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Terai Hideki  寺井 秀樹

… Alternative Names

寺井 秀樹  テライ ヒデキ

TERAI HIDEKI  寺井 秀樹

TERAI Hideki  寺井 秀樹

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Researcher Number 50445293
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1118-1930
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 講師
2025: 北里大学, 北里研究所病院, 医師
Affiliation (based on the past Project Information) *help 2025: 慶應義塾大学, 医学部(信濃町), 講師
2022: 慶應義塾大学, 医学部(信濃町), 講師
2019 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教
2018: 北里大学, 北里研究所病院, 医長
2014: 慶應義塾大学, 医学部, 共同研究員 … More
2012 – 2013: 慶應義塾大学, 医学部, 助教
2011 – 2012: 慶應義塾大学, 医学部, 特任助教
2010: 慶應義塾大学, 医学部, 助教 Less
Review Section/Research Field
Principal Investigator
Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Except Principal Investigator
Respiratory organ internal medicine
Keywords
Principal Investigator
EGFR-TKI / DNAメチル化 / ICI / 肺扁平上皮癌 / STING / drug resistance / CRISPR screening / 非小細胞肺癌 / drug persister / celastrol … More / lung cancer / EGFR / MAPK / SHOC2 / CRISPR/Cas9 / epigenetics / エピジェネティクス / EGFR-TKI耐性化 / FGFR / FGFR1 / FGF2 / 獲得耐性 / ゲフィチニブ / イレッサ / 薬剤耐性 / 肺癌 … More
Except Principal Investigator
PI3K / pathway signature / 染色体転座 / Exon array / 扁平上皮癌 / 腺癌 / FGF / 融合遺伝子 / exon array / microRNA / fibroblast growth factor-9 / pathway signature解析 / 網羅的解析 / 非小細胞肺癌 Less
  • Research Projects

    (6 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (8 People)
  •  肺扁平上皮癌におけるSTING抑制メカニズムの解明と治療標的の探索Principal Investigator

    • Principal Investigator
      寺井 秀樹
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Keio University
  •  Discovery of novel cancer treatment through elucidation of cGAS/STING pathway in lung squamous cell carcinomaPrincipal Investigator

    • Principal Investigator
      寺井 秀樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Keio University
  •  Discovery of novel cancer treatment with CRIPR/Cas9 screeningPrincipal Investigator

    • Principal Investigator
      TERAI HIDEKI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Keio University
      Kitasato University
  •  網羅的遺伝子解析手法を用いたゲフィチニブ耐性化機序の解明Principal Investigator

    • Principal Investigator
      寺井 秀樹
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Keio University
  •  Investigation of the mechanism of gefitinib resistance by comprehensive genetic analysisPrincipal Investigator

    • Principal Investigator
      TERAI Hideki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Keio University
  •  Screening of fusion genes in non-small cell lung cancer

    • Principal Investigator
      SOEJIMA Kenzo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Keio University

All 2021 2020 2019 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model2021

    • Author(s)
      Kobayashi Keigo、Terai Hideki、Yasuda Hiroyuki、Hamamoto Junko、Hayashi Yuichiro、Takeuchi Osamu、Mitsuishi Yoichiro、Masuzawa Keita、Manabe Tadashi、Ikemura Shinnosuke、Kawada Ichiro、Suzuki Yukio、Soejima Kenzo、Fukunaga Koichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 534 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2020.11.110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
  • [Journal Article] Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells2020

    • Author(s)
      Ohgino Keiko、Terai Hideki、Yasuda Hiroyuki、Nukaga Shigenari、Hamamoto Junko、Tani Tetsuo、Kuroda Aoi、Arai Daisuke、Ishioka Kota、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Naoki Katsuhiko、Fukunaga Koichi、Soejima Kenzo
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 10 Pages: 3793-3801

    • DOI

      10.1111/cas.14569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
  • [Journal Article] IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer2020

    • Author(s)
      Manabe Tadashi、Yasuda Hiroyuki、Terai Hideki、Kagiwada Harumi、Hamamoto Junko、Ebisudani Toshiki、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Hayashi Yuichiro、Fukui Kazuhiko、Horimoto Katsuhisa、Fukunaga Koichi、Soejima Kenzo
    • Journal Title

      Molecular Cancer Research

      Volume: 印刷中 Issue: 4 Pages: 549-559

    • DOI

      10.1158/1541-7786.mcr-19-0956

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-19J12401, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K15959, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
  • [Journal Article] SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells2020

