Zheng Can 鄭燦

… Alternative Names

Researcher Number	50443495
Affiliation (Current)	2021: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2015 – 2019: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 2014: 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 2012: 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 2011: 独立行政法人国立循環器病研究センター, 循環動態制御部, 特任研究員 2009 – 2011: Kochi University, 教育研究部・医療学系, 助教 … More
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Laboratory animal science / Basic Section 53020:Cardiology-related Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Medical systems / Biomedical engineering/Biological material science / General pharmacology
Keywords	Principal Investigator 迷走神経刺激 / 心不全 / 飲水行動 / 特発拡張型心筋症 / 自己免疫 / 心筋症 / 迷走神経 / 電気刺激 / 神経電気刺激 / 心機能 … More Except Principal Investigator 急性心筋梗塞 / 慢性心不全 / 心臓リモデリング / 迷走神経刺激 / 迷走神経 / アセチルコリン / 心不全 / 炎症 / 心血管新生 / 心臓病態学 / アンジオテンシンII / α7 nACh受容体(α7 nAChR) / 心機能 / 循環器・高血圧 / トランスレーショナルリサーチ / 神経インターフェース / トレンスレーショナルリサーチ / 心室リモデリング / 心筋間質蛋白分解酵素 / 心筋収縮力 / 心臓電気刺激 / 電気刺激 / 心室収縮力 / 心臓超音波 / 再灌流療法 / 心血管 / 血液 / 心臓 / エネルギー代謝 / 酸素消費量 / ミトコンドリア / 心筋細胞 / 心筋幹細胞 / 増殖・分化 / 炎症・アポトシス / アポトシス / 薬理的迷走神経刺激 / 心血管新生・分化 / 心筋梗塞 / 心血管再生 Less

Combination of drinking behavior modulation with pharmacological vagal activation for treatment of chronic heart failurePrincipal InvestigatorOngoing
- Principal Investigator
  
  鄭燦
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of a new cardiovascular regenerative treatment method by pharmacological vagus nerve stimulation aiming for practical clinical use
- Principal Investigator
  
  Li Meihua
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Drinking behavior modulation significantly prevent cardiac remodeling and improve survival in chronic heart failure ratsPrincipal Investigator
- Principal Investigator
  
  Zheng Can
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Cardiovascular Center Research Institute
Development of a novel cardiovascular regenerative therapy by vagal nerve stimulation
- Principal Investigator
  
  LI MEIHUA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Vagal stimulation, a novel therapeutic approach for cardiovascular regeneration
- Principal Investigator
  
  LI Meihua
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Involvement of a non-neuronal cardiac cholinergic system in energy metabolism and pathophysiological situations
- Principal Investigator
  
  KAKINUMA Yoshihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kochi University
Neural Interface Therapy for Severe Heart Failure
- Principal Investigator
  
  SATO Takayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kochi University
Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction
- Principal Investigator
  
  UEMURA Kazunori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Cardiovascular Center Research Institute
Vagal Nerve Stimulation : A Novel Therapeutic Strategy for Dilated CardiomyopathyPrincipal Investigator
- Principal Investigator
  
  ZHENG Can
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kochi University
A new pharmacotherapy for chronic heart failure after myocardialinfarction
- Principal Investigator
  
  LI Meihua
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

[Journal Article] Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats2020
- Author(s)
  i M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 70 Pages: 11-11
- DOI
  10.1186/s12576-020-00739-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08091, KAKENHI-PROJECT-18K12126, KAKENHI-PROJECT-16KT0022, KAKENHI-PROJECT-17K09544
[Journal Article] Low-dose landiolol reduces heart rate and cardiac oxygen consumption without compromising initial hemodynamic resuscitation in a canine model of endotoxin shock2019
- Author(s)
  Uemura Kazunori、Kawada Toru、Zheng Can、Li Meihua、Sugimachi Masaru
- Journal Title
  
