Takeuchi Masahiro 武内正博

… Alternative Names

Researcher Number	50466702
Other IDs
Affiliation (Current)	2021: 千葉県がんセンター(研究所), 腫瘍・血液内科, 部長
Affiliation (based on the past Project Information) *help	2019: 千葉大学, 医学部附属病院, 講師 2011 – 2018: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 血液内科学 / 血液腫瘍学 / 白血病 / ニッチ / 低酸素 / 細胞接着 / 骨髄線維症 / TGFβ / 巨核球の機能解析 / POEMS症候群 … More Except Principal Investigator POEMS症候群 / 次世代シークエンサー / 微小残存病変 / 形質細胞 / 新規バイオマーカー / 予後予測システム / 悪性リンパ腫 / 急性白血病 / LR11 / びまん性大細胞性B細胞型リンパ腫 / 血管内大細胞性B細胞型リンパ腫 / 血清マーカー / バイオマーカー / 急性骨髄性白血病 / シングルセル解析 / 形質細胞腫瘍 / POEMS syndrome / 次世代シーケンサー / アミロイドーシス / クロナリティ / 骨髄腫類縁疾患 / ALアミロイドーシス Less

骨髄形質細胞の遺伝子発現解析によるALアミロイドーシスの分子病態解明Ongoing
- Principal Investigator
  
  堺田恵美子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Elucidation of the molecular mechanism of POEMS syndrome by single cell analysis of bone marrow plasma cellsOngoing
- Principal Investigator
  
  中世古知昭
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  International University of Health and Welfare
Analysis of the mechanisms of POEMS syndrome with immortalized megakaryocyte progenitor cell linesPrincipal Investigator
- Principal Investigator
  
  Takeuchi Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Establishment of treatment strategy for POEMS syndrome based on MRD detection method with next generation sequencer
- Principal Investigator
  
  Sakaida Emiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Analysis of the mechanism of myelofibrosis with Smad3 knock out micePrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
An establishment of serum soluble LR11, as a novel biomarker in patients with acute leukemia and malignant lymphoma
- Principal Investigator
  
  OHWADA Chikako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Analysis of the function of LR11 on normal leukocytes and leukemia cellsPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Masahiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2020 2019 2018 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells2019
- Author(s)
  Takaishi K, Takeuchi M, Tsukamoto S, Takayama N, Oshima M, Kimura K, Isshiki Y, Kayamori K, Hino Y, Oshima-Hasegawa N, Mitsukawa S, Takeda Y, Mimura N, Ohwada C, Iseki T, Nakamura S, Eto K, Iwama A, Yokote K, Nakaseko C, Sakaida E.
- Journal Title
  
  Haematologica
  
  Volume: Sep 5 Pages: 00-00
- DOI
  10.3324/haematol.2018.214841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-17K09901
[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
- Author(s)
  Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 印刷中 Pages: 2982-2985
- DOI
  10.3109/10428194.2015.1016930
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma.2014
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
- Journal Title
  
  Leukemia and Lymphoma
  
  Volume: (印刷中) Pages: 2391-2394
- DOI
  10.3109/10428194.2014.880430
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409
[Journal Article] The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells2013
- Author(s)
  Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
- Journal Title
  
  J Biol Chem
  
  Volume: 288(17) Pages: 11877-11886
- DOI
  10.1074/jbc.m112.442491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591368, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
[Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013
- Author(s)
  Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
- Journal Title
  
  J Biol Chem
  
  Volume: 288(17) Pages: 11877-86
- Data Source
  KAKENHI-PROJECT-23591368
[Journal Article] LR11: a novel biomarker identified in follicular lymphoma.2013
- Author(s)
  Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
- Journal Title
  
  Br J Haematol.
  
