Hosojima Michihiro 細島康宏

Researcher Number	50464003
Other IDs
Affiliation (Current)	2026: 新潟大学, 医歯学総合研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 新潟大学, 医歯学総合研究科, 特任准教授 2014 – 2015: 新潟大学, 医歯(薬)学総合研究科, 特任准教授
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator メガリン / バイオマーカー / 尿中バイオマーカー / 近位尿細管 / 糖尿病性腎症 / SGLT2阻害薬 / エンドサイトーシス / 糖尿病性腎臓病 / 糖尿病 / 尿中メガリン / 肥満関連腎症 / エクソソーム … More Except Principal Investigator … More 慢性腎臓病 / メガリン / 創薬 / バイオマーカー / 急性腎障害 / 糖尿病性腎臓病 / コホート研究 / SGLT2阻害薬 / in silicoスクリーニング / クライオ電子顕微鏡 / 抗刷子縁抗体病 / 23Na-MRI / Na / diabetic model mouse / Nephrotic syndrome / ネフローゼ症候群 / 対向流増幅系 / ナトリウム / 23Na MRI / MRI Less

抗刷子縁抗体病の実態調査と病態解明に関する研究
- Principal Investigator
  
  蒲澤秀門
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
前向きコホート10年追跡による尿細管マーカーのCKD発症・進展予測能の検討
- Principal Investigator
  
  蒲澤佳子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Elucidation of kidney disease pathogenesis and development of new diagnostics and therapeutics based on detailed analysis of megalin structure and functio
- Principal Investigator
  
  Saito Akihiko
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Analyzing the Pathophysiological Mechanisms of Nephrotic Syndrome using 23Na-MRI
- Principal Investigator
  
  Kaseda Ryohei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Urinary excretion mechanism of a novel urinary biomarker of diabetic kidney disease, extracellular domain type of megalinPrincipal Investigator
- Principal Investigator
  
  HOSOJIMA MICHIHIRO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury
- Principal Investigator
  
  Saito Akihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Significance of urinary megalin excretion linked to the pathophysiology of obesity- or metabolic syndrome-related nephropathyPrincipal Investigator
- Principal Investigator
  
  Hosojima Michihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Hosojima Michihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University

All 2024 2023 2022 2021 2020 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] The endocytosis receptor megalin: From bench to bedside2023
- Author(s)
  Goto S, Hosojima M, Kabasawa H, Saito A
- Journal Title
  
  International Journal of Biochemistry and Cell Biology
  
  Volume: 15 Pages: 106393-106393
- DOI
  10.1016/j.biocel.2023.106393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21436
[Journal Article] Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study2022
- Author(s)
  Iida Tomomichi、Hosojima Michihiro、Kabasawa Hideyuki、Yamamoto-Kabasawa Keiko、Goto Sawako、Tanaka Takahiro、Kitamura Nobutaka、Nakada Mitsutaka、Itoh Shino、Ogasawara Shinya、Kaseda Ryohei、Suzuki Yoshiki、Narita Ichiei、Saito Akihiko
- Journal Title
  
  Journal of Diabetes and its Complications
  
  Volume: 36 Issue: 11 Pages: 108312-108312
- DOI
  10.1016/j.jdiacomp.2022.108312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09690, KAKENHI-PROJECT-23K21436
[Journal Article] Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity2021
- Author(s)
  Arita M, Watanabe S, Aoki N, Kuwahara S, Suzuki R, Goto S, Abe Y, Takahashi M, Sato M, Hokari S, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Kondo R, Hayashi M, Ohshima Y, Kabasawa H, Hosojima M, Koya T, Saito A, Kikuchi T.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 750-750
- DOI
  10.1038/s41598-020-80853-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0019, KAKENHI-PROJECT-19K08673, KAKENHI-PROJECT-20H04127, KAKENHI-PROJECT-23K20323, KAKENHI-PROJECT-18H02825
[Journal Article] 連載ミニ連載Ⅱ.エクソソーム:老化関連疾患の分子機構から体液診断まで２.腎疾患におけるエクソソームバイオマーカー2018
- Author(s)
  細島康宏、蒲澤秀門、桑原頌治、斎藤亮彦
- Journal Title
  
  CLINICAL CALCIUM
  
  Volume: 28 Issue: 2 Pages: 252-259
- DOI
  10.20837/4201802252
- ISSN
  0917-5857
- Year and Date
  2018-02-28
- Data Source
  KAKENHI-PROJECT-18H02825
[Journal Article] 特集腎疾患領域のゲノム医療と新規治療ターゲット 6.メガリンをターゲットとした腎臓病の診断･治療法の開発2018
- Author(s)
  桑原頌治，細島康宏，蒲澤秀門，忰田亮平，斎藤亮彦
- Journal Title
  
