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Koga Nobuyasu  古賀 信康

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KOGA Nobuyasu  古賀 信康

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Researcher Number 50432571
Other IDs
Affiliation (Current) 2022: 大阪大学, 蛋白質研究所, 教授
2022: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授(兼任)
Affiliation (based on the past Project Information) *help 2018 – 2022: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 准教授
2015 – 2017: 分子科学研究所, 協奏分子システム研究センター, 准教授
Review Section/Research Field
Principal Investigator
Biophysics / Basic Section 43020:Structural biochemistry-related
Except Principal Investigator
Basic Section 43020:Structural biochemistry-related / Complex systems
Keywords
Principal Investigator
タンパク質分子デザイン / 分子モーター / F1-ATPase / 構造変化 / P-loop / 分子動力学シミュレーション / 1分子回転計測実験 / 改造 / 分子シミュレーション / 計算機デザイン … More / 生化学実験 / 合理デザイン / 生物物理 / 分子モータータンパク質 / 計算機シミュレーション / シーソーモチーフ / タンパク質人工設計 / タンパク質複合体 … More
Except Principal Investigator
タンパク質デザイン / タンパク質 / 合理的設計 / 合理的デザイン / バイオインフォマティクス / 合理デザイン / 生物分子モーター / DNAナノテクノロジー / ATP加水分解酵素 Less
  • Research Projects

    (4 results)
  • Research Products

    (48 results)
  • Co-Researchers

    (13 People)
  •  多様な形状の新規回転対称多量体タンパク質の合理デザインPrincipal Investigator

    • Principal Investigator
      古賀 信康
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
  •  物理的に設計可能な蛋白質フォールド空間の解明:理論と実験的検証

    • Principal Investigator
      千見寺 浄慈
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Nagoya University
  •  生体発動分子の創成:自然界の生体分子の改造とゼロからの設計

    • Principal Investigator
      古田 健也
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      National Institute of Information and Communications Technology
  •  Understanding of the mechanisms of F1-ATPase by redesigning beta-subunit's P-loopPrincipal Investigator

    • Principal Investigator
      KOGA Nobuyasu
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Biophysics
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
      Institute for Molecular Science

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 実験医学2019年11月号2019

    • Author(s)
      小杉貴洋、古賀理恵、古賀信康
    • Total Pages
      147
    • Publisher
      羊土社
    • ISBN
      9784758125253
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Book] 実験医学2019年11月号 p.3089‐3095「合理デザインによる新規タンパク質の創出:現状とその可能性」2019

    • Author(s)
      小杉貴洋、古賀理恵、古賀信康
    • Total Pages
      147
    • Publisher
      羊土社
    • ISBN
      9784758125253
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Book] 「化学」計算機でゼロからタンパク質をデザイン ―望みのタンパク質分子のテーラーメイド創出を目指して2016

    • Author(s)
      古賀理恵, 古賀信康
    • Total Pages
      80
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Journal Article] タンパク質の合理設計技術開発2021

    • Author(s)
      古賀理恵,古賀信康
    • Journal Title

      化学と工業

      Volume: 74(8) Pages: 576-578

    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] Role of backbone strain in de novo design of complex α/β protein structures2021

    • Author(s)
      Koga Nobuyasu、Koga Rie、Liu Gaohua、Castellanos Javier、Montelione Gaetano T.、Baker David
    • Journal Title

      Nature Communications

      Volume: 12 Pages: 3921-3921

    • DOI

      10.1038/s41467-021-24050-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] Exploration of novel αβ-protein folds through <i>de novo</i> design2021

    • Author(s)
      Minami Shintaro、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Koga Rie、Chikenji George、Koga Nobuyasu
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.08.06.455475

    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] The register shift rules for βαβ-motifs for de novo protein design2021

    • Author(s)
      Murata Hiroto、Imakawa Hayao、Koga Nobuyasu、Chikenji George
    • Journal Title

      PLOS ONE

      Volume: 16

    • DOI

      10.1371/journal.pone.0256895

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] State-Targeting Stabilization of Adenosine A2A Receptor by Fusing a Custom-Made De Novo Designed α-Helical Protein2021

    • Author(s)
      Mitsumoto Masaya、Sugaya Kanna、Kazama Kazuki、Nakano Ryosuke、Kosugi Takahiro、Murata Takeshi、Koga Nobuyasu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Pages: 12906-12906

    • DOI

      10.3390/ijms222312906

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05420, KAKENHI-PLANNED-18H05425
  • [Journal Article] Positive Charge Introduction on the Surface of Thermostabilized PET Hydrolase Facilitates PET Binding and Degradation2021

    • Author(s)
      Nakamura Akihiko、Kobayashi Naoya、Koga Nobuyasu、Iino Ryota
    • Journal Title

      ACS Catalysis

      Volume: 11 Pages: 8550-8564

    • DOI

      10.1021/acscatal.1c01204

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05420, KAKENHI-PROJECT-19H03094
  • [Journal Article] Design of complicated all-α protein structures2021

