KANAZAWA Ippei 金沢一平

… Alternative Names

Researcher Number	50452553
Affiliation (based on the past Project Information) *help	2018 – 2019: 島根大学, 学術研究院医学・看護学系, 講師 2015 – 2017: 島根大学, 医学部, 講師 2012 – 2015: 島根大学, 医学部, 助教 2010: 島根大学, 医学部, 助教 2008: 島根大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Endocrinology / Orthopaedic surgery / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator General internal medicine(including psychosomatic medicine) / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator AMPK / 骨芽細胞 / オステオカルシン / 骨細胞 / 骨形成 / 脂肪細胞 / C/EBPβ / PPARγ / 筋芽細胞 / 骨代謝 … More Except Principal Investigator 骨粗鬆症 / 椎体骨折 / 骨芽細胞 / IGF-I / 骨代謝 / 老年医学 / 糖尿病 / メバロン酸経路 / 2型糖尿病 / osteocalcin / osteoclcin / 動脈硬化 / adiponectin / AMP Kinase / Rho-kinase / Bone morphogenetic protein-2 / インクレチン / DPP-4 / GLP-1 / GIP / 骨形成 / 骨折 / AGEs / オステオグリシン / 筋芽細胞 / 筋骨連関 / サルコペニア / グルコース / 筋肉 / オステオカルシン / スクレロスチン / FAM5C / 内分泌学 / 筋代謝 Less

細胞内エネルギーセンサーAMPKの骨・糖代謝連関における重要性を明らかにするPrincipal Investigator
- Principal Investigator
  
  金沢一平
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shimane University
Regulation of muscle metabolism by bone
- Principal Investigator
  
  Sugimoto Toshitsugu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Shimane University
An in vivo study to examine the roles of AMPK in bone formation by using osteoblast-specific AMPK knockout micePrincipal Investigator
- Principal Investigator
  
  Kanazawa Ippei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Shimane University
The regulation of bone metabolism by digestive tract: A study on the mechanism of incretin-induced bone formation
- Principal Investigator
  
  Sugimoto Toshitsugu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Shimane University
The roles of osteocalcin in the relationships among bone, adipose tissue, and muscle.Principal Investigator
- Principal Investigator
  
  KANAZAWA Ippei
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
  Orthopaedic surgery
- Research Institution
  Shimane University
エネルギー代謝調節因子は骨代謝を制御し、骨と糖代謝を結ぶ重要な因子となりうるか？Principal Investigator
- Principal Investigator
  
  金沢一平
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Endocrinology
- Research Institution
  Shimane University
The pathogenesis of osteoporosis associated with diabetes mellitus
- Principal Investigator
  
  YAMAGUCHI TORU
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Shimane University

All 2019 2018 2017 2016 2015 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Serum levels of Insulin-like growth factor-I, pentosidine, and adiponectin as markers for assessing bone condition in women with type 2 diabetes.2010
- Author(s)
  Kanazawa I, Yamaguchi T.
- Total Pages
  30
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-20590699
[Book] Serum levels of Insulin-like growth factor-I, pentosidine, and adiponectin as markers for assessing bone condition in women with type 2 diabetes.
- Author(s)
  Kanazawa I, Yamaguchi T
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Phloretin suppresses bone morphogenetic protein-2-induced osteoblastogenesis and mineralization via inhibition of phosphatidylinositol 3-kinases/Akt pathway2019
- Author(s)
  Takeno A, Kanazawa I, Tanaka K, Notsu M, Sugimoto T
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20
- DOI
  10.3390/ijms20102481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08515
[Journal Article] Glucose uptake inhibition decreases expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells2018
- Author(s)
  TakenoA, Kanazawa I, Notsu M, Tanaka K, SUgimoto T
- Journal Title
  
