KAKU Gyourei 郭暁麗

… Alternative Names

Researcher Number	50443114
Other IDs
Affiliation (Current)	2021: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員 2021: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員
Affiliation (based on the past Project Information) *help	2021: 公益財団法人東京都医学総合研究所, その他部局等, 研究員 2012 – 2018: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 2011: (財)東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 2010: (財)東京都医学総合研究所, 東京都神経科学総合研究所, 研究員 2010: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 2009: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Ophthalmology / Neurochemistry/Neuropharmacology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 多発性硬化症 / 視神経炎 / EAE / 抗酸化物質 / グリア / 自然免疫 / ASK1 / グリア細胞 / グリア自然免疫 / Angiotensin II … More Except Principal Investigator Dock3 / 緑内障 / 神経保護 / 神経変性疾患 / 視神経再生 / Dockファミリー / 細胞死 / アクチン / 微小管 / アルツハイマー病 / 多発性硬化症 / 軸索再生 / アクチン骨格 / GEF Less

軸索再生と再髄鞘化をターゲットとした遺伝子治療による視機能回復の検討Principal InvestigatorOngoing
- Principal Investigator
  
  郭暁麗
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
New therapy of multiple sclerosis through regulating cell-type specific ASK1 and Dock proteinsPrincipal Investigator
- Principal Investigator
  
  GUO Xiaoli
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Effects of the modulation of the innate immunity and Dock family member on multiple sclerosisPrincipal Investigator
- Principal Investigator
  
  GUO Xiaoli
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Dock family proteins in neurodegeneration
- Principal Investigator
  
  NAMEKATA Kazuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of new therapeutic avenues of multiple sclerosis with a focus on glial activationPrincipal Investigator
- Principal Investigator
  
  KAKU Gyourei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Mechanisms related to the pathogenesis of the optic neuritis and the development of new therapeutic avenuesPrincipal Investigator
- Principal Investigator
  
  KAKU Gyourei
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  財団法人東京都医学研究機構
   Tokyo Metropolitan Organization for Medical Research

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014
- Author(s)
  Guo X
- Total Pages
  505
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25430082
[Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014
- Author(s)
  Xiaoli Guo
- Total Pages
  356
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25430082
[Book] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する日本眼科学会雑誌2013
- Author(s)
  香留崇, 行方和彦, 郭暁麗, 仙波賢太郎, 橘高大二, 川村和人, 木村敦子, 原田知加子, 一條秀憲, 三田村佳典, 原田高幸
- Data Source
  KAKENHI-PROJECT-23300138
[Book] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する.2013
- Author(s)
  留　崇、行方和彦、郭　暁麗、仙波賢太郎、橘高大二、川村和人、木村敦子、原田知加子、一條秀憲、三田村佳典、原田高幸.
- Total Pages
  11
- Publisher
  日本眼科学会雑誌
- Data Source
  KAKENHI-PROJECT-23300138
[Book] Dock3 はグリコーゲン合成酵素キナーゼ-3β (GSK-3β)による微小管重合を介して軸索伸長を促進する日本眼科学会会誌2012
- Author(s)
  行方和彦, 原田知加子, 郭暁麗, 木村敦子, 橘高大二, 渡邉快記, 原田高幸
- Data Source
  KAKENHI-PROJECT-23300138
[Book] TLR-ASK1-p38経路による神経炎症と脱髄症状の制御日本眼科学会会誌2011
- Author(s)
  郭暁麗, 原田知加子, 行方和彦, 松沢厚, Monsterrat Camps, Hong Ji, Dominique Swinnen, Catherine Jorand-Lebrun, Mathilde Muzerelle, Pierre-Alain Vitte, Thomas Rückle, 木村敦子, 神山邦子, 松本陽, 一條秀憲, 原田高幸
- Data Source
  KAKENHI-PROJECT-23300138
[Book] Spermidine 投与による実験的自己免疫性脳脊髄炎の軽症化日本眼科学会会誌2011
- Author(s)
  郭暁麗, 原田知加子, 行方和彦, 木村敦子, 三田村佳典, 吉田寛, 松本陽, 原田高幸
- Data Source
  KAKENHI-PROJECT-23300138
[Book] 網膜の変性と再生過程におけるグリアおよび神経特異的なTrkB シグナルの機能解析日本眼科学会会誌2011
- Author(s)
  原田知加子, 郭暁麗, 行方和彦, 木村敦子, 中村和昭, 田中光一, Luis F. Parada, 原田高幸
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.2019
- Author(s)
  Sano Hiroki、Namekata Kazuhiko、Kimura Atsuko、Shitara Hiroshi、Guo Xiaoli、Harada Chikako、Mitamura Yoshinori、Harada Takayuki
- Journal Title
  
  Cell Death Dis
  
  Volume: 10 Pages: 75-75
- DOI
  10.1038/s41419-019-1365-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11288, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-19K09943, KAKENHI-PROJECT-18K19625
[Journal Article] Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning.2019
- Author(s)
  Harada Chikako、Kimura Atsuko、Guo Xiaoli、Namekata Kazuhiko、Harada Takayuki
- Journal Title
  
