Tsuchiya Kosuke 土屋晃介

… Alternative Names

Researcher Number	50437216
Other IDs	https://orcid.org/0000-0001-8540-6920
External Links
Affiliation (Current)	2021: 金沢大学, がん進展制御研究所, 准教授
Affiliation (based on the past Project Information) *help	2014 – 2020: 金沢大学, がん進展制御研究所, 助教 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 助教 2007 – 2010: Kyoto University, 医学研究科, 助教 2008: Kyoto University, 大学院・医学研究科, 助教
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including mycology) / Basic Section 49050:Bacteriology-related Except Principal Investigator Basic Section 49050:Bacteriology-related
Keywords	Principal Investigator リステリア / 自然免疫 / インフラマソーム / AIM2 / NLRP3 / ASC / 細胞内寄生菌 / カスパーゼ1 / 肺炎球菌 / 感染防御 … More Except Principal Investigator パイロトーシス / 生理活性物質 / リステリア Less

パイロトーシス細胞が放出するリステリア増殖抑制因子の解析Ongoing
- Principal Investigator
  
  須田貴司
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kanazawa University
Host-pathogen interactions in antibiotic therapy for listeriosisPrincipal InvestigatorOngoing
- Principal Investigator
  
  土屋晃介
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kanazawa University
Caspase-1-independent roles for inflammasome-forming proteins in bacterial infectionsPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Kohsuke
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kanazawa University
Role of the inflammasome in bacterial infectionsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Kohsuke
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Roles for intracellular innate immune receptors in host responses to Listeria monocytogenes infectionPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Kohsuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University
Analysis on the induction mechanism of innate immune response to Listeria monocytogenes through Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Kohsuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto University

[Book] パイロトーシスの分子機構と意義2016
- Author(s)
  土屋晃介
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26460523
[Book] 生体の科学：AIM2（absent in melanoma 2）はインフラマソームの活性化に関与する2011
- Author(s)
  土屋晃介、光山正雄
- Total Pages
  6
- Publisher
  （財）金原一郎医学医療振興財団・医学書院
- Data Source
  KAKENHI-PROJECT-23590504
[Book] 感染・炎症・免疫：細胞質内リステリアの認識に関わる新規分子AIM22011
- Author(s)
  土屋晃介
- Total Pages
  3
- Publisher
  医薬の門社
- Data Source
  KAKENHI-PROJECT-23590504
[Journal Article] Inflammasome-associated Cell Death: Pyroptosis, Apoptosis, and Physiological Implications.2020
- Author(s)
  Tsuchiya K.
- Journal Title
  
  Microbiology and Immunology
  
  Volume: In press
- DOI
  10.1111/1348-0421.12771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07106
[Journal Article] Caspase-7 mediates caspase-1-induced apoptosis independently of Bid.2020
- Author(s)
  Mahib M.R., Hosojima S., Kushiyama H., Kinoshita T., Shiroishi T., Suda T.*, Tsuchiya K.
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 64 Pages: 143-152
- DOI
  10.1111/1348-0421.12756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07106
[Journal Article] ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.2019
- Author(s)
  Fang R., Uchiyama R., Sakai S., Hara H., Tsutsui H., Suda T., Mitsuyama M., Kawamura I., Tsuchiya K.
- Journal Title
  
  Mucosal Immunology
  
  Volume: 12 Pages: 1092-1103
- DOI
  10.1038/s41385-019-0181-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07106
[Journal Article] Caspase-1 initiates apoptosis in the absence of gasdermin D.2019
- Author(s)
  Tsuchiya K, Nakajima S, SHosojima S, Nguyen DT, Hattori T, Le TM, Hori O, Mahib MR, Yamaguchi Y, Miura M, Kinoshita T, Kushiyama H, Sakurai M, Shiroishi T, Suda T
- Journal Title
  
  Nat Commun.
  
