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TSURUMA Kazuhiro  鶴間 一寛

ORCIDConnect your ORCID iD *help
Researcher Number 50524980
Affiliation (based on the past Project Information) *help 2015 – 2018: 岐阜薬科大学, 薬学部, 講師
2013 – 2014: 岐阜薬科大学, 薬学部, 助教
2009 – 2011: Gifu Pharmaceutical University, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Pharmacology in pharmacy / Ophthalmology
Except Principal Investigator
Ophthalmology / Pharmacology in pharmacy
Keywords
Principal Investigator
小胞体ストレス / 発現調節 / スプライシング / GRP78 / 小胞体ストレス応答機構 / GPNMB / 神経変性疾患 / 網膜色素上皮細胞 / 光障害 / 酸化ストレス / SEMA4A / 網膜色素変性症 … More
Except Principal Investigator
… More 神経科学 / 再生医学 / 網膜神経節細胞 / 網膜 / HGF受容体 / アストロサイト / 網膜再生 / 網膜発生 / ミクログリア / プログラニュリン / retinal development / retinal regeneration / microglia / Progranulin / 膜タンパク質ライブラリ / SOD1G93A / Na+,K+-ATPase / MEK/ERK経路 / PI3K/Akt経路 / Na+, K+-ATPase / GluA1 / 記憶 / GPNMB Less
  • Research Projects

    (4 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (6 People)
  •  The role of progranulin in retinal regeneration

    • Principal Investigator
      Hara Hideaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Gifu Pharmaceutical University
  •  Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function

    • Principal Investigator
      Hara Hideaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Gifu Pharmaceutical University
  •  Investigation of GPNMB function in endoplasmic reticulum stress and oxidative stress responsesPrincipal Investigator

    • Principal Investigator
      Tsuruma Kazuhiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Gifu Pharmaceutical University
  •  Involvement of endoplasmic reticulum stress in retinitis pigmentosa, and analysis of its molecular mechanismPrincipal Investigator

    • Principal Investigator
      TSURUMA Kazuhiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Gifu Pharmaceutical University

All 2018 2017 2016 2015 2014 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Granulin 1 Promotes Retinal Regeneration in Zebrafish2018

    • Author(s)
      Tsuruma Kazuhiro、Saito Yuichi、Okuyoshi Hiroyuki、Yamaguchi Akihiro、Shimazawa Masamitsu、Goldman Daniel、Hara Hideaki
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 59 Issue: 15 Pages: 6057-6057

    • DOI

      10.1167/iovs.18-24828

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17J10301, KAKENHI-PROJECT-16K11325
  • [Journal Article] RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Muller glia cells.2017

    • Author(s)
      Inoue Y., Shimazawa M., Noda Y., Nagano R., Otsuka T., Kuse Y., Nakano Y., Tsuruma K., Nakagami Y. and Hara H.
    • Journal Title

      Journal of Neurochemistry

      Volume: 印刷中 Issue: 5 Pages: 750-765

    • DOI

      10.1111/jnc.14029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15J07651, KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16K11325
  • [Journal Article] Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration2017

    • Author(s)
      Inoue Yuki、Shimazawa Masamitsu、Nagano Ryota、Kuse Yoshiki、Takahashi Kei、Tsuruma Kazuhiro、Hayashi Masahiro、Ishibashi Takashi、Maoka Takashi、Hara Hideaki
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 134 Issue: 3 Pages: 147-157

    • DOI

      10.1016/j.jphs.2017.05.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
  • [Journal Article] Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular NeovascularizationHighlights2017

    • Author(s)
      Inoue Yuki、Shimazawa Masamitsu、Nakamura Shinsuke、Takata Shinsuke、Hashimoto Yuhei、Izawa Hiroshi、Masuda Tomomi、Tsuruma Kazuhiro、Sakaue Tomohisa、Nakayama Hironao、Higashiyama Shigeki、Hara Hideaki
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 38 Issue: 1 Pages: 174-185

    • DOI

      10.1161/atvbaha.117.310337

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16J11563, KAKENHI-PROJECT-16K20013
  • [Journal Article] Progranulin increases phagocytosis by retinal pigment epithelial cells in culture2017

