Matsumoto Mitsuharu 松本光晴

Researcher Number	50505972
Other IDs	https://orcid.org/0000-0002-8529-2748
Affiliation (Current)	2025: 協同乳業株式会社研究所, 研究所, 研究所長
Affiliation (based on the past Project Information) *help	2019 – 2024: 協同乳業株式会社研究所, 研究所, 主幹研究員 2023: 協同乳業株式会社研究所, 研究所, 所長
Review Section/Research Field	Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 38020:Applied microbiology-related / Medium-sized Section 52:General internal medicine and related fields / Studies on the Super-Aging Society
Keywords	Principal Investigator ポリアミン / ゼノファジー / DNAメチル化 / Fusobacterium nucleatum / コリバクチン産生大腸菌 / 腸内環境 / GLP-1 / 認知症 / 脳腸相関 / 腸内細菌 … More / ホルモン / 腸脳相関 / 腸内細菌叢 / 認知的柔軟性 … More Except Principal Investigator 腸内細菌 / ポリアミン / 代謝産物 / 難消化性ペプチド / 腸脳連関 / 自律神経 / オートファジー / メタボローム解析 / 腸内細菌叢 / パーキンソン病 / メタボローム / 腸内マイクロバイオーム / 心血管疾患 / Staphylococcus / Latilactobacillus / 乳酸菌 / プトレッシン / 酒粕 / プロバイオティクス / 発酵食品由来細菌 / みそ / かぶらずし / Staphy. epidermidis / Latilacto. curvatus / 発酵食品 / 健康寿命 / キイロショウジョウバエ / ノトバイオート動物 / ノトバイオートハエ / 寿命延伸 Less

Gut microbiomics
- Principal Investigator
  
  鈴木亨
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  The University of Tokyo
Development of technology for intestinal polyamine production by combining non-digestible peptides and bacteria derived from fermented foods.
- Principal Investigator
  
  栗原新
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Kindai University
New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogensPrincipal Investigator
- Principal Investigator
  
  松本光晴
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyodo Milk Industry Co., Ltd.
The gut-heart axis as a therapeutic target
- Principal Investigator
  
  鈴木亨
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  The University of Tokyo
Research on microbiome-gut axis in initial pathogenesis of Parkinson's disease
- Principal Investigator
  
  Saiki Shinji
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  University of Tsukuba
Strategy for dementia prevention based on the gut microbiota-brain axis on cognitive flexibilityPrincipal Investigator
- Principal Investigator
  
  Matsumoto Mitsuharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyodo Milk Industry Co., Ltd.
Optimization of polyamine levels in the intestinal tract by controlling gut microbiota using lactic acid bacteria from traditional fermented foods
- Principal Investigator
  
  Kurihara Shin
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Kindai University
Analysis of the effect of gut microbes on the extension of healthy life span using the gnotobiotic fly
- Principal Investigator
  
  Kurihara Shin
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Kindai University

All 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Strain-level detection of <i>Fusobacterium nucleatum</i> in colorectal cancer specimens by targeting the CRISPR?Cas region2023
- Author(s)
  Shimomura Yumi, Sugi Yutaka, Kume Aiko, Tanaka Wataru, Yoshihara Tsutomu, Matsuura Tetsuya, Komiya Yasuhiko, Ogata Yusuke, Suda Wataru, Hattori Masahira, Higurashi Takuma, Nakajima Atsushi, Matsumoto Mitsuharu
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 6
- DOI
  10.1128/spectrum.05123-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17454
[Journal Article] Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice2023
- Author(s)
  Kayo Ikuta, Daisuke Joho, Masaki Kakeyama, Mitsuharu Matsumoto
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00575
[Journal Article] 腸内細菌叢由来ポリアミンが健康長寿の延伸に関与する2023
- Author(s)
  松本光晴
- Journal Title
  
