TSURUMA Kazuhiro 鶴間一寛

Researcher Number	50524980
Affiliation (based on the past Project Information) *help	2015 – 2018: 岐阜薬科大学, 薬学部, 講師 2013 – 2014: 岐阜薬科大学, 薬学部, 助教 2009 – 2011: Gifu Pharmaceutical University, 薬学部, 助教
Review Section/Research Field	Principal Investigator Ophthalmology / General physiology / Pharmacology in pharmacy Except Principal Investigator Pharmacology in pharmacy / Ophthalmology
Keywords	Principal Investigator 小胞体ストレス / 網膜色素変性症 / SEMA4A / 酸化ストレス / 光障害 / 網膜色素上皮細胞 / 神経変性疾患 / GPNMB / 小胞体ストレス応答機構 / GRP78 / スプライシング / 発現調節 … More Except Principal Investigator … More

The role of progranulin in retinal regeneration
- Principal Investigator
  
  Hara Hideaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Gifu Pharmaceutical University
Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function
- Principal Investigator
  
  Hara Hideaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Gifu Pharmaceutical University
Investigation of GPNMB function in endoplasmic reticulum stress and oxidative stress responsesPrincipal Investigator
- Principal Investigator
  
  Tsuruma Kazuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
  Pharmacology in pharmacy
- Research Institution
  Gifu Pharmaceutical University
Involvement of endoplasmic reticulum stress in retinitis pigmentosa, and analysis of its molecular mechanismPrincipal Investigator
- Principal Investigator
  
  TSURUMA Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Gifu Pharmaceutical University

All 2018 2017 2016 2015 2014 2011 2010 Other

All Journal Article Presentation

[Journal Article] Granulin 1 Promotes Retinal Regeneration in Zebrafish2018
- Author(s)
  Tsuruma Kazuhiro、Saito Yuichi、Okuyoshi Hiroyuki、Yamaguchi Akihiro、Shimazawa Masamitsu、Goldman Daniel、Hara Hideaki
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 59 Pages: 6057-6057
- DOI
  10.1167/iovs.18-24828
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J10301, KAKENHI-PROJECT-16K11325
[Journal Article] Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization.2018
- Author(s)
  Inoue Yuki、Shimazawa Masamitsu、Nakamura Shinsuke、Takata Shinsuke、Hashimoto Yuhei、Izawa Hiroshi、Masuda Tomomi、Tsuruma Kazuhiro、Sakaue Tomohisa、Nakayama Hironao、Higashiyama Shigeki、Hara Hideaki
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 38 Pages: 174-185
- DOI
  10.1161/atvbaha.117.310337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16J11563, KAKENHI-PROJECT-16K20013
[Journal Article] RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Muller glia cells.2017
- Author(s)
  Inoue Y., Shimazawa M., Noda Y., Nagano R., Otsuka T., Kuse Y., Nakano Y., Tsuruma K., Nakagami Y. and Hara H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 印刷中
- DOI
  10.1111/jnc.14029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J07651, KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16K11325
[Journal Article] Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration2017
- Author(s)
  Inoue Yuki、Shimazawa Masamitsu、Nagano Ryota、Kuse Yoshiki、Takahashi Kei、Tsuruma Kazuhiro、Hayashi Masahiro、Ishibashi Takashi、Maoka Takashi、Hara Hideaki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 134 Pages: 147-157
- DOI
  10.1016/j.jphs.2017.05.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
[Journal Article] Progranulin increases phagocytosis by retinal pigment epithelial cells in culture2017
- Author(s)
  Murase Hiromi、Tsuruma Kazuhiro、Kuse Yoshiki、Shimazawa Masamitsu、Hara Hideaki
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 95 Pages: 2500-2510
- DOI
  10.1002/jnr.24081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
[Journal Article] CCR3 is associated with death of cells of photoreceptor cell-line induced by light exposure.2017
- Author(s)
  Kuse Yoshiki、Tsuruma Kazuhiro、Kanno Yusuke、Shimazawa Masamitsu、Hara Hideaki
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 8 Pages: 1-8
- DOI
  10.3389/fphar.2017.00207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
[Journal Article] Progranulin deficiency causes the retinal ganglion cell loss during development.2017
- Author(s)
  Kuse Yoshiki、Tsuruma Kazuhiro、Mizoguchi Takahiro、Shimazawa Masamitsu、Hara Hideaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 1679-1679
- DOI
  10.1038/s41598-017-01933-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
[Journal Article] GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response2017
- Author(s)
  Noda Yasuhiro、Tsuruma Kazuhiro、Takata Masafumi、Ishisaka Mitsue、Tanaka Hirotaka、Nakano Yusuke、Nagahara Yuki、Shimazawa Masamitsu、Hara Hideaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 12160-12160
- DOI
  10.1038/s41598-017-11828-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11325
[Journal Article] A pharmacological approach in newly established retinal vein occlusion model2017
- Author(s)
  Fuma S., Nishinaka A., Inoue Y., Tsuruma K., Shimazawa M., Kondo M. and Hara H
- Journal Title
  
