Ohishi Tomokazu 大石智一

… Alternative Names

Researcher Number	50442546
Other IDs	https://orcid.org/0000-0002-9039-4474
Affiliation (Current)	2021: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 主任研究員
Affiliation (based on the past Project Information) *help	2018 – 2019: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 主任研究員 2015: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 2015: 公益財団法人微生物化学研究会, 沼津支所, 研究員 2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 2012 – 2013: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員 2011 – 2012: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員
Review Section/Research Field	Principal Investigator Tumor biology / Tumor biology / Tumor therapeutics / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator アクチン細胞骨格 / 細胞運動 / ポリ(ADP-リボシル)化 / ポリADP-リボシル化 / 浸潤 / ポリADP-リボースポリメラーゼ / がんー間質相互作用 / 大腸がん / がん－間質相互作用 / 大腸がん肝転移 / がん-間質相互作用 / がん関連線維芽細胞

Identification and functional analysis of a liver stromal cell-derived factor contributing to liver metastasis of colorectal cancer cellsPrincipal InvestigatorOngoing
- Principal Investigator
  
  大石智一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Microbial Chemistry Research Foundation
The molecular mechanisms and regulation of acquisition of tumor invasive abilities through actin cytoskeleton remodelingPrincipal Investigator
- Principal Investigator
  
  OHISHI Tomokazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
  Tumor therapeutics
- Research Institution
  Microbial Chemistry Research Foundation
  Tokyo Metropolitan Institute of Medical Science
  Japanese Foundation for Cancer Research
Elucidation of the mechanism of cancer cell invasion through a novel actin cytoskeleton-associated protein TAB182Principal Investigator
- Principal Investigator
  
  OHISHI Tomokazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation For Cancer Research

All 2020 2019 2018 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells2020
- Author(s)
  Ohishi Tomokazu、Abe Hikaru、Sakashita Chiharu、Saqib Uzma、Baig Mirza S.、Ohba Shun‐ichi、Inoue Hiroyuki、Watanabe Takumi、Shibasaki Masakatsu、Kawada Manabu
- Journal Title
  
  Int. J. Cancer
  
  Volume: 146 Pages: 3474-3484
- DOI
  10.1002/ijc.32959
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-17K08384
[Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.2020
- Author(s)
  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Pages: 1-11
- DOI
  10.1016/j.chembiol.2019.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-19K15717, KAKENHI-PROJECT-16H06276
[Journal Article] Anti-CD133 monoclonal antibody CMab-43 exerts antitumor activity in a mouse xenograft model of colon cancer2019
- Author(s)
  Kato Yukinari、Ohishi Tomokazu、Yamada Shinji、Itai Shunsuke、Furusawa Yoshikazu、Sano Masato、Nakamura Takuro、Kawada Manabu、Kaneko Mika K.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: 38 Pages: 75-78
- DOI
  10.1089/mab.2019.0002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K07705, KAKENHI-PROJECT-17K07299
[Journal Article] Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer2019
- Author(s)
  Kato Yukinari、Ohishi Tomokazu、Yamada Shinji、Itai Shunsuke、Takei Junko、Sano Masato、Nakamura Takuro、Harada Hiroyuki、Kawada Manabu、Kaneko Mika K.
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: 38 Pages: 157-161
- DOI
  10.1089/mab.2019.0017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K07705
[Journal Article] Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives2016
- Author(s)
  Tomokazu Ohishi, Fumitaka Koga, Toshiro Migita
- Journal Title
  
