SAKUMA Hiroshi 佐久間啓

… Alternative Names

佐久間啓サクマヒロシ

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Researcher Number	50425683
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, プロジェクトリーダー 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, プロジェクトリーダー
Affiliation (based on the past Project Information) *help	2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, プロジェクトリーダー 2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, プロジェクトリーダー 2022 – 2023: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, プロジェクトリーダー 2015 – 2023: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー 2020: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, プロジェクトリーダー 2012 – 2014: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所免疫研究部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator ミクログリア / MOG抗体関連疾患 / アストロサイト / 免疫応答 / バイオマーカー / 症例レジストリ / 脳炎・脳症 / NMDA受容体脳炎 / 自己免疫性脳炎 / MOG抗体 … More / 抗神経抗体 / バイオレポジトリ / てんかん / 脱髄性疾患 / 小児神経疾患 / けいれん重積 / 実験的自己免疫性脳脊髄炎 / ジフテリア毒素 / TRECK法 / ジフテリア毒素受容体 / 前駆細胞 / 造血幹細胞 / Time-lapse imaging / TGFβ / IL-34 / 骨髄未分化細胞 / NLRP3インフラマソーム / NF-κB / ADP / NLRP3 インフラマソーム / P2Y12受容体 / インターロイキン34 / トランスクリプトーム解析 / プリン受容体 / トランスクリプトーム / 神経炎症 … More Except Principal Investigator 分子標的療法 / 小児 / てんかん / 神経免疫 / NLRP3インフラマソーム / 自然免疫 / 小児てんかん / 難治性てんかん / 慢性便秘症 / 食物繊維 / 次世代シークエンサー / 腸内細菌 / 腸内細菌叢解析 / ビフィズス菌 / 腸内細菌叢 / 重症心身障害 Less

脳炎・脳症の臨床的多様性を生み出す因子の多層性解析Principal Investigator
- Principal Investigator
  
  佐久間啓
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidation of the neuroimmunological pathology involved in intractable childhood epilepsy and development of new molecular targeted drugs.
- Principal Investigator
  
  福田光成
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL
バイオレポジトリを活用した小児自己免疫性脳炎の新規診断技術開発と病態解明Principal Investigator
- Principal Investigator
  
  佐久間啓
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
神経免疫系を介した小児難治性てんかんの病態解明と新たな分子標的療法の開発
- Principal Investigator
  
  福田光成
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL
Pathophysiology of demyelinating diseases and epilepsy using microglia removal model by TRECK systemPrincipal Investigator
- Principal Investigator
  
  SAKUMA Hiroshi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
metagenome analysis of intestinal microbiota in patients with severe motor and intellectual disabilities and the effect of intervention with bifidobacterium
- Principal Investigator
  
  TANUMA Naoyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Tracking of microglial development and differentiation in the developing brainPrincipal Investigator
- Principal Investigator
  
  SAKUMA Hiroshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Transcriptome analysis of microglia using animal model of brain diseasesPrincipal Investigator
- Principal Investigator
  
  SAKUMA Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  National Center of Neurology and Psychiatry

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2011

All Journal Article Presentation

[Journal Article] Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study2024
- Author(s)
  Mariko Kasai, Hiroshi Sakuma, Yuichi Abe, Ichiro Kuki, Yoshihiro Maegaki, Kei Murayama, Yuka Murofushi, Hiroaki Nagase, Masahiro Nishiyama, Akihisa Okumura, Yasunari Sakai, Hiroko Tada, Masashi Mizuguchi, Jun-Ichi Takanashi; Japanese Pediatric Neuro-COVID-19 Study Group
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 15 Pages: 122867-122867
- DOI
  10.1016/j.jns.2024.122867
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19576, KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-23K07192, KAKENHI-PROJECT-19K08237
[Journal Article] Oxygen-Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes2024
- Author(s)
  Moriyama Kengo、Horino Asako、Kohyama Kuniko、Nishito Yasumasa、Morio Tomohiro、Sakuma Hiroshi
- Journal Title
  
  Brain Sciences
  
  Volume: 14 Issue: 3 Pages: 244-244
- DOI
  10.3390/brainsci14030244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08311
[Journal Article] Paediatric antibody prevalence in seizure score to predict autoimmune aetiology in seizure disorders2024
- Author(s)
  Mori T, Matsuda S, Nishida Hi, Kohyama K, Fukuda M, Sakuma H.
- Journal Title
  