  Shock
  
  Volume: Jul Pages: 102-110
- DOI
  10.1097/shk.0000000000001224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09544, KAKENHI-PROJECT-18K12126, KAKENHI-PROJECT-18K08091
[Journal Article] Chronic Vagal Nerve Stimulation Exerts Additional Beneficial Effects on the Beta-Blocker-Treated Failing Heart2019
- Author(s)
  Li Meihua, Zheng Can, Kawada Toru, Inagaki Masashi, Uemura Kazunori, Sugimachi Masaru
- Journal Title
  
  J Physiol Sci
  
  Volume: 69 Pages: 295-303
- DOI
  10.1007/s12576-018-0646-0
- NAID
  40021819001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0022, KAKENHI-PROJECT-18K12126, KAKENHI-PROJECT-18K08091, KAKENHI-PROJECT-17K09544
[Journal Article] Acute ivabradine treatment reduces heart rate without increasing atrial fibrillation inducibility irrespective of underlying vagal activity in dogs.2017
- Author(s)
  Uemura K, Inagaki M, Zheng C, Kawada T, Li M, Fukumitsu M, Sugimachi M
- Journal Title
  
  Heart and Vessels
  
  Volume: 32 Pages: 484-494
- DOI
  10.1007/s00380-016-0922-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099, KAKENHI-PROJECT-16KT0022, KAKENHI-PROJECT-17K09544, KAKENHI-PROJECT-15K01307
[Journal Article] Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure2017
- Author(s)
  Zheng C, Li M, Kawada T, Inagaki M, Uemura K, Sugimachi M
- Journal Title
  
  Physiological Reports
  
  Volume: 5
- DOI
  10.14814/phy2.13497
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0022, KAKENHI-PROJECT-17K09544, KAKENHI-PROJECT-15K01307
[Journal Article] Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock.2017
- Author(s)
  Uemura Kazunori、Kawada Toru、Zheng Can、Li Meihua、Sugimachi Masaru
- Journal Title
  
  BMC Anesthesiol.
  
  Volume: 17 Pages: 1-13
- DOI
  10.1186/s12871-017-0437-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09544, KAKENHI-PROJECT-15K01307
[Journal Article] Less Invasive and Inotrope-Reduction Approach to Automated Closed-Loop Control of Hemodynamics in Decompensated Heart Failure.2016
- Author(s)
  Uemura K, Kawada T, Zheng C, Sugimachi M.
- Journal Title
  
  IEEE Trans Biomed Eng.
  
  Volume: Nov 11. [Epub ahead of print] Pages: 1-10
- DOI
  10.1109/tbme.2015.2499782
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K01307, KAKENHI-PROJECT-26430103
[Journal Article] Acute Effects of Vagotomy on Baroreflex Equilibrium Diagram in Rats with Chronic Heart Failure2016
- Author(s)
  Kawada T, Li M, Zheng C, Sugimachi M
- Journal Title
  
  Clin Med Insights Cardiol.
  
  Volume: 10 Pages: 139-47
- DOI
  10.4137/cmc.s38443
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461099
[Journal Article] Acute arterial baroreflex-mediated changes in plasma catecholamine concentrations in a chronic rat model of myocardial infarction2016
- Author(s)
  Kawada T, Akiyama T, Li M, Zheng C, Turner MJ, Shirai M, Sugimachi M.
- Journal Title
  
  Physiol Rep
  
  Volume: 4(15)
- DOI
  10.14814/phy2.12880
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26461099, KAKENHI-PROJECT-26462774
[Journal Article] Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats.2015
- Author(s)
  Kawada T, Li M, Sata Y, Zheng C, Turner MJ, Shimizu S, Sugimachi M
- Journal Title
  
  Clinical Medicine Insights: Cardiology
  
  Volume: 9(Suppl 1) Pages: 1-9
- DOI
  10.4137/cmc.s18759
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26750153, KAKENHI-PROJECT-26461099
[Journal Article] A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities2015
- Author(s)
  Uemura K, Inagaki M, Zheng C, Li M, Kawada T, Sugimachi M.
- Journal Title
  
  Heart Vessels
  
  Volume: 30 Pages: 516-26
- DOI
  10.1007/s00380-014-0525-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500565, KAKENHI-PROJECT-24591087, KAKENHI-PROJECT-15K01307, KAKENHI-PROJECT-15K09113, KAKENHI-PROJECT-26430103, KAKENHI-PROJECT-26461099, KAKENHI-PROJECT-25610036
[Journal Article] Chronic vagal nerve stimulation improves baroreflex neural arc function in heart failure rats.2014
- Author(s)
  Kawada T, Li M, Zheng C, Shimizu S, Uemura K, Turner MJ, Yamamoto H, Sugimachi M
- Journal Title
  
  J Appl Physiol (1985).
  