  British Journal of Ophthalmology
  
  Volume: 103 Pages: 161-166
- DOI
  10.1136/bjophthalmol-2018-312724
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-19K09943, KAKENHI-PROJECT-18K19625
[Journal Article] レニン・アンジオテンシン系は視神経炎モデル動物における神経変性を制御する2018
- Author(s)
  郭暁麗、行方和彦、木村敦子、原田知加子、原田高幸
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 122 Pages: 140-140
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.2018
- Author(s)
  Akaiwa Kei、Namekata Kazuhiko、Azuchi Yuriko、Sano Hiroki、Guo Xiaoli、Kimura Atsuko、Harada Chikako、Mitamura Yoshinori、Harada Takayuki
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 59 Pages: 2080-2089
- DOI
  10.1167/iovs.17-23276
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K11288
[Journal Article] エダラボンは視神経外傷後の網膜神経節細胞死を抑制する2018
- Author(s)
  秋山悟一、安土ゆり子、郭暁麗、野呂隆彦、木村敦子、原田知加子、行方和彦、原田高幸
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 122 Pages: 63-63
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Ripasudil点眼は正常眼圧緑内障モデルマウスにおいて網膜神経節細胞死を抑制する2018
- Author(s)
  赤岩慶、行方和彦、安土ゆり子、郭　暁麗、木村敦子、原田知加子、三田村佳典、原田高幸
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 122 Pages: 593-594
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury2018
- Author(s)
  Azuchi Y, Namekata K, Shimada T, Guo X, Kimura A, Harada C, Saito A, Yamagata K, Harada T.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 10132-10132
- DOI
  10.1038/s41598-018-28425-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07086, KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-18H02536, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635
[Journal Article] ASK1 in neurodegeneration2017
- Author(s)
  Guo X., Namekata K., Kimura A., Harada C. & Harada T
- Journal Title
  
  Advances in Biological Regulation
  
  Volume: 66 Pages: 63-71
- DOI
  10.1016/j.jbior.2017.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-15H04999
[Journal Article] Edaravone prevents retinal degeneration in adult mice following optic nerve injury2017
- Author(s)
  Guo, X., Kimura, A., Azuchi, Y., Akiyama, G., Noro, T., Harada, C., Namekata, K., Harada, T.
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 6 Pages: 33950-33950
- DOI
  10.1038/srep33950
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-16K20341
[Journal Article] The Renin-Angiotensin System Regulates Neurodegeneration in a Mouse Model of Optic Neuritis2017
- Author(s)
  Guo X., Namekata K., Kimura A., Harada C. & Harada T
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 187 Pages: 2876-2885
- DOI
  10.1016/j.ajpath.2017.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-15H04999
[Journal Article] Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis2017
- Author(s)
  Kimura, A., Namekata, K., Guo, X., Noro, T., Harada, C., Harada, T.
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2017 Pages: 2817252-2817252
- DOI
  10.1155/2017/2817252
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-17K07123, KAKENHI-PROJECT-17K11499
[Journal Article] Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.2017
- Author(s)
  Akaiwa K., Namekata K., Azuchi Y., Guo X., Kimura A., Harada C., Mitamura Y. & Harada T
- Journal Title
  
  Cell Death Dis
  
  Volume: 8
- DOI
  10.1038/cddis.2017.341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11288, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-15H04999
[Journal Article] Edaravoneは正常眼圧緑内障モデルマウスにおいて網膜神経節細胞死を抑制する2017
- Author(s)
  赤岩慶、行方和彦、安土ゆり子、郭暁麗、木村敦子、原田知加子、三田村佳典、原田高幸
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 121 Pages: 784-784
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis2017
- Author(s)
  Azuchi, Y., Kimura, A., Guo, X., Akiyama, G., Noro, T., Harada, C., Nishigaki, A., Namekata, K., Harada, T.
- Journal Title
  
  Neuroscience Letters.
  
  Volume: 639 Pages: 82-7
- DOI
  10.1016/j.neulet.2016.12.057
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-16K08635, KAKENHI-PROJECT-16K11308, KAKENHI-PROJECT-16K20341, KAKENHI-PROJECT-16K07076, KAKENHI-PROJECT-17K07123
[Journal Article] Dock3-NMDA receptor interaction as a target for glaucoma therapy2017
- Author(s)
  Kimura A., Namekata K., Guo X., Harada C. & Harada T
- Journal Title
  
  Histology and Histopathology
  
  Volume: 32 Pages: 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration2016
- Author(s)
  Kimura A., Namekata K., Guo X., Harada C. and Harada T
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 17
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Spermidineは正常眼圧緑内障モデルマウスにおける神経変性を改善する2016
- Author(s)
  野呂隆彦、行方和彦、安土ゆり子、木村敦子、郭暁麗、原田知加子、中野　匡、常岡　寛、原田高幸
- Journal Title
  
  日本眼科学会雑誌120
  
  Volume: 120 Pages: 56-56
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] カロリー制限は正常眼圧緑内障モデルマウスにおける神経変性を改善する2016
- Author(s)
  郭　暁麗、木村敦子、安土ゆり子、秋山悟一、野呂隆彦、原田知加子、行方和彦、原田高幸
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 120 Pages: 871-871
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] グリア細胞におけるTrkB受容体シグナルは視神経外傷後の神経保護を促進する2016
- Author(s)
  原田知加子、安土ゆり子、野呂隆彦、郭　暁麗、木村敦子、行方和彦、原田高幸
- Journal Title
  
  日本眼科学会雑誌120
  
  Volume: 120 Pages: 139-139
- Data Source
  KAKENHI-PROJECT-16K07076
[Journal Article] Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma.2015
- Author(s)
  Kimura A, Guo X, Noro T, Harada C, Tanaka K, Namekata K, Harada T.
- Journal Title
  
  Neurosci Lett
  
  Volume: 588 Pages: 108-113
- DOI
  10.1016/j.neulet.2014.12.054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-25640043, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-26861479
[Journal Article] Renin-angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma.2015
- Author(s)
  Semba, K., Namekata, K., Guo, X., Harada, C., Harada, T. and Mitamura, Y
- Journal Title
  