  American Journal of Physiology Endocrinology and Metabolism
  
  Volume: 314
- DOI
  10.1152/ajpendo.00159.2017
- NAID
  120006559369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts <i>via</i> Smad-independent mechanisms2018
- Author(s)
  Takeno A, Kanazawa I, Notsu M, Tanaka K, Sugimoto T
- Journal Title
  
  Endocrine Journal
  
  Volume: 65 Issue: 3 Pages: 291-298
- DOI
  10.1507/endocrj.ej17-0229
  10.1507/endocrj.EJ17-0229
- NAID
  130006575569
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Osteoblast AMP-activated protein kinase regulates glucose metabolism and bone mass in adult mice2018
- Author(s)
  Ippei Kanazawa, Ayumu Takeno, Ken-ichiro Tanaka, Masakazu Notsu, Toshitsugu Sugimoto
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 503 Pages: 1955-61
- DOI
  10.1016/j.bbrc.2018.07.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08515
[Journal Article] Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells2018
- Author(s)
  Ayumu Takeno, Ippei Kanazawa, Masakazu Notsu, Ken-ichiro Tanaka, Toshitsugu Sugimoto
- Journal Title
  
  Int J Mol Sci
  
  Volume: 19
- DOI
  10.3390/ijms19061772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08515
[Journal Article] Osteoblast AMP-activated protein kinase regulates postnatal skeletal development in male mice2018
- Author(s)
  Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T
- Journal Title
  
  Endocrinology
  
  Volume: 159 Pages: 597-608
- DOI
  10.1210/en.2017-00357
- NAID
  120006559368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Association of Osteoglycin and FAM5C with Bone Turnover Markers, Bone Mineral Density, and Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus2017
- Author(s)
  Tanaka KI, Kanazawa I, Kaji H, Sugimoto T
- Journal Title
  
  Bone
  
  Volume: 95 Pages: 5-10
- DOI
  10.1016/j.bone.2016.11.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09240
[Journal Article] Interaction between bone and glucose metabolism [Review]2017
- Author(s)
  Kanazawa I
- Journal Title
  
  Endocrine Journal
  
  Volume: 64 Issue: 11 Pages: 1043-1053
- DOI
  10.1507/endocrj.ej17-0323
  10.1507/endocrj.EJ17-0323
- NAID
  130006224994
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 22016
- Author(s)
  Takeno A, Kanazawa I, Tanaka K, Notsu M, Yokomoto-Umakoshi M, Sugimoto T
- Journal Title
  
  Endocrine Journal
  
  Volume: 63 Issue: 4 Pages: 389-395
- DOI
  10.1507/endocrj.ej15-0480
  10.1507/endocrj.EJ15-0480
- NAID
  130005146451
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus2016
- Author(s)
  Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 未定
- NAID
  120006334822
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] Serum dipeptidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus2016
- Author(s)
  Masakazu Notsu, Ippei Kanazawa, Sayuri Tanaka, Toshitsugu Sugimoto
- Journal Title
  
  Clinical Endocrinology
  
  Volume: 84 Pages: 332-337
- DOI
  10.1111/cen.12971
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] Activation of AMP-activated protein kinase decreases receptor activator of NF-κB ligand expression and increases sclerostin expression by inhibiting the mevalonate pathway in osteocytic MLO-Y4 cells2016
- Author(s)
  Yokomoto-Umakoshi M, Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 469 Pages: 791-796
- DOI
  10.1016/j.bbrc.2015.12.072
- NAID
  120006221290
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である2015
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Journal Title
  
  Osteoporosis Japan
  
  Volume: 23 Pages: 46-50
- Open Access
- Data Source
  KAKENHI-PROJECT-25460899
[Journal Article] Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expression of NADPH oxidase 1 (Nox1) and Nox22015
- Author(s)
  Takeno A, Kanazawa I, Tanaka K, Notsu M, Yokomoto M, Yamaguchi T, Sugimoto T
- Journal Title
  
  Bone
  
  Volume: 77 Pages: 135-141
- DOI
  10.1016/j.bone.2015.04.025
- NAID
  120006221277
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Journal Article] Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus.2011
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T.
- Journal Title
  
  Osteoporos.Int. 22
  
  Pages: 187-194
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus.2011
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Osteoporos.Int.
  
