Sekine Hiroki 関根弘樹

Researcher Number	50506285
Other IDs
Affiliation (Current)	2026: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2026: 山形大学, 医学部, 教授 2024: 東北大学, 医学系研究科, 准教授 2021 – 2023: 東北大学, 加齢医学研究所, 講師 2017 – 2020: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Basic Section 49010:Pathological biochemistry-related / General medical chemistry Except Principal Investigator Basic Section 52040:Radiological sciences-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator 翻訳後修飾 / 代謝 / ビタミン / 酸素 / 生体分子医学 / 転写制御 / タンパク質分解 / タンパク質恒常性 / プロテアソーム / 転写因子 / O-GlcNAc修飾 … More Except Principal Investigator … More オートファジー障害 / オートファジー / アルツハイマー病 / 鉄 / MRI / 慢性低酸素 / 認知症 / 糖尿病生腎臓病 / 低酸素応答 / 単一細胞解析 / ヒト初代培養細胞 / 糖尿病性腎臓病 / 感染症 / 炎症性疾患 / サイトカイン / GATA転写因子 / マクロファージ / マスト細胞 / インターロイキン６ / 肺高血圧症 / 酸化ストレス / 血管内皮細胞 / GATA2 Less

腫瘍微小環境における酸素感知機構とその機能的意義の解明Principal Investigator
- Principal Investigator
  
  関根弘樹
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Yamagata University
認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発
- Principal Investigator
  
  瀧靖之
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
新規酸素感知機構PNPO-PLPシステムによる生体内低酸素への応答・適応機構の解明Principal Investigator
- Principal Investigator
  
  関根弘樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Elucidation of renoprotective effects by pharmacological intervention into oxygen metabolism, using living renal cells from urine of diabetic kidney disease patients
- Principal Investigator
  
  鈴木教郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tohoku University
Therapeutic strategy against infectious and inflammatory diseases by targeting master regulators of mast cells and eosinophils
- Principal Investigator
  
  Moriguchi Takashi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Biochemical analysis of recognition proteins for O-GlcNAcylated proteinPrincipal Investigator
- Principal Investigator
  
  Sekine Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Molecular mechanism of regulation of PSM activity by NRF1 O-GlcNAc modificationPrincipal Investigator
- Principal Investigator
  
  Sekine Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2024 2022 2021 2019 2018 2017

All Journal Article Presentation Book

[Book] がん細胞の代謝とCNC転写因子MRF1, NRF2．医学のあゆみ2019
- Author(s)
  関根弘樹、本橋ほづみ
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17K08618
[Journal Article] PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity2024
- Author(s)
  Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H
- Journal Title
  
  Nature Metabolism
  
  Volume: 6 Issue: 6 Pages: 1108-1127
- DOI
  10.1038/s42255-024-01053-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-24H00605, KAKENHI-PROJECT-23K21372, KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K06409, KAKENHI-PROJECT-23K20040, KAKENHI-PROJECT-23KK0137
[Journal Article] Crosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts2024
- Author(s)
  Norio Suzuki, Yuma Iwamura, Koichiro Kato, Hirotaka Ishioka, Yusuke Konta, Koji Sato, Nao Uchida, Noa Koida, Hiroki Sekine, Tetsuhiro Tanaka, Nanori Kumagai, Taku Nakai
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 74 Issue: 3 Pages: 179-184
- DOI
  10.3164/jcbn.24-8
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14450, KAKENHI-PROJECT-23K07666, KAKENHI-PROJECT-20K17272, KAKENHI-PROJECT-23K21372, KAKENHI-PROJECT-22K19396, KAKENHI-PROJECT-23K07713, KAKENHI-PROJECT-23KK0137
[Journal Article] CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells2022
- Author(s)
  Okazaki Keito、Anzawa Hayato、Katsuoka Fumiki、Kinoshita Kengo、Sekine Hiroki、Motohashi Hozumi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 5 Pages: 567-578
- DOI
  10.1093/jb/mvac013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16350, KAKENHI-PROJECT-20K07335, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05264, KAKENHI-PROJECT-21H04799, KAKENHI-PROJECT-20K07320, KAKENHI-PROJECT-22K15504
[Journal Article] An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts2019
- Author(s)
  Sato Koji、Hirano Ikuo、Sekine Hiroki、Miyauchi Kenichiro、Nakai Taku、Kato Koichiro、Ito Sadayoshi、Yamamoto Masayuki、Suzuki Norio
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 11254-11254
- DOI
  10.1038/s41598-019-47766-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19680, KAKENHI-PROJECT-17K08618
[Journal Article] Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A2018
- Author(s)
  Dodo Mina、Kitamura Hiroshi、Shima Hiroki、Saigusa Daisuke、Wati Sisca Meida、Ota Nao、Katsuoka Fumiki、Chiba Hatsune、Okae Hiroaki、Arima Takahiro、Igarashi Kazuhiko、Koseki Takeyoshi、Sekine Hiroki、Motohashi Hozumi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 165 Issue: 4 Pages: 323-334
- DOI
  10.1093/jb/mvy108
- NAID
  40021893390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-17K08233, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K15591, KAKENHI-PROJECT-18K09216, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-17H04335, KAKENHI-PROJECT-17K08618
[Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018
- Author(s)
  Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 38 Issue: 17 Pages: 00252-18
- DOI
  10.1128/mcb.00252-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07278, KAKENHI-PROJECT-17K19680, KAKENHI-PROJECT-17K19916, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-16H03265, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K08618
[Journal Article] Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes2017
- Author(s)
  Nezu Masahiro、Souma Tomokazu、Yu Lei、Sekine Hiroki、Takahashi Nobuyuki、Wei Andrew Zu-Sern、Ito Sadayoshi、Fukamizu Akiyoshi、Zsengeller Zsuzsanna K.、Nakamura Tomohiro、Hozawa Atsushi、Karumanchi S. Ananth、Suzuki Norio、Yamamoto Masayuki
- Journal Title
  
