Miyamoto Yuki 宮本幸

Researcher Number	50425708
Affiliation *help	2016 – 2018 : 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 研究員 2015 : 国立研究開発法人国立成育医療研究センター, その他部局等, 研究員 2014 : 独立行政法人国立成育医療研究センター, その他部局等, 研究員 2007 : 国立成育医療セ 2006 : 国立成育医療センター(研究所), 薬剤治療研究部, 共同研究員
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator ミエリン / 共培養 / オリゴデンドロサイト / 髄鞘 / シュワン細胞 / DRG神経細胞 / グリア細胞 / 分子神経科学 / 神経細胞 / 末梢神経 / Rhoファミリー / グアニンヌクレオチド交換因子 / 細胞間相互作用

中枢ミエリン形成を司る分子ネットワークの解明Principal InvestigatorOngoing
- Principal Investigator
  
  宮本幸
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center for Child Health and Development
FROM THE QUESTION OF HOW GLIAL CELLS WRAP THEIR MEMBRANE WITH AXONS TO THE POSSIBLE SOLUTION OF HOW DEMYELINATING DISORDERS WERE RECOVEREDPrincipal Investigator
- Principal Investigator
  
  Miyamoto Yuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center for Child Health and Development
末梢神経の初期発生過程とその病態形成のシグナル伝達Principal Investigator
- Principal Investigator
  
  宮本幸
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Research Institute for Child Health and Development

All 2016 2015 2014 2007 2006

All Journal Article Presentation

[Journal Article] Arf6 mediates Schwann cell differentiation and myelination.2016
- Author(s)
  Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, and Junji Yamauchi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 465 Pages : 450-457
- DOI
  10.1016/j.bbrc.2015.08.038
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290028, KAKENHI-PROJECT-26830054, KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-15H04672
[Journal Article] Hypomyelinating leukodystrophy-associated missence mutation in HSPD1 blunts mitochondrial dynamics.2016
- Author(s)
  Yuki Miyamoto, Takahiro Eguchi, Kazuko Kawahara, Nanami Hasegawa, Kazuaki Nakamura, Megumi Funakoshi-Tago, Akito Tanoue, Hiroomi Tamura, and Junji Yamauchi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 462 Pages : 275-281
- DOI
  10.1016/j.bbrc.2015.04.132
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290028, KAKENHI-PROJECT-26830054, KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-25460073
[Journal Article] Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.2016
- Author(s)
  Yuki Miyamoto, Tomohiro Torii, Shuji Takada, Nobuhiko Ohno, Yurika Saitoh, Kazuaki Nakamura, Akihito Ito, Toru Ogata, Nobuo Terada, Akito Tanoue, and Junji Yamauchi
- Journal Title
  
  Mol Biol Cell
  
  Volume : 6 Pages : 3489-3503
- DOI
  10.1091/mbc.E14-05-1020
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290028, KAKENHI-PROJECT-26830054, KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-25460267, KAKENHI-PROJECT-26282159
[Journal Article] Data supporting the role of Fyn in initiating myelination in the peripheral nervous system.2016
- Author(s)
  Yuki Miyamoto, Moe Tamano, Tomohiro Torii, Kazuko Kawahara, Kazuaki Nakamura, Akito Tanoue, Shuji Takada, and Junji Yamauchi
- Journal Title
  
  Data Breif
  
  Volume : 7 Pages : 1098-1105
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830054
[Journal Article] Data supporting mitochondrial morphological changes by spastic paraplegia (SPG) 13-associated HSPD1 mutants.2016
- Author(s)
  Yuki Miyamoto, Megumi Funakoshi-Tago, Nanami Hasegawa, Takahiro Eguchi, Akito Tanoue, Hiroomi Tamura, and Junji Yamauchi
- Journal Title
  
  Data Brief
  
  Volume : 6 Pages : 482-488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830054
[Journal Article] Social isolation impairs remyelination in mice through modulation of interleukin-6.2016
- Author(s)
  Manabu Makinodan, Daisuke Ikawa, Yuki Miyamoto, Junji Yamauchi, Kazuhiko Yamamuro, Yasunori Yamashita, Michihiro Toritsuka, Sohei Kimoto, Kazuki Okumura, Takahira Yamauchi, Shin-ichi Fukami, Hiroki Yoshino, Akio Wanaka, and Toshifumi Kishimoto
- Journal Title
  
  FASEB. J.
  
  Volume : 30 Pages : 4267-4274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830054
[Journal Article] VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.2016
- Author(s)
  Yuki Miyamoto, Tomohiro Torii, Akito Tanoue, and Junji Yamauchi
- Journal Title
  
  Nat. Commun.
  
  Volume : 7 Pages : 13478-13494
- DOI
  10.1038/ncomms13478
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830054
[Journal Article] Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves.2015
- Author(s)
  Tomohiro Torii, Nobuhiko Ohno, Yuki Miyamoto, Kazuko Kawahara, Yurika Saitoh, Kazuaki Nakamura, Shou Takashima, Hiroyuki Sakagami, Akito Tanoue, and Junji Yamauchi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 460 Pages : 819-825
- DOI
  10.1016/j.bbrc.2015.03.113
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830054, KAKENHI-PROJECT-15H04672
[Journal Article] Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth.2014
- Author(s)
  Torii T, Miyamoto Y, Tago K, Sango K, Nakamura K, Sanbe A, Tanoue A, Yamauchi J.
- Journal Title
  
  J Biol Chem.
  