  Volume: In press Pages: 2091-2091
- DOI
  10.1038/s41467-019-09753-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07106, KAKENHI-PROJECT-18K06500, KAKENHI-PROJECT-18K06501, KAKENHI-PROJECT-18KK0435
[Journal Article] Pneumolysin-Dependent Calpain Activation and Interleukin-1α Secretion in Macrophages Infected with Streptococcus pneumoniae.2017
- Author(s)
  Fang R, Wu R, Du H, Jin M, Liu Y, Lei G, Jiang B, Lei Z, Peng Y, Nie K, Tsuchiya K.
- Journal Title
  
  Infect Immun.
  
  Volume: 85
- DOI
  10.1128/iai.00201-17
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460523
[Journal Article] Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation.2016
- Author(s)
  Zhang P, Tsuchiya K, Kinoshita T, Kushiyama H, Suidasari S, Hatakeyama M, Imura H, Kato N, Suda T.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Pages: 24517-24527
- DOI
  10.1074/jbc.m116.743815
- NAID
  120005983002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26110002, KAKENHI-PROJECT-25288064, KAKENHI-PROJECT-26460523
[Journal Article] Serum Syndecan-4 as a Possible Biomarker in Patients With Acute Pneumonia.2016
- Author(s)
  Nikaido T, Tanino Y, Wang X, Sato S, Misa K, Fukuhara N, Sato Y, Fukuhara A, Uematsu M, Suzuki Y, Kojima T, Tanino M, Endo Y, Tsuchiya K, Kawamura I, Frevert C, Munakata M
- Journal Title
  
  J Infect Dis.
  
  Volume: 212 Pages: 1500-1508
- DOI
  10.1093/infdis/jiv234
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-25460596, KAKENHI-PROJECT-26460523, KAKENHI-PROJECT-25293129
[Journal Article] A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.2016
- Author(s)
  Kochi, Y., Miyashita, A., Tsuchiya, K., Mitsuyama, M., Sekimizu, K., and Kaito, C.
- Journal Title
  
  FEMS Microbiology Lett.
  
  Volume: 363
- DOI
  10.1093/femsle/fnw163
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26460523, KAKENHI-PROJECT-16K15274
[Journal Article] Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death.2015
- Author(s)
  Hashino M, Tachibana M, Nishida T, Hara H, Tsuchiya K, Mitsuyama M, Watanabe K, Shimizu T, Watarai M.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 6 Pages: 1145-1145
- DOI
  10.3389/fmicb.2015.01145
- NAID
  120005947001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460523, KAKENHI-PROJECT-13J05928, KAKENHI-PROJECT-24590524
[Journal Article] The inflammasome and its regulation.2014
- Author(s)
  Tsuchiya K, Hara H.
- Journal Title
  
  Crit Rev Immunol.
  
  Volume: 34 Pages: 41-80
- DOI
  10.1615/critrevimmunol.2013008686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590504
[Journal Article] The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL-18 production in an inflammasome-dependent and -independent manner.2014
- Author(s)
  Tsuchiya K, Hara H, Fang R, Hernandez-Cuellar E, Sakai S, Daim S, Chen X, Dewamitta SR, Qu H, Mitsuyama M, Kawamura I.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Pages: 3696-3707
- DOI
  10.1002/eji.201444673
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-26460523
[Journal Article] Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae infection.2014
- Author(s)
  Fang R, Hara H, Sakai S, Hernandez-Cuellar E, Mitsuyama M, Kawamura I, Tsuchiya K.
- Journal Title
  
  Infect. Immun.
  
  Volume: 82 Pages: 2310-2317
- DOI
  10.1128/iai.01572-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-26460523
[Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation2014
- Author(s)
  Yang R, Xi C, Sita DR, Sakai S, Tsuchiya K, Hara H, Shen Y, Qu H, Fang R, Mitsuyama M, Kawamura I.
- Journal Title
  
  Pathog Dis
  
  Volume: 70 Pages: 51-60
- DOI
  10.1111/2049-632x.12075
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24590524
[Journal Article] Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity.2013
- Author(s)
  Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 14 Pages: 1247-1255
- DOI
  10.1038/ni.2749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24590524
[Journal Article] Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection2012
- Author(s)
  Endo Y, et al.
- Journal Title
  
