Takemoto Yasushi 竹本靖

Researcher Number	50453543
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 福島県立医科大学, 医学部, 講師 2017 – 2022: 京都大学, 化学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Chemical biology Except Principal Investigator Basic Section 52040:Radiological sciences-related / Science and Engineering
Keywords	Principal Investigator ケミカルバイオロジー / タンパク質分解 / 小分子化合物 / ラジカル / 光照射 / 心筋分化 / 多能性幹細胞 / ケミカルジェネティクス Except Principal Investigator 個別化医療 / 分子標的 … More / 免疫回避 / 放射線治療抵抗性 / 抗腫瘍免疫 / 化合物ライブラリー / ケミカルバイオロジー Less

活性酸素感受性シグナルペプチドの同定と生理的意義の解明Principal Investigator
- Principal Investigator
  
  竹本靖
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Fukushima Medical University
Enhancing Anti-Tumor Immunity in Radiation Therapy through Molecular Targeted Drugs
- Principal Investigator
  
  吉本由哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
ラジカル感受性ペプチドシグナルの探求Principal Investigator
- Principal Investigator
  
  竹本靖
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Fukushima Medical University
  Kyoto University
Spatiotemporal regulation of protein degradation by small molecule compound and lightPrincipal Investigator
- Principal Investigator
  
  Takemoto Yasushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Kyoto University
Study of myocardial differentiation mechanism of pluripotent stem cells by chemical genetics approachPrincipal Investigator
- Principal Investigator
  
  Takemoto Yasushi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Chemical signals of synthetic nutrient conjugates
- Principal Investigator
  
  Uesugi Motonari
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2023
- Author(s)
  Kittaka Atsushi、Kawagoe Fumihiro、Mototani Sayuri、Takemoto Yasushi、Uesugi Motonari
- Journal Title
  
  Synthesis
  
  Volume: 56 Issue: 09 Pages: 1460-1464
- DOI
  10.1055/a-2236-0413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023
- Author(s)
  Kawagoe Fumihiro、Mototani Sayuri、Mendoza Aileen、Takemoto Yasushi、Uesugi Motonari、Kittaka Atsushi
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 14 Issue: 10 Pages: 2030-2034
- DOI
  10.1039/d3md00352c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K14688, KAKENHI-PROJECT-22K05354, KAKENHI-PROJECT-23K06029, KAKENHI-PROJECT-18K06556
[Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite2022
- Author(s)
  Mendoza, A., Takemoto, Y., Cruzado, KT., Masoud, SS., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M.
- Journal Title
  
  Cell Chem Biol.
  
  Volume: 29 Issue: 4 Pages: 660-669
- DOI
  10.1016/j.chembiol.2021.08.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19H02889, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-22K19101, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-18H05503, KAKENHI-PLANNED-17H06412
[Journal Article] Self-assembling small-molecule adjuvants as antigen nano-carriers2022
- Author(s)
  Jin Shuyu、Zhuo Shao-hua、Takemoto Yasushi、Li Yan-mei、Uesugi Motonari
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 87 Pages: 12228-12231
- DOI
  10.1039/d2cc05016a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05354
[Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue2021
- Author(s)
  Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M.
- Journal Title
  
  Chem Commun.
  
  Volume: 57 Issue: 12 Pages: 1470-1473
- DOI
  10.1039/d0cc07171d
- NAID
  120007002689
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19K23816
[Journal Article] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo2021
- Author(s)
  Kawagoe, F., Mendoza, A., Hayata, Y., Asano, L., Kotake, K., Mototani, S., Kawamura, S., Kurosaki, S., Akagi, Y., Takemoto, Y., Nagasawa, K., Nakagawa, H., Uesugi, M., Kittaka, A.
- Journal Title
  
  J Med Chem.
  
  Volume: 64 Issue: 9 Pages: 5689-5709
- DOI
  10.1021/acs.jmedchem.0c02179
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19H02889, KAKENHI-PROJECT-18K06556
[Journal Article] Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis2021
- Author(s)
  Takemoto Yasushi、Kadota Shin、Minami Itsunari、Otsuka Shinya、Okuda Satoshi、Abo Masahiro、Punzalan Louvy Lynn、Shen Yan、Shiba Yuji、Uesugi Motonari
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 40 Pages: 21824-21831
- DOI
  10.1002/anie.202100523
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05733, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-16H06276
[Journal Article] Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library2020
- Author(s)
  Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Issue: 6 Pages: 708-718
- DOI
  10.1016/j.chembiol.2020.04.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05733, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922
[Journal Article] ケミカルバイオロジーが切り開くビタミンD3の新機能2020
- Author(s)
  竹本靖、上杉志成
- Journal Title
  