  Volume: 116(10) Pages: 1308-1314
- DOI
  10.1152/japplphysiol.00140.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-24500565, KAKENHI-PROJECT-26461099
[Journal Article] Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.2014
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
- Journal Title
  
  Eur J Heart Fail.
  
  Volume: 16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461099
[Journal Article] Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure2014
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
- Journal Title
  
  European Journal of Heart Failure
  
  Volume: 16 Pages: 1056-1065
- DOI
  10.1002/ejhf.164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500565, KAKENHI-PROJECT-24591087, KAKENHI-PROJECT-25610036, KAKENHI-PROJECT-26430103
[Journal Article] Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.2010
- Author(s)
  Uemura K, Zheng C, Li M, Kawada T, Sugimachi M.
- Journal Title
  
  J Card Fail.2010 Aug ; 16(8) : 689-99
  
  Volume: 16 Pages: 689-699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590799
[Journal Article] Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure.2010
- Author(s)
  Okazaki Y, Zheng C, Li M, Sugimachi M.
- Journal Title
  
  J Physiol Sci. 60(1)
  
  Pages: 67-74
- NAID
  10027711328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590853
[Journal Article] Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.2010
- Author(s)
  Uemura K, Zheng C, Li M, Kawada T, Sugimachi M
- Journal Title
  
  J Card Fail. 16
  
  Pages: 689-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500404
[Journal Article] Early Short-Term Vagal Nerve Stimulation Attenuates Cardiac Remodeling After Reperfused Myocardial Infarction.2010
- Author(s)
  Uemura K, Zheng C, Li M, Kawada T, Sugimachi M.
- Journal Title
  
  J Card Fail. 16(8)
  
  Pages: 689-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590853
[Journal Article] Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.2010
- Author(s)
  Uemura K, Zheng C, Li M, Kawada T, Sugimachi M.
- Journal Title
  
  J Card Fail.
  
  Volume: 16(8) Pages: 689-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590799
[Journal Article] 生体情報の長期取得のための神経再生型電極の開発2008
- Author(s)
  杉町勝, 川田徹, 鄭燦, 佐藤隆幸
- Journal Title
  
  人工臓器 37
  
  Pages: 175-178
- NAID
  10025704673
- Data Source
  KAKENHI-PROJECT-20590853
[Journal Article] Electrical acupuncture modifies autonomic balance by resetting the neural arc of arerial baroreflex system2007
- Author(s)
  Suginachi M, Kawada T, Kamiya A, Li M, Zheng C, Sunagawa K
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc. 2007
  
  Pages: 5334-5337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590843
[Journal Article] Angiotensin II attenuates myocardial interstitial acetylcholine release in response to vagal stimulation2007
- Author(s)
  Kawada T, Yamazaki T, Akiyama, Li M, Zheng C, Shishido T, Mori H, Sugimachi M
- Journal Title
  
