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TAKEUCHI Masahiro  武内 正博

ORCIDConnect your ORCID iD *help
Researcher Number 50466702
Affiliation *help 2011 – 2017 : Chiba University, 医学部附属病院, 助教
2007 : 千葉大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Hematology
Except Principal Investigator
Hematology
Keywords
Principal Investigator
血液内科学 / 白血病 / ニッチ / 細胞接着 / 血液腫瘍学 / TGFβ / 低酸素 / 骨髄線維症
Except Principal Investigator
急性骨髄性白血病 / バイオマーカー … More / 微小残存病変 / 血清マーカー / POEMS症候群 / LR11 / 急性白血病 / 悪性リンパ腫 / 予後予測システム / 新規バイオマーカー / 血管内大細胞性B細胞型リンパ腫 / 次世代シークエンサー / びまん性大細胞性B細胞型リンパ腫 Less
  • Research Projects

    (5results)
  • Research Products

    (25results)
  • Co-Researchers

    (11People)
  •  iPS細胞由来巨核球細胞および疾患特異的M蛋白を用いたPOEMS症候群の病態解明Principal InvestigatorOngoing

    • Principal Investigator
      武内 正博
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  次世代シークエンサーによるMRD検出法に基づくPOEMS症候群の治療戦略の確立Ongoing

    • Principal Investigator
      堺田 恵美子
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Analysis of the mechanism of myelofibrosis with Smad3 knock out micePrincipal Investigator

    • Principal Investigator
      TAKEUCHI Masahiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  An establishment of serum soluble LR11, as a novel biomarker in patients with acute leukemia and malignant lymphoma

    • Principal Investigator
      OHWADA Chikako
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Analysis of the function of LR11 on normal leukocytes and leukemia cellsPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Masahiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume : 印刷中 Pages : 1-4

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
    • Journal Title

      Leuk Lymphoma

      Volume : (印刷中) Pages : 2391-2394

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409
  • [Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

    • Author(s)
      Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
    • Journal Title

      J Biol Chem

      Volume : 288(17) Pages : 11877-86

    • Data Source
      KAKENHI-PROJECT-23591368
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume : 163(2) Pages : 277-280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
  • [Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

    • Author(s)
      Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
    • Journal Title

      The Journal of Biological Chemistry

      Volume : 288(17) Pages : 11877-11886

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591368, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
  • [Presentation] Clonal immunoglobulin λ light-chain gene rearrangements detected by next generation sequencing in POEMS Syndrome.2016

    • Author(s)
      Chika Kawajiri-Manako, Naoya Mimura, Masaki Fukuyo, Hiroe Namba-Fukuyo, Bahityar Rahmutulla, Yuhei Nagai, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Emiko Sakaida, Sonoko Misawa, Koutaro Yokote, Satoshi Kuwabara, Atsushi Kaneda, Chiaki Nakaseko
    • Organizer
      The 58th Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09494
  • [Presentation] Clonal IGL gene rearrangements detected by NGS is correlated with disease status in POEMS syndrome2016

    • Author(s)
      川尻千華, 三村尚也, 南波宏枝, 福世真樹, 永尾侑平, 東ヶ崎絵美, 清水亮, 竹田勇輔, 酒井紫緒, 大和田千桂子, 武内正博, 堺田惠美子, 井関徹, 三澤園子, 桑原聡, 築地信, 金田篤志, 中世古知昭.
    • Organizer
      第78回日本血液学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K09494
  • [Presentation] 血清可溶型LR11(sLR11)のIntravascular large B-cell lymphoma(IVLBCL)に対する診断有用性2014

    • Author(s)
      大和田千桂子、中世古知昭、川口岳晴、竹田勇輔、武内正博、堺田惠美子、清水直美、横手幸太郎
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25461409
  • [Presentation] LR11 plays critical roles in leukemogenesis of AML by regulating cell adhesion and homing ability2013

    • Author(s)
      西居圭吾、中世古知昭、武内正博、清水直美、大和田千佳子、塚本祥吉、川口岳晴、姜美子、岩間厚志、武城英明
    • Organizer
      第75回日本血液学会総会
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 濾胞性リンパ腫における可溶型LR11のバイオマーカーとしての有用性2013

    • Author(s)
      川口岳晴,大和田千桂子、山崎敦子、塚本祥吉、酒井紫緒、竹田勇輔、武内正博、堺田恵美子、清水直美、横手幸太郎、武城英明、中世古知昭.
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25461409
  • [Presentation] Serum soluble LR11 is a promising novel biomarker for B cell lymphoma2012

    • Author(s)
      川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
    • Organizer
      53rd ASH annual meeting and exposition(米国血液学会年次総会)
    • Year and Date
      2012-12-10
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] LR11 regulates the hypoxia-induced hematopoietic immature cell adhesion2012

    • Author(s)
      西居圭吾、武内正博、中世古知昭、武城英明ほか
    • Organizer
      第74回日本血液学会総会
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] LR11 Plays a Critical Role in Leukemogenesis of Acute Myeloid Leukemia by Regulating Adhesion and Homing Ability to Bone Marrow2012

    • Author(s)
      西居圭吾、武内正博、中世古知昭、武城英明ほか
    • Organizer
      54th ASH annual meeting and exposition(米国血液学会年次総会)
    • Year and Date
      2012-12-09
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] LR11 regulates the hypoxia-induced hematopoietic immature cell adhesion.2012