  Journal of Molecular Sciences
  
  Volume: 17 Pages: 1-20
- DOI
  10.3390/ijms17010043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06891, KAKENHI-PROJECT-25871074
[Journal Article] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.2014
- Author(s)
  Ohishi, T., Muramatsu, Y., Yoshida, H., Seimiya, H.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: (in press) Pages: 2464-2478
- DOI
  10.1128/mcb.00161-14
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25871074, KAKENHI-PROJECT-26640109
[Presentation] 大腸がん肝転移を支持する肝臓間質細胞由来因子の同定とその抑制2019
- Author(s)
  大石智一、大庭俊一、川田学
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08693
[Presentation] Development of a treatment strategy for liver metastasis of CRCs by targeting a factor secreted from liver stromal cells2018
- Author(s)
  大石智一、川田学
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08693
[Presentation] 大腸がん肝転移に寄与する肝臓間質細胞由来因子の同定2018
- Author(s)
  大石智一、川田学
- Organizer
  第27回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08693
[Presentation] 大腸がん肝転移に関与する肝臓間質細胞由来因子の同定2018
- Author(s)
  大石智一、大庭俊一、川田学
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08693
[Presentation] タンキラーゼ結合タンパク質 TAB182 はアクチン細胞骨格の再構成を介してがん細胞の浸潤を調節する2015
- Author(s)
  大石智一、吉田喜香、村松由起子、清宮啓之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] タンキラーゼ結合蛋白質TAB182による細胞浸潤能の制御2015
- Author(s)
  大石智一、村松由起子、清宮啓之
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル(松山）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] 膀胱がんにおける上皮間葉移行を介した幹細胞性の獲得2015
- Author(s)
  右田敏朗、上田彩乃、大石智一、波多野恵、堀口慎一郎、古賀文隆、芝崎太
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] テロメア蛋白質TRF1による姉妹染色分体のコヒージョン維持2013
- Author(s)
  大石智一、村松由紀子、清宮啓之
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] 「Telomeric protein TRF1 is required for proper chromosome segregation」 Ninth AACR-JCA Joint Conference2013
- Author(s)
  Ohishi T, Muramatsu Y, Seimiya H
- Organizer
  Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] Telomeric protein TRF1ensures proper chromosome segregation in mitosis2013
- Author(s)
  大石智一、村松由紀子、清宮啓之
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] Telomeric protein TRF1 is required for proper chromosome segregation2013
- Author(s)
  大石智一
- Organizer
  Ninth AACR-JCA Joint Conference: Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  マウイ
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] 「Telomeric protein TRF1 is required for proper sister chromatid cohesion」2012
- Author(s)
  村松由起子、大石智一、清宮啓之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] Telomeric protein TRF1 is involved in controlling the spindle microtubule-kinetochore attachment in mitosis2012
- Author(s)
  大石智一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] Aurora A過剰発現による細胞分裂異常はテロメア結合タンパク質TRF1によって媒介される2012
- Author(s)
  大石智一
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] 「Aurora A過剰発現による細胞分裂異常はテロメア結合タンパク質TRF1によって媒介される」2012
- Author(s)
  大石智一、清宮啓之
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] 「Telomeric protein TRF1 is involved in controlling the spindle microtubule-kinetochore attachment in mitosis」2012
- Author(s)
  大石智一、村松由起子、清宮啓之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] Telomeric protein TRF1 is involved in controlling the spindle microtubule-kinetochore attachment in mitosis2011
- Author(s)
  大石智一、広田亨、清宮啓之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] 東京大学大学院新領域創成科学研究科メディカルゲノムサイエンス研究法II発表会2011
- Author(s)
  大石智一
- Organizer
  タイムラプス・イメージングによる細胞分裂の時空間的解析
- Place of Presentation
  東京
- Year and Date
  2011-08-12
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] Aurora A過剰発現による細胞分裂異常はテロメア結合タンパク質TRF1によって媒介される2011
- Author(s)
  大石智一、清宮啓之
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] がん遺伝子Aurora Aによる細胞分裂異常を媒介するテロメアタンパク質TRF12011
- Author(s)
  大石智一、広田亨、鶴尾隆、清宮啓之
- Organizer
  「新学術領域研究」修飾シグナル病第2回研究交流若手ポスター発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation
- Author(s)
  Ohishi T, Muramatsu Y, Yoshida H, Shibasaki F, and Seimiya H
- Organizer
  YONSEII BK21PLUS - CBSM International Joint Symposium
- Place of Presentation
  ソウル、韓国
- Year and Date
  2014-06-21 – 2014-06-25
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] テロメア蛋白質TRF1はAurora-Aの機能を介したAurora-Bの動原体集積に必要である
- Author(s)
  大石智一、村松由起子、吉田喜香、清宮啓之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] Involvement of the telomeric protein TRF1 in regulation of chromosome segregation
- Author(s)
  大石智一、清宮啓之
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23701068
[Presentation] テロメア蛋白質TRF1による染色体分配制御
- Author(s)
  大石智一、村松由起子、吉田喜香、芝崎　太、清宮啓之
- Organizer
  Conference for BioSignal and Medicine (CBSM)
- Place of Presentation
  ホテルラフォーレ修善寺（静岡県伊豆市）
- Year and Date
  2014-11-22 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-25871074
[Presentation] テロメア蛋白質TRF1の染色体分配への関与
- Author(s)
  大石智一、清宮啓之
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23701068

1. WATANABE Takumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KATO Yukinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 清宮啓之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 金子美華

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 川谷誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 長田裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 室井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 川田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 右田敏郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohishi Tomokazu 大石 智一

大石 智一 オオイシ トモカヅ

OHISHI Tomokazu 大石 智一

Research Projects

Research Products

Co-Researchers

Identification and functional analysis of a liver stromal cell-derived factor contributing to liver metastasis of colorectal cancer cellsPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular mechanisms and regulation of acquisition of tumor invasive abilities through actin cytoskeleton remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of cancer cell invasion through a novel actin cytoskeleton-associated protein TAB182Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-CD133 monoclonal antibody CMab-43 exerts antitumor activity in a mouse xenograft model of colon cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 大腸がん肝転移を支持する肝臓間質細胞由来因子の同定とその抑制2019

Author(s)

Organizer

Data Source

[Presentation] Development of a treatment strategy for liver metastasis of CRCs by targeting a factor secreted from liver stromal cells2018

Author(s)

Organizer

Data Source

[Presentation] 大腸がん肝転移に寄与する肝臓間質細胞由来因子の同定2018

Author(s)

Organizer

Data Source

[Presentation] 大腸がん肝転移に関与する肝臓間質細胞由来因子の同定2018

Author(s)

Organizer

Data Source

[Presentation] タンキラーゼ結合タンパク質 TAB182 はアクチン細胞骨格の再構成を介してがん細胞の浸潤を調節する2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] タンキラーゼ結合蛋白質TAB182による細胞浸潤能の制御2015

Author(s)

Organizer

Place of Presentation

Ohishi Tomokazu 大石智一

大石智一オオイシトモカヅ

OHISHI Tomokazu 大石智一