  Volume : 289 Pages : 33887-33903
- DOI
  10.1074/jbc.M114.575787
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430056, KAKENHI-PROJECT-26440062, KAKENHI-PROJECT-26830054
[Journal Article] Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.2014
- Author(s)
  Miyamoto Y, Yamamori N, Torii T, Tanoue A, Yamauchi J
- Journal Title
  
  Mol. Biol. Cell
  
  Volume : 25 Pages : 1532-1542
- DOI
  10.1091/mbc.E13-10-0600
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290028, KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-26830054
[Journal Article] Hypomyelinating leukodystrophy-associated missense mutant of FAM126A/hyccin/DRCTNNB1A aggregates in the endoplasmic reticulum.2014
- Author(s)
  Yuki Miyamoto, Takahiro Eguchi, Tomohiro Torii, Kazuaki Nakamura, Akito Tanoue, and Junji Yamauchi
- Journal Title
  
  J. Clin. Neurosci.
  
  Volume : 21 Pages : 1033-1039
- DOI
  10.1016/j.jocn.2013.09.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-26830054
[Journal Article] In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration.2014
- Author(s)
  Tomohiro Torii, Yuki Miyamoto, Shuji Takada, Hideki Tsumura, Miyuki Arai, Kazuaki Nakamura, Katsuya Ohbuchi, Masahiro Yamamoto, Akito Tanoue, and Junji Yamauchi
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 452 Pages : 782-788
- DOI
  10.1016/j.bbrc.2014.08.156
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26117523, KAKENHI-PROJECT-26830054
[Journal Article] Dock6, a Dock-C subfamily guanine-nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth2007
- Author(s)
  Yuki Miyamoto, Junji Yamauchi, Atsushi Sanbe, Akito Tanoue
- Journal Title
  
  Exp. Cell Res. 313巻4号
  
  Pages : 791-804
- Data Source
  KAKENHI-PROJECT-18700375
[Journal Article] TrkB binds and tyrosine-phosphorylates Tiam1 leading to activation of Rac1 and induction of changes in cellular morphology2006
- Author(s)
  Yuki Miyamoto, Junji Yamauchi, Akito Tanoue, Chengbiao Wu, William C. Mobley
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103巻27号
  
  Pages : 10444-10449
- Data Source
  KAKENHI-PROJECT-18700375
[Journal Article] JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells2006
- Author(s)
  Yuki Miyamoto, Junji Yamauchi, Atsushi Sanbe, Akito Tanoue
- Journal Title
  
  Exp. Cell Res. 312巻15号
  
  Pages : 2954-2961
- Data Source
  KAKENHI-PROJECT-18700375
[Presentation] Disease-assoiated modification of hereditary demyelinating disorder-related protein dynamics2015
- Author(s)
  宮本　幸、山内淳司
- Organizer
  日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26830054
[Presentation] Derivation of oligodendrocytes from human iPS cells and monkey ES cells maintained in a single-cell and feeder-free culture2015
- Author(s)
  山下智子、土井綾乃、小林桜子、小野貴史、鈴木　豊、荒木利博、青木久範、佐藤直也、宮本　幸、山内淳司、板東良雄、吉田成孝
- Organizer
  日本神経科学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-26830054
[Presentation] Tyro3受容体とFynキナーゼは、ミエリン形成を司る新しいシグナル複合体を形成する2015
- Author(s)
  宮本　幸、山内淳司
- Organizer
  日本分子生物学会・日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26830054
[Presentation] ErbB3 is required for Schwann cell precursor migration2015
- Author(s)
  宮本　幸、山内淳司
- Organizer
  日本神経科学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-26830054
[Presentation] 中枢神経脱随疾患HLD5変異による以上FAM126A蛋白質は脳梁で凝集し脱随を誘導する可能性がある2014
- Author(s)
  宮本　幸、鳥居知宏、田上昭人、山内淳司
- Organizer
  日本神経化学会
- Place of Presentation
  奈良県文化会館
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-26830054
[Presentation] 末梢神経の発生・再生過程を制御するDock6による新規メカニズム2014
- Author(s)
  宮本　幸、鳥居知宏、田上昭人、山内淳司
- Organizer
  日本神経科学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26830054

1. KAWAHARA Kazuko

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
2. Yamauchi Junji

# of Collaborated Projects : 0results

# of Collaborated Products : 6results
3. Yamamoto Nobuhiko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
4. TAGO MEGUMI

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
5. 阪上洋行

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
6. 三五一憲

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. 多胡憲治

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. 寺田信生

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. 緒方徹

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Miyamoto Yuki 宮本 幸

Research Projects

Research Products

Co-Researchers

中枢ミエリン形成を司る分子ネットワークの解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FROM THE QUESTION OF HOW GLIAL CELLS WRAP THEIR MEMBRANE WITH AXONS TO THE POSSIBLE SOLUTION OF HOW DEMYELINATING DISORDERS WERE RECOVEREDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

末梢神経の初期発生過程とその病態形成のシグナル伝達Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Arf6 mediates Schwann cell differentiation and myelination.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypomyelinating leukodystrophy-associated missence mutation in HSPD1 blunts mitochondrial dynamics.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Data supporting the role of Fyn in initiating myelination in the peripheral nervous system.2016

Author(s)

Journal Title

Data Source

[Journal Article] Data supporting mitochondrial morphological changes by spastic paraplegia (SPG) 13-associated HSPD1 mutants.2016

Author(s)

Journal Title

Data Source

[Journal Article] Social isolation impairs remyelination in mice through modulation of interleukin-6.2016

Author(s)

Journal Title

Data Source

[Journal Article] VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypomyelinating leukodystrophy-associated missense mutant of FAM126A/hyccin/DRCTNNB1A aggregates in the endoplasmic reticulum.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dock6, a Dock-C subfamily guanine-nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth2007

Miyamoto Yuki 宮本幸