  Developmental Medicine and Child Neurology
  
  Volume: in press Issue: 10 Pages: 1319-1328
- DOI
  10.1111/dmcn.15927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08223
[Journal Article] Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein2023
- Author(s)
  Kohyama Kuniko、Nishida Hiroya、Kaneko Kimihiko、Misu Tatsuro、Nakashima Ichiro、Sakuma Hiroshi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 17 Pages: 1014071-1014071
- DOI
  10.3389/fnins.2023.1014071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07892, KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-19K08311
[Journal Article] Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2.2023
- Author(s)
  Sakuma H, Takanashi JI, Okumura A, et al.
- Journal Title
  
  Front Neurosci
  
  Volume: 17 Pages: 1085082-1085082
- DOI
  10.3389/fnins.2023.1085082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07810, KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-23K07192, KAKENHI-PROJECT-19K08237
[Journal Article] Time course of serum cytokine level changes within 72?h after onset in children with acute encephalopathy and febrile seizures2023
- Author(s)
  Tomioka Kazumi、Nishiyama Masahiro、Tokumoto Shoichi、Yamaguchi Hiroshi、Aoki Kazunori、Seino Yusuke、Toyoshima Daisaku、Kurosawa Hiroshi、Tada Hiroko、Sakuma Hiroshi、Nozu Kandai、Maruyama Azusa、Tanaka Ryojiro、Iijima Kazumoto、Nagase Hiroaki
- Journal Title
  
  BMC Neurology
  
  Volume: 23 Issue: 1 Pages: 7-7
- DOI
  10.1186/s12883-022-03048-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09047, KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-22K09119, KAKENHI-PROJECT-22K15941, KAKENHI-PROJECT-23K15615, KAKENHI-PROJECT-19K18353, KAKENHI-PROJECT-20K17894
[Journal Article] Changes in the treatment of pediatric acute encephalopathy in Japan between 2015 and 2021: A national questionnaire-based survey2023
- Author(s)
  Murofushi Yuka、Sakuma Hiroshi、Tada Hiroko、Mizuguchi Masashi、Takanashi Jun-ichi
- Journal Title
  
  Brain and Development
  
  Volume: 45 Issue: 3 Pages: 153-160
- DOI
  10.1016/j.braindev.2022.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07831, KAKENHI-PROJECT-23K07192, KAKENHI-PROJECT-19K08237
[Journal Article] Unexplained Progressive Neurological Deficits after Corpus Callosotomy May Be Caused by Autoimmune Encephalitis: A Case of Suspected Postoperative Anti-NMDAR Encephalitis2023
- Author(s)
  Hatano Keisuke、Fujimoto Ayataka、Sato Keishiro、Yamamoto Takamichi、Sakuma Hiroshi、Enoki Hideo
- Journal Title
  
