Koga Nobuyasu 古賀信康

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KOGA Nobuyasu 古賀信康

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Researcher Number	50432571
Other IDs
Affiliation (Current)	2022: 大阪大学, 蛋白質研究所, 教授 2022: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授(兼任)
Affiliation (based on the past Project Information) *help	2018 – 2022: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 准教授 2015 – 2017: 分子科学研究所, 協奏分子システム研究センター, 准教授
Review Section/Research Field	Principal Investigator Biophysics / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Complex systems
Keywords	Principal Investigator タンパク質分子デザイン / 分子モーター / F1-ATPase / 構造変化 / P-loop / 分子動力学シミュレーション / １分子回転計測実験 / 改造 / 分子シミュレーション / 計算機デザイン … More / 生化学実験 / 合理デザイン / 生物物理 / 分子モータータンパク質 / 計算機シミュレーション / シーソーモチーフ / タンパク質人工設計 / タンパク質複合体 … More Except Principal Investigator タンパク質デザイン / タンパク質 / 合理的設計 / 合理的デザイン / バイオインフォマティクス / 合理デザイン / 生物分子モーター / DNAナノテクノロジー / ATP加水分解酵素 Less

多様な形状の新規回転対称多量体タンパク質の合理デザインPrincipal Investigator
- Principal Investigator
  
  古賀信康
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
物理的に設計可能な蛋白質フォールド空間の解明：理論と実験的検証
- Principal Investigator
  
  千見寺浄慈
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Nagoya University
生体発動分子の創成：自然界の生体分子の改造とゼロからの設計
- Principal Investigator
  
  古田健也
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  National Institute of Information and Communications Technology
Understanding of the mechanisms of F1-ATPase by redesigning beta-subunit's P-loopPrincipal Investigator
- Principal Investigator
  
  KOGA Nobuyasu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
  Institute for Molecular Science

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 実験医学2019年11月号2019
- Author(s)
  小杉貴洋、古賀理恵、古賀信康
- Total Pages
  147
- Publisher
  羊土社
- ISBN
  9784758125253
- Data Source
  KAKENHI-PLANNED-18H05420
[Book] 実験医学2019年11月号　p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019
- Author(s)
  小杉貴洋、古賀理恵、古賀信康
- Total Pages
  147
- Publisher
  羊土社
- ISBN
  9784758125253
- Data Source
  KAKENHI-PLANNED-18H05420
[Book] 「化学」計算機でゼロからタンパク質をデザイン ―望みのタンパク質分子のテーラーメイド創出を目指して2016
- Author(s)
  古賀理恵, 古賀信康
- Total Pages
  80
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-15H05592
[Journal Article] タンパク質の合理設計技術開発2021
- Author(s)
  古賀理恵，古賀信康
- Journal Title
  
  化学と工業
  
  Volume: 74(8) Pages: 576-578
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Role of backbone strain in de novo design of complex α/β protein structures2021
- Author(s)
  Koga Nobuyasu、Koga Rie、Liu Gaohua、Castellanos Javier、Montelione Gaetano T.、Baker David
- Journal Title
  
  Nature Communications
  
  Volume: 12 Pages: 3921-3921
- DOI
  10.1038/s41467-021-24050-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Exploration of novel αβ-protein folds through <i>de novo</i> design2021
- Author(s)
  Minami Shintaro、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Koga Rie、Chikenji George、Koga Nobuyasu
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2021.08.06.455475
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] The register shift rules for βαβ-motifs for de novo protein design2021
- Author(s)
  Murata Hiroto、Imakawa Hayao、Koga Nobuyasu、Chikenji George
- Journal Title
  