  Microbiome Science
  
  Volume: 2 Pages: 37-43
- Data Source
  KAKENHI-PROJECT-20H00575
[Journal Article] Putrescine Production by Latilactobacillus curvatus KP 3-4 Isolated from Fermented Foods2022
- Author(s)
  Hirano Rika、Kume Aiko、Nishiyama Chisato、Honda Ryosuke、Shirasawa Hideto、Ling Yiwei、Sugiyama Yuta、Nara Misaki、Shimokawa Hiromi、Kawada Hiroki、Koyanagi Takashi、Ashida Hisashi、Okuda Shujiro、Matsumoto Mitsuharu、Takagi Hiroki、Kurihara Shin
- Journal Title
  
  Microorganisms
  
  Volume: 10 Issue: 4 Pages: 697-697
- DOI
  10.3390/microorganisms10040697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02908, KAKENHI-PROJECT-21K17850
[Journal Article] Impact of intestinal microbiota on cognitive flexibility by a novel touch screen operant system task in mice2022
- Author(s)
  Tamada H, Ikuta K, Makino Y, Joho D, Suzuki T, Kakeyama M, Matsumoto M
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 882339-882339
- DOI
  10.3389/fnins.2022.882339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00575
[Journal Article] Systemic Metabolic Alteration Dependent on the Thyroid‐Liver Axis in Early <scp>PD</scp>2022
- Author(s)
  Miyamoto Kengo、Saiki Shinji、Matsumoto Hirotaka、Suzuki Ayami、Yamashita Yuri、Iseki Tatou、Ueno Shin‐Ichi、Shiina Kenta、Kataura Tetsushi、Kamagata Koji、Imamichi Yoko、Sasazawa Yukiko、Fujimaki Motoki、Akamatsu Wado、Hattori Nobutaka
- Journal Title
  
  Annals of Neurology
  
  Volume: 93 Issue: 2 Pages: 303-316
- DOI
  10.1002/ana.26510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07425, KAKENHI-PROJECT-22K19512, KAKENHI-PROJECT-22K17810, KAKENHI-PROJECT-23K24247, KAKENHI-PROJECT-21H04820
[Journal Article] Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon2021
- Author(s)
  Nakamura Atsuo、Kurihara Shin、Takahashi Daisuke、Ohashi Wakana、Nakamura Yutaka、Kimura Shunsuke、Onuki Masayoshi、Kume Aiko、Sasazawa Yukiko、Furusawa Yukihiro、Obata Yuuki、Fukuda Shinji、Saiki Shinji、Matsumoto Mitsuharu、Hase Koji
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 2105-2105
- DOI
  10.1038/s41467-021-22212-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19738, KAKENHI-PUBLICLY-20H05340, KAKENHI-PROJECT-20H00575, KAKENHI-PROJECT-17K15734, KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-21K07425
[Journal Article] 腸内細菌叢と宿主の共益的なポリアミン代謝は大腸における上皮増殖とマクロファージ分化を調節する2021
- Author(s)
  中村篤央，松本光晴，長谷耕二
- Journal Title
  
