Investigator
  
  横田健一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  St. Marianna University School of Medicine
Defining the impact of the circadian MR activation on hypertensionPrincipal Investigator
- Principal Investigator
  
  Kenichi Yokota
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
Role of novel transcription cofactor C14orf43 in the molecular mechanism of MR-sensitive hypertensionPrincipal Investigator
- Principal Investigator
  
  YOKOTA Kenichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Contribution of novel MR cofactor CASZ1 to onset of hypertensionPrincipal Investigator
- Principal Investigator
  
  YOKOTA KENICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Identification and functional analysis of novel MR co-regulatorPrincipal Investigator
- Principal Investigator
  
  YOKOTA Kenichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
Oxidative stress induced change of Ubiquitin modification in Mineralocorticoid receptor and cardiovascular disorderPrincipal Investigator
- Principal Investigator
  
  YOKOTA Kenichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  The University of Tokyo
アルドステロン作用におけるミネラルコルチコイド受容体のSUMO化修飾の役割Principal Investigator
- Principal Investigator
  
  横田健一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University

All 2023 2022 2019 2018 2017 2016 2015 2012 2011 2010 2009 2007 Other

All Journal Article Presentation Book

[Book] 内科学書2019
- Author(s)
  横田健一　伊藤裕
- Total Pages
  3672
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-17K09734
[Book] 臨床雑誌内科2019
- Author(s)
  横田健一
- Total Pages
  170
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-17K09734
[Book] 成人病と生活習慣病2018
- Author(s)
  齋藤洸平　横田健一
- Total Pages
  104
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-17K09734
[Book] 副腎不全medicina49(9)2012
- Author(s)
  横田健一, 柴田洋孝
- Data Source
  KAKENHI-PROJECT-23791051
[Book] ミネラルコルチコイド受容体の活性化による心血管障害原発性アルドステロン症診療マニュアル2011
- Author(s)
  横田健一, 柴田洋孝, 伊藤裕
- Data Source
  KAKENHI-PROJECT-23791051
[Journal Article] Adrenal arterial embolization: a possible new treatment for patients with primary aldosteronism2023
- Author(s)
  Yokota Kenichi
- Journal Title
  
  Hypertension Research
  
  Volume: 47 Issue: 2 Pages: 358-360
- DOI
  10.1038/s41440-023-01456-y
- Data Source
  KAKENHI-PROJECT-21K08236
[Journal Article] Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification2022
- Author(s)
  Jo Rie、Shibata Hirotaka、Kurihara Isao、Yokota Kenichi、Kobayashi Sakiko、Murai-Takeda Ayano、Mitsuishi Yuko、Hayashi Takeshi、Nakamura Toshifumi、Itoh Hiroshi
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 1 Pages: 19-31
- DOI
  10.1038/s41440-022-01036-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08236, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-23K09671, KAKENHI-PROJECT-22K20914
[Journal Article] Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor2022
- Author(s)
  Kohata Nao、Kurihara Isao、Yokota Kenichi、Kobayashi Sakiko、Murai-Takeda Ayano、Mitsuishi Yuko、Nakamura Toshifumi、Morisaki Mitsuha、Kozuma Takahide、Torimitsu Takuto、Kawai Miki、Itoh Hiroshi
- Journal Title
  
  Hypertension Research
  
  Volume: 45 Issue: 4 Pages: 641-649
- DOI
  10.1038/s41440-022-00859-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08713, KAKENHI-PROJECT-21K08236, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535
[Journal Article] CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity2022
- Author(s)
  Yokota Kenichi、Shibata Hirotaka、Kurihara Isao、Itoh Hiroshi、Sone Masakatsu
- Journal Title
  