  Volume: 22 Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes.2011
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Bone
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum Insulin-like growth factor-I is a maker far assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus.2011
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Osteoporos.Int.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1 year treatment of type 2 diabetes.2010
- Author(s)
  Kanazawa I, Yamaguchi T, Sugimoto T.
- Journal Title
  
  Metabolism 59
  
  Pages: 1252-1256
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1 year treatment of type 2 diabetes.2010
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Metabolism
  
  Volume: 59 Pages: 1252-1256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.2010
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T.
- Journal Title
  
  Endocr.J. 57
  
  Pages: 415-421
- NAID
  10029584777
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Baseline atherosclerosis parameters could assess the risk of bone loss in type 2 diabetes mellitus during pioglitazone treatment.2010
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Osteoporos.Int.
  
  Volume: 21 Pages: 2013-2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis.2010
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Am J Med Sci.
  
  Volume: 339 Pages: 519-524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Effects of treatment with risedronate and alfacalcidol on progression of atherosclerosis in postmenopausal women with type 2 diabetes mellitus accompanied with osteoporosis.2010
- Author(s)
  Kanazawa I, Yamaguchi T, Hayashi K, Takase H, Shimizu T, Sugimoto T.
- Journal Title
  
  Am J Med Sci. 339
  
  Pages: 519-524
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Baseline atherosclerosis parameters could assess the risk of bone loss in type 2 diabetes mellitus during pioglitazone treatment.2010
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamamoto M, Yamauchi M, Kurioka S, Sugimoto T.
- Journal Title
  
  Osteoporos.Int. 21
  
  Pages: 2013-2018
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Relationships between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus.2010
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  J.Bone Miner.Metab.
  
  Volume: 28 Pages: 554-560
- NAID
  10027684019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Relationships between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus.2010
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Sugimoto T.
- Journal Title
  
  J.Bone Miner.Metab. 28
  
  Pages: 554-60
- NAID
  10027684019
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.2010
- Author(s)
  Kanazawa I, Yamaguchi T, et al.
- Journal Title
  
  Endocr.J.
  
  Volume: 57 Pages: 415-421
- NAID
  10029584777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus.2010
- Author(s)
  Kanazawa I, Yano S, Yamaguchi T, Notsu Y, Nabika T, Sugimoto T.
- Journal Title
  
  Clin.Endocrinol. 73
  
  Pages: 463-468
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing bone morphogenetic protein-2 signal.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Hayashi K, Yamauchi M, Sugimoto T.
- Journal Title
  
  Horm.Metab.Res. 41
  
  Pages: 612-616
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellit us.2009
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  Eur. J. Endocrinol. 160
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I,Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T.
- Journal Title
  
  J.Clin.Endocrinol.Metab. 94
  
  Pages: 45-49
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing bone morphogenetic protein-2 signal.2009
- Author(s)
  Kanazawa I
- Journal Title
  
  Horm. Metab. Res. 41
  
  Pages: 612-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol-lowering effect in patients with type 2 diabetes and hypercholesterolemia.2009
- Author(s)
  Kanazawa I
- Journal Title
  
  Intern.Med. 48
  
  Pages: 1869-1873
- NAID
  130000122199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  J. Clin. Endocrinol. Metab. 94
  
  Pages: 45-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and ertebral fractures in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  Eur.J.Endocrinol. 160
  
  Pages: 265-273
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  J.Clin.Endocrinol.Metab. 94
  
  Pages: 3031-3037
- NAID
  40016591700
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Activation of AMP -kinase and inhibition of Rho -kinase induce the mineralization of osteoblastic MC3T3 -E1cells through endot helial NOS and BMP -2 expression.2009
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  Am. J. Phys iol. Endocrinol. Me tab. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin/bone specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.2009
- Author(s)
  Kanazawa I
- Journal Title
  