  日本農芸化学会機関誌「化学と生物」
  
  Volume: 58 Pages: 141-142
- Data Source
  KAKENHI-PLANNED-17H06408
[Journal Article] Discovery of a Small-Molecule-Dependent Photolytic Peptide2020
- Author(s)
  Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Goetze, Shin-ichi Sato, Motonari Uesugi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 3 Pages: 1142-1146
- DOI
  10.1021/jacs.9b09178
- NAID
  120006813278
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05733, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922
[Journal Article] Chemical decontamination of iPS cell-derived neural cell mixtures2018
- Author(s)
  Mao Di、Chung Xie Khim Watson、Andoh-Noda Tomoko、Qin Ying、Sato Shin-ichi、Takemoto Yasushi、Akamatsu Wado、Okano Hideyuki、Uesugi Motonari
- Journal Title
  
  Chem Commun (Camb). 1355
  
  Volume: 54 Issue: 11 Pages: 1355-1358
- DOI
  10.1039/c7cc08686e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K19197, KAKENHI-PROJECT-17K13267, KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-17K19200, KAKENHI-PUBLICLY-17H05706, KAKENHI-PROJECT-26220206
[Presentation] プロテオミクスによるX線照射により分解されるタンパク質の同定2023
- Author(s)
  竹本靖、竹本操、吉本由哉、鈴木義行
- Organizer
  第149回日本医学放射線学会　北日本地方会
- Data Source
  KAKENHI-PROJECT-22K05354
[Presentation] ビタミンD代謝産物による脂質ベータ酸化とカルニチン生合成の制御2022
- Author(s)
  竹本靖、Mendoza Aileen、Cruzado Kevin Tan、Masoud Shadi Sedghi、永田亜希子、Tantipanjaporn Ajcharapan、奥田聡、川越文裕、坂本良太、小田木陽、本谷小佑里、冨樫萌香、川谷誠、青野晴美、長田裕之、中川勇人、東達也、橘高敦史、長澤和夫、上杉志成
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22K05354
[Presentation] TMEM43によるSREBPシグナルの制御2022
- Author(s)
  ツェレンダグバマンチル、竹本靖、上杉志成
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K05354
[Presentation] 心筋分化促進化合物KY02111の標的分子の同定2022
- Author(s)
  竹本靖、門田真、南一成、大塚慎也、奥田聡、プンザランリーンルービー、シェンヤン、柴祐司、上杉志成
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K05354
[Presentation] 光反応性プローブを用いた生理活性小分子化合物の標的同定2022
- Author(s)
  竹本　靖
- Organizer
  JT講演会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06408
[Presentation] 光反応性プローブを用いた生理活性小分子化合物の標的同定2022
- Author(s)
  竹本靖
- Organizer
  JT講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K05733
[Presentation] Discovery of a Small-Molecule-Dependent Photolytic Peptide2021
- Author(s)
  Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Goetze, Shin-ichi Sato, Motonari Uesugi
- Organizer
  Pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05733
[Presentation] 人工ビタミン D3 の創出と応用2019
- Author(s)
  竹本靖、上杉志成
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06408
[Presentation] YM-53601によるスクアレン合成酵素の光分解機構の解析2019
- Author(s)
  竹本靖、Di Mao、Louvy Punzalan、Sebastian Goetze、上杉志成
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K05733
[Presentation] 小分子化合物依存的な光分解性ペプチドの発見2019
- Author(s)
  竹本靖、上杉志成
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第6回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06408
[Presentation] YM-53601によるスクアレン合成酵素の光分解機構の解析2018
- Author(s)
  竹本靖、Di Mao、Sebastian Gotze、上杉志成
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K13267
[Presentation] Discovery of “photo-degradation tag of protein” derived from squalene synthase2018
- Author(s)
  Yasushi Takemoto, Di Mao, Louvy Punzalan, Sebastian Goetze, Motonari Uesugi
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13267

1. Uesugi Motonari (10402926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 吉本由哉 (80594390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鈴木義行 (60334116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 川越文裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 赤松和土

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takemoto Yasushi 竹本 靖

Research Projects

Research Products

Co-Researchers

活性酸素感受性シグナルペプチドの同定と生理的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhancing Anti-Tumor Immunity in Radiation Therapy through Molecular Targeted Drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ラジカル感受性ペプチドシグナルの探求Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatiotemporal regulation of protein degradation by small molecule compound and lightPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of myocardial differentiation mechanism of pluripotent stem cells by chemical genetics approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical signals of synthetic nutrient conjugates

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure?activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-0522023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Self-assembling small-molecule adjuvants as antigen nano-carriers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-genetic cell-surface modification with a self-assembling molecular glue2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library2020

Author(s)

Journal Title

DOI

Takemoto Yasushi 竹本靖