  Volume: 163(2) Pages: 277-280
- DOI
  10.1111/bjh.12467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
[Presentation] 自家移植後再燃 POEMS 症候群に対し複数回移植は有用である2020
- Author(s)
  松井慎一郎、大和田千桂子、相関祥穂、塩入勇翔、礒貝俊太郎、中尾三四郎、柴宮明日香、石井改、山﨑美貴、三科達三、長井友莉恵、日野裕太郎、木村賢司、栢森健介、大島渚、塚本祥吉、三川紫緒、竹田勇輔、三村尚也、武内正博、井関徹、中世古知昭、堺田惠美子
- Organizer
  第42回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] 再発POEMS症候群に対する再移植の有用性2019
- Author(s)
  柴宮明日香、大和田千桂子、松井愼一郎、中尾三四郎、石井改、長井友莉恵、三科達三、山崎美貴、一色佑介、高石浩司、木村賢司、大島渚、塚本祥吉、竹田勇輔、三川紫緒、三村尚也、武内正博、井関徹、三澤園子、桑原聡、中世古知昭、堺田惠美子
- Organizer
  第81回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells2018
- Author(s)
  Koji Takaishi, Masahiro Takeuchi, Shokichi Tsukamoto, Naoya Takayama, Motohiko Oshima, Yusuke Isshiki, Kensuke Kayamori, Naoya Mimura, Chikako Ohwada, Tohru Iseki, Sou Nakamura, Koji Eto, Atsushi Iwama, Koutaro Yokote, Chiaki Nakaseko and Emiko Sakaida
- Organizer
  2018 American Society of Hematology Annual Meeting
- Data Source
  KAKENHI-PROJECT-17K09901
[Presentation] Clonal immunoglobulin λ light-chain gene rearrangements detected by next generation sequencing in POEMS Syndrome.2016
- Author(s)
  Chika Kawajiri-Manako, Naoya Mimura, Masaki Fukuyo, Hiroe Namba-Fukuyo, Bahityar Rahmutulla, Yuhei Nagai, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Emiko Sakaida, Sonoko Misawa, Koutaro Yokote, Satoshi Kuwabara, Atsushi Kaneda, Chiaki Nakaseko
- Organizer
  The 58th Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09494
[Presentation] Clonal IGL gene rearrangements detected by NGS is correlated with disease status in POEMS syndrome2016
- Author(s)
  川尻千華, 三村尚也, 南波宏枝, 福世真樹, 永尾侑平, 東ヶ崎絵美, 清水亮, 竹田勇輔, 酒井紫緒, 大和田千桂子, 武内正博, 堺田惠美子, 井関徹, 三澤園子, 桑原聡, 築地信, 金田篤志, 中世古知昭.
- Organizer
  第78回日本血液学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09494
[Presentation] 血清可溶型LR11（sLR11）のIntravascular large B-cell lymphoma（IVLBCL）に対する診断有用性2014
- Author(s)
  大和田千桂子、中世古知昭、川口岳晴、竹田勇輔、武内正博、堺田惠美子、清水直美、横手幸太郎
- Organizer
  第111回日本内科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461409
[Presentation] 濾胞性リンパ腫における可溶型LR11のバイオマーカーとしての有用性2013
- Author(s)
  川口岳晴，大和田千桂子、山崎敦子、塚本祥吉、酒井紫緒、竹田勇輔、武内正博、堺田恵美子、清水直美、横手幸太郎、武城英明、中世古知昭.
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461409
[Presentation] LR11 plays critical roles in leukemogenesis of AML by regulating cell adhesion and homing ability2013
- Author(s)
  西居圭吾、中世古知昭、武内正博、清水直美、大和田千佳子、塚本祥吉、川口岳晴、姜美子、岩間厚志、武城英明
- Organizer
  第75回日本血液学会総会
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] LR11 regulates the hypoxia-induced hematopoietic immature cell adhesion.2012
- Author(s)
  西居圭吾、武内正博、中世古知昭、武城英明　ほか
- Organizer
  日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] LR11 Plays a Critical Role in Leukemogenesis of Acute Myeloid Leukemia by Regulating Adhesion and Homing Ability to Bone Marrow2012
- Author(s)
  西居圭吾、武内正博、中世古知昭、武城英明ほか
- Organizer
  54th ASH annual meeting and exposition(米国血液学会年次総会)
- Year and Date
  2012-12-09
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Serum soluble LR11 is a promising novel biomarker for B cell lymphoma2012
- Author(s)
  川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
- Organizer
  53rd ASH annual meeting and exposition(米国血液学会年次総会)
- Year and Date
  2012-12-10
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] LR11 regulates the hypoxia-induced hematopoietic immature cell adhesion2012
- Author(s)
  西居圭吾、武内正博、中世古知昭、武城英明ほか
- Organizer
  第74回日本血液学会総会
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] 可溶型LR11はCD87・CD11b複合体を介して単球系THP-1細胞を活性化する2011
- Author(s)
  塚本祥吉、武内正博、杉田泰雅、山崎敦子、川口岳晴、酒井紫緒、竹田勇輔、大和田千桂子、清水直美、堺田恵美子、西居圭吾、姜美子、横手幸太郎、武城英明、中世古知昭
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Serum soluble LR11 is a promising novel biomarker for malignant lymphoma2011
- Author(s)
  川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
- Organizer
  第73回日本血液学会学術集会
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Serum soluble LR11 is a promising novel biomarker for B cell lymphoma.2011
- Author(s)
  川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
- Organizer
  53ｒｄ　ASH annual meeting and exposition　（米国血液学会年次総会）
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Soluble LR11/SorLA, a Potential Circulating Marker Indicating the G-CSF-Induced Mobilization of Hematopoietic Stem Cells, Is a Modulator of G-CSF-Mediated Migration of HL-60 Cells2011
- Author(s)
  清水直美、中世古知昭、武内正博、大和田千桂子、塚本祥吉、川口岳晴、西居桂吾、姜美子、横手幸太郎、深町勇、武城英明
- Organizer
  53rd ASH annual meeting and exposition(米国血液学会年次総会)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Soluble LR11/SorLA, a Potential Circulating Marker Indicating the G-CSF-Induced Mobilization of Hematopoietic Stem Cells, Is a Modulator of G-CSF-Mediated Migration of HL-60 Cells2011
- Author(s)
  清水直美、中世古知昭、武内正博、大和田千桂子、塚本祥吉、川口岳晴、西居桂吾、姜美子、横手幸太郎、深町勇、武城英明
- Organizer
  53ｒｄ　ASH annual meeting and exposition　（米国血液学会年次総会）
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] 可溶性LR11は白血病細胞株HL-60の新たな走化性因子であり、G-CSFによる遊走能を増強する2011
- Author(s)
  清水直美、中世古知昭、酒井紫緒、塚本祥吉、川口岳晴、竹田勇輔、大和田千桂子、武内正博、堺田恵美子、井関徹、西居桂吾、姜美子、横手幸太郎、武城英明
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] 可溶型LR11はCD87・CD11b複合体を介して単球系THP-1細胞を活性化する2011
- Author(s)
  塚本祥吉、武内正博、杉田泰雅、山崎敦子、川口岳晴、酒井紫緒、竹田勇輔、大和田千桂子、清水直美、堺田恵美子、西居圭吾、姜美子、横手幸太郎、武城英明、中世古知昭
- Organizer
  第73回日本血液学会学術集会
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] 可溶性LR11は白血病細胞株HL-60の新たな走化性因子であり、G-CSFによる遊走能を増強する2011
- Author(s)
  清水直美、中世古知昭、酒井紫緒、塚本祥吉、川口岳晴、竹田勇輔、大和田千桂子、武内正博、堺田恵美子、井関徹、西居桂吾、姜美子、横手幸太郎、武城英明
- Organizer
  第73回日本血液学会学術集会
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] Serum soluble LR11 is a promising novel biomarker for malignant lymphoma.2011
- Author(s)
  川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591368
[Presentation] 血管内大細胞性リンパ腫（IVLBCL）の診断におけるLR11の有用性
- Author(s)
  大和田千桂子、中世古知昭、川口岳晴、竹田勇輔、武内正博1、堺田恵美子、清水直美、横手幸太郎
- Organizer
  第111回日本内科学会総会
- Place of Presentation
  東京、国際フォーラム
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461409
[Presentation] LR11 plays a critical role in leukemogenesis of AML by regulating cell adhes ion and homing ability
- Author(s)
  西居桂吾、中世古知昭、武内正博、清水直美、大和田千桂子、塚本祥吉、川口岳晴、姜美子、岩間厚志、武城英明
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591368