  Cell Death Dis
  
  Volume: 5
- DOI
  10.1038/cddis.2014.296
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462717, KAKENHI-PROJECT-25640043
[Journal Article] Spermidine ameliorates neurodegeneration in a mouse model of normal tension glaucoma.2015
- Author(s)
  Noro, T., Namekata, K., Azuchi, Y., Kimura, A., Guo, X., Harada, C., Nakano, T., Tsuneoka, H., Harada, T.
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 56 Pages: 5012-5019
- DOI
  10.1167/iovs.15-17142
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-26861479
[Journal Article] Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis2015
- Author(s)
  Guo, X., Namekata, K., Kimura, A., Noro, T., Azuchi, Y., Semba, K., Harada, C., Yoshida, H., Mitamura, Y. and Harada, T
- Journal Title
  
  Neurosci Lett
  
  Volume: 592 Pages: 27-31
- DOI
  10.1016/j.neulet.2015.02.059
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640043, KAKENHI-PROJECT-15K20266, KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-26861479
[Journal Article] Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.2015
- Author(s)
  Noro, T., Namekata, K., Kimura, A., Guo, X., Azuchi, Y., Harada, C., Nakano, T., Tsuneoka, H. and Harada, T.
- Journal Title
  
  Cell Death and Disease
  
  Volume: 6
- DOI
  10.1038/cddis.2015.93
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640043, KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-26861479
[Journal Article] Valproic acid prevents NMDA-induced retinal ganglion cell death via stimulation of neuronal TrkB receptor signaling2015
- Author(s)
  Kimura A, Namekata K, Guo X, Noro T, Harada C, Harada T.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 185 Pages: 756-64
- DOI
  10.1016/j.ajpath.2014.11.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-25640043, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-26861479, KAKENHI-PROJECT-25430082
[Journal Article] TrkB signaling in retinal glia stimulates neuroprotection after optic nerve injury2015
- Author(s)
  Harada, C., Azuchi, Y., Noro, T., Guo, X., Kimura, A., Namekata, K., Harada, T.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 185 Pages: 3238-3247
- DOI
  10.1016/j.ajpath.2015.08.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04999, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-26640048, KAKENHI-PROJECT-26861479
[Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury2013
- Author(s)
  Katome T., Namekata K., Guo X., Semba K., Kittaka D., Kawamura K., Kimura A., Harada C., Ichijo H., Mitamura Y. & Harada T
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 20 Pages: 270-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma2013
- Author(s)
  Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada, T.
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 20 Pages: 1250-1256
- DOI
  10.1038/cdd.2013.91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-25640043
[Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma2013
- Author(s)
  Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada, T
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 20 Pages: 1250-1256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury2013
- Author(s)
  Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 20 Pages: 270-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury2013
- Author(s)
  Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 20 Pages: 270-280
- DOI
  10.1038/cdd.2012.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-22591929, KAKENHI-PROJECT-23300138, KAKENHI-PROJECT-23659033, KAKENHI-PROJECT-23700459, KAKENHI-PROJECT-23792024, KAKENHI-PROJECT-23890254, KAKENHI-PROJECT-24791884, KAKENHI-PROJECT-25430082, KAKENHI-PROJECT-25462766, KAKENHI-PROJECT-25640043
[Journal Article] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する2013
- Author(s)
  香留崇、行方和彦、郭暁麗、仙波賢太郎、橘高大二、川村和人、木村敦子、原田知加子、一條秀憲、三田村佳典、原田高幸
- Journal Title
  
  日眼会誌
  
  Volume: 117(2) Pages: 161-161
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3はグリコーゲン合成酵素キナーゼ-3β (GSK-3β)による微小管重合を介して軸索伸長を促進する2012
- Author(s)
  行方和彦、原田知加子、郭暁麗、木村敦子、橘高大二、渡邉快記、原田高幸
- Journal Title
  
  日眼会誌
  
  Volume: 116(5) Pages: 527-527
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy2012
- Author(s)
  Katome T, Namekata K, Naito T, Semba K, Guo X, Harada C, Harada T, Mitamura Y
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 98(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG2012
- Author(s)
  Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A, Harada C, Harada T
- Journal Title
  
  Genes Cells
  
  Volume: 17(8) Pages: 688-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy2012
- Author(s)
  2. Katome T, Namekata K, Naito T, Semba K, Guo X, Harada C, Harada T, Mitamura Y
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 98 Pages: 9-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG2012
- Author(s)
  Namekata K., Watanabe H., Guo X., Kittaka D., Kawamura K., Kimura A., Harada C. & Harada T
- Journal Title
  
  Genes to Cells
  
  Volume: 17(8) Pages: 688-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG2012
- Author(s)
  3. Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A, Harada, C, Harada T
- Journal Title
  
  Genes to Cells
  
  Volume: 17 Pages: 688-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly.2012
- Author(s)
  Namekata K., Harada C., Guo X., Kimura H., Kittaka D., Watanabe H., Harada T.
- Journal Title
  
  J Neurosci.
  