    • Author(s)
      Terai Hideki、Hamamoto Junko、Emoto Katsura、Masuda Takeshi、Manabe Tadashi、Kuronuma Satoshi、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Nakayama Sohei、Kawada Ichiro、Suzuki Yusuke、Takeuchi Osamu、Suzuki Yukio、Ohtsuki Sumio、Yasuda Hiroyuki、Soejima Kenzo、Fukunaga Koichi
    • Journal Title

      Molecular Cancer Research

      Volume: 19 Issue: 2 Pages: 317-328

    • DOI

      10.1158/1541-7786.mcr-20-0664

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
  • [Journal Article] Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab.2019

    • Author(s)
      Oashi A, Yasuda H, Kobayashi K, Tani T, Hamamoto J, Masuzawa K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K
    • Journal Title

      Mol Cancer Ther

      Volume: 18 Issue: 9 Pages: 1593-1601

    • DOI

      10.1158/1535-7163.mct-18-1036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K08184
  • [Journal Article] Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations2019

    • Author(s)
      Hasegawa H, Yasuda H, Hamamoto J, Masuzawa K, Tani T, Nukaga S, Hirano T, Kobayashi K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K.
    • Journal Title

      Lung Cancer

      Volume: 127 Pages: 146-52

    • DOI

      10.1016/j.lungcan.2018.11.039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-18K08184
  • [Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013

    • Author(s)
      Terai H, Soejima K, Yasuda H, et al
    • Journal Title

      Mol Cancer Res

      Volume: 印刷中 Issue: 7 Pages: 759-767

    • DOI

      10.1158/1541-7786.mcr-12-0652

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590870, KAKENHI-PROJECT-23501311, KAKENHI-PROJECT-24790822
  • [Journal Article] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2013

    • Author(s)
      Hamamoto J, Soejima K, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Yasuda H, Hayashi Y, Sakamoto M, Takebayashi T, Betsuyaku T
    • Journal Title

      Mol Med Rep

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013

    • Author(s)
      Terai H, Soejima KN, Yasuda H, Nakayama S, Hamamoto J, Arai D, Ishioka K, Ohgino K, Ikemura S, Sato T, Yoda S, Satomi R, Naoki K, Betsuyaku T.
    • Journal Title

      Molecular Cancer Research

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Journal Article] The PCR-Invader method (structure-specific 5' nuclease based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens ; comparison with direct sequencing2011

    • Author(s)
      Naoki K, Soejima K, Okamoto H, Hamamoto J, Hida N, Nakachi I, Yasuda H, Nakayama S, Yoda S, Satomi R, Ikemura S, Terai H, Sato T, Watanabe K
    • Journal Title

      Int J ClinOncol

      Volume: 16 Pages: 335-344

    • NAID

      10029527544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] EGFRチロシンキナーゼ阻害剤の初期耐性におけるSHOC2の役割2019

    • Author(s)
      浜本 純子、寺井 秀樹、眞鍋 維志、小林 慧悟、増澤 啓太、安田 浩之、川田 一郎、副島 研造
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K08184
  • [Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure2013

    • Author(s)
      Terai H, Soejima K, Naoki K, Yasuda H, Satomi R, Nakayama S, Yoda S, Ikemura S, Sato T, Ishioka K, Arai D, Ohgino K, Hamamoto J, Betsuyaku T
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      ワシントン(アメリカ)
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Kenzo Soejima, Katsuhiko Naoki et al. Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure2013

    • Author(s)
      Hideki Terai
    • Organizer
      103th AACR annual meeting
    • Place of Presentation
      Washington, DC.
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Presentation] FGF9 overexpression promotes tumorigenic potential of non-small cell lung cancer (NSCLC) cells and is associated with poor prognosis in NSCLC2013

    • Author(s)
      Ishioka K, Soejima K, Yasuda H, Ohgino K, Arai D, Kuroda A, Tani T, Sato T, Terai H, Ikemura S, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      ワシントン(アメリカ)
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2013

    • Author(s)
      H. Terai, K. Soejima, K. Naoki, H. Yasuda, R. Satomi, S. Nakayama, S.Yoda, S. Ikemura, T. Sato, K. Ishioka, D. Arai, K. Ohgino, J. Hamamoto, T. Betsuyaku
    • Organizer
      2013 AACR annual meeting
    • Place of Presentation
      Washington, DC, USA
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2013