  PLOS ONE
  
  Volume: 16
- DOI
  10.1371/journal.pone.0256895
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein2021
- Author(s)
  Mitsumoto Masaya、Sugaya Kanna、Kazama Kazuki、Nakano Ryosuke、Kosugi Takahiro、Murata Takeshi、Koga Nobuyasu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Pages: 12906-12906
- DOI
  10.3390/ijms222312906
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05420, KAKENHI-PLANNED-18H05425
[Journal Article] Positive Charge Introduction on the Surface of Thermostabilized PET Hydrolase Facilitates PET Binding and Degradation2021
- Author(s)
  Nakamura Akihiko、Kobayashi Naoya、Koga Nobuyasu、Iino Ryota
- Journal Title
  
  ACS Catalysis
  
  Volume: 11 Pages: 8550-8564
- DOI
  10.1021/acscatal.1c01204
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05420, KAKENHI-PROJECT-19H03094
[Journal Article] Design of complicated all-α protein structures2021
- Author(s)
  Sakuma Koya、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Suzuki Kano、Kobayashi Naoya、Murata Takeshi、Kosugi Takahiro、Koga Rie、Koga Nobuyasu
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2021.07.14.449347
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine2020
- Author(s)
  R. Koga, M. Yamamoto, K. Takahiro, N. Kobayashi, T. Sugiki, T. Fujiwara and N. Koga
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Pages: 31149-31156
- DOI
  10.1073/pnas.2002120117
- NAID
  120006952207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06152, KAKENHI-PLANNED-18H05420
[Journal Article] De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function2020
- Author(s)
  Kosugi Takahiro、Iida Tatsuya、Tanabe Mikio、Iino Ryota、Koga Nobuyasu
- Journal Title
  
  bioRxiv
  
  Volume: 2020.09.09
- DOI
  10.1101/2020.09.09.288571
- Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Consistency Principle for Protein Design2020
- Author(s)
  KOGA Rie、KOGA Nobuyasu
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 60 Pages: 325-330
- DOI
  10.2142/biophys.60.325
- NAID
  130007945849
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein2019
- Author(s)
  Basak Sujit、Nobrega R. Paul、Tavella Davide、Deveau Laura M.、Koga Nobuyasu、Tatsumi-Koga Rie、Baker David、Massi Francesca、Matthews C. Robert
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Pages: 6806-6811
- DOI
  10.1073/pnas.1818744116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Journal Article] ShadowR : a novel chromoprotein with reduced non-specific binding and improved expression in living cells2019
- Author(s)
  Murakoshi H., Horiuchi H., Kosugi T., Onda M., Sato A., Koga N., Nabekura J.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 12072-12072
- DOI
  10.1038/s41598-019-48604-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14825, KAKENHI-PUBLICLY-18H04748, KAKENHI-PUBLICLY-19H05434, KAKENHI-PROJECT-18H02708, KAKENHI-PROJECT-18K19382, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-18H05420
[Journal Article] Consistency principle for protein design2019
- Author(s)
  Koga Rie、Koga Nobuyasu
- Journal Title
  