  腎と骨代謝
  
  Volume: 31 Issue: 1 Pages: 53-58
- DOI
  10.19020/KB.0000000098
- ISSN
  0914-5265, 2433-2496
- Year and Date
  2018-01-01
- Data Source
  KAKENHI-PROJECT-18H02825
[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017
- Author(s)
  De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 5 Pages: 1391-1404
- DOI
  10.2337/db16-1031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-26461216, KAKENHI-PROJECT-26670429, KAKENHI-PROJECT-26860630
[Patent] シクロデキストリン誘発腎障害の抑制2022
- Inventor(s)
  斎藤亮彦，後藤佐和子，細島康宏，蒲澤秀門，平山吉朗
- Industrial Property Rights Holder
  斎藤亮彦，後藤佐和子，細島康宏，蒲澤秀門，平山吉朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-194619
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] Association of calcium-to-magnesium intake ratio with albuminuria in community-dwelling Japanese adults2024
- Author(s)
  Keiko Kabasawa, Michihiro Hosojima, Kazutoshi Nakamura, Ribeka Takachi, Junta Tanaka, Ichiei Narita, Yumi Ito
- Organizer
  Kidney Week 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07694
[Presentation] Association of dietary acid load and its dietary sources with aciduria in community-dwelling Japanese adults2024
- Author(s)
  Keiko Kabasawa, Michihiro Hosojima, Hideyuki Kabasawa, Ribeka Takachi, Kazutoshi Nakamura, Junta Tanaka, Yumi Ito
- Organizer
  Kidney Week 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07694
[Presentation] 溶血関連腎症におけるメガリンの役割とその治療戦略2022
- Author(s)
  後藤佐和子，細島康宏，蒲澤秀門，成田一衛，斎藤亮彦
- Organizer
  第65回日本腎臓学会年次学術総会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] 2型糖尿病患者における尿中メガリン測定による腎予後予測2022
- Author(s)
  飯田倫理，細島康宏，蒲澤秀門，蒲澤佳子，後藤佐和子，田中崇裕，北村信隆，忰田亮平，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第65回日本腎臓学会年次学術総会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] 2型糖尿病患者における尿中メガリンの腎予後予測能の検討2022
- Author(s)
  飯田倫理，細島康宏，蒲澤秀門，蒲澤佳子，後藤佐和子，田中崇裕，北村信隆，忰田亮平，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] SGLT2阻害薬使用時における尿中メガリンおよびメガリンリガンド分子の動態2022
- Author(s)
  細島康宏、蒲澤秀門、後藤佐和子、鈴木芳樹、成田一衛、斎藤亮彦
- Organizer
  第37回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] メガリンを介する腎内レニン-アンジオテンシン(Ang)系(RAS)の動的均衡化制御機構2020
- Author(s)
  後藤佐和子、吉田豊、細島康宏、蒲澤秀門、忰田亮平、成田一衛、斎藤亮彦
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] マウス尿中メガリン測定用サンドイッチELISAの開発とその応用2020
- Author(s)
  早福莉那、後藤佐和子、細島康宏、蒲澤秀門、忰田亮平、成田一衛、斎藤亮彦
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] Two forms of urinary megalin excretion are novel predictors of the progression of early-stage diabetic kidney disease in type 2 diabetes2018
- Author(s)
  Tomomichi Iida, Michihiro Hosojima, et al.
- Organizer
  ISN Frontiers Meetings
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09690
[Presentation] The role of Megalin in the Regulation of Renal RAS: Investigation Using LC/MS-Based Multiple-Reaction Monitoring Quantification of Angiotensin Peptides2018
- Author(s)
  Goto S, Yoshida Y, Hosojima M, Kuwahara S, Iida T, Kabasawa H, Kaseda R, Narita I, Saito A
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] Sodium Glucose Transporter 2 inhibition With Dapagliflozin Downregulates Megalin in Proximal Convoluted Tubules for Renoprotection2018
- Author(s)
  Iida T, Kuwahara S, Hosojima M, Tanaka-Ishikawa T, Wada E, Kabasawa H, Goto S, Ugamura D, Yoshizawa Y, Kaseda R, Narita I, Saito A
- Organizer
  American Society of Nephrology Kidney Week 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] In vitro analysis of the regulation of megalin expression by bardoxolone methyl in proximal tubular epithelial cells2018
- Author(s)
  Yoshizawa Y, Kuwahara S, Hosojima M, Kabasawa H, Kaseda R, Ugamura D, Goto S, Iida T, Suzuki Y, Narita I, Saito A
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] SGLT2阻害薬ダパグリフロジンの腎近位尿細管細胞における血糖値非依存的なメガリン発現抑制作用2018
- Author(s)
  飯田倫理，桑原頌治，細島康宏，石川友美，後藤佐和子，蒲澤秀門，忰田亮平，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] 近位尿細管エンドサイトーシス受容体メガリンを標的とした新しい診断・予防・治療戦略2018
- Author(s)
  細島康宏，蒲澤秀門，桑原頌治，斎藤亮彦
- Organizer
  第30回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] Inhibition of sodium glucose transporter 2 with depagliflozin downregulates megalin expression in proximal tubular epithelial cells2018
- Author(s)
  Iida T, Kuwahara S, Hosojima M, Ishikawa T, Goto S, Kabasawa H, Kaseda R, Suzuki Y, Narita I, Saito A
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] Bardoxolone methylによる腎近位尿細管のメガリン調節機能の検討2018
- Author(s)
  吉澤優太，桑原頌治，細島康宏，蒲澤秀門，忰田亮平，宇賀村大亮，後藤佐和子，飯田倫理，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] LC/MCによるアンジオテンシンペプチドの定量法を用いた腎内RAS調節におけるメガリンの役割の検証2018
- Author(s)
  後藤佐和子，細島康宏，桑原頌治，蒲澤秀門，忰田亮平，鈴木芳樹，成田一衛，吉田豊，斎藤亮彦
- Organizer
  第30回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] 尿中A-メガリンはシスプラチン腎症の発症予測マーカーとなりうる2018
- Author(s)
  蒲澤秀門，飯田倫理，細島康宏，桑原頌治，成田一衛，斎藤亮彦
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] Investigation of the role of megalin in the renal RAS by LC/MS-based multiple-reaction monitoring quantification of angiotensin peptides2018
- Author(s)
  Goto S, Yoshida Y, Hosojima M, Kuwahara S, Kabasawa H, Kaseda R, Suzuki Y, Narita I, Saito A
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02825
[Presentation] 早期の糖尿病腎症における腎予後予測マーカーとしての尿中メガリン測定の意義2017
- Author(s)
  飯田倫理，細島康宏ら
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09690
[Presentation] Mechanisms underlying urinary excretion of full-length and extracellular domain forms of megalin2016
- Author(s)
  Shankhajit De，Shoji Kuwahara，Michihiro Hosojima，Tomomi Ishikawa，Ryohei Kaseda，Yusuke Yoshioka，Yoshiki Suzuki，Ichiei Narita，Takahiro Ochiya，Hiroyuki Kurosawa, Yoshiaki Hirayama, Akihiko Saito
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26860630
[Presentation] Mechanism of Increased Urinary Full-Length Megalin Excretion in Type 2 Diabetes Mellitus Patients with Nephropathy2015
- Author(s)
  Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, MD, PhD, Tomomi Ishikawa, MD, Ryohei Kaseda, MD, PhD, Yusuke Yoshioka, PhD, Yoshiki Suzuki, Ichiei Narita, MD, PhD, Takahiro Ochiya, PhD, Akihiko Saito, MD, PhD.
- Organizer
  American Society of Nephrology 48th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860630