  Calcif. Tissue Int. 85
  
  Pages: 228-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin/bone specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  Calcif.Tissue Int. 85
  
  Pages: 228-234
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes.2009
- Author(s)
  Yamaguchi T, Kanazawa I, Yamamoto M, Kurioka S, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  Bone 45
  
  Pages: 174-179
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol- lowering effect in patients with type 2 diabetes and hypercholesterolemia.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yamauchi M, Sugimoto T.
- Journal Title
  
  Intern.Med. 48
  
  Pages: 1869-1873
- NAID
  130000122199
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Activation of AMP-kinase and inhibition of Rho-kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.2009
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T.
- Journal Title
  
  Am.J.Physiol.Endocrinol.Metab. 296
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus.2009
- Author(s)
  Kanazawa I
- Journal Title
  
  J. Clin. Endocrinol. Metab. 94
  
  Pages: 3031-3037
- NAID
  40016591700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP -2 expression.2008
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 375
  
  Pages: 414-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum DHEA-S level is associated with the presence of atherosclerosis in postmenopausal women with type 2 iabetes mellitus.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T.
- Journal Title
  
  Endocr.J. 55
  
  Pages: 667-676
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 375
  
  Pages: 414-419
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum DHEA-S level is associated with the presence of atherosc lerosis in postmenopausa 1women with type 2 diabetes mellitus.2008
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  Endocr. J. 55
  
  Pages: 667-676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men.2008
- Author(s)
  Kanazawa I, et al.
- Journal Title
  
  Calcif. Tissue Int. 83
  
  Pages: 324-331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  Calcif.Tissue Int. 83
  
  Pages: 324-331
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus.
- Author(s)
  Yamaguchi T, Kanazawa I, Takaoka S, Sugimoto T.
- Journal Title
  
  Metabolism in press
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Quantitative ultrasound and vertebral fractures in patients with type 2 diabetes.
- Author(s)
  Yamaguchi T, Yamamoto M, Kanazawa I, Yamauchi M, Yano S, Tanaka N, Nitta E, Fukuma A, Uno S, Sho-no T, Sugimoto T.
- Journal Title
  
  J.Bone.Miner.Metab. in press
- NAID
  10030894840
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.
- Author(s)
  Kanazawa I, Yamamoto M, Yamaguchi T, Sugimoto T.
- Journal Title
  
  Exp.Clin.Endocrinol.Diab in press
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients type 2 diabetes mellitus.
- Author(s)
  Kanazawa I, Yano S, Notsu Y, Yamaguchi T,Nabika T, Sugimoto T.
- Journal Title
  
  Clin.Endocrinol.Epub ahead of print
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes.
- Author(s)
  Kanazawa I,Yamaguchi T, Tada Y, Yamauchi M, Yano S, Sugimoto T.
- Journal Title
  
  Bone in press
- Data Source
  KAKENHI-PROJECT-20590699
[Journal Article] Serum Insulin-like growth factor-I is a maker for assessing the severity of vertebral fractures in ostmenopausal women with type 2 diabetes mellitus.
- Author(s)
  Kanazawa I, Yamaguchi T, Sugimoto T.
- Journal Title
  
