ISHIYAMA Kohei 石山宏平

Researcher Number	50437589
Affiliation *help	2017 – 2018 : 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 2016 : 広島大学, 病院(医), 病院助教 2013 – 2015 : 広島大学, 大学病院, 病院助教 2012 : 広島大学, 医歯薬保健学研究院, 特任助教 2011 : 広島大学, 医歯(薬)学総合研究科, 特任助教 2007 : Hiroshima University, Hospital, Assistant Professor 2006 : 広島大学, 病院・医員
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator General surgery
Keywords	Principal Investigator NK細胞 / 膵島移植 / 免疫学 / 糖尿病 / 移植 / 間葉系幹細胞 / 肝臓免疫 / 免疫 / 1型糖尿病 / NK 細胞 … More Except Principal Investigator … More

膵島移植における肝臓内免疫感作の解明と制御法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  石山宏平
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University
The suppressive mechanism of liver immune reactivity after islet transplantation by mesenchymal stem cellsPrincipal Investigator
- Principal Investigator
  
  Ishiyama Kohei
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University
Generation of TRAIL positive NK cells from hematopoietic stem cells / iPS cells in vitro for anti-HCC immunotherapy
- Principal Investigator
  
  TANAKA Yuka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University
Regulation of cytotoxic activity of liver NK cells against islet graftPrincipal Investigator
- Principal Investigator
  
  ISHIYAMA Kohei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University
Regulation of innate and adaptive immune responses in xenotransplantation by modulating CD47sirp α signaling
- Principal Investigator
  
  OHDAN Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University

All 2017 2014 2013 2012 2011 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice.2017
- Author(s)
  Saeki Y, Ishiyama K, Ishida N, Tanaka Y, Ohdan H
- Journal Title
  
  Transplant Proc
  
  Volume : 49(1) Pages : 139-144
- DOI
  10.1016/j.transproceed.2016.10.010
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10427
[Journal Article] Tho persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade : novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation2007
- Author(s)
  H.,Ohdan, W., Zhou, K., Ishiyama, Y., Tanaka, K., Idc, T., Asahara
- Journal Title
  
  Blood 15, 110(13)
  
  Pages : 4567-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Journal Article] Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity2006
- Author(s)
  D.,Tokita, M.,Shishida, H.,Ohdan, T.,Onoe, H.,Hara, Y.,Tanaka, K.,Ishiyama, H.,Mitsuta, K.,Ide, K.,Arihiro, T.,Asahara
- Journal Title
  
  J Immunol 15, 177(6)
  