  Brain Sciences
  
  Volume: 13 Issue: 1 Pages: 135-135
- DOI
  10.3390/brainsci13010135
- Data Source
  KAKENHI-PROJECT-22K07831
[Journal Article] A case of bilateral limbic and recurrent unilateral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein antibody positivity2022
- Author(s)
  Horita Takahiro、Inoue Takeshi、Kuki Ichiro、Nagase Shizuka、Yamamoto Naohiro、Yamada Naoki、Oki Keisuke、Nukui Megumi、Okazaki Shin、Amo Kiyoko、Kawawaki Hisashi、Sakuma Hiroshi、Togawa Masao
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 3 Pages: 254-258
- DOI
  10.1016/j.braindev.2021.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07831
[Journal Article] Fatal X-linked lymphoproliferative disease type 1-associated limbic encephalitis with positive anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody2022
- Author(s)
  Ochiai Satoru、Hayakawa Itaru、Ohashi Eri、Hamano Sho、Miyata Yohane、Sakuma Hiroshi、Hogetsu Keita、Gocho Yoshihiro、Ogura Masao、Uchiyama Toru、Abe Yuichi
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 9 Pages: 630-634
- DOI
  10.1016/j.braindev.2022.06.004
- Data Source
  KAKENHI-PROJECT-22K07831
[Journal Article] Late relapse of anti-N-methyl-d-aspartate receptor encephalitis with amusia and transiently reduced uptake in 123I-iomazenil single-photon emission computed tomography2022
- Author(s)
  Yamada Naoki、Kuki Ichiro、Hattori Taeka、Yamamoto Naohiro、Nagase Shizuka、Nukui Megumi、Inoue Takeshi、Okazaki Shin、Kawawaki Hisashi、Horino Asako、Sakuma Hiroshi
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 8 Pages: 558-561
- DOI
  10.1016/j.braindev.2022.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07831
[Journal Article] A pediatric case of autoimmune glial fibrillary acidic protein astrocytopathy with unique brain imaging patterns and increased cytokines/chemokines2022
- Author(s)
  Yamamoto Naohiro、Inoue Takeshi、Kuki Ichiro、Matsubara Kohei、Yamada Naoki、Nagase-Oikawa Shizuka、Oki Keisuke、Nukui Megumi、Okazaki Shin、Sakuma Hiroshi、Kimura Akio、Shimohata Takayoshi、Kawawaki Hisashi
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 10 Pages: 753-758
- DOI
  10.1016/j.braindev.2022.06.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07457, KAKENHI-PROJECT-22K07831
[Journal Article] Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy.2021
- Author(s)
  Yamanaka G, Takamatsu T, Morichi S, Yamazaki T, Mizoguchi I, Ohno K, Watanabe Y, Ishida Y, Oana S, Suzuki S, Kashiwagi Y, Takata F, Sakuma H, Yoshimoto T, Kato M, Kawashima H
- Journal Title
  
  J Neuroimmunol.
  
  Volume: 352 Pages: 577475-577475
- DOI
  10.1016/j.jneuroim.2021.577475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-20K17909, KAKENHI-PROJECT-18K11658, KAKENHI-PROJECT-21K12256
[Journal Article] Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study2021
- Author(s)
  Yamaguchi Hiroshi、Nishiyama Masahiro、Tokumoto Shoichi、Ishida Yusuke、Tomioka Kazumi、Aoki Kazunori、Seino Yusuke、Toyoshima Daisaku、Takeda Hiroki、Kurosawa Hiroshi、Sakuma Hiroshi、Tada Hiroko、Nozu Kandai、Maruyama Azusa、Tanaka Ryojiro、Iijima Kazumoto、Nagase Hiroaki
- Journal Title
  
  Cytokine
  
  Volume: 137 Pages: 155324-155324
- DOI
  10.1016/j.cyto.2020.155324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-20K17894, KAKENHI-PROJECT-18K08918, KAKENHI-PROJECT-18K15711, KAKENHI-PROJECT-19K18353
[Journal Article] Early-life stress induces the development of Alzheimer's disease pathology via angiopathy2021
- Author(s)
  Tanaka Tomoko、Hirai Shinobu、Hosokawa Masato、Saito Takashi、Sakuma Hiroshi、Saido Takaomi、Hasegawa Masato、Okado Haruo
- Journal Title
  
  Experimental Neurology
  
  Volume: 337 Pages: 113552-113552
- DOI
  10.1016/j.expneurol.2020.113552
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-18K19383, KAKENHI-PROJECT-17K16408, KAKENHI-PROJECT-18H02537
[Journal Article] Intrathecal dexamethasone therapy for febrile infection‐related epilepsy syndrome2021
- Author(s)
  Horino Asako、Kuki Ichiro、Inoue Takeshi、Nukui Megumi、Okazaki Shin、Kawawaki Hisashi、Togawa Masao、Amo Kiyoko、Ishikawa Junichi、Ujiro Atsushi、Shiomi Masashi、Sakuma Hiroshi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 8 Issue: 3 Pages: 645-655
- DOI
  10.1002/acn3.51308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08311
[Journal Article] Improvement in recurrent anti-myelin oligodendrocyte glycoprotein antibody - positive cerebral cortical encephalitis not requiring anti - inflammatory therapy following the decrease in cytokine/chemokine levels2020
- Author(s)
  Takamatsu Tomoko、Yamanaka Gaku、Uryu Hideko、Takeshita Mika、Morishita Natsumi、Morichi Shinichiro、Ishida Yu、Oana Shingo、Terashi Hiroo、Shichino Hiroyuki、Sakuma Hiroshi、Kawashima Hisashi
- Journal Title
  
