Kinochi Kenichiro 木内謙一郎

… Alternative Names

Kinouchi Kenichiro 木内謙一郎

木内謙一郎キノウチケンイチロウ

Less

Researcher Number	50528578
Other IDs	https://orcid.org/0000-0003-4743-2583
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 医学部(信濃町), 准教授 2022 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2020 – 2021: 慶應義塾大学, 医学部(信濃町), 助教 2019: 慶應義塾大学, 医学部(信濃町), 特任助教 2010 – 2011: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54040:Metabolism and endocrinology-related / Circulatory organs internal medicine Except Principal Investigator Basic Section 42030:Animal life science-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 体内時計 / T細胞 / エピジェネティックス / 代謝 / 概日時計 / 概日リズム / オートファジー / レニン・アンジオテンシン系 / (プロ)レニン受容体 Except Principal Investigator 糖尿病 … More / 先天性心疾患 / 転写因子 / リプログラミング / 心筋分化 / 心臓発生 / 再生医療 / 慢性腎臓病 / 内分泌代謝 / 液性因子 / 母児連関 / 概日リズム / 質量分析イメージング / ストレプトゾトシン / アミノ酸 / 身体能力 / 間欠絶食 / ヒストンアセチル化 / エピゲノム / ミトコンドリア / BCAA / サルコペニア / 2型糖尿病 / 脂肪組織 / 血管内皮細胞NAD(+)合成系 / 肥満 / インスリン抵抗性 / NMN / 老化 / NAD(+)中間代謝産物 / 血管内皮細胞 / NAD(+)合成系 / NAMPT Less

妊娠母体概日リズムのエクソソームを介した次世代への疾患伝播の検討Principal Investigator
- Principal Investigator
  
  木内謙一郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Dissecting the transcriptional network of organogenesis based on reprogramming factors
- Principal Investigator
  
  橋本寿之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Keio University
脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防
- Principal Investigator
  
  山口慎太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Keio University
Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.
- Principal Investigator
  
  Miyashita Kazutoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
母児概日リズム同期と次世代疾患感受性の多層多元的代謝リズムパネルからの理解
- Principal Investigator
  
  伊藤裕
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Keio University
Circadian clock and proliferative metabolism in the intestinal T lymphocytesPrincipal Investigator
- Principal Investigator
  
  Kinouchi Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
心筋特異的(プロ)レニン受容体欠損により発症する心筋症の病態解明と標的治療の開発Principal Investigator
- Principal Investigator
  
  木内謙一郎
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Keio University

All 2023 2022 2021 2011 2010

All Journal Article Presentation

[Journal Article] Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism2023
- Author(s)
  Yamaguchi Shintaro、Kojima Daiki、Iqbal Tooba、Kosugi Shotaro、Franczyk Michael P.、Qi Nathan、Sasaki Yo、Yaku Keisuke、Kaneko Kenji、Kinouchi Kenichiro、Itoh Hiroshi、Hayashi Kaori、Nakagawa Takashi、Yoshino Jun
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 674 Pages: 162-169
- DOI
  10.1016/j.bbrc.2023.07.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K11593, KAKENHI-PROJECT-23K24762
[Journal Article] Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation2023
- Author(s)
  Endo Sho、Uto Asuka、Miyashita Kazutoshi、Sato Masaaki、Inoue Hiroyuki、Fujii Kentaro、Hagiwara Aika、Ryuzaki Masaki、Oshida Takuma、Kinouchi Kenichiro、Itoh Hiroshi
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 7 Issue: 7
- DOI
  10.1210/jendso/bvad082
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-21K08583
[Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023
- Author(s)
  Mitsuno Ryunosuke、Kaneko Kenji、Nakamura Toshifumi、Kojima Daiki、Mizutani Yosuke、Azegami Tatsuhiko、Yamaguchi Shintaro、Yamada Yoshitake、Jinzaki Masahiro、Kinouchi Kenichiro、Yoshino Jun、Hayashi Kaori
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 8 Issue: 1
- DOI
  10.1210/jendso/bvad154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377
[Journal Article] Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats2021
- Author(s)
  Ryuzaki Masaki、Miyashita Kazutoshi、Sato Masaaki、Inoue Hiroyuki、Fujii Kentaro、Hagiwara Aika、Uto Asuka、Endo Sho、Oshida Takuma、Kinouchi Kenichiro、Itoh Hiroshi
- Journal Title
  
