KOBAYASHI Atsushi 小林篤史

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Kobayashi Atsushi 小林篤史

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Researcher Number	50431507
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医歯薬学総合研究系), 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 長崎大学, 医歯薬学総合研究科(医歯薬学総合研究系), 教授 2017 – 2021: 北海道大学, 獣医学研究院, 准教授 2016 – 2017: 北海道大学, 獣医学研究科, 准教授 2015: 北海道大学, (連合)獣医学研究科, 准教授 2011: Tohoku University, 医学(系)研究科(研究院), 助教 2007 – 2010: Tohoku University, 大学院・医学系研究科, 助教 2006: 東北大学, 大学院医学系研究科, 助手
Review Section/Research Field	Principal Investigator Neurology / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 42020:Veterinary medical science-related / Veterinary medical science / Virology Except Principal Investigator Medium-sized Section 63:Environmental analyses and evaluation and related fields / Veterinary medical science
Keywords	Principal Investigator プリオン / 神経変性疾患 / GPIアンカー / 脳神経疾患 / プリオン病 / クロイツフェルト・ヤコブ病 / 蛋白質 / 脳・神経 / 重鎖抗体可変領域 / 疾患モデル … More / ウイルス / 脳 / 神経病態生化学 / 神経科学 / 超音波 / アミロイド / プリオン蛋白 … More Except Principal Investigator 化学物質感受性決定帰国 / 発達神経毒性試験ｎ / バイオマーカー / 化学物質感受性決定機構 / 発達神経毒性試験 / mlAOPコンセプト / ネオニコチノイド / 自然免疫 / 次世代シークエンサー / RNA-sequencing / プリオン病 / 神経科学 / 脳神経疾患 / 感染症 / 獣医学 / ERストレス / 網羅的遺伝子発現解析 / 小胞体ストレス応答 / AFT3 / RNA-seq / アストロサイト / ミクログリア / 神経細胞 / プリオン Less

GPI付加シグナル配列が蛋白質ミスフォールディングを促進するメカニズムの解明Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagasaki University
アルパカ重鎖抗体可変領域（VHH）を用いたプリオン病の新規治療法開発Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagasaki University
Elucidation of the mechanisms of the prion protein misfoldingPrincipal Investigator
- Principal Investigator
  
  Kobayashi Atsushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Evaluation of Chemical Susceptibility Diversity by mlAOP Concept and its Application to Understanding Insecticide Poisoning
- Principal Investigator
  
  IKENAKA Yoshinori
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Hokkaido University
Elucidation of the mechanisms of prion protein conversion caused by an amino acid substitution in glycosylphosphatidylinositol anchoring signal peptidePrincipal Investigator
- Principal Investigator
  
  Kobayashi Atsushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talk
- Principal Investigator
  
  HOROUICHI MOTOHIRO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
濾胞樹状細胞からのプリオン神経侵入経路の解明Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Identification of the origin of prion infectionPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Atsushi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
培養細胞を用いたPMCA法によるヒトプリオンの増幅Principal Investigator
- Principal Investigator
  
  小林篤史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Virology
- Research Institution
  Tohoku University

All 2020 2019 2018 2017 2016 2015 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Clinical Neuroscience, ニューロジェネティクス新時代－次世代シークエンサーが拓く新しい世界2018
- Author(s)
  小林篤史 (分担, 小林靖編)
- Total Pages
  106
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-16K18790
[Book] The Handbook of Clinical Neurology, Human Prion Diseases2018
- Author(s)
  Kobayashi A, Kitamoto T, Mizusawa H (Edited by Pocchiari M and Manson J)
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-16K18790
[Journal Article] 総説プリオン病研究の進歩-医原性プリオン感染について2020
- Author(s)
  小林篤史
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Issue: 4 Pages: 437-443
- DOI
  10.11477/mf.1416201542
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2020-04-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963
[Journal Article] α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein2020
- Author(s)
  Kobayashi Atsushi、Hirata Tetsuya、Nishikaze Takashi、Ninomiya Akinori、Maki Yuta、Takada Yoko、Kitamoto Tetsuyuki、Kinoshita Taroh
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 22 Pages: 7789-7798
- DOI
  10.1074/jbc.ra120.013444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H04753, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] Susceptibility of rat immortalized neuronal cell line Rn33B expressing equine major histocompatibility class 1 to equine herpesvirus‐1 infection is differentiation dependent2020
- Author(s)
  Minato Erina、Kobayashi Atsushi、Aoshima Keisuke、Fukushi Hideto、Kimura Takashi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 64 Issue: 2 Pages: 123-132
- DOI
  10.1111/1348-0421.12761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02343
[Journal Article] Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection2020
- Author(s)
  Goto Shinya、Konnai Satoru、Hirano Yuki、Kohara Junko、Okagawa Tomohiro、Maekawa Naoya、Sajiki Yamato、Watari Kei、Minato Erina、Kobayashi Atsuhi、et al.
- Journal Title
  