  Volume: 32 Pages: 264-274
- DOI
  10.1523/jneurosci.4884-11.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138, KAKENHI-PROJECT-23792024, KAKENHI-PROJECT-23890254, KAKENHI-PROJECT-24700392
[Journal Article] Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly2012
- Author(s)
  Namekata K., Harada C., Guo X., Kimura A., Kittaka D., Watanabe H. & Harada T
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32(1) Pages: 264-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly2012
- Author(s)
  Namekata K., Harada C., Guo X., Kimura A., Kittaka D., Watanabe H. & Harada T.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32 Pages: 264-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly2012
- Author(s)
  Namekata K, Harada C, Guo X, Kimura A, Kittaka D, Watanabe H, and Harada T
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32 (1) Pages: 264-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Expression of promyelocytic leukemia protein and vascular endothelial growth factor in aqueous humor and vitreous fluid in patients with proliferative diabetic retinopathy2012
- Author(s)
  Katome T., Namekata K., Naito T., Semba K., Guo X., Harada C., Harada T. & Mitamura Y
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 98(2) Pages: 9-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis2011
- Author(s)
  Guo X, Harada C, Namekata K, Kimura A., Mitamura Y., Yoshida H., Matsumuto Y., Harada T
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52(5) Pages: 2696-2703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] ia- and neuron-specitic functions of TrkB signalling during retinal degeneration and regenerati2011
- Author(s)
  Harada, C.
- Journal Title
  
  Nat Commun.
  
  Volume: 2 Pages: 189-189
- DOI
  10.1038/ncomms1190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300137, KAKENHI-PROJECT-23700459, KAKENHI-PROJECT-23792024, KAKENHI-PROJECT-23890254
[Journal Article] Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration2011
- Author(s)
  Harada C., Guo X., Namekata K., Kimura A., Nakamura K., Tanaka K., Parada L.F. & Harada T
- Journal Title
  
  Nature Communications
  
  Volume: 2 Pages: 189-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Glia-and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration.2011
- Author(s)
  Harada C., Guo X., Namekata K., Kimura A., Nakamura K., Tanaka K., Parada L.F., Harada T
- Journal Title
  
  Nature Communications 2
  
  Pages: 189-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Spermidine投与による実験的自己免疫性脳脊髄炎の軽症化2011
- Author(s)
  郭暁麗、原田知加子、行方和彦、木村敦子、三田村佳典、吉田寛、松本陽、原田高幸
- Journal Title
  
  日眼会誌
  
  Volume: 115(8) Pages: 729-729
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] TLR-ASK1-p38経路による神経炎症と脱髄症状の制御2011
- Author(s)
  郭暁麗、原田知加子、行方和彦、松沢厚、Monsterrat Camps、Hong Ji、Dominique Swinnen、Catherine Jorand-Lebrun、Mathilde Muzerelle、Pierre-Alain Vitte、Thomas Ruckle、木村敦子、神山邦子、松本陽、一條秀憲、原田高幸
- Journal Title
  
  日眼会誌
  
  Volume: 115(5) Pages: 485-485
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis2011
- Author(s)
  Guo X., Harada C., Namekata K., Kimura A., Mitamura Y., Yoshida H., Matsumuto Y. & Harada T
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 52 Pages: 2696-2703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] 網膜の変性と再生過程におけるグリアおよび神経特異的なTrkBシグナルの機能解析2011
- Author(s)
  原田知加子、郭暁麗、行方和彦、木村敦子、中村和昭、田中光一、Luis F. Parada、原田高幸
- Journal Title
  
  日眼会誌
  
  Volume: 115(7) Pages: 637-637
- Data Source
  KAKENHI-PROJECT-23700459
[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis.2011
- Author(s)
  Guo X., Harada C., Namekata K., Kimura A., Mitamura Y., Yoshida H., Matsumuto Y., Harada T
- Journal Title
  
  Investigative Ophthalmology & Visual Science 52
  
  Pages: 2696-2703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration2011
- Author(s)
  Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T
- Journal Title
  
  Nature Communications
  
  Volume: 2 Pages: 189-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300138
[Journal Article] Expression of epiplakinl in the developing and adult mouse retina.2010
- Author(s)
  Yoshida T., Guo X., Namekata K., Mitamura Y., Kume S., Harada T
- Journal Title
  
  Japanese Journal of Ophthamology 54
  
  Pages: 85-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.2010
- Author(s)
  Guo X., Harada C., Namekata K., Matsuzawa A., Camps M., Ji H., Swinnen D., Jorand-Lebrun C., Muzerelle M., Vitte P., Ruckle T., Kimura A., Kohyama K., Matsumoto Y., Ichijo H., Harada T
- Journal Title
  
  EMBO Molecular Medicine 2
  
  Pages: 504-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.2010
- Author(s)
  Guo, X., et al.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.2010
- Author(s)
  Namekata K., Harada C., Taya C., Guo X., Kimura H., Parada L.F., Harada T
- Journal Title
  
  Proc Natl Acad Sci USA 107
  
  Pages: 7586-7591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.2010
- Author(s)
  Guo X., Harada C., Namekata K., Mitamura Y., Yoshida H., Matsumoto Y., Harada T
- Journal Title
  
  PLoS ONE 5(9)
  
  Pages: 13083-13083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.2010
- Author(s)
  Guo, X., et al.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 2 Pages: 504-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma.2010
- Author(s)
  Harada C., Namekata K., Guo X., Yoshida H., Mitamura Y., Matsumoto Y., Tanaka K., Ichijo H., Harada T
- Journal Title
  
  Cell Death and Differentiation 17
  
  Pages: 100-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Expression of NG2-possitive cells during optic neuritis.2010
- Author(s)
  Nakamura K., Guo X., Harada C., Mitamura Y., Matsumoto Y., Harada T
- Journal Title
  
  Japanese Journal of Ophthamology 54
  
  Pages: 100-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice.2009
- Author(s)
  Namekata K., Harada C., Guo X., Kikushima K., Kimura A., Fuse A., Mitamura Y., Kohyama K., Matsumoto Y., Tanaka K., Harada T
- Journal Title
  