  Osteoporos.Int. in press
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] Insulin-like growth factor-Iは終末糖化産物AGEsによるアポトーシス促進、筋芽細胞分化抑制を改善する2019
- Author(s)
  足立奈緒子、金沢一平、田中賢一郎、竹野歩、野津雅和、田中小百合、杉本利嗣
- Organizer
  第62回日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-16K09240
[Presentation] Insulin-like growth factor-I protects against the detrimental effects of advanced glycation end products and high glucose in myoblastic C2C12 cells2019
- Author(s)
  Ippei Kanazawa, Naoko Adachi, Ken-ichiro Tanaka, Ayumu Takeno, Masakazu Notsu, Sayuri Tanaka, Toshitsugu Sugimoto
- Organizer
  American Diabetes Association 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09240
[Presentation] Phloretinがマウス骨髄間葉系細胞ST2の骨芽細胞分化に与える影響2019
- Author(s)
  竹野歩、金沢一平、田中賢一郎、野津雅和、杉本利嗣
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08515
[Presentation] GLUT阻害剤phloretinはグルコース取り込みとは独立してマウス骨髄間葉系細胞ST2の骨芽細胞および脂肪分化を制御する2018
- Author(s)
  竹野歩、金沢一平、野津雅和、田中賢一郎、杉本利嗣
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08515
[Presentation] Phloretinがマウス骨髄間葉系細胞ST2の骨芽細胞および脂肪分化に与える影響2018
- Author(s)
  竹野歩、金沢一平、野津雅和、田中賢一郎、杉本利嗣
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08515
[Presentation] 骨芽細胞AMP-activated protein kinaseの骨伸長、骨量増加における役割の検討2017
- Author(s)
  金沢一平、竹野歩、田中賢一郎、野津雅和、杉本利嗣
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 骨代謝と糖・エネルギー代謝の相互関連性についての研究2017
- Author(s)
  金沢一平
- Organizer
  第90回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 糖代謝における骨細胞グルコース感知の重要性についての検討2017
- Author(s)
  竹野歩、金沢一平、野津雅和、田中賢一郎、杉本利嗣
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Effects of glucose uptake inhibition by phloretin on expressions of RANKL and osteocalcin in osteocytic MLO-Y4-A2 cells2017
- Author(s)
  Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T
- Organizer
  American Society for Bone and Mineral Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] The in vivo roles of osteoblast AMP-activated protein kinase in skeletal development2017
- Author(s)
  Kanazawa I, Takeno A, Tanaka KI, Notsu M, Sugimoto T
- Organizer
  American Society for Bone and Mineral Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Osteoblast AMP-activated protein kinase regulates skeletal development in vivo2017
- Author(s)
  Kanazawa I, Takeno A, Tanaka KI, Notsu M, Sugimoto T
- Organizer
  Australian & New Zealand Bone & Mineral Society meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 骨細胞の糖代謝における役割について2017
- Author(s)
  竹野歩、金沢一平、杉本利嗣
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 骨細胞におけるglucose transporter阻害はAMP-activated protein kinase活性化とMAPK経路抑制を介してosteocalcin、RANKL発現を低下させる2017
- Author(s)
  竹野歩、金沢一平、野津雅和、田中賢一郎、杉本利嗣
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Roles of glucose transporter in expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells2017
- Author(s)
  Takeno A, Kanazawa I, Notsu M, Tanaka KI, Sugimoto T
- Organizer
  Australian & New Zealand Bone & Mineral Society meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] マウス骨細胞系MLO-Y4細胞株においてシンバスタチンはNADPH oxidase 1 および2発現の抑制を介してホモシステインによるアポトーシス促進を解除する2016
- Author(s)
  竹野歩、金沢一平、田中賢一郎、野津雅和、横本真希、杉本利嗣
- Organizer
  第34回日本骨代謝学会学術集会
- Place of Presentation
  大阪府（大阪国際会議場）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 骨細胞系MLO-Y4細胞においてAMP-activated protein kinase活性化はメバロン酸経路を阻害することによりRANKL発現を減少させ、スクレロスチン発現を増加させる2016
- Author(s)
  横本真希、金沢一平、竹野歩、田中賢一郎、野津雅和、杉本利嗣
- Organizer
  第34回日本骨代謝学会学術集会
- Place of Presentation
  大阪府（大阪国際会議場）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Simvastatin rescues Homocysteine-Induced Apoptosis of Osteocytic MLO-Y4 Cells by Decreasing the Expressions of NADPH oxidase 1 (Nox1) and Nox22016
- Author(s)
  Takeno A, Kanazawa I, Tanaka KI, Notsu M, Yokomoto-Umakoshi M, Sugimoto T
- Organizer
  American Society for Bone and Mineral Research 2016 Annual Meeting
- Place of Presentation
  America, Atlanta
- Year and Date
  2016-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Activation of AMP-activated Protein Kinase Protects Against Homocysteine-Induced Apoptosis of Osteocytic MLO-Y4 Cells by Regulating the Expressions of NADPH oxidase 1 (Nox1) and Nox22015
- Author(s)
  Takeno A, Kanazawa I, Tanaka KI, Notsu M, Yokomoto M, Yamaguchi T, Sugimoto T
- Organizer
  American Society for Bone and Mineral Research 2015 Annual Meeting
- Place of Presentation
  America, Seattle
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Metformin protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by activation of AMP-activated protein kinase2015