  Frontiers in Veterinary Science
  
  Volume: 7 Pages: 12-12
- DOI
  10.3389/fvets.2020.00012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19KK0172, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-18J13237, KAKENHI-PROJECT-19J21826, KAKENHI-PROJECT-19K06425, KAKENHI-PROJECT-20K21357, KAKENHI-PROJECT-19K15993
[Journal Article] Characterization of Sporadic Creutzfeldt-Jakob Disease and History of Neurosurgery to Identify Potential Iatrogenic Cases2020
- Author(s)
  Hamaguchi Tsuyoshi、Sakai Kenji、Kobayashi Atsushi、Kitamoto Tetsuyuki、Ae Ryusuke、Nakamura Yosikazu、Sanjo Nobuo、Arai Kimihito、Koide Mizuho、Katada Fumiaki、Harada Masafumi、Murai Hiroyuki、Murayama Shigeo、Tsukamoto Tadashi、Mizusawa Hidehiro、Yamada Masahito
- Journal Title
  
  Emerging Infectious Diseases
  
  Volume: 26 Issue: 6 Pages: 1140-1146
- DOI
  10.3201/eid2606.181969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17H04194, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588
[Journal Article] Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-2372019
- Author(s)
  Yamada Shinji、Itai Shunsuke、Nakamura Takuro、Takei Junko、Sano Masato、Konnai Satoru、Kobayashi Atsushi、Nakagun Shotaro、Kobayashi Yoshiyasu、Kaneko Mika K.、Kato Yukinari
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 38 Issue: 3 Pages: 104-107
- DOI
  10.1089/mab.2019.0014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19H03114
[Journal Article] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019
- Author(s)
  Kobayashi Atsushi、Iwasaki Yasushi、Takao Masaki、Saito Yuko、Iwaki Toru、Qi Zechen、Torimoto Ryouta、Shimazaki Taishi、Munesue Yoshiko、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Kondo Hinako、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 印刷中 Issue: 6 Pages: 1276-1283
- DOI
  10.1016/j.ajpath.2019.02.012
- NAID
  120006847766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06506, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738
[Journal Article] Autopsy case of MV2K‐type sporadic Creutzfeldt‐Jakob disease with spongiform changes of the cerebral cortex2019
- Author(s)
  Iwasaki Yasushi、Hiraga Keita、Ito Shota、Ando Tetsuo、Akagi Akio、Riku Yuichi、Mimuro Maya、Miyahara Hiroaki、Kobayashi Atsushi、Kitamoto Tetsuyuki、Yoshida Mari
- Journal Title
  
  Neuropathology
  
  Volume: 39 Issue: 6 Pages: 452-460
- DOI
  10.1111/neup.12595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Prostaglandin E2 Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection2019
- Author(s)
  Sajiki Yamato、Konnai Satoru、Okagawa Tomohiro、Nishimori Asami、Maekawa Naoya、Goto Shinya、Watari Kei、Minato Erina、Kobayashi Atsushi、et al.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 5 Pages: 1313-1324
- DOI
  10.4049/jimmunol.1900342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02332, KAKENHI-PROJECT-18J13237, KAKENHI-PROJECT-19J21826
[Journal Article] High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines2019
- Author(s)
  Morita Atsuya、Aoshima Keisuke、Gulay Kevin Christian Montecillo、Onishi Shinichi、Shibata Yuki、Yasui Hironobu、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  Research in Veterinary Science
  