  J. Immunol.
  
  Volume: 189 Pages: 5860-5866
- DOI
  10.4049/jimmunol.1200836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22570144, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590522
[Journal Article] Nitric oxide inhibits the NLRP3 inflammasome.2012
- Author(s)
  Hernandez-Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, Akira S, Mitsuyama M
- Journal Title
  
  J Immunol
  
  Volume: 189 Pages: 2012-2012
- DOI
  10.4049/jimmunol.1202479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-23890087, KAKENHI-PROJECT-24590522, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659196
[Journal Article] Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability.2012
- Author(s)
  Yamamoto T, Hara H, Tsuchiya K, Sakai S, Fang R, Matsuura M, Nomura T, Sato F, Mitsuyama M, Kawamura I
- Journal Title
  
  Infect. Immun.
  
  Volume: 80 Pages: 2323-2332
- DOI
  10.1128/iai.06162-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-24590523, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659196
[Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.2011
- Author(s)
  Sylvia Daim、河村伊久雄、土屋晃介, 他8名
- Journal Title
  
  Journal of Medical Microbiology
  
  Volume: 60 Pages: 5182-591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Critical role of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniaeinfection2011
- Author(s)
  R. Fang, K. Tsuchiya, I. Kawamura, Y. Shen, H. Hara, S. Sakai, T. Yamamoto, T. Fernandes-Alnemri, R. Yang, E. Hernandez-Cuellar, S. R. Dewamitta, Y. Xu, H. Qu, E. S. Alnemri, and M. Mitsuyama
- Journal Title
  
  Journal of Immunology
  
  Volume: 187 Pages: 4890-4899
- DOI
  10.4049/jimmunol.1100381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590479, KAKENHI-PROJECT-22390082, KAKENHI-PROJECT-23590504, KAKENHI-PROJECT-23890087
[Journal Article] PD-1-PDL-1 pathawy impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin.2010
- Author(s)
  酒井俊祐、河村伊久雄、岡崎拓、土屋晃介, 他2名
- Journal Title
  
  International Immunology
  
  Volume: 22 Pages: 912-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenea.2010
- Author(s)
  Sita R.Dewamitta、野村卓正、河村伊久雄、原英樹、土屋晃介, (他8名)
- Journal Title
  
  Infection and Immunity
  
  Volume: 78 Pages: 1884-1894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes2010
- Author(s)
  Sita R.Dewamitta、野村卓正、河村伊久雄、原英樹、土屋晃介, 他8名
- Journal Title
  
  Infection and Immunity 78巻
  
  Pages: 1884-1894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages2010
- Author(s)
  Yanna Shen、河村伊久雄、野村卓正、土屋晃介, 他7名
- Journal Title
  
  nfection and Immunity 78巻
  
  Pages: 2857-2867
- NAID
  120002381103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  土屋晃介、原英樹、河村伊久雄, 他7名
- Journal Title
  
  The Journal of Immunology 185巻
  
  Pages: 1186-1195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenea.2010
- Author(s)
  土屋晃介、原英樹、河村伊久雄, 他7名
- Journal Title
  
  The Jouraal of Immunology
  
  Volume: 185 Pages: 1186-1195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Racl activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.2010
- Author(s)
  Yanna Shen、河村伊久雄、野村卓正、土屋晃介, 他7名
- Journal Title
  
  Infection and Immunity
  
  Volume: 78 Pages: 2857-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpa in activation and interleukin-1 alpha secretion in macrophages infected with List eria monocytogenes.2010
- Author(s)
  Dewamitta S.R., Nomura T., Kawamura I., Hara H., Tsuchiya K., Kurenuma T., Shen Y., Daim S., Yamamoto T., Qu H., Sakai S., Xu Y., Mitsuyama M.
- Journal Title
  
  Infection and Immunity 78
  
  Pages: 1884-1894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages2010
- Author(s)
  Sylvia Daim、河村伊久雄、土屋晃介, 他8名
- Journal Title
  
  Journal of Medical Microbiology 60巻
  
  Pages: 5182-5191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] PD-1-PDL-1 pathawy impairs Th1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guerin2010
- Author(s)
  酒井俊祐、河村伊久雄、岡崎拓、土屋晃介, 他2名
- Journal Title
  