    • Author(s)
      Murase Hiromi、Tsuruma Kazuhiro、Kuse Yoshiki、Shimazawa Masamitsu、Hara Hideaki
    • Journal Title

      Journal of Neuroscience Research

      Volume: 95 Issue: 12 Pages: 2500-2510

    • DOI

      10.1002/jnr.24081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
  • [Journal Article] CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure2017

    • Author(s)
      Kuse Yoshiki、Tsuruma Kazuhiro、Kanno Yusuke、Shimazawa Masamitsu、Hara Hideaki
    • Journal Title

      Frontiers in Pharmacology

      Volume: 8 Pages: 1-8

    • DOI

      10.3389/fphar.2017.00207

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
  • [Journal Article] Progranulin deficiency causes the retinal ganglion cell loss during development2017

    • Author(s)
      Kuse Yoshiki、Tsuruma Kazuhiro、Mizoguchi Takahiro、Shimazawa Masamitsu、Hara Hideaki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1679-1679

    • DOI

      10.1038/s41598-017-01933-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11325, KAKENHI-PROJECT-15J07651
  • [Journal Article] GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response2017

    • Author(s)
      Noda Yasuhiro、Tsuruma Kazuhiro、Takata Masafumi、Ishisaka Mitsue、Tanaka Hirotaka、Nakano Yusuke、Nagahara Yuki、Shimazawa Masamitsu、Hara Hideaki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12160-12160

    • DOI

      10.1038/s41598-017-11828-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11325
  • [Journal Article] A pharmacological approach in newly established retinal vein occlusion model2017

    • Author(s)
      Fuma S., Nishinaka A., Inoue Y., Tsuruma K., Shimazawa M., Kondo M. and Hara H
    • Journal Title

      Scientific Reports

      Volume: 7, 43509 Issue: 1 Pages: 43509-43509

    • DOI

      10.1038/srep43509

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-26462683, KAKENHI-PROJECT-16K11325
  • [Journal Article] Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood brain barrier2017

    • Author(s)
      Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, Hara H.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 37 Issue: 1 Pages: 123-139

    • DOI

      10.1177/0271678x15621499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K19960, KAKENHI-PROJECT-16K11325
  • [Journal Article] Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo2016

    • Author(s)
      Izawa H., Shimazawa M., Inoue Y., Uchida S., Moroe H., Tsuruma K. and Hara H.
    • Journal Title

      Free Radic. Biol. Med

      Volume: 96 Pages: 304-312

    • DOI

      10.1016/j.freeradbiomed.2016.03.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15J07670, KAKENHI-PROJECT-16K11325
  • [Journal Article] Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.2016

    • Author(s)
      Ono Y., Tsuruma K., Takata M., Shimazawa M. and Hara H.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 23241-23241

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Journal Article] The extracellular fragment of GPNMB improves memory and increases hippocampal GluA1 levels in mice.2015

    • Author(s)
      Murata K., Yoshino Y., Tsuruma K., Moriguchi S., Oyagi A., Tanaka H., Ishisaka M., Shimazawa M., Fukunaga K., Hara H.
    • Journal Title

      Journal of Neurochemistry

      Volume: 132 Pages: 583-594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Journal Article] Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia reperfusion injury.2014

    • Author(s)
      Nakano Y., Suzuki Y., Takagi T., Kitashoji A., Ono Y., Tsuruma K., Yoshimura S., Shimazawa M., Iwama T. and Hara H.
    • Journal Title

      Neuroscience

      Volume: 277 Pages: 123-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] Astrocyte activation and retinal ganglion cell loss during retinal development in progranulin deficient mice.2017

    • Author(s)
      久世祥己、鶴間一寛、溝口貴洋、嶋澤雅光、原英彰
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K11325
  • [Presentation] マウス網膜発生期におけるプログラニュリンの役割2017

    • Author(s)
      久世祥己、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第2回プログラニュリン研究会
    • Data Source
      KAKENHI-PROJECT-16K11325
  • [Presentation] 小胞体ストレス存在下におけるGPNMBのBiP pre-mRNAスプライシング促進作用2016

    • Author(s)
      野田泰裕, 鶴間一寛, 髙田真史, 田中彦孝, 嶋澤雅光, 原英彰
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-25870605
  • [Presentation] 未定2016