  Volume: 127 Pages: 1-10
- DOI
  10.1016/j.rvsc.2019.09.011
- NAID
  120006937029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18K14575
[Journal Article] PMab-247 Detects Bear Podoplanin in Immunohistochemical Analysis2019
- Author(s)
  Takei Junko、Furusawa Yoshikazu、Yamada Shinji、Nakamura Takuro、Sayama Yusuke、Sano Masato、Konnai Satoru、Kobayashi Atsushi、Harada Hiroyuki、Kaneko Mika K.、Kato Yukinari
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 38 Issue: 4 Pages: 171-174
- DOI
  10.1089/mab.2019.0019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K07705, KAKENHI-PROJECT-19H03114
[Journal Article] Autopsied case of sporadic Creutzfeldt-Jakob disease pathologically classified as MM1+2C-type2019
- Author(s)
  Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kobayashi A, Kitamoto T, Yoshida M.
- Journal Title
  
  Neuropathology
  
  Volume: 印刷中 Issue: 3 Pages: 240-247
- DOI
  10.1111/neup.12557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-18H02738
[Journal Article] Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models2019
- Author(s)
  Kobayashi Atsushi、Qi Zechen、Shimazaki Taishi、Munesue Yoshiko、Miyamoto Tomomi、Isoda Norikazu、Sawa Hirofumi、Aoshima Keisuke、Kimura Takashi、Mohri Shirou、Kitamoto Tetsuyuki、Yamashita Tadashi、Miyoshi Ichiro
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 3 Pages: 677-686
- DOI
  10.1016/j.ajpath.2018.11.009
- NAID
  120006770947
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-19K22588, KAKENHI-PROJECT-19KK0213, KAKENHI-PROJECT-17K07129
[Journal Article] Two distinct prions in fatal familial insomnia and its sporadic form2019
- Author(s)
  Takeuchi Atsuko、Mohri Shirou、Kai Hideaki、Tamaoka Akira、Kobayashi Atsushi、Mizusawa Hidehiro、Iwasaki Yasushi、Yoshida Mari、Shimizu Hiroshi、Murayama Shigeo、Kuroda Shigetoshi、Morita Masanori、Parchi Piero、Kitamoto Tetsuyuki
- Journal Title
  
  Brain Communications
  
  Volume: 1 Issue: 1
- DOI
  10.1093/braincomms/fcz045
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K07490, KAKENHI-PROJECT-19K07841
[Journal Article] Epitope Mapping of Anti-Bear Podoplanin Monoclonal Antibody PMab-2472019
- Author(s)
  Kato Yukinari、Takei Junko、Furusawa Yoshikazu、Sayama Yusuke、Sano Masato、Konnai Satoru、Kobayashi Atsushi、Harada Hiroyuki、Takahashi Maki、Suzuki Hiroyoshi、Yamada Shinji、Kaneko Mika K.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 38 Issue: 5 Pages: 230-233
- DOI
  10.1089/mab.2019.0025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-19K07705, KAKENHI-PROJECT-19H03114
[Journal Article] Exogenous Expression of Equine MHC Class I Molecules in Mice Increases Susceptibility to Equine Herpesvirus 1 Pulmonary Infection2019
- Author(s)
  Minato Erina、Aoshima Keisuke、Kobayashi Atsushi、Ohnishi Naomi、Sasaki Nobuya、Kimura Takashi
- Journal Title
  
  Veterinary Pathology
  
  Volume: 印刷中 Issue: 5 Pages: 703-710
- DOI
  10.1177/0300985819834616
- NAID
  120006781559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-17K14999, KAKENHI-PROJECT-16H05022
[Journal Article] Specific amyloid-b42 deposition in the brain of a Gerstmann-Straussler-Scheinker disease patient with a P105L mutation on the prion protein gene.2018
- Author(s)
  Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T
- Journal Title
  
  Prion
  
  Volume: 12 Issue: 5-6 Pages: 315-319
- DOI
  10.1080/19336896.2018.1541689
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09752, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] Immunohistochemical Detection of Sheep Podoplanin Using an Antibovine Podoplanin Monoclonal Antibody PMab-442018
- Author(s)
  Kato Yukinari、Yamada Shinji、Itai Shunsuke、Kobayashi Atsushi、Konnai Satoru、Kaneko Mika K.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 6 Pages: 265-268
- DOI
  10.1089/mab.2018.0036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963
[Journal Article] An autopsy report of three kindred in a Gerstmann-Str?ussler-Scheinker disease P105L family with a special reference to prion protein, tau, and beta-amyloid2018
- Author(s)
  Ishizawa Keisuke、Mitsufuji Takashi、Shioda Kei、Kobayashi Atsushi、Komori Takashi、Nakazato Yoshihiko、Kitamoto Tetsuyuki、Araki Nobuo、Yamamoto Toshimasa、Sasaki Atsushi
- Journal Title
  