  Am J Physiol Heart Circ Physiol 293(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590843
[Patent] 心不全治療薬2005
- Inventor(s)
  杉町勝・李梅花・鄭燦・佐藤隆幸・砂川賢二
- Industrial Property Number
  2005-286284
- Filing Date
  2005-09-30
- Acquisition Date
  2007-04-12
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Chronic vagal nerve stimulation suppress thirst through decreasing vasopressin secretion in the rats with chronic heart failure2019
- Author(s)
  C. Zheng , M. Li , Ｋ. Uemura , T. Kawada , M. Inagaki , M. Sugimachi
- Organizer
  ESC Asia with APSC & AFC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08091
[Presentation] Oral Administration of Donepezil Markedly Prevents the Progression of Chronic Heart Failure in Renal Artery Stenosis-Induced Hypertensive Rats.2019
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Toshiaki Shishido, Sugimachi M.
- Organizer
  ESC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08091
[Presentation] Donepezil Treatment Prevents the Progression of Chronic Heart Failure and Improves the Prognosis in Spontaneously Hypertensive Rats with Myocardial Infarction.2019
- Author(s)
  Li Meihua 李　梅花、稲垣　正司、鄭　燦、川田　徹、上村　和紀、杉町　勝 [迷走神経刺激は心筋梗塞ラットにおける間葉系幹細胞移植の治療効果を増強する] (第58回生体医工学会、日本　沖縄)
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-17K09544
[Presentation] Feasibility and Efficacy of Early Donepezil with or Without Metoprolol in Reperfused Myocardial Infarction Rats2018
- Author(s)
  Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Masaru Sugimachi
- Organizer
  欧州心臓病学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08091
[Presentation] Pericardiectomy decreases exercise capacity through elimination respiratory suction2018
- Author(s)
  Can Zheng, Meihua Li, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Masaru Sugimachi
- Organizer
  欧州心臓病学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08091
[Presentation] Donepezil but not Metoprolol Improves Myocardial Salvage and Prevents Cardiac Remodeling after Reperfused Myocardial Infarction in Rats2017
- Author(s)
  LI M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi
- Organizer
  JCS 2017
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Donepezil Markedly Prevents the Progression of Cardiac Remodeling and Improves Survival in Spontaneously Hypertensive Rats with Myocardial Infarction2017
- Author(s)
  LI M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi
- Organizer
  JCS 2017
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Correlation of Thirst and the Prognosis in Chronic Heart Failure Rats2017
- Author(s)
  C. Zheng, M. Li, T. Kawada, M. Inagaki, K. Uemura, M. Sugimachi
- Organizer
  第81回　日本循環器学会学術集会
- Place of Presentation
  金沢，日本
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Prognostic significance of thirst augmentation in chronic heart failure rats2016
- Author(s)
  C. Zheng, M. Li, T. Kawada, M. Inagaki, K. Uemura, M. Sugimachi
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Drinking behavioral and hemodynamic responses to daily fluid restriction in chronic heart failure rats2016
- Author(s)
  C. Zheng, M. Li, T. Kawada, M. Sugimachi
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Vagal Stimulation Promotes Cardiovascular Regeneration by Activation of Endogenous Cardiac Stem Cells in Acute Myocardial Infarction Rats2016
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Shishido T, Sugimachi M
- Organizer
  ESC 2016
- Place of Presentation
  ローマ
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Central Donepezil Infusion Prevents Progression of Cardiac Remodeling and Improves Long-term Survival in Chronic Heart Failure Rats with Myocardial Infarction2016
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi M.
- Organizer
  The 80th Annual Scientific Meeting of the Japanise Circulation Society
- Place of Presentation
  SENDAI, Japan
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Contribution of Central Donepezil to Prevention of Cardiac Dysfunction and Improvement of Long-term Survival in Chronic Heart Failure Rats after Myocardial Infarction2016
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Shishido T, Sugimachi M
- Organizer
  ESC 2016
- Place of Presentation
  ローマ
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Donepezil Administration as a Novel Therapy for Improved Myocardial Salvage after Reperfused Myocardial Infarction2016
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi M
- Organizer
  ESC 2016
- Place of Presentation
  ローマ
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Central donepezil infusion prevents progression of cardiac remodeling and dysfunction in chronic heart failure rats with extensive myocardial infarction2016
- Author(s)
  M. Li, C. Zheng, T. Kawada, M. Inagaki, K. Uemura, T. Shishido, M. Sugimachi
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Prognostic significance of thirst augmentation in chrnic heart failure rats2016