  Hypertension Research
  
  Volume: 46 Issue: 2 Pages: 417-420
- DOI
  10.1038/s41440-022-01131-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08236, KAKENHI-PROJECT-23K09671
[Journal Article] Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review2022
- Author(s)
  Yokota Kenichi、Kurihara Isao、Nakamura Toshifumi、Nakatsuka Seishi、Miyashita Kazutoshi、Kobayashi Sakiko、Murai-Takeda Ayano、Sone Masakatsu、Itoh Hiroshi
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 1 Pages: 103-110
- DOI
  10.2169/internalmedicine.7340-21
- NAID
  130008139088
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08236
[Journal Article] Epidermal growth factor receptor/extracellular signal-regulated kinase pathway enhances mineralocorticoid receptor transcriptional activity through protein stabilization2018
- Author(s)
  Mitsuishi Yuko、Shibata Hirotaka、Kurihara Isao、Kobayashi Sakiko、Yokota Kenichi、Murai-Takeda Ayano、Hayashi Takeshi、Jo Rie、Nakamura Toshifumi、Morisaki Mitsuha、Itoh Hiroshi
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: in press Pages: 30017-30017
- DOI
  10.1016/j.mce.2018.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-15K09296, KAKENHI-PROJECT-18K16007
[Journal Article] Intestinal Mineralocorticoid Receptor Contributes to Epithelial Sodium Channel?Mediated Intestinal Sodium Absorption and Blood Pressure Regulation2018
- Author(s)
  Nakamura Toshifumi、Kurihara Isao、Kobayashi Sakiko、Yokota Kenichi、Murai‐Takeda Ayano、Mitsuishi Yuko、Morisaki Mitsuha、Kohata Nao、Oshima Yosuke、Minami Yukiko、Shibata Hirotaka、Itoh Hiroshi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 7 Issue: 13
- DOI
  10.1161/jaha.117.008259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734, KAKENHI-PROJECT-18K08250, KAKENHI-PROJECT-18K16007, KAKENHI-PROJECT-16K09656, KAKENHI-PROJECT-17K16095
[Journal Article] High Glucose Stimulates Mineralocorticoid Receptor Transcriptional Activity Through the Protein Kinase C β Signaling2017
- Author(s)
  Hayashi Takeshi、Shibata Hirotaka、Kurihara Isao、Yokota Kenichi、Mitsuishi Yuko、Ohashi Kennosuke、Murai-Takeda Ayano、Jo Rie、Ohyama Takako、Sakamoto Masaya、Tojo Katsuyoshi、Tajima Naoko、Utsunomiya Kazunori、Itoh Hiroshi
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 5 Pages: 794-802
- DOI
  10.1536/ihj.16-649
- NAID
  130006179200
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09734
[Journal Article] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016
- Author(s)
  Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 101 Issue: 1 Pages: 6-9
- DOI
  10.1210/jc.2015-3285
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10650, KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-25461254, KAKENHI-PROJECT-25461397
[Journal Article] 副腎不全2012
- Author(s)
  横田健一
- Journal Title
  
  medicina
  
  Volume: 49 Pages: 1588-1592
- Data Source
  KAKENHI-PROJECT-23791051
[Journal Article] 原発性アルドステロン症の局在診断2012
- Author(s)
  横田健一
- Journal Title
  
  ホルモンと臨床
  
  Volume: 59 Pages: 52-58
- Data Source
  KAKENHI-PROJECT-23791051
[Journal Article] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS12011
- Author(s)
  N.Suda, H.Shibata, et al.
- Journal Title
  
  Endocrinology
  
  Volume: 152 Issue: 6 Pages: 2266-2277
- DOI
  10.1210/en.2010-1232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591018, KAKENHI-PROJECT-23791051
[Journal Article] Signal-sensing activation of a histone lysine demethylase complex2011
- Author(s)
  Baba A
- Journal Title
  
  Nat Cell Biol.
  
  Volume: 13 Issue: 6 Pages: 669-76
- DOI
  10.1038/ncb2228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689066, KAKENHI-PROJECT-23791051
[Journal Article] Coactivation of N-terminal Transactivation of Mineralocorticoid Receptor by Ubc92007
- Author(s)
  Kenichi Yokota
- Journal Title
  
  Journal of Biological Chemistry Vol. 282 Issue 3
  
  Pages: 1998-2010
- Data Source
  KAKENHI-PROJECT-18790640
[Journal Article] Coactivation of N-terminal Transactivation ofMineralocorticoid Receptor by Ubc92007
- Author(s)
  Kenichi Yokota
- Journal Title
  