  Sci Rep
  
  Volume: 7, 43509 Pages: 43509-43509
- DOI
  10.1038/srep43509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-26462683, KAKENHI-PROJECT-16K11325
[Journal Article] Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier.2017
- Author(s)
  Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism
  
  Volume: 37 Pages: 123-139
- DOI
  10.1177/0271678x15621499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19960, KAKENHI-PROJECT-16K11325
[Journal Article] Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo2016
- Author(s)
  Izawa H., Shimazawa M., Inoue Y., Uchida S., Moroe H., Tsuruma K. and Hara H.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 96 Pages: 304-312
- DOI
  10.1016/j.freeradbiomed.2016.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16K11325
[Journal Article] Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.2016
- Author(s)
  Ono Y., Tsuruma K., Takata M., Shimazawa M. and Hara H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 23241-23241
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460103
[Journal Article] The extracellular fragment of GPNMB improves memory and increases hippocampal GluA1 levels in mice.2015
- Author(s)
  Murata K., Yoshino Y., Tsuruma K., Moriguchi S., Oyagi A., Tanaka H., Ishisaka M., Shimazawa M., Fukunaga K., Hara H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 132 Pages: 583-594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460103
[Journal Article] Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia reperfusion injury.2014
- Author(s)
  Nakano Y., Suzuki Y., Takagi T., Kitashoji A., Ono Y., Tsuruma K., Yoshimura S., Shimazawa M., Iwama T. and Hara H.
- Journal Title
  