  Neuroscience Letter 465
  
  Pages: 160-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis.2009
- Author(s)
  Guo, X.
- Journal Title
  
  Neuroscience Letters 462
  
  Pages: 281-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis.2009
- Author(s)
  Guo X., Harada C., Namekata K., Kikushima K., Mitamura Y., Yoshida H., Matsumoto Y., Harada T
- Journal Title
  
  Neuroscience Letter 462
  
  Pages: 281-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis.
- Author(s)
  Guo, X., et al.
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791726
[Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma
- Author(s)
  Namekata, K., Kimura, A., Kawamura, K., Guo, X., Harada, C., Tanaka, K. and Harada, T
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700459
[Patent] 視神経保護剤2015
- Inventor(s)
  原田高幸、行方和彦、郭　暁麗　他
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-25430082
[Patent] Dock8を含む神経炎症又は脱髄疾患の予防又は治療用医薬組成物2013
- Inventor(s)
  原田高幸、行方和彦、郭暁麗
- Industrial Property Rights Holder
  原田高幸、行方和彦、郭暁麗
- Industrial Property Number
  2013-026753
- Filing Date
  2013-02-18
- Data Source
  KAKENHI-PROJECT-23700459
[Patent] Dock8を含む神経炎症又は脱髄疾患の予防又は治療用医薬組成物2013
- Inventor(s)
  原田高幸、行方和彦、郭　暁麗
- Industrial Property Rights Holder
  原田高幸、行方和彦、郭　暁麗
- Industrial Property Rights Type
  特許
- Filing Date
  2013-02-18
- Data Source
  KAKENHI-PROJECT-23700459
[Patent] Dock8を含む神経炎症又は脱髄疾患の予防又は治療用医薬組成物2013
- Inventor(s)
  原田高幸、行方和彦、郭暁麗
- Industrial Property Rights Holder
  原田高幸、行方和彦、郭暁麗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-026753
- Filing Date
  2013-02-25
- Data Source
  KAKENHI-PROJECT-23300138
[Patent] Dock8を含む神経炎症又は脱髄疾患の予防又は治療用医薬組成物2013
- Inventor(s)
  原田高幸, 行方和彦, 郭暁麗
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-026753
- Filing Date
  2013-02-18
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Spontaneous normal tension glaucoma in aged marmosets2019
- Author(s)
  Takayuki Harada, Takahiko Noro, Kazuhiko Namekata, Atsuko Kimura, Nanako Hashimoto, Keiko Moriya-Ito, Xiaoli Guo, Chikako Harada, Tadashi Nakano, Takashi Inoue, Erika Sasaki
- Organizer
  8th World Glaucoma Cogress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Topical ripasudil prevents retinal ganglion cell death in a mouse model of normal tension glaucoma2018
- Author(s)
  Takayuki Harada, Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura
- Organizer
  13th European Glaucoma Society Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] DOCK8 regulates microglial activity in neuroinflammation2018
- Author(s)
  Kazuhiko Namekata, Xiaoli Guo, Atsuko Kimura, Nobutaka Arai, Chikako Harada, Takayuki Harada
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Loss of neuritin accelerates RGC loss and retinal degeneration in adult mice following optic nerve injury2018
- Author(s)
  Yuriko Azuchi, Kazuhiko Namekata, Tadayuki Shimada, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Atsuko Nishigaki, Kanato Yamagata, Takayuki Harada
- Organizer
  48th Annual Meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Dock10 deficiency reduces neuroinflammation in optic neuritis2018
- Author(s)
  Xiaoli Guo, Kazuhiko Namekata, Yuriko Azuchi, Atsuko Kimura, Takahiko Noro, Chikako Harada, Takayuki Harada
- Organizer
  The ARVO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] 正常眼圧緑内障モデルマウスを用いたEdaravoneによる網膜神経節細胞保護効果の検討2018
- Author(s)
  赤岩慶、行方和彦、安土ゆり子、郭　暁麗、木村敦子、原田知加子、三田村佳典、原田高幸
- Organizer
  第１２２回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] New therapeutic targets on neurodegenerative and demyelination diseases2018
- Author(s)
  郭　暁麗
- Organizer
  Overseas Chinese, Chinese and High-level Talents Travel to Jiangsu
- Invited
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Can valproic acid treat neurodegenerative diseases?2018
- Author(s)
  Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Yuriko Azuchi, Chikako Harada, Takayuki Harada
- Organizer
  International Conference on Neurovascular and Neurodegenerative Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Manipulation of retinal glutamate levels by overexpression of GLAST reduces retinal ganglion cell death in an experimental model of glaucoma2018
- Author(s)
  Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Yuriko Azuchi, Chikako Harada, Takayuki Harada
- Organizer
  19th International Congress of Neuropathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] 細胞種特異的なASK1遺伝子の欠損が神経炎症に与える影響の検討2017
- Author(s)
  郭暁麗、行方和彦、木村敦子、原田知加子、新井信隆、原田高幸
- Organizer
  第58回日本神経病理学会総会
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Dietary restriction promotes cell survival in a mouse model of normal tension glaucoma2017
- Author(s)
  Guo X., Namekata K., Kimura A., Noro T., Akiyama G., Azuchi Y., Harada C. & Harada T
- Organizer
  第2回 TMEDフォーラム
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] カロリー制限による正常眼圧緑内障モデルにおける神経細胞及び視機能の保護2017
- Author(s)
  郭暁麗、木村敦子、安土ゆり子、秋山悟一、野呂隆彦、原田知加子、行方和彦、原田高幸
- Organizer
  第121回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Overexpression of GLAST protects retinal ganglion cells following optic nerve injury2016
- Author(s)
  Kimura A., Namekata K., Guo X., Azuchi Y., Noro T., Akiyama G., Harada C. and Harada T
- Organizer
  XXII International Congress of Eye Research (ISER 2016)
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Spermidine stimulates neuroprotection and optic nerve regeneration following optic nerve injury.2016
- Author(s)
  Noro, T., Namekata, K., Kimura, A., Guo, X., Azuchi, Y., Harada C. and Harada, T.
- Organizer
  14th IGAKUKEN International Symposium, IGAKUKEN Summit for Japan and Korea Science Leaders 2016
- Place of Presentation
  東京都医学総合研究所（東京都世田谷区）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Dock8 deficiency suppresses microglial migration and neuroinflammation2016
- Author(s)
  Namekata K., Guo X., Kimura A., Harada C. and Harada T
- Organizer
  46th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] レニンーアンジオテンシン系は正常眼圧緑内障モデルマウスにおける神経変性を制御する2016
- Author(s)
  仙波賢太郎、行方和彦、郭　暁麗、原田知加子、原田高幸
- Organizer
  第120回　日本眼科学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-04-09
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Dietary restriction promotes cell survival in a mouse model of normal tension glaucoma2016
- Author(s)
  Guo X., Namekata K., Kimura A., Noro T., Akiyama G., Azuchi Y., Harada C. and Harada T
- Organizer