  Sci Signal
  
  Volume: 10 Issue: 479
- DOI
  10.1126/scisignal.aam5711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19680, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-17K08618
[Journal Article] Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activatpr NRF22017
- Author(s)
  Alam MM, Okazaki K, Nguyen LTT, Ota N, Kitamura H, Murakami S, Shima H, Igarashi K, Sekine H, Motohashi H
- Journal Title
  
  J Biol Chem
  
  Volume: 印刷中 Issue: 18 Pages: 7519-7530
- DOI
  10.1074/jbc.m116.773960
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-17K15591, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-17K08618
[Presentation] 慢性低酸素時の炎症反応促進におけるリソソーム活性低下の分子機構2021
- Author(s)
  関根弘樹
- Organizer
  第94回日本生化学会大会　WEB開催
- Data Source
  KAKENHI-PROJECT-20K07320
[Presentation] Vitamin B6 is an oxygen-sensitive nutrient shaping macrophage inflammatory phenotype under chronic hypoxia by suppressing lysosomal activity.2021
- Author(s)
  Hiroki Sekine, Akihiro Kishino, Hayato Anzawa, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Kengo Kinosita, Hozumi Motgohashi.
- Organizer
  Cod Spring Harbor Meeting “Mechanisms of Metabolic Signaling” Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07320
[Presentation] Chronic hypoxia enhances proinflammatory response of macrophages by inhibiting lysosomal activity.2021
- Author(s)
  Hiroki Sekine.
- Organizer
  第16回生命医科学研究所ネットワーク国際シンポジウム & Key Forum 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07320
[Presentation] グルコース・グルタミンによるヘキソサミン経路を介したタンパク質の分解制御2019
- Author(s)
  関根弘樹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] 低酸素誘導性因子HIF2aによる転写活性化の分子基盤2019
- Author(s)
  関根弘樹
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] O-結合型糖鎖修飾によるがん細胞のプロテアソーム阻害剤の分子機構2018
- Author(s)
  関根弘樹
- Organizer
  第6回がんと代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] O-GlcNAcylation signal confers resistance to proteasome inhibitors on cancer cells by increasing NRF1 stability.2018
- Author(s)
  Hiroki Sekine.
- Organizer
  The 77th Annual Meeting of the Japanese Cancer Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] O-GlcNAcylation signal confers resistance to proteasome inhibitors on cancer cells by increasing NRF1 stability.2017
- Author(s)
  Hiroki Sekine, Keito Okazaki, Md. Morshedul Alam, Hozumi Motohashi.
- Organizer
  第12回研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] O-GlcNAcylation signal confers resistance to proteasome inhibitors on cancer cells by increasing NRF1 stability.2017
- Author(s)
  Hiroki Sekine.
- Organizer
  未来型医療拠点キックオフ第二回カロリンスカ研究所・東北大学合同会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08618
[Presentation] 翻訳後修飾を介したプロテアソームサブユニット遺伝子発現制御機構2017
- Author(s)
  関根弘樹
- Organizer
  第33回がん・エピゲノム研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08618

1. Moriguchi Takashi (10447253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 遠藤智之 (00400317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 鈴木教郎 (20447254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 佐藤浩司 (60888650)

# of Collaborated Projects: 1 results

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5. 田中哲洋 (90508079)

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6. 中井琢 (90971193)

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7. 瀧靖之 (10375115)

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8. 古本祥三 (00375198)

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9. 領家梨恵 (10737464)

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10. 米田哲也 (20305022)

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11. 岡村信行 (40361076)

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12. 舘脇康子 (40722202)

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13. 中瀬泰然 (60390928)

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14. SHIMA Hiroki

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# of Collaborated Products: 2 results
15. 岡崎慶斗

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# of Collaborated Products: 1 results
16. 本橋ほづみ

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# of Collaborated Products: 2 results
17. 赤池孝章

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Sekine Hiroki 関根 弘樹

Research Projects

Research Products

Co-Researchers

腫瘍微小環境における酸素感知機構とその機能的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規酸素感知機構PNPO-PLPシステムによる生体内低酸素への応答・適応機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of renoprotective effects by pharmacological intervention into oxygen metabolism, using living renal cells from urine of diabetic kidney disease patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic strategy against infectious and inflammatory diseases by targeting master regulators of mast cells and eosinophils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biochemical analysis of recognition proteins for O-GlcNAcylated proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of regulation of PSM activity by NRF1 O-GlcNAc modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] がん細胞の代謝とCNC転写因子MRF1, NRF2．医学のあゆみ2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018

Sekine Hiroki 関根弘樹