  Pages : 3615-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] 膵島移植後のInstant blood-mediated inflammatory reaction環境下における肝臓内Memory Natural Killer細胞の活性化機構の解明2014
- Author(s)
  石山宏平、佐伯吉弘、平田文宏、田中友加、大段秀樹
- Organizer
  日本膵・膵島移植研究会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] 間葉系幹細胞産生プロスタグランディン E2を介した肝臓内 NK 細胞活性抑制効果の検討2013
- Author(s)
  平田文宏、石山宏平、その他
- Organizer
  第40回日本膵・膵島移植研究会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 肝臓内免疫応答制御による膵島グラフト機能傷害克服の試み2013
- Author(s)
  石山宏平、その他
- Organizer
  第40回日本膵・膵島移植研究会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 膵島移植後グラフト傷害に対する肝臓内Memory Natural killer細胞の機能解析2013
- Author(s)
  佐伯吉弘、石山宏平、平田文宏、田中友加、大段秀樹
- Organizer
  日本消化器外科学会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] Mesenchymal Stem Cells Suppress Cytotoxic Activity of Natural Killer Cells in Islet Cell Transplantation2013
- Author(s)
  Y. Saeki, K. Ishiyama, F. Hirata, Y. Tanaka, H. Ohdan
- Organizer
  American Transplant Congress
- Place of Presentation
  シアトル、USA
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] Mesenchymal Stem Cells Suppress Cytotoxic Activity of Natural Killer Cells in Islet Cell2013
- Author(s)
  Yoshihiro Saeki, Kohei Ishiyama, et al
- Organizer
  Transplantation, American Transplant Congress 2013
- Place of Presentation
  Seattle USA
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] Unlicensed NK Cells Differentiated from CD34+ Hematopoietic Progenitor Cells Exhibit Anti-HCC and Anti-HCV Activity2013
- Author(s)
  Ryuichi Hotta, Yuka Tanaka, Seiichi Shimizu, Masahiro Ohira, Kohei Ishiyama, Nobuhiko Hiraga, Kazuaki Chayama, Hideki Ohdan
- Organizer
  American Transplant Congress2013
- Place of Presentation
  Seattle, America
- Data Source
  KAKENHI-PROJECT-24591880
[Presentation] 肝臓内免疫応答制御による膵島グラフト機能傷害克服の試み2013
- Author(s)
  石山　宏平
- Organizer
  第40回日本膵・膵島移植研究会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] Hotta R, Ishiyama K, Ohira M, Igarashi Y, Tanaka Y, Onoe T, Ide K, Tashiro H, Ohdan H. Adoptive Immunotherapy with Donor Derived-Liver Natural Killer Cells Prevents HCC Recurrence after Liver Transplantation in Recipients Exceeding the Milan Criteria.2012
- Author(s)
  Hotta R, Ishiyama K, Ohira M, Igarashi Y, Tanaka Y, Onoe T, Ide K, Tashiro H, Ohdan H
- Organizer
  American Transplantation Congress 2012
- Place of Presentation
  Boston, America
- Data Source
  KAKENHI-PROJECT-24591880
[Presentation] TRAIL-TRAIL受容体を介した肝臓内NK細胞による移植膵島傷害の解明2012
- Author(s)
  石山　宏平
- Organizer
  第112回日本外科学会定期学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 間葉系幹細胞を用いた肝臓内 NK 細胞活性化制御による移植膵島生着率改善の検討2012
- Author(s)
  田文宏、石山宏平、その他
- Organizer
  第39回日本臓器保存生物医学会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 肝臓内免疫応答による移植後膵島グラフト機能傷害克服の試み2012
- Author(s)
  石山宏平、その他
- Organizer
  第48回日本移植学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] TRAIL-TRAIL 受容体を介した肝臓内 NK 細胞による移植膵島傷害の解明2012
- Author(s)
  石山宏平、その他
- Organizer
  第112回日本外科学会定期学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 肝臓内免疫応答による移植後膵島グラフト傷害機構の解明と克服2012
- Author(s)
  石山　宏平
- Organizer
  第48回日本移植学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] 肝臓は膵島移植に適した場所か?-肝臓内NK細胞による膵島移植後のグラフト傷害の解明-2011
- Author(s)
  石山宏平
- Organizer
  第47回日本移植学会
- Place of Presentation
  仙台国際センター(仙台)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23890132
[Presentation] Rejection and Cytotoxicity against xenogeneic antigen N-glycolylneuraminic acid (NeuGc)2008
- Author(s)
  H., Tahara, H., Ohdan, K., Ide, N., Basnet, K.,Ishiyama, M., Shishida, Y., Tanaka, T., Irei, M., Ohira, Y., Igarashi, K., Kajitani, M., Banshodani, H., Takematsu, Y., Kozutsumi, T., Asahara
- Organizer
  The 11th meeting of Japanese Xenotransplantaion Society
- Place of Presentation
  Osaka
- Year and Date
  2008-02-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Comparative detection of natural antibodies to a-Gal and NeuGc epitopes in human sera2008
- Author(s)
  N., Basnet, H., Ohdan, H., Tahara, K., Ide, K., Ishiyama, M., Shishida, Y., Tanaka, T., Irei, M., Ohira, Y., Igarashi, K., Kajitani, M., Banshodani, H., Takematsu, Y., Kozutsumi, T., Asahara
- Organizer
  The 11th meeting of Japanese Xenotransplantaion Society
- Place of Presentation
  Osaka
- Year and Date
  2008-02-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Mechanism of avoidance of xenogeneic rejection by macrophages through intracellular inhibitory CD47-SHIPα signaling2007
- Author(s)
  K., Ide, H., Ohdan, H., Tahara, N., Basnet, K.,Ishiyama, Y., Tanaka, M., Shishida, T., Irei, M., Ohira, Y., Igarashi, T., Asahara
- Organizer
  The 10th meeting of Japanese Xenotransplantaion Society
- Place of Presentation
  Tokyo
- Year and Date
  2007-03-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Antibody-dependent rejection against xenogeneic antigen N-glycolylneuraminic acid (NeuGc)2007
- Author(s)
  H., Tahara, H., Ohdan, K., Ide, N., Basnet, K., Ishiyama, M., Shishida, Y., Tanaka, T., Irei, M., Ohira, Y., Igarashi, K., Kajitani, M., Banshodani, H., Takematsu, Y., Kozutsumi, T., Asahara
- Organizer
  The 43th annual meeting of Japan Society for Transplantation
- Place of Presentation
  Sendai
- Year and Date
  2007-11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Immunogenicity of xenogeneic antigen N-glycolylneuraminic acid (NeuGc)2007
- Author(s)
  H., Tahara, H., Ohdan, K., Ide, N., Basnet, K., Ishiyama, M., Shishida, Y., Tanaka, T., Irei, M., Ohira, Y., Igarashi, H., Takematsu, Y., Kozutsumi, T., Asahara
- Organizer
  The 107th annual congress of Japan Surgical Society
- Place of Presentation
  Osaka
- Year and Date
  2007-04-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Immunogenicity of xenogeneic antigen N-glycolylneuraminic acid (NeuGc)2007
- Author(s)
  H., Tahara, H., Ohdan, K., Ide, N., Basnet, K., Ishiyama, M., Shishida, Y., Tanaka, T., Irei, M., Ohira, Y., Igarashi, M., Doskali, H., Takematsu, Y., Kozutsumi, T., Asahara
- Organizer
  The 10th meeting of Japanese Xenotransplantaion Society
- Place of Presentation
  Tokyo
- Year and Date
  2007-03-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] Avoidance of xenogeneic rejection by macrophages through intracellular inhibitory CD47-SIRPα signaling2006
- Author(s)
  K., Ide, H., Ohdan, H., Tahara, K., Ishiyama, Y., Tanaka, M., Shishida, T., Irei, M., Ohira, T., Asahara
- Organizer
  The 42th annual meeting of Japan Society for Transplantation
- Place of Presentation
  Chiba
- Year and Date
  2006-09-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390348
[Presentation] 膵島保護へむけた膵島移植における肝臓内Natural Killer細胞活性化機構の解明
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  日本臓器保存生物医学会
- Place of Presentation
  大阪
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] 膵島移植後早期から長期にかけて肝臓内memory NK細胞がグラフトに与える免疫応答機構の解析
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  日本膵・膵島移植研究会
- Place of Presentation
  東京
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] 肝移植後活性化NK 細胞移入療法がT 細胞抗ドナー応答に与える影響解析
- Author(s)
  田中友加,石山宏平, 大平真裕, 清水誠一, 井手健太郎, 尾上隆司, 小林剛, 田代裕尊, 大段秀樹.
- Organizer
  第32回日本肝移植研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-03 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24591880
[Presentation] 膵島移植後グラフト傷害に対する肝臓内Memory Natural killer細胞の機能解析
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  日本消化器外科学会
- Place of Presentation
  福島
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] 膵島移植のInstant blood―mediated inflammatory reaction（IBMIR）環境下におけるNatural Killer（NK）細胞の活性化機構の解明
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  日本外科学会
- Place of Presentation
  京都
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] 膵島移植後におけるIBMIRを介した肝臓内NK細胞活性化メカニズムの解析
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  日本移植学会
- Place of Presentation
  東京
- Year and Date
  2014-09-10 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25461948
[Presentation] Liver DX5- natural killer cells play a crucial role on the instant blood-mediated inflammatory reaction after islet transplantation
- Author(s)
  佐伯吉弘、石山宏平
- Organizer
  American Transplant Congress
- Place of Presentation
  サンフランシスコ、USA
- Year and Date
  2014-07-26 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-25461948