  Brain and Behavior
  
  Volume: 8 Issue: 10
- DOI
  10.1002/brb3.1117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18H02738
[Journal Article] Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells2018
- Author(s)
  Aoshima Keisuke、Fukui Yuki、Gulay Kevin Christian Montecillo、Erdemsurakh Ochbayar、Morita Atsuya、Kobayashi Atsushi、Kimura Takashi
- Journal Title
  
  BMC Veterinary Research
  
  Volume: 14 Issue: 1 Pages: 301-301
- DOI
  10.1186/s12917-018-1624-8
- NAID
  120006536948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-16H05022
[Journal Article] Development of a quick bioassay for the evaluation of transmission properties of acquired prion diseases.2018
- Author(s)
  Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
- Journal Title
  
  Neuroscience Letters
  
  Volume: 668 Pages: 43-47
- DOI
  10.1016/j.neulet.2018.01.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05022, KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] A domain responsible for spontaneous conversion of bank vole prion protein2018
- Author(s)
  Kobayashi Atsushi、Matsuura Yuichi、Takeuchi Atsuko、Yamada Masahito、Miyoshi Ichiro、Mohri Shirou、Kitamoto Tetsuyuki
- Journal Title
  
  Brain Pathology
  
  Volume: 29 Issue: 2 Pages: 155-163
- DOI
  10.1111/bpa.12638
- NAID
  120006803949
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K07490, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738, KAKENHI-PROJECT-17K07129
[Journal Article] Anti-Horse Podoplanin Monoclonal Antibody PMab-219 is Useful for Detecting Lymphatic Endothelial Cells by Immunohistochemical Analysis2018
- Author(s)
  Kato Yukinari、Yamada Shinji、Itai Shunsuke、Kobayashi Atsushi、Konnai Satoru、Kaneko Mika K.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 6 Pages: 272-274
- DOI
  10.1089/mab.2018.0044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963
[Journal Article] Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-442018
- Author(s)
  Kato Yukinari、Yamada Shinji、Itai Shunsuke、Konnai Satoru、Kobayashi Atsushi、Kaneko Mika K.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 6 Pages: 269-271
- DOI
  10.1089/mab.2018.0037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05963
[Journal Article] Generation and validation of novel anti-bovine CD163 monoclonal antibodies ABM-1A9 and ABM-2D62018
- Author(s)
  Yoshinori Shimamoto, Junko Nio-Kobayashi, Hiroshi Watarai, Masashi Nagano, Natsuko Saito, Eiki Takahashi, Hidetoshi Higuchi, Atsushi Kobayashi, Takashi Kimura, Hiroshi Kitamura
- Journal Title
  
  Veterinary Immunology and Immunopathology
  
  Volume: 198 Pages: 6-13
- DOI
  10.1016/j.vetimm.2018.02.004
- NAID
  120006798133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06805, KAKENHI-PROJECT-17K08502, KAKENHI-PROJECT-16K14591, KAKENHI-PROJECT-18K05963, KAKENHI-PROJECT-18K06035, KAKENHI-PROJECT-16H05022
[Journal Article] Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene2018
- Author(s)
  Ito Yoko、Sanjo Nobuo、Hizume Masaki、Kobayashi Atsushi、Ohgami Tetsuya、Satoh Katsuya、Hamaguchi Tsuyoshi、Yamada Masahito、Kitamoto Tetsuyuki、Mizusawa Hidehiro、Yokota Takanori
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 496 Issue: 4 Pages: 1055-1061
- DOI
  10.1016/j.bbrc.2018.01.119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-18H02738
[Journal Article] c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium2017
- Author(s)
  Sehgal Anuj、Kobayashi Atsushi、Donaldson David S.、Mabbott Neil A.
- Journal Title
  
  Immunobiology
  
  Volume: 222 Issue: 2 Pages: 316-326
- DOI
  10.1016/j.imbio.2016.09.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Journal Article] Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification2016
- Author(s)
  Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shusei Uno and Tetsuyuki Kitamoto
- Journal Title
  
  Laboratory Investigation
  
  Volume: in press Issue: 5 Pages: 581-7
- DOI
  10.1038/labinvest.2016.27
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09307, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-16K18790
[Journal Article] Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases.2015
- Author(s)
  Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T.
- Journal Title
  
  Neuropathology.
  