- Author(s)
  Kanazawa I, Takeno A, Tanaka KI, Notsu M, Yokomoto M, Yamaguchi T, Sugimoto T
- Organizer
  51th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Sweden, Stockholm
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 血中DPP-4濃度高値は多発椎体骨折リスクと関連する2015
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市海峡メッセ下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] AMP kinase活性化はホモシステインによる骨細胞MLO-Y4のアポトーシス誘導を解除する2015
- Author(s)
  竹野歩、金沢一平、田中賢一郎、野津雅和、横本真希、山口徹、杉本利嗣
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京都（京王プラザホテル）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] 2型糖尿病における血清DPP-4濃度とCT診断による内臓脂肪型肥満との関連性の検討2015
- Author(s)
  田中小百合、金沢一平、野津雅和、杉本利嗣
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市海峡メッセ下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] Visceral fat obesity and metabolic syndrome increase serum DPP-4 levels in type 2 diabetes mellitus2015
- Author(s)
  Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
- Organizer
  51th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Sweden, Stockholm
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460899
[Presentation] AMP kinase活性化はホモシステインによる骨細胞MLO-Y4のアポトーシス誘導を解除する2015
- Author(s)
  竹野歩、金沢一平、田中賢一郎、野津雅和、横本真希、山口徹、杉本利嗣
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  東京都（ホテルニューオータニ東京）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09433
[Presentation] Quantitative ultrasound of the calcaneus is not useful for assessing the risk of vertebral fractures in patients with type 2 diabetes.2010
- Author(s)
  Yamaguchi T, Yamamoto M, Kanazawa I, Yamauchi M, Kurioka S, Yano S, Sugimoto T
- Organizer
  IOF Regionals Singapore' 10 1st Asia-Pacific Osteoporosis Meeting
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in patients with type 2 diabetes.2009
- Author(s)
  Yamaguchi T, Kanazawa I, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T
- Organizer
  2nd Joint Meeting of the International Bone & Mineral Society and the Australian and New Zealand Bone and Mineral Society.
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 骨芽細胞におけるAMP-kinaseおよびメバロン酸経路の役割2009
- Author(s)
  山口徹、金沢一平、林公美、矢野彰三、山内美香、山本昌弘、杉本利嗣シンポジウム
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 2型糖尿病における血中オステオカルシンと糖・脂肪代謝、動脈硬化指標への関与の検討2009
- Author(s)
  金沢一平
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  前橋
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes.2009
- Author(s)
  Yamaguchi T, Kanazawa I, Yamamoto M, Yamauchi M, Yano S, Sugimoto T
- Organizer
  The 31th American Society for Bone and Mineral Research
- Place of Presentation
  Denver, CO, USA
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 骨芽細胞様細胞MC3T3-E1においてメバロン酸経路阻害薬はグルココルチコイドによる石灰化抑制を解除する2008
- Author(s)
  金沢一平, ほか
- Organizer
  第81回日本内分泌学会総会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] Inhibition of the mevalonate pathway rescues the dexamethasone inducedsuppression of the mineralization of osteoblastic cells2008
- Author(s)
  Kanazawa I, et al.
- Organizer
  The 30^<th> American Society for Bone and Mineral Research
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 2型糖尿病における血中アディポネクチンの骨代謝への関与の検討-男性2型糖尿病においては総アディポネクチン値が骨脆弱性の指標となりうる2008
- Author(s)
  金沢一平, ほか
- Organizer
  第10回日本骨粗鬆症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 血糖コントロール不良な2型糖尿病患者の短期治療介入における骨代謝マーカー、アディボネクチンの経時的推移とその変化量の相互関連性についての検討2008
- Author(s)
  金沢一平, ほか
- Organizer
  第10回日本骨粗鬆症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] Inhibition of the mevalonate pathway rescues the dexamethasoneinducedsuppression of the mineralization of osteoblastic ells.2008
- Author(s)
  Kanazawa I, Yamaguchi T, Yano S, Hayashi K, Yamauchi M, Sugimoto
- Organizer
  The 30^<th> American Society for Bone and Mineral Research, Montreal
- Place of Presentation
  Canada
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 男性2型糖尿病患者において骨芽細胞成熟の指標(オステオカルチン/骨型ALP比)は骨密度非依存性に椎体骨折の存在を予測しえる2008
- Author(s)
  金沢一平, ほか
- Organizer
  第26回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] MetforminはAMP-kinase活性化を介してeNOS・BMP-2発現を増強し、骨芽細胞の分化・石灰化を増強する2008
- Author(s)
  金沢一平, ほか
- Organizer
  第26回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590699
[Presentation] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である
- Author(s)
  野津雅和、金沢一平、田中小百合、杉本利嗣
- Organizer
  第16回日本骨粗鬆症学会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2014-10-23 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25460899