  46th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Neuroprotective effects of valproic acid in mouse models of normal tension glaucoma2016
- Author(s)
  Kimura, A., Namekata, K., Guo, X., Noro, T., Harada, C. and Harada, T
- Organizer
  TOBIRA 第５回研究交流フォーラム
- Place of Presentation
  御茶ノ水ソラシティ（東京都千代田区）
- Year and Date
  2016-05-23
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Combinatorial therapy with ASK1 deficiency and valproic acid in a murine model of multiple sclerosis2016
- Author(s)
  Azuchi, Y., Guo, X., Kimura, A., Noro, T., Akiyama, G., Drozdz M., Harada, C., Saito, A., Namekata K. and Harada, T
- Organizer
  14th IGAKUKEN International Symposium, IGAKUKEN Summit for Japan and Korea Science Leaders 2016
- Place of Presentation
  東京都医学総合研究所（東京都世田谷区）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] ASK1 deficiency and valproic acid synergistically reduce demyelination and visual impairment in experimental autoimmune encephalomyelitis2016
- Author(s)
  Azuchi Y., Kimura A., Guo X., Noro T., Akiyama G., Drozdz M., Harada C., Saito A., Namakata K. and Harada T
- Organizer
  The 39th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Valproic acid suppresses retinal ganglion cell death in mouse models of normal tension glaucoma2016
- Author(s)
  Kimura, A., Namekata, K., Guo, X., Noro, T., Azuchi, Y., Harada, C. and Harada, T
- Organizer
  14th IGAKUKEN International Symposium, IGAKUKEN Summit for Japan and Korea Science Leaders 2016
- Place of Presentation
  東京都医学総合研究所（東京都世田谷区）
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K07076
[Presentation] Neuroprotection by valproic acid and spermidine in a mouse model of normal tension glaucoma2015
- Author(s)
  Takayuki Harada, Atsuko Kimura, Takahiko Noro, Xiaoli Guo, Kazuhiko Namekata, Chikako Harada
- Organizer
  45th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Brimonidine protects retinal neurons and visual function in a murine model of optic neuritis2015
- Author(s)
  Xiaoli Guo
- Organizer
  第119回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌、札幌
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Dock3はERKシグナルを介して視神経の脱髄を抑制する2015
- Author(s)
  行方和彦、郭暁麗
- Organizer
  第119回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌、札幌
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Dock3はERKシグナルを介して視神経の脱髄を抑制する2015
- Author(s)
  行方和彦、木村敦子、郭　曉麗、原田知加子、原田高幸
- Organizer
  第119回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Brimonidine suppresses loss of retinal neurons and visual function in murine models of glaucoma and optic neuritis2015
- Author(s)
  Xiaoli Guo, Kazuhiko Namekata, Atsuko Kimura, Takahiko Noro, Chikako Harada, Takayuki Harada
- Organizer
  45th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Brimonidine protects retinal neurons and visual function in a murine model of optic neuritis2015
- Author(s)
  Guo X., Namekata K., Kimura A., Noro T., Harada C., Harada T
- Organizer
  第119回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Valproic acid protects retinal neurons from NMDA-induced neurotoxicity via stimulation of neuronal TrkB receptors2015
- Author(s)
  Atsuko Kimura, Xiaoli Guo
- Organizer
  2015 Asia-ARVO (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Year and Date
  2015-02-18
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Spermidine stimulates neuroprotection and optic nerve regeneration following optic nerve injury2015
- Author(s)
  Takahiko Noro, Xiaoli Guo
- Organizer
  2015 Asia-ARVO (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Year and Date
  2015-02-18
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Dock3 protects retinal neurons in a mouse model of normal tension glaucoma2014
- Author(s)
  Kazuhiko Namekata, Xiaoli Guo
- Organizer
  World Ophthalmology Congress of the International Council of Ophthalmology (WOC) 2014
- Place of Presentation
  Tokyo International Forum / Imperial Hotel, Tokyo
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Combined inhibition of angiotensin II type 1 receptor and ASK1 significantly attenuates autoimmune optic neuritis2014
- Author(s)
  Xiaoli Guo
- Organizer
  The ARVO (The Association for Research in Vision and Ophthalmology) 2014 Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Dock8/10 regulate severity of inflammatory demyelination disorder2014
- Author(s)
  Kazuhiko Namekata, Xiaoli Guo
- Organizer
  The ARVO (The Association for Research in Vision and Ophthalmology) 2014 Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2014-05-08
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Inhibition of angiotensin II ameliorates autoimmune optic neuritis by suppressing innate immune responses2014
- Author(s)
  Xiaoli Guo
- Organizer
  World Ophthalmology Congress of the International Council of Ophthalmology (WOC) 2014
- Place of Presentation
  Tokyo International Forum / Imperial Hotel, Tokyo
- Year and Date
  2014-04-05
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] Dock8 is a therapeutic target for CNS inflammation2013
- Author(s)
  Kazuhiko Namekata, Chikako Harada, Xiaoli Guo, Takayuki Harada
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2013-11-10
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Interaction between renin-angiotensin and innate immune systems inautoimmune neuroinflammation2013
- Author(s)
  Xiaoli Guo, Kazuhiko Namekata, Chikako Harada, Takayuki Harada
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2013-11-10
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Roles of ASK1 in neuroprotection and axonal regeneration after optic nerve injury2013
- Author(s)
  Daiji Kittaka, Kazuhiko Namekata, Takuji Kurimoto, Xiaoli Guo, Chikako Harada, Takayuki Harada
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2013-11-10
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity. Oral session : Macrophages and micro glial regulation of ocular inflammation2012
- Author(s)
  Guo X, Harada C, Namekata K, Kimura A, Harada T
- Organizer
  XX International Congress of Eye Research (ISER2012)
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-07-23
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] The role of Dock3 in axon regeneration following optic nerve injury2012
- Author(s)
  Namekata K., Harada C., Guo X., Kimura A. & Harada T
- Organizer
  Poster session: Retinal cell biology XX International Congress of Eye Research (ISER 2012)