  Volume: - Issue: 3 Pages: 305-310
- DOI
  10.1111/neup.12270
- NAID
  120006219897
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-16K18790
[Journal Article] Co-occurrence of types 1 and 2 PrPres in sporadic Creutzfeldt Jakob disease MM12011
- Author(s)
  Kobayashi A
- Journal Title
  
  Am J Pathol
  
  Volume: 178 Pages: 1309-1315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590922
[Journal Article] Experimental Verification of a Traceback Phenomenon in Prion Infection.2010
- Author(s)
  Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T.
- Journal Title
  
  J Virol. 84
  
  Pages: 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Journal Title
  
  J Virol
  
  Volume: 84 Pages: 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590922
[Journal Article] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Journal Title
  
  J Virol 84
  
  Pages: 3230-3238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] A traceback phenomenon can reveal the origin of prion infection2009
- Author(s)
  Kobayashi A
- Journal Title
  
  Neuropathology 29
  
  Pages: 619-624
- NAID
  10028192468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Amino acid conditions near the GPI anchor attachment site of prion protein for the conversion and the GPI anchoring.2009
- Author(s)
  Hizume M, Kobayashi A, Mizusawa H, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun. 391
  
  Pages: 1681-1686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] A traceback phenomenon can reveal the origin of prion infection.2009
- Author(s)
  Kobayashi A, Asano M, Mohri S, Kitamoto T.
- Journal Title
  
  Neuropathology 29
  
  Pages: 619-624
- NAID
  10028192468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] The number of octapeptide repeat affects the expression and conversion of prion protein.2009
- Author(s)
  Hiraga C, Kobayashi A, Kitamoto T.
- Journal Title
  
  Biochem Biophys Res Commun. 382
  
  Pages: 715-719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients2008
- Author(s)
  Kobayashi A
- Journal Title
  