- Author(s)
  Zheng C, Li M, Kawada T, Inagaki M, Uemura K, Sugimachi M
- Organizer
  ESC 2016
- Place of Presentation
  ローマ
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Drinking behavioral and hemodynamics responses to daily fluid restriction in chrnic heart failure rats2016
- Author(s)
  Zheng C, Li M, Kawada T, Sugimachi M
- Organizer
  ESC 2016
- Place of Presentation
  ローマ
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Early donepezil administration as a novel therapy for improved myocardial salvage after reperfused myocardial infarction2016
- Author(s)
  M. Li, C. Zheng, T. Kawada, M. Inagaki, K. Uemura, T. Shishido, M. Sugimachi
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Central donepezil infusion prevents progression of cardiac remodeling and dysfunction in chronic heart failure rats with extensive myocardial infarction2015
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, SUgimachi M.
- Organizer
  ESC CONGRESS 2015
- Place of Presentation
  LONDON
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] ドネペジルの早期投与による再灌流心筋梗塞ラットにおける心臓リモデリングの抑制作用2015
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、上村和紀、宍戸稔聡、杉町勝
- Organizer
  第36回日本循環制御医学会総会
- Place of Presentation
  NAGOYA, Japan
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Augmented Thirst as a Clue for Fluid Management in Chronic Heart Failure2015
- Author(s)
  Can, Zheng
- Organizer
  BIT’s 7th Annual International Congress of Cardiology
- Place of Presentation
  Shanghai, China
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Early Donepezil Treatment is Superior to Metoprolol for Preventing Cardiac Remodeling in Reperfused Myocardial Infarction Rats2015
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
- Organizer
  The 79th Annual Scientific Meeting of the Japanise Circulation Society
- Place of Presentation
  OSAKA, Japan
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Beneficial effects of Central Donepezil Infusion on Cardiac Remodeling in Chronic Heart Failure Rats with Extensive Myocardial Infarction2015
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi M.
- Organizer
  HAKADA conference
- Place of Presentation
  HUKUOKA, Japan
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Novel Therapeutic Approach in Heart Failure: Pharmacological Parasympathetic Activation2015
- Author(s)
  Li M, Zheng C, Sugimachi M.
- Organizer
  BIT's 7th Annual International Congress of Cardiology-2015
- Place of Presentation
  SHANGHAI, China
- Year and Date
  2015-12-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] ロサルタンによる心筋梗塞ラットの水代謝の是正及び心臓リモデリングの抑制効果􁴾2015
- Author(s)
  鄭　燦
- Organizer
  第３６回日本循環制御医学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26430103
[Presentation] Peripheral but not central blockade of α7-Nicotinic acetylcholine receptors attenuates cardio-protective effects of donepezil in chronic heart failure rats.2013
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Sugimachi M.
- Organizer
  The 77th Ammual Scientific Meeting of the Japanise Circulation Socity.
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] 心筋梗塞後重症心不全治療における末梢性α7-ニコチン性アセチルコリン受容体を介したアセチルコリンエステラーゼ阻害薬(ドネペジル)の心臓保護作用2013
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、上村和紀、杉町勝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Contribution of peripheral versus Central α7-nicotinic acetylcholine receptors to cardio-protective effects of donepezil in chronic heart failure rats.2012
- Author(s)
  Li M, Zheng C, Inagaki M, Kawada T, Uemura K, Sugimachi M.
- Organizer
  AHA 2012
- Place of Presentation
  Los Angeres, Calif.
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] アセチルコリンエステラーゼ阻害薬(ドネペジル)とロサルタンの長期併用投与による心筋梗塞後重症心不全ラットの心機能・長期生存率の改善作用2012
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、杉町勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道、日本
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Chronic vagal stimulation promotes cardiac regeneration by activation of endogenous cardiac stem cells in rats after acute myocardial infarction.2012
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Sugimachi M.
- Organizer
  AHA 2012
- Place of Presentation
  Los Angeres, Calif.
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] アセチルコリンエステラーゼ阻害薬(ドネペジル)とロサルタンの長期併用投与による心筋梗塞後重症心不全ラットの心機能・長期生存率の改善作用2012
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、杉町勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  Hokaidou, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] 末梢性α7-ニコチン性アセチルコリン受容体を介したドネペジルの心筋梗塞後重症心不全における心臓保護作用2012
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、上村和紀、杉町勝
- Organizer
  第33回日本循環制御医学会総会
- Place of Presentation
  栃木、日本
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Restoration of Vagal Tone by Donepezil, on top of losartan treatment, markedly suppresses ventricular dysfunction and improves long-term survival in chronic heart failure rats.2011
