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NAKASHIMA DAI  中嶋 大

ORCIDConnect your ORCID iD *help
Researcher Number 50431747
Other IDs
Affiliation (Current) 2025: 千葉大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help 2025: 千葉大学, 医学部附属病院, 講師
2016 – 2024: 千葉大学, 大学院医学研究院, 助教
2017: 千葉大学, 医学部附属病院, 助教
2014 – 2015: 千葉大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords
Principal Investigator
Plod2 / コラーゲンクロスリンク / LH2 / 口腔扁平上皮癌 / Lysyl Hydroxylase 2 / 免疫チェックポイント阻害薬 / LH2-derived collagen線維 / inhibitor / tamoxifen / collagen barrier … More / KOマウス / ナノインデンテーション試験 / クロスリンク解析 / 口腔癌 / GFP標識癌細胞 / 転移モデル / 低酸素応答 / HIF1-α / HIF-1α / 胎生致死 / PLOD2 / CRISPR/Cas9 / ノックアウトマウス / 術前補助的化学療法 / AKT 経路 / AKT経路 / S-1 / 口腔扁上皮癌 / Decorin … More
Except Principal Investigator
口腔癌 / H3K27ac / スーパーエンハンサー / 口腔扁平上皮癌 / 環状RNA / non coding RNA / miRNA / エクソソーム / 遺伝子パスウェイ解析 / セツキシマブ / LH2-conditional KOマウス / リシン水酸化酵素2 / Collagen cross-link / Collagen Barrier / Collagen highway / LH2強制発現OSCC細胞株 / コラーゲン・ハイウェイ / リシン水酸化酵素2 / ノンコーディングRNA / 人工合成環状RNA / microRNA / スーパーエンハンサー薬剤耐性 / BRD4 / ChiPseq法 / PRAUR / 薬剤耐性 / CHIP-seq / CHIP-Seq / ChIP-seq / 抗癌剤耐性 / long non coding RNA / H3K27 / Chip-seq法 / スーパーエンハンサー(SE) / エピジェネティックな修飾 / 機能特異性 / 疾患特異性 / 組織特異性 / ChIP-seq 法 / CircRNA Array / circRNA miRNA / circRNA Array / circRNA / non codingRNA / 癌 / Ginkgolide B / CDDP / オート・クライン / PAFR / PAF / 樹状細胞 / ファージディスプレイ法 / ファージディスプレイ / ミサイル療法 / siRNA / drug delivery system / sh導入 / セツキシマブ耐性 / in vivo / MTS assay / cetuximab / PLAUR阻害薬 / 頭頸部癌 / Resveratrol / PLAUR / 耐性 / 頭頚部癌 Less
  • Research Projects

    (12 results)
  • Research Products

    (1 results)
  • Co-Researchers

    (13 People)
  •  口腔がん細胞の顎骨浸潤に対するLH2関連分子ネットワークの解明と制御薬剤の開発Principal Investigator

    • Principal Investigator
      中嶋 大
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of regulatory mechanisms of cancer cell metastasis focusing on both cancer cells and cancer-associated ECM by scRNA-seq analysis

    • Principal Investigator
      宮本 勲
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  LH2-Colをターゲットとする免疫チェックポイント耐性克服療法の開発Principal Investigator

    • Principal Investigator
      中嶋 大
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of the mechanism of inhibition of cancer progression and development of new drugs by artificial synthetic cyclic RNAs

    • Principal Investigator
      笠松 厚志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Development of therapeutic methods for drug-resistant oral cancer targeting super-enhancers

    • Principal Investigator
      Uzawa Katsuhiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of the mechanism of platelet-activating factor (PAF)-associated cell proliferation in cancer and non-cancer cells.

    • Principal Investigator
      Iyoda Manabu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Elucidation of the role of non-coding RNA adsorbed cyclic RNA in cancer growth invasion and metastasis.

    • Principal Investigator
      Kasamatsu Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明

    • Principal Investigator
      椎葉 正史
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Evaluate changes in collagen cross-linking in lysyl hydroxylase 2 knockout mice and elucidate the role of PLOD2 in cancer metastasisPrincipal Investigator

    • Principal Investigator
      Nakashima Dai
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Chiba University
  •  Development of siRNA / missile therapy using exosomes for oral cancer cells

    • Principal Investigator
      Uzawa Katsuhiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Elucidation of the resistant mechanism and the development of drugs for overcoming resistance against Cetuximab in head and neck cancer.

    • Principal Investigator
      OGAWARA Katsunori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University
  •  Development of the new predictive method of S-1 neoadjuvant chemosensitivity using DecorinPrincipal Investigator

    • Principal Investigator
      NAKASHIMA DAI
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Surgical dentistry
    • Research Institution
      Chiba University

All 2020

All Presentation

  • [Presentation] 安藤壽晃癌抑制型環状RNA: 口腔癌誘発性マイクロRNAの特異的吸着効果による新規診断法の開発2020

    • Author(s)
      安藤壽晃 鵜澤一弘 笠松厚志 田中希 野淵嵩史 駒綾香 大島早智 伊豫田学 中嶋大 坂本洋右 椎葉正史
    • Organizer
      日本口腔外科学会
    • Data Source
      KAKENHI-PROJECT-19H03847
  • 1.  Uzawa Katsuhiro (30302558)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 2.  Kasamatsu Atsushi (60375730)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 3.  丹沢 秀樹 (50236775)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  Iyoda Manabu (40431746)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  坂本 洋右 (50451745)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  椎葉 正史 (20301096)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OGAWARA Katsunori (20372360)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  大和地 正信 (70451747)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  小池 一幸 (10618060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  田村 裕 (50263174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  菅波 晃子 (10527922)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  関 直彦 (50345013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  宮本 勲 (00741836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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