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Kinochi Kenichiro  木内 謙一郎

… Alternative Names

Kinouchi Kenichiro  木内 謙一郎

木内 謙一郎  キノウチ ケンイチロウ

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Researcher Number 50528578
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4743-2583
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help 2025: 慶應義塾大学, 医学部(信濃町), 准教授
2022 – 2024: 慶應義塾大学, 医学部(信濃町), 講師
2020 – 2021: 慶應義塾大学, 医学部(信濃町), 助教
2019: 慶應義塾大学, 医学部(信濃町), 特任助教
2010 – 2011: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54040:Metabolism and endocrinology-related / Circulatory organs internal medicine
Except Principal Investigator
Basic Section 42030:Animal life science-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 52010:General internal medicine-related
Keywords
Principal Investigator
体内時計 / T細胞 / エピジェネティックス / 代謝 / 概日時計 / 概日リズム / オートファジー / レニン・アンジオテンシン系 / (プロ)レニン受容体
Except Principal Investigator
糖尿病 … More / 先天性心疾患 / 転写因子 / リプログラミング / 心筋分化 / 心臓発生 / 再生医療 / 慢性腎臓病 / 内分泌代謝 / 液性因子 / 母児連関 / 概日リズム / 質量分析イメージング / ストレプトゾトシン / アミノ酸 / 身体能力 / 間欠絶食 / ヒストンアセチル化 / エピゲノム / ミトコンドリア / BCAA / サルコペニア / 2型糖尿病 / 脂肪組織 / 血管内皮細胞NAD(+)合成系 / 肥満 / インスリン抵抗性 / NMN / 老化 / NAD(+)中間代謝産物 / 血管内皮細胞 / NAD(+)合成系 / NAMPT Less
  • Research Projects

    (7 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (11 People)
  •  妊娠母体概日リズムのエクソソームを介した次世代への疾患伝播の検討Principal Investigator

    • Principal Investigator
      木内 謙一郎
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Keio University
  •  Dissecting the transcriptional network of organogenesis based on reprogramming factors

    • Principal Investigator
      橋本 寿之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Keio University
  •  脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防

    • Principal Investigator
      山口 慎太郎
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Keio University
  •  Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.

    • Principal Investigator
      Miyashita Kazutoshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Keio University
  •  母児概日リズム同期と次世代疾患感受性の多層多元的代謝リズムパネルからの理解

    • Principal Investigator
      伊藤 裕
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Keio University
  •  Circadian clock and proliferative metabolism in the intestinal T lymphocytesPrincipal Investigator

    • Principal Investigator
      Kinouchi Kenichiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Keio University
  •  心筋特異的(プロ)レニン受容体欠損により発症する心筋症の病態解明と標的治療の開発Principal Investigator

    • Principal Investigator
      木内 謙一郎
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Keio University

All 2023 2022 2021 2011 2010

All Journal Article Presentation

  • [Journal Article] Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism2023

    • Author(s)
      Yamaguchi Shintaro、Kojima Daiki、Iqbal Tooba、Kosugi Shotaro、Franczyk Michael P.、Qi Nathan、Sasaki Yo、Yaku Keisuke、Kaneko Kenji、Kinouchi Kenichiro、Itoh Hiroshi、Hayashi Kaori、Nakagawa Takashi、Yoshino Jun
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 674 Pages: 162-169

    • DOI

      10.1016/j.bbrc.2023.07.007

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K11593, KAKENHI-PROJECT-23K24762
  • [Journal Article] Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation2023

    • Author(s)
      Endo Sho、Uto Asuka、Miyashita Kazutoshi、Sato Masaaki、Inoue Hiroyuki、Fujii Kentaro、Hagiwara Aika、Ryuzaki Masaki、Oshida Takuma、Kinouchi Kenichiro、Itoh Hiroshi
    • Journal Title

      Journal of the Endocrine Society

      Volume: 7 Issue: 7

    • DOI

      10.1210/jendso/bvad082

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-21K08583
  • [Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023

    • Author(s)
      Mitsuno Ryunosuke、Kaneko Kenji、Nakamura Toshifumi、Kojima Daiki、Mizutani Yosuke、Azegami Tatsuhiko、Yamaguchi Shintaro、Yamada Yoshitake、Jinzaki Masahiro、Kinouchi Kenichiro、Yoshino Jun、Hayashi Kaori
    • Journal Title

      Journal of the Endocrine Society

      Volume: 8 Issue: 1

    • DOI

      10.1210/jendso/bvad154

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377
  • [Journal Article] Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats2021

    • Author(s)
      Ryuzaki Masaki、Miyashita Kazutoshi、Sato Masaaki、Inoue Hiroyuki、Fujii Kentaro、Hagiwara Aika、Uto Asuka、Endo Sho、Oshida Takuma、Kinouchi Kenichiro、Itoh Hiroshi
    • Journal Title

      Journal of Hypertension

      Volume: 40 Issue: 1 Pages: 33-45

    • DOI

      10.1097/hjh.0000000000002974

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-20K17500
  • [Journal Article] Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies2021

    • Author(s)
      Kinouchi Kenichiro、Mikami Yohei、Kanai Takanori、Itoh Hiroshi
    • Journal Title

      Molecular Aspects of Medicine

      Volume: 80 Pages: 100984-100984

    • DOI

      10.1016/j.mam.2021.100984

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09012, KAKENHI-PROJECT-20H00536, KAKENHI-PROJECT-20H03666, KAKENHI-PROJECT-21K18270
  • [Journal Article] Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in <i>Dpp-4</i> Promoter2021