  BIOPHYSICS
  
  Volume: 16 Issue: 0 Pages: 304-309
- DOI
  10.2142/biophysico.16.0_304
- NAID
  130007752765
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 整合性原理と新規タンパク質デザイン2022
- Author(s)
  古賀信康
- Organizer
  自然科学研究機構・計算科学研究センター, スーパーコンピューターワークショップ2021「生体分子の構造・機能・デザインの計算科学」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 創って理解する　生命現象をつかさどる分子「タンパク質」2022
- Author(s)
  古賀信康
- Organizer
  第33回自然科学研究機構シンポジウム「宇宙と、分子と、私たち」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Exploration of novel protein structures by de novo design2021
- Author(s)
  古賀信康
- Organizer
  OIST, Mini Symposium “New Protein by Evolution and Engineering”
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 合理設計による新規タンパク質配列空間の探索2021
- Author(s)
  古賀信康
- Organizer
  東京工業大学, Cell Biology Center Colloquium
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] De novo design of novel protein structures2021
- Author(s)
  古賀信康
- Organizer
  Molecular Engine International Mini-workshop「Molecular Engine in Virtual or Real World?」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 自然に観測されないトポロジーを持つタンパク質の人工設計2021
- Author(s)
  古賀信康
- Organizer
  ExCELLSシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] EXPLORATION OF NOVEL ALPHA-BETA PROTEIN FOLDS BY DE NOVO DESIGN2020
- Author(s)
  S. Minami, N. Kobayashi, T. Sugiki, R. Koga, G. Chikenji, N. Koga
- Organizer
  The Biophysical Society Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 合理設計による新規タンパク質フォールドの探索2020
- Author(s)
  古賀信康
- Organizer
  第５８回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03166
[Presentation] Biomolecular Design to Control their Functions2020
- Author(s)
  古賀信康
- Organizer
  第58回日本生物物理学会年会シンポジウム「Biomolecular Design to Control their Functions」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Exploration of novel protein folds by de novo design2020
- Author(s)
  古賀信康
- Organizer
  2020 World Conference on Protein Science 「Physics of Protein Evolution」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] 合理設計によるタンパク質配列空間の探索：NMRによる構造決定はその羅針盤2020
- Author(s)
  古賀信康
- Organizer
  大阪大学蛋白質研究所セミナ―
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Toward creation of artificial proteins self-assembling into diverse symmetric structures: computational design and experimental2020
- Author(s)
  N. Kobayashi, N. Koga
- Organizer
  The 1st International Symposium on Molecular Engine
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Exploration of novel protein folds by de novo design2020
- Author(s)
  古賀信康
- Organizer
  日本生物物理学会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] DESIGN OF GLOBIN-LIKE COMPLICATED FOLDS2020
- Author(s)
  K. Sakuma, N. Kobayashi, T. Sugiki, K. Suzuki, N. Kobayashi, T. Kosugi, T. Murata, R. Koga, N. Koga
- Organizer
  The Biophysical Society Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Toward creation of artificial proteins self-assembling into diverse symmetric structures: computational design and Experimental2020
- Author(s)
  N. Kobayashi, N. Koga
- Organizer
  The 1st International Symposium on Molecular Engine
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] De novo design of ATP-binding protein with two-domain structure2019
- Author(s)
  H. Yamada, K. Nakamura, T. Kosugi, N. Koga
- Organizer
  2nd Tokyo ATPase Workshop
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Exploration of novel alpha-beta protein folds by de novo design2019
- Author(s)
  S. Minami, R. Koga, G. Chikenji, T. Sugiki, N. Kobayashi
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19H03166
[Presentation] Rotation of the engineered F1-ATPase with non-catalytic α-type P-loops2018
- Author(s)
  上野博史, 古賀理恵、政池知子, 野地博行, 古賀信康
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] ヒンジ領域を非触媒型に置換した触媒サブユニットをもつ F1-ATPase の回転トルクと反応速度2018
- Author(s)
  佐藤友保, 上野博史, 林久美子, 古賀理恵, 古賀信康, 野地博行, 政池知子
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] Toward generation of de novo designed protein structure library2018
- Author(s)
  N. Koga
- Organizer
  Frontier Bio-organization forum 2018
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] DBTL in protein design2018
- Author(s)
  N. Koga
- Organizer
  Trends in Computational Molecular Biology
- Invited
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] Impact of the sequence difference of P-loop on the conformational changes of F1-ATPase2018
- Author(s)
  R. Koga, H. Ueno, T. Masaike, H. Noji, N. Koga
- Organizer
  The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
- Data Source
  KAKENHI-PLANNED-18H05420
[Presentation] F1-ATPaseの構造変化にα とβ のP-loop配列の違いが及ぼす影響2018
- Author(s)
  古賀理恵、上野博史, 政池知子, 野地博行, 古賀信康
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] Impact of the sequence difference of P-loop on the conformational changes of F1-ATPase2018
- Author(s)
  Rie Koga, Hiroshi Ueno, Tomoko Masaike, Hiroyuki Noji and Nobuyasu Koga
- Organizer
  The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] Rotation of the engineered F1-ATPase with α-type P-loop on catalytic β subunit2017
- Author(s)
  上野　博史、古賀　理恵、政池　知子、古賀　信康、野地　博行
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] 回転分子モーターF1-ATPaseの構造変化メカニズムの解明に向けて2017
- Author(s)
  古賀　理恵、上野　博史、政池　知子、野地　博行、古賀　信康
- Organizer
  第１７回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] タンパク質分子の合理設計2016
- Author(s)
  古賀信康
- Organizer
  東京大学第４回応化談話会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-12-18
- Invited
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] Synthetic approach for understanding molecular motors2016
- Author(s)
  古賀信康
- Organizer
  統合バイオ・リトリート
- Place of Presentation
  三河リゾートサンクス（愛知県西尾市）
- Year and Date
  2016-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] 分子モーターの合理デザイン：ゼロからの創製と自然界のタンパク質の改造2016
- Author(s)
  古賀信康
- Organizer
  分子モーター討論会
- Place of Presentation
  大阪大学蛋白質研究所（大阪府吹田市）
- Year and Date
  2016-07-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] A synthetic approach to understanding protein molecules2015
- Author(s)
  Nobuyasu Koga
- Organizer
  JST CREST-PRESTO joint international symposium
- Place of Presentation
  The University of Tokyo, Japan
- Year and Date
  2015-11-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] 主鎖二面角パターンによるαβ型タンパク質構造のデザイン2015
- Author(s)
  Yu-Ru Lin, 古賀理恵, Gaohua Liu, Gaetano T. Montelione, David Baker, 古賀信康
- Organizer
  日本生物物理学会
- Place of Presentation
  金沢大学角間キャンパス (石川県金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15H05592
[Presentation] Design of ideal protein structures2015
- Author(s)
  Nobuyasu Koga
- Organizer
  The 15th KIAS Conference on Protein Structure and Function, Korea Institute for Advanced Study
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-09-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05592