    • Author(s)
      野田泰裕、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第11回小胞体ストレス研究会
    • Place of Presentation
      岐阜大学サテライトキャンパス
    • Year and Date
      2016-10-10
    • Data Source
      KAKENHI-PROJECT-25870605
  • [Presentation] マウス網膜再生におけるプログラニュリンの機能解析2016

    • Author(s)
      久世祥己 鶴間一寛 嶋澤雅光 原英彰
    • Organizer
      第1回プログラニュリン研究会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-16K11325
  • [Presentation] GPNMB 細胞外フラグメントの新規受容体探索に関する研究2015

    • Author(s)
      小野陽子、髙田真史、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第127回日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] 脳虚血における膜貫通糖タンパク質GPNMBの役割2014

    • Author(s)
      中野雄介、鈴木悠起也、高木俊範、北庄司輝、小野陽子、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第126回日本薬理学会近畿部会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] 網膜障害における小胞体ストレスの関与2011

    • Author(s)
      鶴間一寛
    • Organizer
      第6回小胞体ストレス研究会
    • Place of Presentation
      岡山大学
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] 網膜障害における小胞体ストレスの関与2011

    • Author(s)
      鶴間一寛、原英彰
    • Organizer
      第6回小胞体ストレス研究会
    • Place of Presentation
      岡山
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress2010

    • Author(s)
      鶴間一寛(Kazuhiro Tsuruma)
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      アメリカ サンディエゴ
    • Year and Date
      2010-11-13
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] 網膜色素変性症における変異型SEMA4Aと小胞体ストレスの関与2010

    • Author(s)
      鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第117回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] The association between retinitis pigmentosa related gene SEMA4A and endoplasmic reticulum stress2010

    • Author(s)
      Tsuruma K., Shimazawa M. and Hara H
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, California
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と小胞体ストレスの関与2010

    • Author(s)
      鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第30回日本眼薬理学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] 網膜色素変性症原因遺伝子SEMA4Aの機能変化と光ストレスと小胞体ストレスの関連2010

    • Author(s)
      鶴間一寛、原英彰
    • Organizer
      第5回小胞体ストレス研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-29
    • Data Source
      KAKENHI-PROJECT-21791699
  • [Presentation] 膜貫通糖タンパク質GPNMBは変異TDP-43誘発運動神経細胞死を抑制する

    • Author(s)
      長原悠樹、大内一輝、小野陽子、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      愛知・名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] Extracellular fragment of GPNMB enhances memory and learning ability by increasing AMPA receptor subunit GluA1 protein level in mouse hippocampus.

    • Author(s)
      Hara H., Yoshino Y., Murata K., Tsuruma K., Oyagi A., Moriguchi S., Tanaka H., Shimazawa M. and Fukunaga K.
    • Organizer
      17th World Congress of Basic and Clinical Pharmacology (WCP2014)
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] GPNMB細胞外フラグメントの新規受容体としてのNa+,K+-ATPaseの同定

    • Author(s)
      小野陽子、鶴間一寛、嶋澤雅光、原英彰
    • Organizer
      心血管膜輸送研究会2014
    • Place of Presentation
      愛知・岡崎
    • Year and Date
      2014-09-04 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] GPNMB resists skeletal muscle lesion in the SOD1 (G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

    • Author(s)
      Nagahara Y., Tanaka H., Tsuruma K., Ono Y., Noda Y., Nikawa T., Shimazawa M. and Hara H.
    • Organizer
      17th World Congress of Basic and Clinical Pharmacology (WCP2014)
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-25460103
  • [Presentation] Extracellular fragment of GPNMB has protective effects via Na+, K+-ATPase against SOD1(G93A)- and serum free stress-induced cell death.

    • Author(s)
      Ono Y., Tanaka H., Takata M., Tsuruma K., Shimazawa M. and Hara H.
    • Organizer
      17th World Congress of Basic and Clinical Pharmacology (WCP2014)
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-25460103
  • 1.  Hara Hideaki (20381717)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 20 results
  • 2.  青木 正志 (70302148)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Yoshimura Shinichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  Iwama Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  Imai Takahiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  高木 俊範
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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