  Acta Neuropathol 116
  
  Pages: 561-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790608
[Journal Article] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2007
- Author(s)
  Kobayashi A., Asano M., Mohri S., Kitamoto T.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 30022-30028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890017
[Presentation] Pathomechanisms of prion protein propagation2020
- Author(s)
  Atsushi Kobayashi
- Organizer
  第61回日本神経病理学会総会学術研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] An adverse outcome pathway-based assessment of steatogenic effects of imidacloprid in livers of C57BL/6J Male Mice2020
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Jussiaea V. BARIUAN, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, and Mayumi ISHIZUKA.
- Organizer
  The 8th Sapporo Summer Symposium for One Health (8th SaSSOH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] An adverse outcome pathway-based assessment of steatogenic effects of imidacloprid in livers of C57BL/6J Male Mice2020
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Jussiaea V. BARIUAN, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, and Mayumi ISHIZUKA
- Organizer
  環境化学オンライン研究発表会2020
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Potentiation of High Fat Diet-induced Diabetogenesis by Neonicotinoid Insecticides: Elucidation of the Mechanistic Pathways using In vivo Assays2019
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atushi KOBAYASHI, Shouta M.M. NAKAYAMA, Mayumi ISHIZUKA
- Organizer
  International CHEMICAL HAZARD Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Interactions of Imidacloprid with High Fat Diet Potentiate Signals of Type 2 Diabetogenesis in a Rodent Model2019
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Shouta M.M. NAKAYAMA and Mayumi ISHIZUKA
- Organizer
  第 3 回環境化学会北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Time trend of blood Pb concentration and toxicological effects of Pb gunshots through oral administration in waterfowl’s2019
- Author(s)
  Hiroshi Sato, Chihiro Ishii, Shouta M. M. Nakayama, Takahiro Ichise, Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara,Ryota Torimoto, Atushi Kobayashi, Takashi Kimura, Yoshinori Ikenaka, Mayumi Ishizuka
- Organizer
  第 3 回環境化学会北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] 孤発性クロイツフェルト・ヤコブ病におけるプリオン株混在の新規組み合わせ2019
- Author(s)
  小林篤史, 岩崎靖, 高尾昌樹, 齊藤祐子, 岩城徹, 毛利資郎, 北本哲之
- Organizer
  第60回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] Characterization of “sporadic CJD” with history of neurosurgery to identify potentially iatrogenic cases2019
- Author(s)
  Tsuyoshi Hamaguchi, Kenji Sakai, Atsushi Kobayashi, Tetsuyuki Kitamoto, Ryusuke Ae, Yosikazu Nakamura, Nobuo Sanjo, Kimihito Arai, Mizuho Koide, Fumiaki Katada, Masafumi Harada, Hiroyuki Murai, Shigeo Murayama, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada
- Organizer
  Asian Pacific Prion Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] Interactions of Imidacloprid with High Fat Diet Potentiate Signals of Type 2 Diabetogenesis in a Rodent Model2019
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Shouta M.M. NAKAYAMA and Mayumi ISHIZUKA
- Organizer
  The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] 鉛散弾の経口投与によるバルバリーガモの鉛の血中濃度の経時変化および体内分布の解析2019
- Author(s)
  佐藤裕、石井千尋、中山翔太、一瀬貴大、齊藤慶輔、渡邊有希子、小笠原浩平、鳥本亮太、小林篤史、木村亨史、池中良徳、石塚真由美
- Organizer
  第162回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Organ Pb distribution and temporal change of blood Pb concentrations with oral administration of Pb bullets in waterfowls and raptors2019
- Author(s)
  Hiroshi SATO, Chihiro ISHII, Shouta M. M. NAKAYAMA, Takahiro ICHISE, Keisuke SAITO, Yukiko WATANABE, Kohei OGASAWARA, Ryota TORIMOTO, Atushi KOBAYASHI, Takashi KIMURA, Yoshinori IKENAKA, Mayumi ISHIZUKA
- Organizer
  International Symposium on Chemical Hazard in Wildlife
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019
- Author(s)
  Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Shouta M.M. Nakayama, Mayumi Ishizuka
- Organizer
  第28回環境化学討論会
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] Elucidation of the Effects of Low Dose Exposures to Imidacloprid on Hepatic Lipid Homeostasis in a C57BL/6J Mice Model2019
- Author(s)
  Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, Mayumi ISHIZUKA
- Organizer
  International Symposium on Chemical Hazard in Wildlife
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease2019
- Author(s)
  Atsushi Kobayashi, Yasushi Iwasaki, Masaki Takao, Yuko Saito, Toru Iwaki, Shirou Mohri, Tetsuyuki Kitamoto
- Organizer
  Asian Pacific Prion Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019
- Author(s)
  Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Ryo Yamazaki, Shouta M.M. Nakayama, Mayumi Ishizuka
- Organizer
  SETAC-Australasia 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04132
[Presentation] What is abnormal prion protein (PrPSc)?2018
- Author(s)
  Atsushi Kobayashi
- Organizer
  19th International Congress of Neuropathology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] 遺伝性CJD-V180Iの脳に蓄積するプリオン蛋白の解明2018
- Author(s)
  三條伸夫、日詰正樹、伊藤陽子、小林篤史、佐藤克也、大上哲也、浜口毅、山田正仁、北本哲之、水澤英洋、横田隆徳
- Organizer
  第37回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] Characterization of “sporadic CJD” with history of neurosurgery to identify iatrogenic cases2018
- Author(s)
  Tsuyoshi Hamaguchi,1 Kenji Sakai,1 Atsushi Kobayashi,2 Tetsuyuki Kitamoto,3 Ryusuke Ae,4 Yosikazu Nakamura,4 Nobuo Sanjo,5 Kimihito Arai,6 Mizuho Koide,6 Fumiaki Katada,7 Masafumi Harada,8 Hiroyuki Murai,9 Shigeo Murayama,10 Tadashi Tsukamoto,10 Hidehiro Mizusawa,10 Masahito Yamada.1
- Organizer
  EuroCJD meeting 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05963
[Presentation] Diagnostic approach for a novel acquired CJD subgroup, acquired CJD-MMiK2017
- Author(s)
  Atsushi Kobayashi
- Organizer
  Asian Pacific Prion Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Neuropathological and biochemical criteria for a new subtype of acquired Creutzfeldt-Jakob disease (MMiK)2017
- Author(s)
  Atsushi Kobayashi, Masahito Yamada, Atsuko Takeuchi, Shirou Mohri, and Tetsuyuki Kitamoto
- Organizer
  第36回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Colocalization of Aβ42 with PrPSc-plaques in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation.2016
- Author(s)
  Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Canada, Toronto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Differential association of amyloid-β with PrPSc pathology in each genetic prion disease.2016
- Author(s)
  Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] 遺伝性プリオン病の病型毎のPrPScとAβの沈着パターンに関する病理学的解析2016
- Author(s)
  古川迪子、三條伸夫、小林篤史、浜口毅、山田正仁、北本哲之、水澤英洋、横田隆徳
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京都千代田区、東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Identification of the origin of Creutzfeldt-Jakob disease after cadaver-sourced pituitary growth hormone treatment using an amplification property in protein misfolding cyclic amplificatiton.2016
- Author(s)
  Takeuchi A, Yamamoto M, Parchi P, HaiK S, Morita M, Kobayashi A, Kitamoto T
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Iatrogenic transmission of Creutzfeldt-Jakob disease2016
- Author(s)
  Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Paul Brown, Daniela Saverioni, Yuichi Matsuura, Atsuko Takeuchi, Shirou Mohri, Tetsuyuki Kitamoto
- Organizer
  PRION2016
- Place of Presentation
  東京都千代田区、一ツ橋ホール
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Mechanisms of transmission of prion diseases2016
- Author(s)
  Atsushi Kobayashi
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫県神戸市、神戸ポートピアホテル
- Invited
- Data Source
  KAKENHI-PROJECT-16K18790
[Presentation] Experimental verification of a traceback phenomenon in prion infection2010
- Author(s)
  Kobayashi A
- Organizer
  Asia-Oceania Symposium on Prion Diseases
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-22590922
[Presentation] ヒト異常型プリオン蛋白特異的抗体の作製2009
- Author(s)
  小林篤史
- Organizer
  2009年プリオン研究会
- Place of Presentation
  宮城県
- Data Source
  KAKENHI-PROJECT-20790608
[Presentation] Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain2008
- Author(s)
  Kobayashi A., Asano M., Mohri S., Kitamoto T.
- Organizer
  Transmissible Spongiform Encephalopathies, The definitive American TSE Meeting
- Place of Presentation
  アメリカ合衆国,ボルチモア
- Year and Date
  2008-02-10
- Data Source
  KAKENHI-PROJECT-18890017