  消化器病サイエンス
  
  Volume: 5 Pages: 233-236
- Data Source
  KAKENHI-PROJECT-20H00575
[Patent] ディスバイオーシスに伴う認知機能低下の症状を予防又は処置するための組成物および組合せ2023
- Inventor(s)
  生田かよ, 松本光晴, 掛山正心
- Industrial Property Rights Holder
  生田かよ, 松本光晴, 掛山正心
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-061138
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20H00575
[Patent] 中高齢の対象の認知的柔軟性を高めるための組成物および組合せ2022
- Inventor(s)
  生田かよ, 松本光晴, 掛山正心
- Industrial Property Rights Holder
  生田かよ, 松本光晴, 掛山正心
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-134149
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内ポリアミン産生誘導物質は菌叢撹乱マウスの認知的柔軟性の低下を改善する2023
- Author(s)
  生田かよ，掛山正心，松本光晴
- Organizer
  第77回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内細菌由来 Putrescine が腸管透過性に及ぼす影響2023
- Author(s)
  中村篤央，生田かよ，久米愛子，栗原新，長谷耕二，松本光晴
- Organizer
  日本ポリアミン学会第13回年会
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内細菌叢は生理活性物質ポリアミンの主要な供給源2022
- Author(s)
  生田かよ, 中村篤央, 松本光晴
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内マイクロバイオーム由来ポリアミンの生理機能2022
- Author(s)
  松本光晴
- Organizer
  第26回腸内細菌学会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] Effects of polyamines produced by intestinal bacteria on intestinal permeability.2022
- Author(s)
  Nakamura A, Ikuta K, Kume A, Kurihara S, Hase K, Matsumoto M
- Organizer
  International Human Microbiome Consortium 9th Congress 2022 KOBE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] マウスの加齢に伴う認知的柔軟性の低下を捉えるタッチパネル装置定量評価系の確立2022
- Author(s)
  生田かよ，松本光晴，掛山正心
- Organizer
  第22回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内細菌叢と宿主の共役的なポリアミン代謝は大腸の上皮増殖とマクロファージ分化を調節する2021
- Author(s)
  中村篤央，栗原新，松本光晴，長谷耕二
- Organizer
  日本農芸化学会 2021年度大会
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] Functions of polyamines produced by intestinal microbiome.2021
- Author(s)
  Mitsuharu Matsumoto
- Organizer
  The 11th Asian Conference for Lactic Acid Bacteria. Symposium 5. Microbial Metabolite and Cross-talk of Gut microbiota
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 健康寿命延伸を目指した腸内細菌叢の代謝産物を標的とする機能性食品開発2021
- Author(s)
  松本光晴
- Organizer
  Visionary 農芸化学100 シンポジウム　食・腸内細菌・健康研究領域第3回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H00575
[Presentation] 腸内ポリアミン産生誘導が若齢マウスの学習記憶に与える影響2020
- Author(s)
  生田かよ，玉田葉月，松本光晴，掛山正心
- Organizer
  第74回日本栄養・食料学会大会
- Data Source
  KAKENHI-PROJECT-20H00575

1. Kurihara Shin (20630966)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. Saiki Shinji (00339996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 坪井貴司 (80415231)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 鈴木亨 (90359620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 倉石貴透 (90613167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 掛山正心 (30353535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 小柳喬 (20535041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 芦田久 (40379087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 相澤健一 (70436484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小林俊輔 (30579272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石川大 (30622675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 鎌形康司 (60568153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 宮本潤基 (20805668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 日暮琢磨 (90622580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. SASAZAWA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 久米愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsumoto Mitsuharu 松本 光晴

Research Projects

Research Products

Co-Researchers

Gut microbiomics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of technology for intestinal polyamine production by combining non-digestible peptides and bacteria derived from fermented foods.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The gut-heart axis as a therapeutic target

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on microbiome-gut axis in initial pathogenesis of Parkinson's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategy for dementia prevention based on the gut microbiota-brain axis on cognitive flexibilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Optimization of polyamine levels in the intestinal tract by controlling gut microbiota using lactic acid bacteria from traditional fermented foods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the effect of gut microbes on the extension of healthy life span using the gnotobiotic fly

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Strain-level detection of <i>Fusobacterium nucleatum</i> in colorectal cancer specimens by targeting the CRISPR?Cas region2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice2023

Author(s)

Journal Title

Data Source

[Journal Article] 腸内細菌叢由来ポリアミンが健康長寿の延伸に関与する2023

Author(s)

Journal Title

Data Source

[Journal Article] Putrescine Production by Latilactobacillus curvatus KP 3-4 Isolated from Fermented Foods2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of intestinal microbiota on cognitive flexibility by a novel touch screen operant system task in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Systemic Metabolic Alteration Dependent on the Thyroid‐Liver Axis in Early <scp>PD</scp>2022

Author(s)

Journal Title

DOI

Data Source

Matsumoto Mitsuharu 松本光晴