    • Author(s)
      Sakuma Koya、Kobayashi Naohiro、Sugiki Toshihiko、Nagashima Toshio、Fujiwara Toshimichi、Suzuki Kano、Kobayashi Naoya、Murata Takeshi、Kosugi Takahiro、Koga Rie、Koga Nobuyasu
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.07.14.449347

    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] Robust folding of a de novo designed ideal protein even with most of the core mutated to valine2020

    • Author(s)
      R. Koga, M. Yamamoto, K. Takahiro, N. Kobayashi, T. Sugiki, T. Fujiwara and N. Koga
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Pages: 31149-31156

    • DOI

      10.1073/pnas.2002120117

    • NAID

      120006952207

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06152, KAKENHI-PLANNED-18H05420
  • [Journal Article] De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function2020

    • Author(s)
      Kosugi Takahiro、Iida Tatsuya、Tanabe Mikio、Iino Ryota、Koga Nobuyasu
    • Journal Title

      bioRxiv

      Volume: 2020.09.09

    • DOI

      10.1101/2020.09.09.288571

    • Open Access
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] Consistency Principle for Protein Design2020

    • Author(s)
      KOGA Rie、KOGA Nobuyasu
    • Journal Title

      Seibutsu Butsuri

      Volume: 60 Pages: 325-330

    • DOI

      10.2142/biophys.60.325

    • NAID

      130007945849

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein2019

    • Author(s)
      Basak Sujit、Nobrega R. Paul、Tavella Davide、Deveau Laura M.、Koga Nobuyasu、Tatsumi-Koga Rie、Baker David、Massi Francesca、Matthews C. Robert
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Pages: 6806-6811

    • DOI

      10.1073/pnas.1818744116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Journal Article] ShadowR : a novel chromoprotein with reduced non-specific binding and improved expression in living cells2019

    • Author(s)
      Murakoshi H., Horiuchi H., Kosugi T., Onda M., Sato A., Koga N., Nabekura J.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 12072-12072

    • DOI

      10.1038/s41598-019-48604-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14825, KAKENHI-PUBLICLY-18H04748, KAKENHI-PUBLICLY-19H05434, KAKENHI-PROJECT-18H02708, KAKENHI-PROJECT-18K19382, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-18H05420
  • [Journal Article] Consistency principle for protein design2019

    • Author(s)
      Koga Rie、Koga Nobuyasu
    • Journal Title

      BIOPHYSICS

      Volume: 16 Issue: 0 Pages: 304-309

    • DOI

      10.2142/biophysico.16.0_304

    • NAID

      130007752765

    • ISSN
      2189-4779
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 整合性原理と新規タンパク質デザイン2022

    • Author(s)
      古賀信康
    • Organizer
      自然科学研究機構・計算科学研究センター, スーパーコンピューターワークショップ2021「生体分子の構造・機能・デザインの計算科学」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 創って理解する 生命現象をつかさどる分子「タンパク質」2022

    • Author(s)
      古賀信康
    • Organizer
      第33回自然科学研究機構シンポジウム「宇宙と、分子と、私たち」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Exploration of novel protein structures by de novo design2021

    • Author(s)
      古賀信康
    • Organizer
      OIST, Mini Symposium “New Protein by Evolution and Engineering”
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 合理設計による新規タンパク質配列空間の探索2021

    • Author(s)
      古賀信康
    • Organizer
      東京工業大学, Cell Biology Center Colloquium
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] De novo design of novel protein structures2021

    • Author(s)
      古賀信康
    • Organizer
      Molecular Engine International Mini-workshop「Molecular Engine in Virtual or Real World?」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 自然に観測されないトポロジーを持つタンパク質の人工設計2021

    • Author(s)
      古賀信康
    • Organizer
      ExCELLSシンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] EXPLORATION OF NOVEL ALPHA-BETA PROTEIN FOLDS BY DE NOVO DESIGN2020

    • Author(s)
      S. Minami, N. Kobayashi, T. Sugiki, R. Koga, G. Chikenji, N. Koga
    • Organizer
      The Biophysical Society Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 合理設計による新規タンパク質フォールドの探索2020

    • Author(s)
      古賀信康
    • Organizer
      第58回日本生物物理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03166
  • [Presentation] Biomolecular Design to Control their Functions2020

    • Author(s)
      古賀信康
    • Organizer
      第58回日本生物物理学会年会シンポジウム「Biomolecular Design to Control their Functions」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Exploration of novel protein folds by de novo design2020

    • Author(s)
      古賀信康
    • Organizer
      2020 World Conference on Protein Science 「Physics of Protein Evolution」
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] 合理設計によるタンパク質配列空間の探索:NMRによる構造決定はその羅針盤2020

    • Author(s)
      古賀信康
    • Organizer
      大阪大学蛋白質研究所セミナ―
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Toward creation of artificial proteins self-assembling into diverse symmetric structures: computational design and experimental2020

    • Author(s)
      N. Kobayashi, N. Koga
    • Organizer
      The 1st International Symposium on Molecular Engine
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Exploration of novel protein folds by de novo design2020

    • Author(s)
      古賀信康
    • Organizer
      日本生物物理学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] DESIGN OF GLOBIN-LIKE COMPLICATED FOLDS2020

