NAKASHIMA DAI 中嶋大

Researcher Number	50431747
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 医学部附属病院, 講師 2016 – 2024: 千葉大学, 大学院医学研究院, 助教 2017: 千葉大学, 医学部附属病院, 助教 2014 – 2015: 千葉大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 口腔癌 / Plod2 / コラーゲンクロスリンク / LH2 / 口腔扁平上皮癌 / ATAC-seq / リシン水酸化酵素 2 / Lysyl Hydroxylase 2 / 免疫チェックポイント阻害薬 / LH2-derived collagen線維 … More / inhibitor / tamoxifen / collagen barrier / KOマウス / ナノインデンテーション試験 / クロスリンク解析 / GFP標識癌細胞 / 転移モデル / 低酸素応答 / HIF1-α / HIF-1α / 胎生致死 / PLOD2 / CRISPR/Cas9 / ノックアウトマウス / 術前補助的化学療法 / AKT 経路 / AKT経路 / S-1 / 口腔扁上皮癌 / Decorin … More Except Principal Investigator 口腔癌 / H3K27ac / スーパーエンハンサー / 口腔扁平上皮癌 / 環状RNA / non coding RNA / miRNA / エクソソーム / 遺伝子パスウェイ解析 / セツキシマブ / LH2-conditional KOマウス / リシン水酸化酵素2 / Collagen cross-link / Collagen Barrier / Collagen highway / LH2強制発現OSCC細胞株 / コラーゲン・ハイウェイ / リシン水酸化酵素２ / ノンコーディングRNA / 人工合成環状RNA / microRNA / スーパーエンハンサー薬剤耐性 / BRD4 / ChiPseq法 / PRAUR / 薬剤耐性 / CHIP-seq / CHIP-Seq / ChIP-seq / 抗癌剤耐性 / long non coding RNA / H3K27 / Chip-seq法 / スーパーエンハンサー(SE) / エピジェネティックな修飾 / 機能特異性 / 疾患特異性 / 組織特異性 / ChIP-seq 法 / CircRNA Array / circRNA miRNA / circRNA Array / circRNA / non codingRNA / 癌 / Ginkgolide B / CDDP / オート・クライン / PAFR / PAF / 樹状細胞 / ファージディスプレイ法 / ファージディスプレイ / ミサイル療法 / siRNA / drug delivery system / sh導入 / セツキシマブ耐性 / in vivo / MTS assay / cetuximab / PLAUR阻害薬 / 頭頸部癌 / Resveratrol / PLAUR / 耐性 / 頭頚部癌 Less

口腔がん細胞の顎骨浸潤に対するLH2関連分子ネットワークの解明と制御薬剤の開発Principal Investigator
- Principal Investigator
  
  中嶋大
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Elucidation of regulatory mechanisms of cancer cell metastasis focusing on both cancer cells and cancer-associated ECM by scRNA-seq analysis
- Principal Investigator
  
  宮本勲
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
LH2-Colをターゲットとする免疫チェックポイント耐性克服療法の開発Principal Investigator
- Principal Investigator
  
  中嶋大
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Elucidation of the mechanism of inhibition of cancer progression and development of new drugs by artificial synthetic cyclic RNAs
- Principal Investigator
  
  笠松厚志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of therapeutic methods for drug-resistant oral cancer targeting super-enhancers
- Principal Investigator
  
  Uzawa Katsuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Elucidation of the mechanism of platelet-activating factor (PAF)-associated cell proliferation in cancer and non-cancer cells.
- Principal Investigator
  
  Iyoda Manabu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Elucidation of the role of non-coding RNA adsorbed cyclic RNA in cancer growth invasion and metastasis.
- Principal Investigator
  
  Kasamatsu Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明
- Principal Investigator
  
  椎葉正史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Evaluate changes in collagen cross-linking in lysyl hydroxylase 2 knockout mice and elucidate the role of PLOD2 in cancer metastasisPrincipal Investigator
- Principal Investigator
  
  Nakashima Dai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of siRNA / missile therapy using exosomes for oral cancer cells
- Principal Investigator
  
  Uzawa Katsuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Elucidation of the resistant mechanism and the development of drugs for overcoming resistance against Cetuximab in head and neck cancer.
- Principal Investigator
  
  OGAWARA Katsunori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Development of the new predictive method of S-1 neoadjuvant chemosensitivity using DecorinPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA DAI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University

All 2020

All Presentation

[Presentation] 安藤壽晃癌抑制型環状RNA: 口腔癌誘発性マイクロRNAの特異的吸着効果による新規診断法の開発2020
- Author(s)
  安藤壽晃　鵜澤一弘　笠松厚志　田中希　野淵嵩史　駒綾香　大島早智　伊豫田学　中嶋大　坂本洋右　椎葉正史
- Organizer
  日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-19H03847

1. Uzawa Katsuhiro (30302558)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
2. Kasamatsu Atsushi (60375730)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
3. 丹沢秀樹 (50236775)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. Iyoda Manabu (40431746)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 坂本洋右 (50451745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 椎葉正史 (20301096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OGAWARA Katsunori (20372360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大和地正信 (70451747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小池一幸 (10618060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田村裕 (50263174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 菅波晃子 (10527922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 関直彦 (50345013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮本勲 (00741836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 福嶋玲雄 (00833576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 齋藤智昭 (40833554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKASHIMA DAI 中嶋 大

Research Projects

Research Products

Co-Researchers

口腔がん細胞の顎骨浸潤に対するLH2関連分子ネットワークの解明と制御薬剤の開発Principal Investigator

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LH2-Colをターゲットとする免疫チェックポイント耐性克服療法の開発Principal Investigator

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Principal Investigator

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Evaluate changes in collagen cross-linking in lysyl hydroxylase 2 knockout mice and elucidate the role of PLOD2 in cancer metastasisPrincipal Investigator

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Review Section

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Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

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Development of the new predictive method of S-1 neoadjuvant chemosensitivity using DecorinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Presentation] 安藤壽晃癌抑制型環状RNA: 口腔癌誘発性マイクロRNAの特異的吸着効果による新規診断法の開発2020

Author(s)

Organizer

Data Source

NAKASHIMA DAI 中嶋大