  International Immunology 22巻
  
  Pages: 912-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages.2009
- Author(s)
  Kurenuma T., Kawamura I., Hara H., Uchiyama R., Daim S., Dewamitta S.R., Sakai S., Tsuchiya K., Nomura T., Mitsuyama M.
- Journal Title
  
  Infection and Immunity 77
  
  Pages: 3992-4001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages2009
- Author(s)
  暮沼武士、河村伊久雄、原英樹、内山良介、Daim S.、Dewamitta S.R.、井俊祐、土屋晃介, 他2名
- Journal Title
  
  Infection and Immunity 77巻(有)
  
  Pages: 3992-4001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790416
[Journal Article] Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytoplasm2008
- Author(s)
  Hara H, Tsuchiya K, Nomura T, Kawamura I, Shoma S, Mitsuyama M
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 7859-7868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro : a novel function of pneumolysin in casoase-1 activation2008
- Author(s)
  Shoma S, Tsuchiya K, Kawamura I, Nomura T, Hara H, Uchiyama R, Daim S, Mitsuyama M
- Journal Title
  
  Infection and Immunity 76
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-I-Dependent Cylokines in Infeclion with Streptococcus pneumoniae in vitro: a Novel function of pneumolysin in Caspase-1 Activation2008
- Author(s)
  Shereen Shoma. Kohsuke Tsuchiya. Ikuo Kawamura, Takamasa Nomura, Hideki Hara, Pyosuke Uchiyama. Sylvia Daim, and Masao Mitsuyama
- Journal Title
  
  Infection and Immunity 76
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Critical involvement of pneumolysin in production of interleukin-lalpa and caspase-1-depentdent cytokines in infection with Streptococcus pneumoniae in vitro : a novel function of pneumolysin in caspase-1 activation2008
- Author(s)
  Shoma S, Tsuchiya K, Kawamura I, Nomura T, Hara H, Uchiyama R, Daim S, Mitsuyama M.
- Journal Title
  
  Infection and Immunity 76
  
  Pages: 1547-1557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Dependency of caspase-1 activation induced in macrophages by Listeria monocytogenes on cytolysin, listeriolysin O, after evasion from phagosome into the cytolpas,2008
- Author(s)
  Hara H, Tsuchiya K, Nomura T, Kawamura I, Shoma S, Mitsuyama M.
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 7859-7868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Involvement of Caspase-9 in the Inhibition of Necrosis of RAW 264 Cells Infected with Mycobacterium tubereulosis2007
- Author(s)
  Ryosuke Uchiyama, Ikuo Kawamura, Takao Fujimura, Michiko Kawanishi. Kohsuke Tsuchiya, Takanari Tominaga, Taijin Kaku, Yutaka Fukasawa, Shunsuke Sakai, Takamasa Nomura. and Masao Mitsuyama
- Journal Title
  
  Infection and Immunity 75
  
  Pages: 2894-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuverculosis2007
- Author(s)
  Uchiyama R, Kawamura I, Fujimura T, Kawanishi M, Tsuchiya K, Tominaga T, Kaku T, Fukasawa Y, Sakai S, Nomura T, Mitsuyama M.
- Journal Title
  
  Infection and Immunity 75
  
  Pages: 2894-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Cytolysin-Depcndent Escape of the Bacterium From the Phagosome Is Required but Not Surricient For Induction of the thi Immune Response against Listeria monocytogenes Infection: Distinct Role of Listeriolysin O Determined by Cytolysin Gene Replacement2007
- Author(s)
  Hideki Hara. Ikuo Kawamura, Takamasa Nomura, Takanari Tominaga, Kohsuke Tsuchiya, and Masao Mitsuyama
- Journal Title
  
  Infection and Immunity 75
  
  Pages: 3791-3801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Journal Article] Cytolysin-dependent escape of the bacterium from the phagosome is required but not sufficient for induction of the Th1 Immune rewponse against Listeria monocytogenes infection : distinct role of Listeriolysin O determined by cytolysin gene replacement2007
- Author(s)
  Hara H, Kawamura I, Nomura T, Tominaga T, Tsuchiya K, Mitsuyama M.
- Journal Title
  