  Multiple Sclerosis and Related Disorders
  
  Volume: 43 Pages: 102168-102168
- DOI
  10.1016/j.msard.2020.102168
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-20K17909
[Journal Article] Extracellular ADP augments microglial inflammasome and NF‐κB activation via the P2Y12 receptor2019
- Author(s)
  Suzuki Tomonori、Kohyama Kuniko、Moriyama Kengo、Ozaki Mariko、Hasegawa Setsuko、Ueno Taro、Saitoe Minoru、Morio Tomohiro、Hayashi Masaharu、Sakuma Hiroshi
- Journal Title
  
  European Journal of Immunology
  
  Volume: 50 Issue: 2 Pages: 205-219
- DOI
  10.1002/eji.201848013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-16H02461, KAKENHI-PROJECT-19H01013
[Journal Article] Effects of antiepileptic drugs on microglial properties2018
- Author(s)
  Taiki Shima, Hiroshi Sakuma, Tomonori Suzuki, Kuniko Kohyama, Takako Matsuoka, Masaharu Hayashi, Akihisa Okumura, Toshiaki Shimizu
- Journal Title
  
  E&S
  
  Volume: 10 Issue: 1 Pages: 22-32
- DOI
  10.3805/eands.10.22
- NAID
  130006721857
- ISSN
  1882-5567
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461556
[Journal Article] Cytokine-induced differentiation of hematopoietic cells into microglia-like cells in?vitro2018
- Author(s)
  Igarashi Ayuko、Sakuma Hiroshi、Hayashi Masaharu、Noto Daisuke、Miyake Sachiko、Okumura Akihisa、Shimizu Toshiaki
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 8 Issue: 2 Pages: 139-149
- DOI
  10.1111/cen3.12429
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461556, KAKENHI-PROJECT-18K07890, KAKENHI-PROJECT-17H04218
[Journal Article] MicroRNA-101a regulates microglial morphology and inflammation2017
- Author(s)
  Saika Reiko、Sakuma Hiroshi、Noto Daisuke、Yamaguchi Shuhei、Yamamura Takashi、Miyake Sachiko
- Journal Title
  