    • Author(s)
      西居圭吾、武内正博、中世古知昭、武城英明 ほか
    • Organizer
      日本血液学会総会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Soluble LR11/SorLA, a Potential Circulating Marker Indicating the G-CSF-Induced Mobilization of Hematopoietic Stem Cells, Is a Modulator of G-CSF-Mediated Migration of HL-60 Cells2011

    • Author(s)
      清水直美、中世古知昭、武内正博、大和田千桂子、塚本祥吉、川口岳晴、西居桂吾、姜美子、横手幸太郎、深町勇、武城英明
    • Organizer
      53rd ASH annual meeting and exposition(米国血液学会年次総会)
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 可溶性LR11は白血病細胞株HL-60の新たな走化性因子であり、G-CSFによる遊走能を増強する2011

    • Author(s)
      清水直美、中世古知昭、酒井紫緒、塚本祥吉、川口岳晴、竹田勇輔、大和田千桂子、武内正博、堺田恵美子、井関徹、西居桂吾、姜美子、横手幸太郎、武城英明
    • Organizer
      第73回日本血液学会学術集会
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 可溶型LR11はCD87・CD11b複合体を介して単球系THP-1細胞を活性化する2011

    • Author(s)
      塚本祥吉、武内正博、杉田泰雅、山崎敦子、川口岳晴、酒井紫緒、竹田勇輔、大和田千桂子、清水直美、堺田恵美子、西居圭吾、姜美子、横手幸太郎、武城英明、中世古知昭
    • Organizer
      第73回日本血液学会学術集会
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Serum soluble LR11 is a promising novel biomarker for malignant lymphoma2011

    • Author(s)
      川口岳晴、大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城英明、中世古知昭
    • Organizer
      第73回日本血液学会学術集会
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Soluble LR11/SorLA, a Potential Circulating Marker Indicating the G-CSF-Induced Mobilization of Hematopoietic Stem Cells, Is a Modulator of G-CSF-Mediated Migration of HL-60 Cells2011

    • Author(s)
      清水直美、中世古知昭、武内正博、大和田千桂子、塚本祥吉、川口岳晴、西居桂吾、姜美子、横手幸太郎、深町勇、武城英明
    • Organizer
      53rd ASH annual meeting and exposition (米国血液学会年次総会)
    • Place of Presentation
      サンディエゴ
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 可溶性LR11は白血病細胞株HL-60の新たな走化性因子であり、G-CSFによる遊 走能を増強する2011

    • Author(s)
      清水直美、中世古知昭、酒井紫緒、塚本祥吉、川口岳晴、竹田 勇輔、大和田千桂子、武内正博、堺田恵美子、井関徹、西居桂吾、姜美子、横手幸太郎、武城英明
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 可溶型LR11はCD87・CD11b複合体を介して単球系THP-1細胞を活性化する2011

    • Author(s)
      塚本祥吉、武内正博、杉田泰雅、山崎敦子、川口岳晴、酒井紫緒、竹田勇輔、 大和田千桂子、清水直美、堺田恵美子、西居圭吾、姜美子、横手幸太郎、武城 英明、中世古知昭
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Serum soluble LR11 is a promising novel biomarker for malignant lymphoma.2011

    • Author(s)
      川口岳晴、 大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城 英明、中世古知昭
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Serum soluble LR11 is a promising novel biomarker for B cell lymphoma.2011

    • Author(s)
      川口岳晴、 大和田千桂子、酒井紫緒、竹田勇輔、清水直美、武内正博、堺田恵美子、田久保耕平、海老沼宏幸、深町勇、東守洋、田丸淳一、横手幸太郎、武城 英明、中世古知昭
    • Organizer
      53rd ASH annual meeting and exposition (米国血液学会年次総会)
    • Place of Presentation
      サンディエゴ
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] LR11 plays a critical role in leukemogenesis of AML by regulating cell adhes ion and homing ability

    • Author(s)
      西居桂吾、中世古知昭、武内正博、清水直美、大和田千桂子、塚本祥吉、川口岳晴、姜美子、岩間厚志 、武城英明
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] 血管内大細胞性リンパ腫(IVLBCL)の 診断におけるLR11の有用性

    • Author(s)
      大和田千桂子、中世古知昭、川口岳晴、竹田勇輔 、武内正博1、堺田恵美子 、清水直美 、横手幸太郎
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京、国際フォーラム
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-25461409
  • 1.  OHWADA Chikako (80436352)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 20results
  • 2.  NAKASEKO Chiaki (30323398)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 25results
  • 3.  BUJO Hideaki (80291300)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 21results
  • 4.  IWAMA Atsushi (70244126)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 2results
  • 5.  SAKAIDA Emiko (60422218)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 8results
  • 6.  YOKOTE Koutaro (20312944)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results
  • 7.  HIGASHI Morihiro
    # of Collaborated Projects : 0results
    # of Collaborated Products : 3results
  • 8.  TAMARU Jun-ichi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 3results
  • 9.  SHIMIZU Naomi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 4results
  • 10.  JIANG Meizi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 3results
  • 11.  SHIMIZU Takahiko
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results

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