    • Author(s)
      H. Terai, K. Soejima, K. Naoki, et al.
    • Organizer
      103th AACR Annual Meeting
    • Place of Presentation
      Washington, DC.
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] 肺癌におけるTFPI-2のメチル化によるTMPRSS4の過剰発現と癌化2012

    • Author(s)
      浜本純子,副島研造,安田浩之,荒井大輔,石岡宏太,池村辰之介,寺井秀樹,猶木克彦,別役智子
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] FGF9 (fibroblast growth factor 9) 発現肺癌における臨床および遺伝子発現に関する検討2012

    • Author(s)
      120. 扇野圭子,副島研造,荒井大輔,石岡宏太,池村辰之介,寺井秀樹,浜本純子,猶木克彦,別役智子
    • Organizer
      日本臨床腫瘍学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Kenzo Soejima, Katsuhiko Naoki, etal. Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2012

    • Author(s)
      Hideki Terai
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2012

    • Author(s)
      寺井秀樹、副島研造、猶木克彦、安田浩之、池村辰之介、佐藤崇、荒井大輔、石岡宏太、扇野圭子、濱本純子、別役智子
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌・ホテルロイトン札幌
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Presentation] 肺癌患者における気道上皮被覆液のプロテオーム解析2011

    • Author(s)
      寺井秀樹、副島研造、渡辺真純、猶木克彦、安田浩之、里見良輔、中山荘平、依田聡、池村辰之介、佐藤崇、諸澤麻衣子、浅野浩一郎
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-04-23
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Analysis of aberrant DNA methylation and expression of corresponding mRNA in EGFR-TKI-sensitive lung cancer cell line with long-term gefitinib exposure.2011

    • Author(s)
      H. Terai, K. Soejima, K. Naoki, et al.
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] 肺癌患者の気道上皮被覆液を用いたプロテオーム解析.2011

    • Author(s)
      寺井秀樹, 副島研造, 渡辺真純
    • Organizer
      第34回日本呼吸器内視鏡学会総会
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Analysis of aberrant DNA methylation and expression of corre sponding mRNA in EGFR-TKI-sensitive lung cancer cell line with long-term gefitinib exposure2011

    • Author(s)
      H.Terai, K Soejima, K.Naoki, R.Satomi, S.Nakayama, S.Yoda, S.Ikemura, T.Sato, J.Hamamoto, K.Asano, T.Betsuyaku
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Expression of fibroblast growth factor-9 is associated with poor prognosis of resected non-small cell lung cancer patients2011

    • Author(s)
      Ohgino K, Soejima K, Arai D, Ishioka K, Terai H, Ikemura S, Sato T, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
    • Organizer
      American Association for Cancer Resereach
    • Place of Presentation
      米国、シカゴ
    • Year and Date
      2011-04-03
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma.2011

    • Author(s)
      Junko Hamamoto, Hideki Terai, Katsuhiko Naoki, Takashi Sato, Kenzo Soejima.
    • Organizer
      American Association for Cancer Resereach
    • Place of Presentation
      米国、オーランド
    • Year and Date
      2011-04-06
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2011

    • Author(s)
      Hamamoto J, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, SatoT, Izumi Y, Kawamura M, Nomori H, Hayashi Y, Sakamoto M, Takebayashi T, Soejima K
    • Organizer
      American Association for Cancer Resereach
    • Place of Presentation
      米国、オーランド
    • Year and Date
      2011-04-06
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] 肺癌患者における気道上皮被覆液のプロテオーム解析.2011

    • Author(s)
      寺井秀樹、副島研造、渡辺真純
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590870
  • [Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.

    • Author(s)
      Hideki Terai
    • Organizer
      2013 104th AACR Annual Meeting
    • Place of Presentation
      Washington D. C. Convention Center
    • Data Source
      KAKENHI-PROJECT-24790822
  • [Presentation] Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib

    • Author(s)
      Hideki Terai
    • Organizer
      104th AACR Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-26860616
  • [Presentation] Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib

    • Author(s)
      Hideki Terai
    • Organizer
      2014 105th AACR Annual Meeting
    • Place of Presentation
      San Diego Convention Center
    • Data Source
      KAKENHI-PROJECT-24790822
  • 1.  SOEJIMA Kenzo (30236145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 2.  HAMAMOTO Junko (40570239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 3.  NAOKI Katsuhiko (40265806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 4.  SATO Takashi (20464836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 5.  KAWAMURA Masafumi (70169770)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  MASUDA Takeshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  増澤 啓太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  安田 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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