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Takaki H, Sugimachi M.
- Organizer
  ESC 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Vagal stimulation markedly suppressed arrhythmic death and prevented cardiac dysfunction in rats after acute myocardial infarction.2011
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Shishido T, Sugimachi M.
- Organizer
  ESC 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] アンジオテンシンII受容体拮抗薬とアセチルコリンエステラーゼ阻害薬の併用投与による心筋梗塞後重症心不全ラットの心機能・心臓リモデリングの改善作用2011
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、杉町勝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(原定)
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Vagal Stimulation Markedly Suppressed Arrhythmic Death and Prevented Cardiac Dysfunction in Rats after Acute Myocardial Infarction2011
- Author(s)
  Li M, Inagaki M, Zheng C, et al
- Organizer
  ESC 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Vagal Stimulation Promotes Myocardial Regeneration by Activation of Cardiac Stem Cells in Acute Myocardial Infarction Rats2011
- Author(s)
  Li M, Inagaki M, Zheng C, et al
- Organizer
  The 75th Ammual Scientific Meeting of the Japanise Circulation Socity
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Restoration of Vagal Tone by Donepezil, on Top of Losartan Treatment, Markedly Improves Long-term Survival in Chronic Heart Failure Rats2011
- Author(s)
  Li M, Zheng C, Kawada T, et al
- Organizer
  The 75th Ammual Scientific Meeting of the Japanise Circulation Socity
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] Restoration of Vagal Tone by Donepezil, on Top of Losartan Treatment, Markedly Suppresses Ventricular Dysfunction and Improves Long-term Survival in Chronic Heart Failure Rats2011
- Author(s)
  Li M, Zheng C, Kawada T, et al
- Organizer
  ESC 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] A new intelligent technique of fluid restriction in small animals.2010
- Author(s)
  鄭燦
- Organizer
  第31回日本循環制御医学会総会
- Place of Presentation
  大阪府千里ライフサイエンスセンター
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20300177
[Presentation] 急性期からの迷走神経の慢性電気刺激は心筋梗塞ラットの致死性不整脈と心臓リモデリングを抑制する2010
- Author(s)
  李梅花、稲垣正司、鄭燦、川田徹、上村和紀、宍戸稔聡、杉町勝
- Organizer
  第32回日本循環制御医学会総会
- Place of Presentation
  富山、日本
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] A New Intelligent Technique of Fluid Restriction in Small Animals2010
- Author(s)
  鄭燦
- Organizer
  第31回日本循環制御医学会総会
- Place of Presentation
  千里ライフセンター(大阪府)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] A new intelligent technique of fluid restriction in small animals.2010
- Author(s)
  鄭燦
- Organizer
  第31回日本循環制御医学会総会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20300177
[Presentation] Vagal stimulation markedly suppressed arrhythmic death and prevented cardiac dysfunction in rats after acute myocardial infarction.2010
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Shishido T, Sugimachi M.
- Organizer
  19^<th> International Conference of the Cardiovascular System Dynamics Society.
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] 急性期からの迷走神経の慢性電気刺激は心筋梗塞ラットの致死性不整脈と心臓リモデリングを抑制する2010
- Author(s)
  李梅花、稲垣正司、鄭燦、川田徹、上村和紀、宍戸稔聡、杉町勝
- Organizer
  第31回日本循環制御医学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590799
[Presentation] A New Intelligent Technique of Fluid Restriction in Small Animals.2010
- Author(s)
  鄭燦
- Organizer
  第31回日本循環制御医学会総会
- Place of Presentation
  千里ライフセンター,大阪
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Drinking Style of Myocardial Infarcted Rats : A Proposal for Fluid Restriction Prescription for Patients with Chronic Heart Failure.2009
- Author(s)
  Zheng C. Li M, Kawada T, Sugimachi M, Sato T.
- Organizer
  第73回日本循環器学会総会・学術総会
- Place of Presentation
  大阪
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Donepezil Markedly Suppresses Ventricular Dysfunction and Improves Neurohumoral States on Top of Losartan in Rats with Extensive Myocardial Infarction.2009
- Author(s)
  鄭燦
- Organizer
  AHA Scientific Sessions 2009.
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Drinking style of Myocardial Infarcted Rats : A Proposal for Fluid Restriction Prescription for Patients with Chronic Heart Failure2009
- Author(s)
  鄭燦
- Organizer
  第73回日本循環器学会総会・学術集会
- Place of Presentation
  大阪市, 大阪国際会議場
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Blockade of a7-nicotinic acetylcholine receptors attenuates cardio-prote effects of donepezil in rats with extensive myocardial infarction2009
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Akiyama T, Sugimachi M
- Organizer
  Circulation Journal. 2009; 73 (SupplementI). 第73回日本循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] 重症心不全に対する迷走神経刺激療法2009
- Author(s)
  宍戸稔聡、李梅花、鄭燦、上村和紀、川田徹、杉町勝
- Organizer
  第24回生体・生理工学シンポジウム
- Place of Presentation
  仙台市、東北大学
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Blockade of α7-Nicotinic Acetylcholine Receptors Attenuates Cardio-protective Effects of Donepezil in Rats with Extensive Myocardial Infarction.2009