1. HOROUICHI MOTOHIRO (30219216)

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2. IKENAKA Yoshinori (40543509)

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# of Collaborated Products: 11 results
3. 竹内敦子 (00535239)

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4. 星信彦 (10209223)

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5. 川合佑典 (10709546)

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6. 石塚真由美 (50332474)

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# of Collaborated Products: 11 results
7. 久保田彰 (60432811)

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8. 水川葉月 (60612661)

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9. 有薗幸司 (70128148)

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10. 平野哲史 (70804590)

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11. 加藤恵介 (80276609)

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12. 宮原裕一 (80311330)

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13. 市川剛 (80438712)

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14. 岡松優子 (90527178)

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15. 中山翔太 (90647629)

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16. KURODA minori

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17. SHAN zhifu

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18. HAMAGUCHI Tsuyoshi

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19. KIMURA shunsuke

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20. TAKAHASHI eiki

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21. 山田正仁

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22. 青島圭佑

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23. 木村享史

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24. 北本哲之

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25. 北村浩

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KOBAYASHI Atsushi 小林 篤史

Kobayashi Atsushi 小林 篤史

Research Projects

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Co-Researchers

GPI付加シグナル配列が蛋白質ミスフォールディングを促進するメカニズムの解明Principal Investigator

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アルパカ重鎖抗体可変領域（VHH）を用いたプリオン病の新規治療法開発Principal Investigator

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Elucidation of the mechanisms of the prion protein misfoldingPrincipal Investigator

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Evaluation of Chemical Susceptibility Diversity by mlAOP Concept and its Application to Understanding Insecticide Poisoning

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Elucidation of the mechanisms of prion protein conversion caused by an amino acid substitution in glycosylphosphatidylinositol anchoring signal peptidePrincipal Investigator

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Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talk

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濾胞樹状細胞からのプリオン神経侵入経路の解明Principal Investigator

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Identification of the origin of prion infectionPrincipal Investigator

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培養細胞を用いたPMCA法によるヒトプリオンの増幅Principal Investigator

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[Book] Clinical Neuroscience, ニューロジェネティクス新時代－次世代シークエンサーが拓く新しい世界2018

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[Book] The Handbook of Clinical Neurology, Human Prion Diseases2018

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[Journal Article] 総説 プリオン病研究の進歩-医原性プリオン感染について2020

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[Journal Article] α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein2020

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KOBAYASHI Atsushi 小林篤史

Kobayashi Atsushi 小林篤史

[Journal Article] 総説プリオン病研究の進歩-医原性プリオン感染について2020