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-07-24
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity2012
- Author(s)
  Guo X., Harada C., Namekata K., Kimura A. & Harada T
- Organizer
  Oral session: Macrophages and microglial regulation of ocular inflammation XX International Congress of Eye Research (ISER2012)
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-07-23
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] The role of Dock3 in axon regeneration following optic nerve injury2012
- Author(s)
  Namekata K, Harada C, Guo X, Kimura A, Harada T
- Organizer
  Poster session : Retinal cell biology, XX International Congress of Eye Research (ISER 2012)
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-07-24
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity.2011
- Author(s)
  Guo X., Harada C., Namekata K., Kimura A., Ichijo H., Harada T
- Organizer
  26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney.
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity2011
- Author(s)
  Guo X., Harada C., Namekata K., Kimura A., Ichijo H. & Harada T
- Organizer
  26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Optic Nerve Regeneration is Enhanced in Dock3 Overexpressing Transgenic Mice.2011
- Author(s)
  Namekata K., Harada C., Guo X., Harada T
- Organizer
  26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney.
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration2011
- Author(s)
  Takayuki Harada, Xiaoli Guo, Kazuhiko Namekata, Luis F.Parada, Chikako Harada
- Organizer
  8_<th> World Congress of Neuroscience, International Brain Research Organization (IBRO)
- Place of Presentation
  Florence
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity2011
- Author(s)
  Guo X., Harada C., Nakamura K., Kimura A., Ichijo H., Harada T
- Organizer
  The 26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] ASK1 deficiency attenuates neural cell death in a mouse model of normal tension glaucoma.2011
- Author(s)
  Harada T., Namekata K., Guo X., Tanaka K., Ichijo H., Harada C
- Organizer
  26^<th> Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney.
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] ASK1 deficiency attenuates neural cell death in a mouse model of normal tension glaucoma2011
- Author(s)
  Harada T., Namekata K, Guo X., Tanaka K, Ichijo H., Harada C
- Organizer
  The 26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] Optic nerve regeneration is enhanced in Dock3 overexpressing transgenic mice2011
- Author(s)
  Namekata K., Harada C., Guo X., Harada T
- Organizer
  The 26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration2011
- Author(s)
  Harada T, Guo X, Namekata K, Luis F. Parada, Harada C
- Organizer
  8th World Congress of Neuroscience, International Brain Research Organization (IBRO)
- Place of Presentation
  Florence, Italy
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] ASK1 deficiency attenuates neural cell death in a mouse model of normal tension glaucoma2011
- Author(s)
  Harada T., Namekata K., Guo X., Tanaka K., Ichijo H. & Harada C
- Organizer
  26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Optic Nerve Regeneration is Enhanced in Dock3 Overexpressing Transgenic Mice2011
- Author(s)
  Namekata K., Harada C., Guo X. & Harada T
- Organizer
  26th Asia Pacific Academy of Ophthalmology (APAO) Congress
- Place of Presentation
  Sydney
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration2011
- Author(s)
  Harada T., Guo X., Namekata K., Parada L.F. & Harada C
- Organizer
  8^<th> World Congress of Neuroscience, International Brain Research Organization (IBRO)
- Place of Presentation
  Florence, Italy
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] 軸索伸長におけるDock3とWAVEの機能解析2010
- Author(s)
  行方和彦、原田知加子、郭暁麗、原田高幸
- Organizer
  BMB2010(第33回日本分子生物学会大会・第83回日本生化学会大会)
- Place of Presentation
  Kobe.
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] 軸索伸長におけるDock3とWAVEの機能解析2010
- Author(s)
  行方和彦(発表者)、原田知加子、郭暁麗、原田高幸
- Organizer
  Neuro2010(第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.2010
- Author(s)
  Namekata K., Harada C., Guo X., Harada T
- Organizer
  Neuro 2010(第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会)
- Place of Presentation
  Kobe.
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] 軸索伸長におけるDock3とWAVEの機能解析2010
- Author(s)
  行方和彦(発表者)、原田知加子、郭暁麗、原田高幸
- Organizer
  BMB2010(第33回日本分子生物学会大会・第83回日本生化学会大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21791726
[Presentation] Roles of ASK1 in neuroprotection and axonal regeneration after optic nerve injury.
- Author(s)
  Daiji Kittaka, Kazuhiko Namekata, Takuji Kurimoto, Xiaoli Guo, Chikako Harada, Takayuki Harada.
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Interaction between renin-angiotensin and innate immune systems in autoimmune neuroinflammation.
- Author(s)
  Xiaoli Guo, Kazuaki Nakamura, Chikako Harada, Kuniko Kohyama, Heather A. Behanna, D. Martin Watterson, Yoh Matsumoto, Takayuki Harada.
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] The role of Dock3 in axon regeneration following optic nerve injury
- Author(s)
  Kazuhiko Namekata, Chikako Harada, Xiaoli Guo, Atsuko Kimura, Takayuki Harada
- Organizer
  XX International Congress of Eye Research (ISER 2012)
- Place of Presentation
  Berin, Germany
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] Interaction between renin-angiotensin and innate immune systems in autoimmune neuroinflammation
- Author(s)
  Guo X
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego、アメリカ
- Data Source
  KAKENHI-PROJECT-25430082
[Presentation] ASK1 inhibition ameliorates optic neuritis by modulating glial innate immunity
- Author(s)
  Xiaoli Guo, Chikako Harada, Kazuhiko Namekata, Atsuko Kimura, Takayuki Harada
- Organizer
  XX International Congress of Eye Research (ISER 2012)
- Place of Presentation
  Berin, Germany
- Data Source
  KAKENHI-PROJECT-23700459
[Presentation] Macrophages and micro glial regulation of ocular inflammation
- Author(s)
  Guo X、他４名
- Organizer
  XX International Congress of Eye Research (ISER 2012)
- Place of Presentation
  ドイツ（ベルリン）
- Data Source
  KAKENHI-PROJECT-23300138
[Presentation] Dock8 is a therapeutic target for CNS inflammation.
- Author(s)
  Kazuhiko Namekata, Chikako Harada, Xiaoli Guo, Takayuki Harada
- Organizer
  43rd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23300138