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Shishido T, Akiyama T, Sugimachi M.
- Organizer
  第73回日本循環器学会総会・学術総会
- Place of Presentation
  大阪
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Donepezil Markedly Suppresses Ventricular Dysfunction and Improves Neurohumoral States on Top of Losartan in Rats With Extensive Myocardial Infarction2009
- Author(s)
  Can Zheng
- Organizer
  AHA Scientific Sessions 2009
- Place of Presentation
  Orlando, USA, Orange County Convention Center
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] アセチルコリンエステラージ阻害薬とアンジオテンシンII受容体拮抗薬の併用投与による心筋梗塞後重症心不全ラットの心機能、心臓リモデリングの改善作用2008
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、佐藤隆幸、杉町勝
- Organizer
  第9回日本neurocardiology研究会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] アンジオテンシンII受容体拮抗薬(ロサルタン)とアセチルコリンエステラージ阻害薬(ドネペジル)の併用投与による心筋梗塞後重症心不全ラットの心機能、心臓リモデリングの改善作用2008
- Author(s)
  李梅花、鄭燦、川田徹、稲垣正司、佐藤隆幸、杉町勝
- Organizer
  第29回日本循環制御医学学会総会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Addition of acetylcholinesterase inhibitor, donepezil improvfurther than losartan alone in rats with extensive myocardial infarction2008
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Shishido T, Sato T, Sugimachi M
- Organizer
  Circulation Journal 2008; 72 (Supplement I). 第72回日本循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Vagal Stimulation markedly Suppresses Arrhythmias and Improve Survival Rate of Endstage Heart Failure Rats.2008
- Author(s)
  Zheng C, Li M, Kawada T, Sugimachi M.
- Organizer
  第72回日本循環器学会総会・学術総会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-20590853
[Presentation] Both acute and chronic-phase vagal stimulation markedly suppressed arrhythmic death and prevented remodeling in rats after large myocardial infarction2008
- Author(s)
  Li M, Inagaki M, Zheng C, Kawada T, Uemura K, Shishido T, Sato T, Sugimachi M
- Organizer
  Circulation Journal. 2008; 72 (Supplement I). 第72回日本循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Restration of vagal tone by donepezil markedly prevents progression of ventricular remodeling and dysfunction in rats after myocardial infarction2007
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Shishido T, Sato T, Sugimachi M
- Organizer
  JACC. 2007; 49(9): Supplement A. ACC 56^<th> Annual Scientific sessions
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Restoration of vagal tone by donepezil markedly improves long-term survival in rats with incurable severe heart failure2007
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Shishido T, Sato T, Sugimachi M
- Organizer
  Circulation Journal. 2007; 71(SupplementI). 第71回日本循環器学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Restration of vagal tone by donepezil markedly improves long-term survival in rats with incurably svere heart failure2007
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Shishido T, Sato T, Sugimachi M
- Organizer
  THE FASEB JOURNAL. 2007; 21(6): Part II(726-13). Experimental Biology
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Chronic vagal stimulation enhances survival of transplanted mesenchymal stem cells and its therapeutic potency in a rat model of myocardial infarction2007
- Author(s)
  Li M, Masashi Inagaki, Zheng C, Kawada T, Uemura T, Nagaya N, Sugimachi M
- Organizer
  Circulation. 2007; 116(19): Supplement IV. American Heart Association, Scientific sessions 2007
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Donepesil exerts its preventive effect on ventricular dysfunction on top of losartan in rats with extensive myocardial infarction2007
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Shishido T, Sato T, Sugimachi M
- Organizer
  Circulation Journal. 2007; 71 (SupplementI). 第71回日本循環器学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-19590843
[Presentation] Peripheral α7-Nicotinic Acetylcholine Receptors Contribute to Cardio-Protective Effects of Central Donepezil Infusion in Chronic Heart Failure Rats
- Author(s)
  Li M, Zheng C, Kawada T, Inagaki M, Uemura K, Sugimachi M.
- Organizer
  AHA 2014
- Place of Presentation
  Chicago, lllinois
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Early Chronic Vagal Stimulation Markedly Suppressed Arrhythmic Death and Prevented Cardiac Remodeling in Rats after Acute Myocardial Infarction
- Author(s)
  Meihua Li, Masashi Inagaki, Can Zheng, Toru Kawada, Kazunori Uemura, Masaru Sugimachi.
- Organizer
  第53回日本生体医工学会大会
- Place of Presentation
  仙台、日本
- Year and Date
  2014-06-24 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-26461099
[Presentation] Losartan Increases Urine Output and Dose not Affects Thirst and Fluid Consumption in Heart Failure Rats
- Author(s)
  Zheng C, Li M, Kawada T, Uemura K, Inagaki M, Sugimachi M
- Organizer
  第７８回日本循環器学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-04-24 – 2015-04-26
- Data Source
  KAKENHI-PROJECT-26430103