    • Author(s)
      K. Sakuma, N. Kobayashi, T. Sugiki, K. Suzuki, N. Kobayashi, T. Kosugi, T. Murata, R. Koga, N. Koga
    • Organizer
      The Biophysical Society Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Toward creation of artificial proteins self-assembling into diverse symmetric structures: computational design and Experimental2020

    • Author(s)
      N. Kobayashi, N. Koga
    • Organizer
      The 1st International Symposium on Molecular Engine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] De novo design of ATP-binding protein with two-domain structure2019

    • Author(s)
      H. Yamada, K. Nakamura, T. Kosugi, N. Koga
    • Organizer
      2nd Tokyo ATPase Workshop
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Exploration of novel alpha-beta protein folds by de novo design2019

    • Author(s)
      S. Minami, R. Koga, G. Chikenji, T. Sugiki, N. Kobayashi
    • Organizer
      第57回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03166
  • [Presentation] Rotation of the engineered F1-ATPase with non-catalytic α-type P-loops2018

    • Author(s)
      上野博史, 古賀理恵、政池知子, 野地博行, 古賀信康
    • Organizer
      第56回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] ヒンジ領域を非触媒型に置換した触媒サブユニットをもつ F1-ATPase の回転トルクと反応速度2018

    • Author(s)
      佐藤友保, 上野博史, 林久美子, 古賀理恵, 古賀信康, 野地博行, 政池知子
    • Organizer
      第56回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] Toward generation of de novo designed protein structure library2018

    • Author(s)
      N. Koga
    • Organizer
      Frontier Bio-organization forum 2018
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] DBTL in protein design2018

    • Author(s)
      N. Koga
    • Organizer
      Trends in Computational Molecular Biology
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] Impact of the sequence difference of P-loop on the conformational changes of F1-ATPase2018

    • Author(s)
      R. Koga, H. Ueno, T. Masaike, H. Noji, N. Koga
    • Organizer
      The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
    • Data Source
      KAKENHI-PLANNED-18H05420
  • [Presentation] F1-ATPaseの構造変化にα とβ のP-loop配列の違いが及ぼす影響2018

    • Author(s)
      古賀理恵、上野博史, 政池知子, 野地博行, 古賀信康
    • Organizer
      第56回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] Impact of the sequence difference of P-loop on the conformational changes of F1-ATPase2018

    • Author(s)
      Rie Koga, Hiroshi Ueno, Tomoko Masaike, Hiroyuki Noji and Nobuyasu Koga
    • Organizer
      The 79th Okazaki Conference: Synthetic, Biological, and Hybrid Molecular Engines
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] Rotation of the engineered F1-ATPase with α-type P-loop on catalytic β subunit2017

    • Author(s)
      上野 博史、古賀 理恵、政池 知子、古賀 信康、野地 博行
    • Organizer
      第55回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] 回転分子モーターF1-ATPaseの構造変化メカニズムの解明に向けて2017

    • Author(s)
      古賀 理恵、上野 博史、政池 知子、野地 博行、古賀 信康
    • Organizer
      第17回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] タンパク質分子の合理設計2016

    • Author(s)
      古賀信康
    • Organizer
      東京大学第4回応化談話会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-12-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] Synthetic approach for understanding molecular motors2016

    • Author(s)
      古賀信康
    • Organizer
      統合バイオ・リトリート
    • Place of Presentation
      三河リゾートサンクス(愛知県西尾市)
    • Year and Date
      2016-11-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] 分子モーターの合理デザイン:ゼロからの創製と自然界のタンパク質の改造2016

    • Author(s)
      古賀信康
    • Organizer
      分子モーター討論会
    • Place of Presentation
      大阪大学蛋白質研究所(大阪府吹田市)
    • Year and Date
      2016-07-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] A synthetic approach to understanding protein molecules2015

    • Author(s)
      Nobuyasu Koga
    • Organizer
      JST CREST-PRESTO joint international symposium
    • Place of Presentation
      The University of Tokyo, Japan
    • Year and Date
      2015-11-05
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] 主鎖二面角パターンによるαβ型タンパク質構造のデザイン2015

    • Author(s)
      Yu-Ru Lin, 古賀理恵, Gaohua Liu, Gaetano T. Montelione, David Baker, 古賀信康
    • Organizer
      日本生物物理学会
    • Place of Presentation
      金沢大学 角間キャンパス (石川県金沢市)
    • Year and Date
      2015-09-13
    • Data Source
      KAKENHI-PROJECT-15H05592
  • [Presentation] Design of ideal protein structures2015

    • Author(s)
      Nobuyasu Koga
    • Organizer
      The 15th KIAS Conference on Protein Structure and Function, Korea Institute for Advanced Study
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-09-17
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05592
  • 1.  千見寺 浄慈 (10420366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  古田 健也 (40571831)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  小杉 貴洋 (00771388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  Koga Rie
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 5.  Ueno Hiroshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 6.  Noji Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  Masaike Tomoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 8.  MURATA Takeshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  小林 直宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  中村 彰彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  堀内 浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  村越 秀治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  鍋倉 淳一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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