  Journal of Biological Chemistry Vol. 282 Issue 3
  
  Pages: 1998-2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790640
[Presentation] Comparison of the Efficacy of Laparoscopic Partial Adrenalectomy and Total Adrenalectomy in the Surgical Treatment of Primary Aldosteronism -Emerging Usefulness of Segmental Adrenal Venous Sampling2019
- Author(s)
  Motoko Nomura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, et al.
- Organizer
  International Aldosterone Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09734
[Presentation] Comparison of the Efficacy of Laparoscopic Partial Adrenalectomy and Total Adrenalectomy in the Surgical Treatment of Primary Aldosteronism -Emerging Usefulness of Segmental Adrenal Venous Sampling2019
- Author(s)
  Motoko Nomura, Isao Kurihara, Sakiko Kobayashi, Kenichi Yokota, et al.
- Organizer
  International Aldosterone Conference 2019（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09734
[Presentation] 高齢者における機能性副腎腫瘍の治療2019
- Author(s)
  横田健一, 栗原勲, 宮下和季, 小林佐紀子, 乃村元子, 伊藤裕
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K09734
[Presentation] Adrenal Cysts with High Aldosterone Levels in Cystic Fluid:A Clinicopathological Study of 5 Adrenal Cyst Cases Using CYP11B2 immunohistochemistry2018
- Author(s)
  N kohata, I Kurihara, S kobayashi, K Yokota et al.
- Organizer
  International Aldosterone Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09734
[Presentation] Usefulness of Dexamethasone Suppression Test in the Diagnosis of Primary Aldosterone Subtypes2018
- Author(s)
  M Nomura, S Kobayashi, I Kurihara, K Miyashita, K Yokota, et al.
- Organizer
  International Aldosterone Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09734
[Presentation] 複数の腫瘍があるPAにおける超選択的副腎静脈サンプリングの意義2015
- Author(s)
  大嶋洋佑, 栗原勲, 宮下和季, 小林佐紀子, 横田健一, 城理絵, 門松賢, 武田彩乃, 小黒草太, 宮嶋哲, 亀山香織, 伊藤裕
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461254
[Presentation] 高脂肪食負荷マウスの副腎におけるアルドステロン合成酵素発現の検討2015
- Author(s)
  盛崎瑞葉, 栗原勲, 小林佐紀子, 横田健一, 城理絵, 武田彩乃, 三石木綿子, 中村俊文, 高畑尚, 伊藤裕
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461254
[Presentation] 新規ミネラルコルチコイド受容体(MR)結合因子Evi1は転写共役因子としてMR活性を調節する2015
- Author(s)
  中村俊文, 栗原勲, 城理絵, 小林佐紀子, 横田健一, 武田彩乃, 三石木綿子, 盛崎瑞葉, 高畑尚, 伊藤裕
- Organizer
  日本高血圧学会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25461254
[Presentation] GH自体が脳梗塞発症のリスクファクターとして疑われた先端巨大症の1例2015
- Author(s)
  住谷智恵子, 横田健一, 栗原勲, 宮下和季, 中島裕也, 小林佐紀子, 乃村元子, 中村俊文, 高畑尚, 戸田正博, 亀山香織, 伊藤裕
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461254
[Presentation] 重度の低K血症を伴いながら正常血圧を呈した原発性アルドステロン症の1例2015
- Author(s)
  渡辺雄佑, 栗原勲, 宮下和季, 小林佐紀子, 横田健一, 中村俊文, 井上博之, 北村和雄, 小黒草太, 伊藤裕
- Organizer
  日本内分泌学会
- Place of Presentation
  ホテルニューオータニ（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461254
[Presentation] 新規MR転写共役因子の探索とその機能解析2011
- Author(s)
  横田健一
- Organizer
  2011年核内受容体研究会(東京)にて招待講演
- Place of Presentation
  東京
- Year and Date
  2011-03-11
- Data Source
  KAKENHI-PROJECT-23791051
[Presentation] 新規MR転写共役因子の探索とその機能解析2011
- Author(s)
  横田健一
- Organizer
  2011 年日本ステロイドホルモン学会(福岡)にて招待講演
- Place of Presentation
  福岡
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-23791051
[Presentation] MR結合新規転写共役因子の探索とその機能解析2011
- Author(s)
  横田健一
- Organizer
  日本ステロイドホルモン学会(招待講演)
- Place of Presentation
  福岡大学（福岡県）
- Data Source
  KAKENHI-PROJECT-23791051
[Presentation] Functional analysis of a novel MR co-activator p1202010
- Author(s)
  横田健一、大竹史明、加藤茂明
- Organizer
  国際内分泌学会
- Place of Presentation
  京都
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20790664
[Presentation] ミネラルコルチコイド受容体(MR)による未知臓器障害メカニズムの解析2009
- Author(s)
  横田健一、大竹史明、加藤茂明
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  群馬
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20790664
[Presentation] ミネラルコルチコイド受容体(MR)による未知臓器障害メカニズムの解析2009
- Author(s)
  横田健一
- Organizer
  日本内分泌学会学術総会
- Place of Presentation
  群馬県民会館
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20790664
[Presentation] 新規MR相互作用因子の探索とその機能解析
- Author(s)
  横田健一
- Organizer
  第31回　内分泌代謝学サマーセミナー
- Place of Presentation
  ゆふいん山水館　大分
- Invited
- Data Source
  KAKENHI-PROJECT-25461254

1. NISHIMOTO Koshiro

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# of Collaborated Products: 1 results
2. 小坂威雄

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# of Collaborated Products: 1 results
3. 向井邦晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 柴田洋孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 栗原勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokota Kenichi 横田 健一

Kenichi Yokota 横田 健一

YOKOTA Kenichi 横田 健一

Research Projects

Research Products

Co-Researchers

Elucidation of the role of a disease susceptibility SNP in CASZ1 in the development of hypertension and primary aldosteronism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Defining the impact of the circadian MR activation on hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of novel transcription cofactor C14orf43 in the molecular mechanism of MR-sensitive hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of novel MR cofactor CASZ1 to onset of hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of novel MR co-regulatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oxidative stress induced change of Ubiquitin modification in Mineralocorticoid receptor and cardiovascular disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルドステロン作用におけるミネラルコルチコイド受容体のSUMO化修飾の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 内科学書2019

Author(s)

Total Pages

Publisher

Data Source

[Book] 臨床雑誌内科2019

Author(s)

Total Pages

Publisher

Data Source

[Book] 成人病と生活習慣病2018

Author(s)

Total Pages

Publisher

Data Source

[Book] 副腎不全medicina49(9)2012

Author(s)

Data Source

[Book] ミネラルコルチコイド受容体の活性化による心血管障害 原発性アルドステロン症診療マニュアル2011

Author(s)

Data Source

[Journal Article] Adrenal arterial embolization: a possible new treatment for patients with primary aldosteronism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor2022

Yokota Kenichi 横田健一

Kenichi Yokota 横田健一

YOKOTA Kenichi 横田健一

[Book] ミネラルコルチコイド受容体の活性化による心血管障害原発性アルドステロン症診療マニュアル2011