    • Author(s)
      Uto Asuka、Miyashita Kazutoshi、Endo Sho、Sato Masaaki、Ryuzaki Masaki、Kinouchi Kenichiro、Mitsuishi Masanori、Meguro Shu、Itoh Hiroshi
    • Journal Title

      Endocrinology

      Volume: 162 Issue: 12

    • DOI

      10.1210/endocr/bqab193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-21K18270
  • [Journal Article] エネルギー代謝・運動の日内ホメオスタシス制御の根幹を成す生体時計2021

    • Author(s)
      木内謙一郎、宮下和季、伊藤裕
    • Journal Title

      Medical Science Digest

      Volume: 47 Pages: 403-407

    • Data Source
      KAKENHI-PROJECT-19K09012
  • [Journal Article] DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation2021

    • Author(s)
      Akihito Hishikawa, Kaori Hayashi (corresponding author), Akiko Kubo, Kazutoshi Miyashita, Akinori Hashiguchi, Kenichiro Kinouchi, Norifumi Yoshimoto, Ran Nakamichi, Riki Akashio, Erina Sugita, Tatsuhiko Azegami, Toshiaki Monkawa, Makoto Suematsu, Hiroshi Itoh.
    • Journal Title

      iScience.

      Volume: 24(12) Issue: 12 Pages: 103436-103436

    • DOI

      10.1016/j.isci.2021.103436

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08688, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-21K06876, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K17291
  • [Journal Article] 副腎皮質ホルモンの概日リズムと内分泌代謝恒常性2021

    • Author(s)
      鳥光拓人、木内謙一郎、栗原勲、伊藤裕
    • Journal Title

      臨床化学

      Volume: 50 Pages: 337-344

    • Data Source
      KAKENHI-PROJECT-19K09012
  • [Journal Article] Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients.2010

    • Author(s)
      Kinouchi K, et al.
    • Journal Title

      Kidney Blood Press Res.

      Volume: 33 Pages: 304-312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Journal Article] The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes2010

    • Author(s)
      Kinouchi K, et al.
    • Journal Title

      Circ Res.

      Volume: 107 Pages: 30-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] 臓器連関における概日リズムの意義と栄養シグナル2022

    • Author(s)
      木内謙一郎
    • Organizer
      第42回 日本肥満学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09012
  • [Presentation] Vascular endothelial NAMPT-mediated NAD+ biosynthesis regulates whole-body blood pressure and insulin resistance.2022

    • Author(s)
      Kosugi S, Yamaguchi S, Homma K, Nagahisa T, Nishioka K, Watanabe Y, Kinouchi K, Hayashi K, Miyashita K, Kanda T, Irie J, Yoshino J, Itoh H.
    • Organizer
      The 29th Scientific Meeting of the International Society of Hypertension (Japan・Kyoto)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07377
  • [Presentation] Temporal Tissue Coordination by the Circadian Clock and Metabolic Cycles2021

    • Author(s)
      Kenichiro Kinouchi, Kazutoshi Miyashita, Hiroshi Itoh
    • Organizer
      The 9th Seoul International Congress of Endocrinology and Metabolism
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09012
  • [Presentation] 内分泌代謝とエピジェネティックスが収斂する概日リズム2021

    • Author(s)
      木内謙一郎
    • Organizer
      第 39 回日本内分泌学会 内分泌代謝学サマーセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K09012
  • [Presentation] 細胞内酸性環境を維持する(プロ)レニン受容体の生理的な機能2011

    • Author(s)
      木内謙一郎
    • Organizer
      第40回日本心脈管作動物質学会
    • Place of Presentation
      高松
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] (Pro)renin receptor is essential for cell survival in murine cardiomyocytes.2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      64^<th> Annual High Blood Pressure Research Conference of the American Heart Association.
    • Place of Presentation
      Washington, USA
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] Comparative effects of telmisartan-based therapy and calcium channel blockers-based therapy on cardio-ankle vascular index in hypertensive patients2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      The 23^<rd> Scientific Meeting of the International Society of Hypertension.
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] Cardiomyocyte-specific Ablation of (Pro)renin Receptor Caused Fulminant Heart Failure Due To Disruption of Intracellular Acidification2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      AHA Scientific Sessions
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-16
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] 心筋細胞特異的(プロ)レニン受容体ノックアウトマウスの解析2010

    • Author(s)
      木内謙一郎
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-16
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] ATP6AP2/(Pro)renin receptor is essential for assembly of the V-ATPase in murine cardiomyocytes.2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      The 23^<rd> Scientific Meeting of the International Society of Hypertension.
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] 細胞内小器官における(プロ)レニン受容体の生理機能の解明2010

    • Author(s)
      木内謙一郎
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension.2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      The 12^<th> Asian Pacific Congress of Nephrology.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-06
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients.2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      The 12^<th> Asian Pacific Congress of Nephrology.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-05-06
    • Data Source
      KAKENHI-PROJECT-22790724
  • [Presentation] Physiological levels of prorenin and (pro)renin receptor influence the ZO-1 mRNA expression in human podocytes.2010

    • Author(s)
      Kinouchi K, et al.
    • Organizer
      The 8^<th> International Podocytes Conference Bristol.
    • Place of Presentation
      Bristol, UK
    • Year and Date
      2010-06-08
    • Data Source
      KAKENHI-PROJECT-22790724
  • 1.  Miyashita Kazutoshi (50378759)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  土居 雅夫 (20432578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  三上 洋平 (80528662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  山口 慎太郎 (50464855)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  本間 康一郎 (10383762)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  久保 亜紀子 (50455573)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  伊藤 裕 (40252457)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  入江 潤一郎 (70306687)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  橋本 寿之 (90528390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HAYASHI Kaori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  吉野 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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