1. LI Meihua (60443496)

# of Collaborated Projects: 7 results

# of Collaborated Products: 76 results
2. KAWADA Toru (30243752)

# of Collaborated Projects: 4 results

# of Collaborated Products: 59 results
3. UEMURA Kazunori (10344350)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
4. INAGAKI Masashi (80359273)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
5. SATO Takayuki (90205930)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAKINUMA Yoshihiko (40233944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ARIKAWA Mikihiko (20432817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NOGUCHI Tatsuya (50566495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YAMASAKI Fumiyasu (10243841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HANDA Takemi (00437716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AKIYAMA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 清水秀二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TURNER MICHAEL

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 白井幹康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zheng Can 鄭 燦

ZHENG Can 鄭 燦

Research Projects

Research Products

Co-Researchers

Combination of drinking behavior modulation with pharmacological vagal activation for treatment of chronic heart failurePrincipal InvestigatorOngoing

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Development of a new cardiovascular regenerative treatment method by pharmacological vagus nerve stimulation aiming for practical clinical use

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Drinking behavior modulation significantly prevent cardiac remodeling and improve survival in chronic heart failure ratsPrincipal Investigator

Principal Investigator

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Development of a novel cardiovascular regenerative therapy by vagal nerve stimulation

Principal Investigator

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Vagal stimulation, a novel therapeutic approach for cardiovascular regeneration

Principal Investigator

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Involvement of a non-neuronal cardiac cholinergic system in energy metabolism and pathophysiological situations

Principal Investigator

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Neural Interface Therapy for Severe Heart Failure

Principal Investigator

Project Period (FY)

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Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction

Principal Investigator

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Research Institution

Vagal Nerve Stimulation : A Novel Therapeutic Strategy for Dilated CardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

A new pharmacotherapy for chronic heart failure after myocardialinfarction

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats2020

Author(s)

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DOI

Data Source

[Journal Article] Low-dose landiolol reduces heart rate and cardiac oxygen consumption without compromising initial hemodynamic resuscitation in a canine model of endotoxin shock2019

Author(s)

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DOI

Data Source

[Journal Article] Chronic Vagal Nerve Stimulation Exerts Additional Beneficial Effects on the Beta-Blocker-Treated Failing Heart2019

Author(s)

Journal Title

DOI

NAID

Zheng Can 鄭燦

ZHENG Can 鄭燦