1. 千見寺浄慈 (10420366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 古田健也 (40571831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 小杉貴洋 (00771388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Koga Rie

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. Ueno Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. Noji Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. Masaike Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. MURATA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小林直宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村彰彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 堀内浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 村越秀治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鍋倉淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koga Nobuyasu 古賀 信康

KOGA Nobuyasu 古賀 信康

Research Projects

Research Products

Co-Researchers

多様な形状の新規回転対称多量体タンパク質の合理デザインPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

物理的に設計可能な蛋白質フォールド空間の解明：理論と実験的検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体発動分子の創成：自然界の生体分子の改造とゼロからの設計

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of the mechanisms of F1-ATPase by redesigning beta-subunit's P-loopPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学2019年11月号2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学2019年11月号 p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 「化学」計算機でゼロからタンパク質をデザイン ―望みのタンパク質分子のテーラーメイド創出を目指して2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] タンパク質の合理設計技術開発2021

Author(s)

Journal Title

Data Source

[Journal Article] Role of backbone strain in de novo design of complex α/β protein structures2021

Author(s)

Journal Title

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[Journal Article] Exploration of novel αβ-protein folds through <i>de novo</i> design2021

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[Journal Article] The register shift rules for βαβ-motifs for de novo protein design2021

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[Journal Article] State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein2021

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[Journal Article] Positive Charge Introduction on the Surface of Thermostabilized PET Hydrolase Facilitates PET Binding and Degradation2021

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[Journal Article] Design of complicated all-α protein structures2021

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Koga Nobuyasu 古賀信康

KOGA Nobuyasu 古賀信康

[Book] 実験医学2019年11月号　p.3089‐3095「合理デザインによる新規タンパク質の創出：現状とその可能性」2019

[Presentation] 創って理解する　生命現象をつかさどる分子「タンパク質」2022