Kobayashi Atsushi 小林篤史

… Alternative Names

Researcher Number	50431507
Other IDs
Affiliation (Current)	2018 : 北海道大学, 獣医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2018 : 北海道大学, 獣医学研究院, 准教授 2016 – 2017 : 北海道大学, 獣医学研究科, 准教授 2015 : 北海道大学, (連合)獣医学研究科, 准教授 2011 : Tohoku University, 医学(系)研究科(研究院), 助教 2007 – 2010 : Tohoku University, 大学院・医学系研究科, 助教 2006 : 東北大学, 大学院医学系研究科, 助手
Review Section/Research Field	Principal Investigator Neurology / Virology / Veterinary medical science / Basic Section 42020:Veterinary medical science-related Except Principal Investigator Veterinary medical science / Medium-sized Section 63:Environmental analyses and evaluation and related fields
Keywords	Principal Investigator 神経変性疾患 / プリオン / 脳・神経 / 脳神経疾患 / 蛋白質 / ウイルス / クロイツフェルト・ヤコブ病 / 神経病態生化学 / プリオン病 / アミロイド … More Except Principal Investigator ERストレス / プリオン / 発達神経毒性試験 / ネオニコチノイド / アストロサイト / RNA-sequencing / mlAOPコンセプト / 感染症 / 化学物質感受性決定機構 / 自然免疫 / 網羅的遺伝子発現解析 / プリオン病 / 獣医学 / 脳神経疾患 / 次世代シークエンサー / 神経科学 / ミクログリア Less

mlAOPコンセプトによる化学物質感受性多様性評価と殺虫剤中毒解明に向けた応用Ongoing
- Principal Investigator
  
  池中良徳
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hokkaido University
プリオン蛋白の異常化機構解明研究Principal InvestigatorOngoing
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Elucidation of the mechanisms of prion protein conversion caused by an amino acid substitution in glycosylphosphatidylinositol anchoring signal peptidePrincipal Investigator
- Principal Investigator
  
  Kobayashi Atsushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talkOngoing
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
濾胞樹状細胞からのプリオン神経侵入経路の解明Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Identification of the origin of prion infectionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Atsushi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
培養細胞を用いたPMCA法によるヒトプリオンの増幅Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Virology
- Research Institution
  Tohoku University

All 2018 2017 2016 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Clinical Neuroscience, ニューロジェネティクス新時代－次世代シークエンサーが拓く新しい世界2018
- Author(s)
  小林篤史 (分担, 小林靖編)
- Total Pages
  106
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16K18790
[Book] The Handbook of Clinical Neurology, Human Prion Diseases2018
- Author(s)
  Kobayashi A, Kitamoto T, Mizusawa H (Edited by Pocchiari M and Manson J)
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-16K18790
[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases2018
- Author(s)
  Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
- Journal Title
  
  Neurosci Lett
  
  Volume : 668 Pages : 43-47
- DOI
  10.1016/j.neulet.2018.01.014
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790
[Journal Article] Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene2018
- Author(s)
  Ito Yoko、Sanjo Nobuo、Hizume Masaki、Kobayashi Atsushi、Ohgami Tetsuya、Satoh Katsuya、Hamaguchi Tsuyoshi、Yamada Masahito、Kitamoto Tetsuyuki、Mizusawa Hidehiro、Yokota Takanori
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume : 496 Pages : 1055-1061
- DOI
  10.1016/j.bbrc.2018.01.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18790
[Journal Article] c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium2017
- Author(s)
  Sehgal Anuj、Kobayashi Atsushi、Donaldson David S.、Mabbott Neil A.
- Journal Title
  
  Immunobiology
  
  Volume : 222 Pages : 316-326
- DOI
  10.1016/j.imbio.2016.09.008
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18790
[Journal Article] Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases2016
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T
- Journal Title
  
  Neuropathology
  
  Volume : 36 Issue : 3 Pages : 305-310
- Publisher
  Wiley-Blackwell
- DOI
  10.1111/neup.12270
- PMID
  info:pmid/26669818
- ISSN
  0919-6544
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K18790, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435
[Journal Article] Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification.2016
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shusei Uno and Tetsuyuki Kitamoto
- Journal Title
  
  Lab Invest.
  
  Volume : in press Pages : 581-7
- DOI
  10.1038/labinvest.2016.27
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09307, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16K18790
[Journal Article] Co-occurrence of types 1 and 2 PrPres in sporadic Creutzfeldt Jakob disease MM12011
- Author(s)
  Kobayashi A
- Journal Title
  
  Am J Pathol
  
  Volume : 178 Pages : 1309-1315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590922
[Journal Article] Experimental Verification of a Traceback Phenomenon in Prion Infection.2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T.
- Journal Title
  
  J Virol. 84
  
  Pages : 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Journal Title
  
  J Virol
  
  Volume : 84 Pages : 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590922
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Journal Title
  
  J Virol 84
  
  Pages : 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] A traceback phenomenon can reveal the origin of prion infection2009
- Author(s)
  Kobayashi A
- Journal Title
  