  Infection and Immunity 75
  
  Pages: 3791-3801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Gasdermin D (GSDMD) mediates IL-1α maturation during inflammasome formation.2019
- Author(s)
  Tsuchiya K, Suda T.
- Organizer
  第 48 回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07106
[Presentation] Pyroptosis enhances antibiotic therapy of listeriosis.2019
- Author(s)
  Tsuchiya K, Suda T.
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18K07106
[Presentation] Caspase-1 initiates apoptosis in the absence of gasdermin D.2019
- Author(s)
  Tsuchiya K, Mahib MR, Suda T.
- Organizer
  The 17th International Congress of Immunology (IUIS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07106
[Presentation] Pyroptosis enhances killing of Listeria monocytogenes by ampicillin in vivo2018
- Author(s)
  土屋晃介（筆頭演者）ほか
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07106
[Presentation] Caspase-1 initiates apoptosis in the absence of gasdermin D2018
- Author(s)
  土屋晃介（筆頭演者）ほか
- Organizer
  第27回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07106
[Presentation] Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D (GSDMD).2017
- Author(s)
  Kohsuke Tsuchiya, Nakajima Shinsuke, and Takashi Suda
- Organizer
  第 46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D (GSDMD).2017
- Author(s)
  Kohsuke Tsuchiya, Mahib Muhammad Mamunur Rashid, Takashi Suda
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] シンポジウム「がん・免疫 -研究と臨床の最前線-」Caspase-1 依存的細胞死の分子機序と生理的役割2017
- Author(s)
  土屋晃介
- Organizer
  日本薬学会・北陸支部第 129 回例会
- Invited
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] A role for the redox master regulator Nrf2 in host defense against Listeria monocytogenes infection2016
- Author(s)
  土屋晃介（筆頭演者）
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄県宜野湾市
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] Involvement of the redox master regulator Nrf2 in host defense against Listeria monocytogenes infection2016
- Author(s)
  土屋晃介（筆頭演者）
- Organizer
  中国免疫学会第十一届全国免疫学学術大会
- Place of Presentation
  中華人民共和国安徽省
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] NLRP3 and ASC contribute to host defense against pneumococcal pneumonia.2014
- Author(s)
  土屋晃介、原英樹、内山良介、河村伊久雄、光山正雄
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京・船堀
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] インフラマソーム構成タンパクによる気道自然免疫の恒常性維持と肺炎球菌への宿主防御機序2014
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第67回日本細菌学会関西支部総会
- Place of Presentation
  兵庫県・西宮市
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] インフラマソーム構成タンパクによる気道自然免疫の恒常性維持と肺炎球菌への宿主防御機序2014
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第67回日本細菌学会関西支部総会
- Place of Presentation
  兵庫県・西宮市
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] Nitric oxide inhibits the NLRP3 inflammasome.2013
- Author(s)
  Tsuchiya K., Hernandez-Cuellar E., Hara H., Fang R., Sakai S., Kawamura I., Mitsuyama M.
- Organizer
  IMMUNOLOGY 2013
- Place of Presentation
  米国・ハワイ・ホノルル
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 一酸化窒素によるNLRP3インフラマソームの抑制2013
- Author(s)
  土屋晃介、Eduardo Hernandez-Cuellar、原英樹、方仁東、酒井俊祐、河村伊久雄、光山正雄
- Organizer
  第24回日本生体防御学会学術総会
- Place of Presentation
  熊本・熊本
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] An inflammasome-independent role of NLRP3 and ASC in host defense against Streptococcus pneumonia.2013
- Author(s)
  土屋晃介、内山良介、原英樹、河村伊久雄、光山正雄
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉・幕張
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 肺炎球菌感染におけるNLRP3とASCの防御的役割の解析2013
- Author(s)
  土屋晃介、酒井俊祐、原英樹、河村伊久雄、光山正雄
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉県・千葉市（幕張メッセ）
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] The inflammasome adaptor ASC plays a host-detrimental role in lethal infection with Listeria monocytogenes2012
- Author(s)
  土屋晃介、原英樹、Rendong Fang、酒井俊祐、Daim Sylvia、Sita R. Dewamitta、Eduard Hernandez、Xi Chen、河村伊久雄、光山正雄
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  兵庫県・神戸市
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 病原細菌による宿主細胞のインフラマソーム形成誘導機序と病原因子の関与の解析（奨励賞受賞講演）2012
- Author(s)
  土屋晃介
- Organizer
  第23回日本生体防御学会学術総会
- Place of Presentation
  東京都・品川区
- Invited
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] The role of inflammasomes in bacterial infections2012
- Author(s)
  土屋晃介（筆頭縁者）、他
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎・長崎
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 致死性リステリア感染モデルにおけるASCの役割の解析2011
- Author(s)
  土屋晃介（筆頭縁者）、他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉・幕張
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] A host-detrimental role of ASC in a lethal infection with Listeria monocytogenes2011
- Author(s)
  土屋晃介（筆頭縁者）、他
- Organizer
  International Union of Microbiological Societies Congresses 2011
- Place of Presentation
  北海道・札幌
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] Mechanism of inflammmasome activation upon infection with Listeria monocytogenes2010
- Author(s)
  土屋晃介、原英樹、野村卓正, 他5名
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of inflammasome activation upon infection with Listeria monocytogenes.2010