1. Sugimoto Toshitsugu (00226458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. YAMAGUCHI TORU (00239899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 39 results
3. YAMAMOTO Masahiro (50346392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. TAKENO AYUMU

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
5. NOTSU MASAKAZU

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
6. TANAKA KENICHIRO

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results

KANAZAWA Ippei 金沢 一平

金沢 一平 カナザワ イッペイ

Research Projects

Research Products

Co-Researchers

細胞内エネルギーセンサーAMPKの骨・糖代謝連関における重要性を明らかにするPrincipal Investigator

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Regulation of muscle metabolism by bone

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An in vivo study to examine the roles of AMPK in bone formation by using osteoblast-specific AMPK knockout micePrincipal Investigator

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The regulation of bone metabolism by digestive tract: A study on the mechanism of incretin-induced bone formation

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The roles of osteocalcin in the relationships among bone, adipose tissue, and muscle.Principal Investigator

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エネルギー代謝調節因子は骨代謝を制御し、骨と糖代謝を結ぶ重要な因子となりうるか？Principal Investigator

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The pathogenesis of osteoporosis associated with diabetes mellitus

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[Book] Serum levels of Insulin-like growth factor-I, pentosidine, and adiponectin as markers for assessing bone condition in women with type 2 diabetes.2010

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[Book] Serum levels of Insulin-like growth factor-I, pentosidine, and adiponectin as markers for assessing bone condition in women with type 2 diabetes.

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[Journal Article] Phloretin suppresses bone morphogenetic protein-2-induced osteoblastogenesis and mineralization via inhibition of phosphatidylinositol 3-kinases/Akt pathway2019

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[Journal Article] Glucose uptake inhibition decreases expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells2018

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NAID

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[Journal Article] Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts <i>via</i> Smad-independent mechanisms2018

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[Journal Article] Osteoblast AMP-activated protein kinase regulates glucose metabolism and bone mass in adult mice2018

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KANAZAWA Ippei 金沢一平

金沢一平カナザワイッペイ