1. SAITO Akihiko (80293207)

# of Collaborated Projects: 8 results

# of Collaborated Products: 20 results
2. KUWAHARA Shoji (70645209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. KABASAWA Hideyuki (20794639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Kaseda Ryohei (20737697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 成田一衛 (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 寺田康彦 (20400640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 後藤佐和子 (10832884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 蒲澤佳子 (70529726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 伊藤由美 (30444160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. DE Shankhajit

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 後藤眞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 阿部貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosojima Michihiro 細島 康宏

Research Projects

Research Products

Co-Researchers

抗刷子縁抗体病の実態調査と病態解明に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

前向きコホート10年追跡による尿細管マーカーのCKD発症・進展予測能の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of kidney disease pathogenesis and development of new diagnostics and therapeutics based on detailed analysis of megalin structure and functio

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyzing the Pathophysiological Mechanisms of Nephrotic Syndrome using 23Na-MRI

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Urinary excretion mechanism of a novel urinary biomarker of diabetic kidney disease, extracellular domain type of megalinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of urinary megalin excretion linked to the pathophysiology of obesity- or metabolic syndrome-related nephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The endocytosis receptor megalin: From bench to bedside2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 連載 ミニ連載Ⅱ.エクソソーム:老化関連疾患の分子機構から体液診断まで ２.腎疾患におけるエクソソームバイオマーカー2018

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] 特集 腎疾患領域のゲノム医療と新規治療ターゲット 6.メガリンをターゲットとした腎臓病の診断･治療法の開発2018

Author(s)

Journal Title

DOI

ISSN

Year and Date

Hosojima Michihiro 細島康宏

[Journal Article] 連載ミニ連載Ⅱ.エクソソーム:老化関連疾患の分子機構から体液診断まで２.腎疾患におけるエクソソームバイオマーカー2018

[Journal Article] 特集腎疾患領域のゲノム医療と新規治療ターゲット 6.メガリンをターゲットとした腎臓病の診断･治療法の開発2018