  J Neuroinflammation
  
  Volume: 14(1) Issue: 1 Pages: 109-109
- DOI
  10.1186/s12974-017-0884-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-26461556
[Journal Article] Development of a culture system to induce microglia-like cells from hematopoietic cells.2014
- Author(s)
  Noto D, Sakuma H, Takahashi K, Yamada M, Yamamura T, Miyake S
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: in press Issue: 6 Pages: 697-713
- DOI
  10.1111/nan.12086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390261, KAKENHI-PROJECT-23591522, KAKENHI-PROJECT-26461556
[Presentation] COVID-19-associated acute encephalopathy.2022
- Author(s)
  Hiroshi Sakuma
- Organizer
  17th Asian Society for Pediatric Research Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07831
[Presentation] 抗myelin oligodendrocyte glycoprotein (MOG) 抗体関連疾患の臨床2022
- Author(s)
  佐久間　啓
- Organizer
  第64回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07831
[Presentation] 難治頻回部分発作重積型急性脳炎の最新情報2022
- Author(s)
  佐久間　啓
- Organizer
  第64回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07831
[Presentation] Overview: Immune therapy for autoimmune encephalitis2022
- Author(s)
  Hiroshi Sakuma
- Organizer
  第64回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07831
[Presentation] 頻脈発作を初発症状とし、性格変化をきたした前頭葉てんかんの一例.2021
- Author(s)
  田村友美恵、今泉孝章、老谷嘉樹、熊田聡子、佐久間啓、井上健司、眞下秀明、柏井洋文、福田光成.
- Organizer
  第74回日本小児神経学会関東地方会.
- Data Source
  KAKENHI-PROJECT-20K08223
[Presentation] 重症心身障害児者の腸内細菌叢の解析2019
- Author(s)
  田沼直之、渡辺肇子、齋藤菜穂、白井育子、小出彩香、古島わかな、伊藤昌弘、冨永恵子、佐久間啓
- Organizer
  第61回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11040
[Presentation] 腸内フローラ解析から見た食事の重要性2019
- Author(s)
  田沼直之, 渡邊肇子, 齋藤菜穂, 白井育子, 小出彩香, 古島わかな, 藏野亘之, 伊藤昌弘, 冨永惠子, 東原千恵美, 佐久間啓
- Organizer
  第45回日本重症心身障害学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11040
[Presentation] 重症心身障害児者の腸内細菌叢の解析2019
- Author(s)
  田沼直之, 冨永惠子, 渡邉肇子, 齋藤菜穂, 白井育子, 小出彩香, 古島わかな, 伊藤昌弘, 佐久間啓
- Organizer
  第61回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11040
[Presentation] 骨髄未分化細胞からミクログリア様細胞への分化に対するコロニー刺激因子の影響2016
- Author(s)
  五十嵐鮎子、佐久間啓、神山邦子、鈴木智典、嶋泰樹、林雅晴
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-26461556
[Presentation] P2Y12受容体シグナルはミクログリアにおけるサイトカイン産生を促進する2016
- Author(s)
  鈴木智典、上野太郎、林雅晴、佐久間啓
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-26461556
[Presentation] CRISP/Cas9 systemを用いたknockout/downミクログリア細胞株の樹立2016
- Author(s)
  鈴木智典、上野太郎、林雅晴、佐久間啓
- Organizer
  第58回日本小児神経学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-26461556
[Presentation] Interleukin-34 facilitates commitment of hematopoietic cells to micloglia-like cells2015
- Author(s)
  Hiroshi Sakuma, Tomonori Suzuki, Masaharu Hayashi, Daisuke Noto, Reiko Saika, Takashi Yamamura, Sachiko Miyake
- Organizer
  第57回日本小児神経学会学術集会
- Place of Presentation
  帝国ホテル大阪（大阪府、大阪市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26461556
[Presentation] CD11b陽性細胞を除去した混合グリア培養におけるミクログリアの再増殖2015
- Author(s)
  佐久間啓，鈴木智典，五十嵐鮎子，神山邦子，林雅晴，三宅幸子
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-26461556
[Presentation] ミクログリア様細胞の分化におけるIL-34の役割2011
- Author(s)
  佐久間　啓
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23591522

1. 福田光成 (80274330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 柏井洋文 (20604333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 松尾健 (10733941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TANUMA Naoyuki (00281676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 眞下秀明 (00869406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 小森隆司 (90205526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 星野愛 (90801928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 石山昭彦 (90377284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石澤圭介 (10327025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IGARASHI Ayuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SAIKA Reiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SUZUKI Tomonori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. SHIMA Taiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 溝口出

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 善本隆之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 葛西真梨子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 三宅幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 中島一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 奥村彰久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 永瀬裕朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 木村暁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKUMA Hiroshi 佐久間 啓

佐久間 啓 サクマ ヒロシ

Research Projects

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脳炎・脳症の臨床的多様性を生み出す因子の多層性解析Principal Investigator

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Elucidation of the neuroimmunological pathology involved in intractable childhood epilepsy and development of new molecular targeted drugs.

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バイオレポジトリを活用した小児自己免疫性脳炎の新規診断技術開発と病態解明Principal Investigator

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神経免疫系を介した小児難治性てんかんの病態解明と新たな分子標的療法の開発

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Pathophysiology of demyelinating diseases and epilepsy using microglia removal model by TRECK systemPrincipal Investigator

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metagenome analysis of intestinal microbiota in patients with severe motor and intellectual disabilities and the effect of intervention with bifidobacterium

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Tracking of microglial development and differentiation in the developing brainPrincipal Investigator

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Transcriptome analysis of microglia using animal model of brain diseasesPrincipal Investigator

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[Journal Article] Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study2024

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[Journal Article] Oxygen-Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes2024

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[Journal Article] Paediatric antibody prevalence in seizure score to predict autoimmune aetiology in seizure disorders2024

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[Journal Article] Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein2023

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[Journal Article] Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2.2023

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[Journal Article] Time course of serum cytokine level changes within 72?h after onset in children with acute encephalopathy and febrile seizures2023

Author(s)

SAKUMA Hiroshi 佐久間啓

佐久間啓サクマヒロシ