1. OHDAN Hideki (10363061)

# of Collaborated Projects : 2results

# of Collaborated Products : 12results
2. TANAKA Yuka (90432666)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results

ISHIYAMA Kohei 石山 宏平

Research Projects

Research Products

Co-Researchers

膵島移植における肝臓内免疫感作の解明と制御法の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The suppressive mechanism of liver immune reactivity after islet transplantation by mesenchymal stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of TRAIL positive NK cells from hematopoietic stem cells / iPS cells in vitro for anti-HCC immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cytotoxic activity of liver NK cells against islet graftPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of innate and adaptive immune responses in xenotransplantation by modulating CD47sirp α signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Role of Natural Killer Cells in the Innate Immune System After Intraportal Islet Transplantation in Mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tho persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade : novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity2006

Author(s)

Journal Title

Description

Data Source

[Presentation] 膵島移植後のInstant blood-mediated inflammatory reaction環境下における肝臓内Memory Natural Killer細胞の活性化機構の解明2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 間葉系幹細胞産生プロスタグランディン E2を介した肝臓内 NK 細胞活性抑制効果の検討2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 肝臓内免疫応答制御による膵島グラフト機能傷害克服の試み2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 膵島移植後グラフト傷害に対する肝臓内Memory Natural killer細胞の機能解析2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Mesenchymal Stem Cells Suppress Cytotoxic Activity of Natural Killer Cells in Islet Cell Transplantation2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Mesenchymal Stem Cells Suppress Cytotoxic Activity of Natural Killer Cells in Islet Cell2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Unlicensed NK Cells Differentiated from CD34+ Hematopoietic Progenitor Cells Exhibit Anti-HCC and Anti-HCV Activity2013

ISHIYAMA Kohei 石山宏平