- Author(s)
  Tsuchiya K., Hara H., Nomura T., Daim S., Dewamitta S.R., Kawamura I., Mitsuyama M.
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of inflammmasome activation upon infection with Listeria monocytogenes2010
- Author(s)
  土屋晃介(筆頭演者)
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Involvement of absent in melanoma 2 (AIM2) in inflammasome activation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  土屋晃介、原英樹、河村伊久雄, 他6名
- Organizer
  The 10th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路夢舞台国際会議場
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Involvement of absent in melanoma 2 (AIM2) in inflammasome activation in macrophages infected with Listeria monocytogenes2010
- Author(s)
  土屋晃介(筆頭演者)
- Organizer
  The 10th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県・淡路市
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of inflammasome activation upon infection with Listeria monocytogenes2010
- Author(s)
  土屋晃介(筆頭演者)
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes2009
- Author(s)
  土屋晃介(筆頭演者)
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪府・大阪市
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes.2009
- Author(s)
  Tsuchiya K., Hara H., Nomura T., Daim S., Dewamitta S.R., Kawamura I., Mitsuyama M.
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪府・大阪市
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes2009
- Author(s)
  土屋晃介(筆頭演者)
- Organizer
  The 9th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県・淡路市
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] MyD88 signals are essential but redundant in host defense againstListeria monocytogenes2009
- Author(s)
  Tsuchiya K., Nomura T., Hara H., Shen Y., Sakai S., Kurenuma T., Yamamoto T., Kawamura I., Mitsuyama M.
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Mechanism of the inflammasome activation upon infection with Listeria monocytogenes.2009
- Author(s)
  Tsuchiya K., Hara H., Nomura T., Daim S., Dewamitta S.R., Kawamura I., Mitsuyama M.
- Organizer
  The 9th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県・淡路市
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21790416
[Presentation] Critical involvement of pneumolysin in the production of caspase-1-dependent cytokines in infection with Streptococcus pneumoniae2008
- Author(s)
  Tsuchiya K., Kawamura I., Nomura T., Mitsuyama M.
- Organizer
  XII. International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  イスタンブール・トルコ
- Year and Date
  2008-08-05
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Critical involvement of pneurnolysin in the production of caspase-1-dependent cytokines in infection with Streptococcus pneumoniae2008
- Author(s)
  Tsuchiya K., Shoma S., Kawamura I., Nomura T., Mitsuyama M
- Organizer
  The 8th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路島
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Critical involvement of pneumolysin in the production of caspase-1-dependent cytokines in infection with Streptococcus pneumoniae.2008
- Author(s)
  Tsuchiya K., Shoma S., Kawamura I., Nomura T., Mitsuyama M.
- Organizer
  The 8th Awaji Interanational Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路市
- Year and Date
  2008-09-07
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Escape of Listeria monocytogenes producing broad-range phospholipase C from autophagy-dependent killing2007
- Author(s)
  Tsuchiya K., Kawamura I., Nomura T., Hara H., Mitsuyama M.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  東京・品川
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] Escape of Listeria monocytogenes producing broad-range phospholipase C from autophagy dependent killing2007
- Author(s)
  Kohsuke Tsuchiya, Ikuo Kawamura, Takamasa Nomura, Ilideki Ilara, Masao. Nitsuyama
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19790319
[Presentation] NLRP3 and ASC contribute to host defense against pneumococcal pneumonia in an inflammasome-independent manner.
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都府・京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 自然免疫機構による細胞内の監視と細胞内寄生菌の感染戦略
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第25回日本生体防御学会学術総会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] 細菌感染におけるインフラマソーム構成タンパクの新たな防御的役割
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜県・岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] 自然免疫機構による細胞内の監視と細胞内寄生菌の感染戦略
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第25回日本生体防御学会学術総会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-26460523
[Presentation] 細菌感染におけるインフラマソーム構成蛋白の新たな防御的役割
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第88回細菌学会総会
- Place of Presentation
  岐阜県・岐阜市
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-23590504
[Presentation] NLRP3 and ASC contribute to host defense against pneumococcal pneumonia in an inflammasome-independent manner
- Author(s)
  土屋晃介（筆頭演者）、他
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都府・京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26460523