  Neuroscience
  
  Volume: 277 Pages: 123-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] Astrocyte activation and retinal ganglion cell loss during retinal development in progranulin deficient mice.2017
- Author(s)
  久世祥己、鶴間一寛、溝口貴洋、嶋澤雅光、原英彰
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K11325
[Presentation] マウス網膜発生期におけるプログラニュリンの役割2017
- Author(s)
  久世祥己、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第2回プログラニュリン研究会
- Data Source
  KAKENHI-PROJECT-16K11325
[Presentation] 小胞体ストレス存在下におけるGPNMBのBiP pre-mRNAスプライシング促進作用2016
- Author(s)
  野田泰裕, 鶴間一寛, 髙田真史, 田中彦孝, 嶋澤雅光, 原英彰
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25870605
[Presentation] 未定2016
- Author(s)
  野田泰裕、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第11回小胞体ストレス研究会
- Place of Presentation
  岐阜大学サテライトキャンパス
- Year and Date
  2016-10-10
- Data Source
  KAKENHI-PROJECT-25870605
[Presentation] マウス網膜再生におけるプログラニュリンの機能解析2016
- Author(s)
  久世祥己　鶴間一寛　嶋澤雅光　原英彰
- Organizer
  第1回プログラニュリン研究会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-16K11325
[Presentation] GPNMB 細胞外フラグメントの新規受容体探索に関する研究2015
- Author(s)
  小野陽子、髙田真史、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第127回日本薬理学会近畿部会
- Place of Presentation
  岐阜
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] 脳虚血における膜貫通糖タンパク質GPNMBの役割2014
- Author(s)
  中野雄介、鈴木悠起也、高木俊範、北庄司輝、小野陽子、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第126回日本薬理学会近畿部会
- Place of Presentation
  和歌山
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] 網膜障害における小胞体ストレスの関与2011
- Author(s)
  鶴間一寛
- Organizer
  第6回小胞体ストレス研究会
- Place of Presentation
  岡山大学
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] 網膜障害における小胞体ストレスの関与2011
- Author(s)
  鶴間一寛、原英彰
- Organizer
  第6回小胞体ストレス研究会
- Place of Presentation
  岡山
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress2010
- Author(s)
  鶴間一寛(Kazuhiro Tsuruma)
- Organizer
  Neuroscience 2010
- Place of Presentation
  アメリカサンディエゴ
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] 網膜色素変性症における変異型SEMA4Aと小胞体ストレスの関与2010
- Author(s)
  鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第117回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress2010
- Author(s)
  Tsuruma K., Shimazawa M. and Hara H
- Organizer
  Neuroscience
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と小胞体ストレスの関与2010
- Author(s)
  鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第30回日本眼薬理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と光ストレスと小胞体ストレスの関連2010
- Author(s)
  鶴間一寛、原英彰
- Organizer
  第5回小胞体ストレス研究会
- Place of Presentation
  東京
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21791699
[Presentation] 膜貫通糖タンパク質GPNMBは変異TDP-43誘発運動神経細胞死を抑制する
- Author(s)
  長原悠樹、大内一輝、小野陽子、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  愛知・名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] Extracellular fragment of GPNMB enhances memory and learning ability by increasing AMPA receptor subunit GluA1 protein level in mouse hippocampus.
- Author(s)
  Hara H., Yoshino Y., Murata K., Tsuruma K., Oyagi A., Moriguchi S., Tanaka H., Shimazawa M. and Fukunaga K.
- Organizer
  17th World Congress of Basic and Clinical Pharmacology (WCP2014)
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] GPNMB細胞外フラグメントの新規受容体としてのNa+，K+-ATPaseの同定
- Author(s)
  小野陽子、鶴間一寛、嶋澤雅光、原英彰
- Organizer
  心血管膜輸送研究会2014
- Place of Presentation
  愛知・岡崎
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] GPNMB resists skeletal muscle lesion in the SOD1 (G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
- Author(s)
  Nagahara Y., Tanaka H., Tsuruma K., Ono Y., Noda Y., Nikawa T., Shimazawa M. and Hara H.
- Organizer
  17th World Congress of Basic and Clinical Pharmacology (WCP2014)
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460103
[Presentation] Extracellular fragment of GPNMB has protective effects via Na+, K+-ATPase against SOD1(G93A)- and serum free stress-induced cell death.
- Author(s)
  Ono Y., Tanaka H., Takata M., Tsuruma K., Shimazawa M. and Hara H.
- Organizer
  17th World Congress of Basic and Clinical Pharmacology (WCP2014)
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25460103

1. Hara Hideaki (20381717)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. 青木正志 (70302148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Yoshimura Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. Iwama Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. Imai Takahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中山寛尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 近藤峰生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高木俊範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSURUMA Kazuhiro 鶴間 一寛

Research Projects

Research Products

Co-Researchers

The role of progranulin in retinal regeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of GPNMB function in endoplasmic reticulum stress and oxidative stress responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of endoplasmic reticulum stress in retinitis pigmentosa, and analysis of its molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Granulin 1 Promotes Retinal Regeneration in Zebrafish2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Muller glia cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progranulin increases phagocytosis by retinal pigment epithelial cells in culture2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCR3 is associated with death of cells of photoreceptor cell-line induced by light exposure.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progranulin deficiency causes the retinal ganglion cell loss during development.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pharmacological approach in newly established retinal vein occlusion model2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo2016

Author(s)

TSURUMA Kazuhiro 鶴間一寛