1. NAMEKATA Kazuhiko (70392355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 54 results
2. KIMURA Atsuko (60569143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 49 results
3. WATANABE Hayaki (70595587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. HARADA takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 37 results
5. KATOME Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 原田知加子

# of Collaborated Projects: 0 results

# of Collaborated Products: 19 results
7. 田中光一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 秋山悟一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 三田村佳典

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
10. 野呂隆彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 仙波賢太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 一條秀憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 橘高大二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 島田忠之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 山形要人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAKU Gyourei 郭 暁麗

郭 暁麗 カク ギヨウレイ

Research Projects

Research Products

Co-Researchers

軸索再生と再髄鞘化をターゲットとした遺伝子治療による視機能回復の検討Principal InvestigatorOngoing

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Review Section

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New therapy of multiple sclerosis through regulating cell-type specific ASK1 and Dock proteinsPrincipal Investigator

Principal Investigator

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Effects of the modulation of the innate immunity and Dock family member on multiple sclerosisPrincipal Investigator

Principal Investigator

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Dock family proteins in neurodegeneration

Principal Investigator

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Development of new therapeutic avenues of multiple sclerosis with a focus on glial activationPrincipal Investigator

Principal Investigator

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Research Institution

Mechanisms related to the pathogenesis of the optic neuritis and the development of new therapeutic avenuesPrincipal Investigator

Principal Investigator

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Research Institution

[Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014

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[Book] Neuroprotection and Neuroregeneration for Retinal Diseases2014

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[Book] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する 日本眼科学会雑誌2013

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Data Source

[Book] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する.2013

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[Book] Dock3 はグリコーゲン合成酵素キナーゼ-3β (GSK-3β)による微小管重合を介して軸索伸長を促進する 日本眼科学会会誌2012

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[Book] TLR-ASK1-p38経路による神経炎症と脱髄症状の制御 日本眼科学会会誌2011

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[Book] Spermidine 投与による実験的自己免疫性脳脊髄炎の軽症化 日本眼科学会会誌2011

Author(s)

Data Source

[Book] 網膜の変性と再生過程におけるグリアおよび神経特異的なTrkB シグナルの機能解析 日本眼科学会会誌2011

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[Journal Article] Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.2019

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[Journal Article] Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning.2019

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Journal Title

DOI

KAKU Gyourei 郭暁麗

郭暁麗カクギヨウレイ

[Book] ASK1-p38 経路の阻害は視神経外傷後の神経細胞死を抑制する日本眼科学会雑誌2013

[Book] Dock3 はグリコーゲン合成酵素キナーゼ-3β (GSK-3β)による微小管重合を介して軸索伸長を促進する日本眼科学会会誌2012

[Book] TLR-ASK1-p38経路による神経炎症と脱髄症状の制御日本眼科学会会誌2011

[Book] Spermidine 投与による実験的自己免疫性脳脊髄炎の軽症化日本眼科学会会誌2011

[Book] 網膜の変性と再生過程におけるグリアおよび神経特異的なTrkB シグナルの機能解析日本眼科学会会誌2011