1. 須田貴司 (70250090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 東恭平 (10463829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HARA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
4. Kinoshita Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. ENDO Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. TANINO Mishie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SUZUKI Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SAKAI Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. YAMAMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. FANG Rendong

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SHEN Yena

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# of Collaborated Products: 1 results
12. QU Huixin

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# of Collaborated Products: 1 results
13. SEKIMIZU kazuhisa

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# of Collaborated Products: 2 results
14. 河村伊久雄

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# of Collaborated Products: 3 results
15. 井村久則

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# of Collaborated Products: 1 results
16. 藤田禎三

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# of Collaborated Products: 1 results
17. 谷野功典

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# of Collaborated Products: 1 results
18. 小嶋哲人

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# of Collaborated Products: 1 results
19. 光山正雄

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# of Collaborated Products: 3 results
20. 松浦基博

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# of Collaborated Products: 1 results
21. 堀修

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# of Collaborated Products: 1 results
22. 服部剛志

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23. 垣内力

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# of Collaborated Products: 1 results

Tsuchiya Kosuke 土屋 晃介

TSUCHIYA Kohsuke 土屋 晃介

Research Projects

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Co-Researchers

パイロトーシス細胞が放出するリステリア増殖抑制因子の解析Ongoing

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Host-pathogen interactions in antibiotic therapy for listeriosisPrincipal InvestigatorOngoing

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Caspase-1-independent roles for inflammasome-forming proteins in bacterial infectionsPrincipal Investigator

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Role of the inflammasome in bacterial infectionsPrincipal Investigator

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Roles for intracellular innate immune receptors in host responses to Listeria monocytogenes infectionPrincipal Investigator

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Analysis on the induction mechanism of innate immune response to Listeria monocytogenes through Toll-like receptorsPrincipal Investigator

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[Book] パイロトーシスの分子機構と意義2016

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[Book] 生体の科学：AIM2（absent in melanoma 2）はインフラマソームの活性化に関与する2011

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[Book] 感染・炎症・免疫：細胞質内リステリアの認識に関わる新規分子AIM22011

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[Journal Article] Inflammasome-associated Cell Death: Pyroptosis, Apoptosis, and Physiological Implications.2020

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[Journal Article] Caspase-7 mediates caspase-1-induced apoptosis independently of Bid.2020

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[Journal Article] ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.2019

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[Journal Article] Caspase-1 initiates apoptosis in the absence of gasdermin D.2019

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[Journal Article] Pneumolysin-Dependent Calpain Activation and Interleukin-1α Secretion in Macrophages Infected with Streptococcus pneumoniae.2017

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Tsuchiya Kosuke 土屋晃介

TSUCHIYA Kohsuke 土屋晃介