  Neuropathology 29
  
  Pages : 619-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Amino acid conditions near the GPI anchor attachment site of prion protein for the conversion and the GPI anchoring.2009
- Author(s)
  Hizume M, Kobayashi A, Mizusawa H, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun. 391
  
  Pages : 1681-1686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] A traceback phenomenon can reveal the origin of prion infection.2009
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T.
- Journal Title
  
  Neuropathology 29
  
  Pages : 619-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein.2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun. 382
  
  Pages : 715-719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A
- Journal Title
  
  Acta Neuropathol 116
  
  Pages : 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2007
- Author(s)
  Kobayashi A., Asano M., Mohri S., Kitamoto T.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages : 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890017
[Presentation] Diagnostic approach for a novel acquired CJD subgroup, acquired CJD-MMiK2017
- Author(s)
  Atsushi Kobayashi
- Organizer
  Asian Pacific Prion Symposium 2017
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Neuropathological and biochemical criteria for a new subtype of acquired Creutzfeldt-Jakob disease (MMiK)2017
- Author(s)
  Atsushi Kobayashi, Masahito Yamada, Atsuko Takeuchi, Shirou Mohri, and Tetsuyuki Kitamoto
- Organizer
  第36回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Colocalization of Aβ42 with PrPSc-plaques in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation.2016
- Author(s)
  Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Canada, Toronto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Differential association of amyloid-β with PrPSc pathology in each genetic prion disease.2016
- Author(s)
  Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] 遺伝性プリオン病の病型毎のPrPScとAβの沈着パターンに関する病理学的解析2016
- Author(s)
  古川迪子、三條伸夫、小林篤史、浜口毅、山田正仁、北本哲之、水澤英洋、横田隆徳
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京都千代田区、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Identification of the origin of Creutzfeldt-Jakob disease after cadaver-sourced pituitary growth hormone treatment using an amplification property in protein misfolding cyclic amplificatiton.2016
- Author(s)
  Takeuchi A, Yamamoto M, Parchi P, HaiK S, Morita M, Kobayashi A, Kitamoto T
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Iatrogenic transmission of Creutzfeldt-Jakob disease2016
- Author(s)
  Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Paul Brown, Daniela Saverioni, Yuichi Matsuura, Atsuko Takeuchi, Shirou Mohri, Tetsuyuki Kitamoto
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Mechanisms of transmission of prion diseases2016
- Author(s)
  Atsushi Kobayashi
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫県神戸市、神戸ポートピアホテル
- Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Organizer
  Asia-Oceania Symposium on Prion Diseases
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-22590922
[Presentation] ヒト異常型プリオン蛋白特異的抗体の作製2009
- Author(s)
  小林篤史
- Organizer
  2009年プリオン研究会
- Place of Presentation
  宮城県
- Data Source
  KAKENHI-PROJECT-20790608
[Presentation] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2008
- Author(s)
  Kobayashi A., Asano M., Mohri S., Kitamoto T.
- Organizer
  Transmissible Spongiform Encephalopathies, The definitive American TSE Meeting
- Place of Presentation
  アメリカ合衆国,ボルチモア
- Year and Date
  2008-02-10
- Data Source
  KAKENHI-PROJECT-18890017

1. 竹内敦子 (00535239)

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2. 堀内基広 (30219216)

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3. 池中良徳 (40543509)

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4. 星信彦 (10209223)

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5. 川合佑典 (10709546)

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6. 石塚真由美 (50332474)

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7. 久保田彰 (60432811)

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8. 水川葉月 (60612661)

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9. 有薗幸司 (70128148)

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10. 加藤恵介 (80276609)

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11. 宮原裕一 (80311330)

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12. 市川剛 (80438712)

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13. 中山翔太 (90647629)

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14. 岡松優子 (90527178)

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15. Kitamoto Tetsuyuki

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16. 木村享史

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Kobayashi Atsushi 小林 篤史

KOBAYASHI Atsushi 小林 篤史

Research Projects

Research Products

Co-Researchers

mlAOPコンセプトによる化学物質感受性多様性評価と殺虫剤中毒解明に向けた応用Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プリオン蛋白の異常化機構解明研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms of prion protein conversion caused by an amino acid substitution in glycosylphosphatidylinositol anchoring signal peptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talkOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

濾胞樹状細胞からのプリオン神経侵入経路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the origin of prion infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

培養細胞を用いたPMCA法によるヒトプリオンの増幅Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Clinical Neuroscience, ニューロジェネティクス新時代－次世代シークエンサーが拓く新しい世界2018

Author(s)

Total Pages

Publisher

Data Source

[Book] The Handbook of Clinical Neurology, Human Prion Diseases2018

Author(s)

Publisher

Data Source

[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases2016

Author(s)

Journal Title

Publisher

DOI

PMID

ISSN

Language

Data Source

Kobayashi Atsushi 小林篤史

KOBAYASHI Atsushi 小林篤史

[Presentation] Colocalization of Aβ42 with PrPSc-plaques in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation.2016