1. OHWADA Chikako (80436352)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. NAKASEKO Chiaki (30323398)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
3. SAKAIDA Emiko (60422218)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. BUJO Hideaki (80291300)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
5. IWAMA Atsushi (70244126)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 三村尚也 (00422220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 塚本祥吉 (00814617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. YOKOTE Koutaro (20312944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 竹田勇輔 (60772746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 清水直美

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 姜美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 東守洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 田丸淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 清水孝彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeuchi Masahiro 武内 正博

TAKEUCHI Masahiro 武内 正博

Research Projects

Research Products

Co-Researchers

骨髄形質細胞の遺伝子発現解析によるALアミロイドーシスの分子病態解明Ongoing

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Elucidation of the molecular mechanism of POEMS syndrome by single cell analysis of bone marrow plasma cellsOngoing

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Analysis of the mechanisms of POEMS syndrome with immortalized megakaryocyte progenitor cell linesPrincipal Investigator

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Establishment of treatment strategy for POEMS syndrome based on MRD detection method with next generation sequencer

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Analysis of the mechanism of myelofibrosis with Smad3 knock out micePrincipal Investigator

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An establishment of serum soluble LR11, as a novel biomarker in patients with acute leukemia and malignant lymphoma

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Analysis of the function of LR11 on normal leukocytes and leukemia cellsPrincipal Investigator

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[Journal Article] Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells2019

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[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

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[Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma.2014

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[Journal Article] The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells2013

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[Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

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[Journal Article] LR11: a novel biomarker identified in follicular lymphoma.2013

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[Presentation] 自家移植後再燃 POEMS 症候群に対し複数回移植は有用である2020

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Takeuchi Masahiro 武内正博

TAKEUCHI Masahiro 武内正博