  Journal of Hypertension
  
  Volume: 40 Issue: 1 Pages: 33-45
- DOI
  10.1097/hjh.0000000000002974
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-20K17500
[Journal Article] Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies2021
- Author(s)
  Kinouchi Kenichiro、Mikami Yohei、Kanai Takanori、Itoh Hiroshi
- Journal Title
  
  Molecular Aspects of Medicine
  
  Volume: 80 Pages: 100984-100984
- DOI
  10.1016/j.mam.2021.100984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09012, KAKENHI-PROJECT-20H00536, KAKENHI-PROJECT-20H03666, KAKENHI-PROJECT-21K18270
[Journal Article] Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in <i>Dpp-4</i> Promoter2021
- Author(s)
  Uto Asuka、Miyashita Kazutoshi、Endo Sho、Sato Masaaki、Ryuzaki Masaki、Kinouchi Kenichiro、Mitsuishi Masanori、Meguro Shu、Itoh Hiroshi
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 12
- DOI
  10.1210/endocr/bqab193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-21K18270
[Journal Article] エネルギー代謝・運動の日内ホメオスタシス制御の根幹を成す生体時計2021
- Author(s)
  木内謙一郎、宮下和季、伊藤裕
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 403-407
- Data Source
  KAKENHI-PROJECT-19K09012
[Journal Article] DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation2021
- Author(s)
  Akihito Hishikawa, Kaori Hayashi (corresponding author), Akiko Kubo, Kazutoshi Miyashita, Akinori Hashiguchi, Kenichiro Kinouchi, Norifumi Yoshimoto, Ran Nakamichi, Riki Akashio, Erina Sugita, Tatsuhiko Azegami, Toshiaki Monkawa, Makoto Suematsu, Hiroshi Itoh.
- Journal Title
  
  iScience.
  
  Volume: 24(12) Issue: 12 Pages: 103436-103436
- DOI
  10.1016/j.isci.2021.103436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08688, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-21K06876, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K17291
[Journal Article] 副腎皮質ホルモンの概日リズムと内分泌代謝恒常性2021
- Author(s)
  鳥光拓人、木内謙一郎、栗原勲、伊藤裕
- Journal Title
  
  臨床化学
  
  Volume: 50 Pages: 337-344
- Data Source
  KAKENHI-PROJECT-19K09012
[Journal Article] Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients.2010
- Author(s)
  Kinouchi K, et al.
- Journal Title
  
  Kidney Blood Press Res.
  
  Volume: 33 Pages: 304-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790724
[Journal Article] The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes2010
- Author(s)
  Kinouchi K, et al.
- Journal Title
  
  Circ Res.
  
  Volume: 107 Pages: 30-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] 臓器連関における概日リズムの意義と栄養シグナル2022
- Author(s)
  木内謙一郎
- Organizer
  第42回　日本肥満学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09012
[Presentation] Vascular endothelial NAMPT-mediated NAD+ biosynthesis regulates whole-body blood pressure and insulin resistance.2022
- Author(s)
  Kosugi S, Yamaguchi S, Homma K, Nagahisa T, Nishioka K, Watanabe Y, Kinouchi K, Hayashi K, Miyashita K, Kanda T, Irie J, Yoshino J, Itoh H.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension (Japan・Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] Temporal Tissue Coordination by the Circadian Clock and Metabolic Cycles2021
- Author(s)
  Kenichiro Kinouchi, Kazutoshi Miyashita, Hiroshi Itoh
- Organizer
  The 9th Seoul International Congress of Endocrinology and Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09012
[Presentation] 内分泌代謝とエピジェネティックスが収斂する概日リズム2021
- Author(s)
  木内謙一郎
- Organizer
  第 39 回日本内分泌学会内分泌代謝学サマーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K09012
[Presentation] 細胞内酸性環境を維持する(プロ)レニン受容体の生理的な機能2011
- Author(s)
  木内謙一郎
- Organizer
  第40回日本心脈管作動物質学会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] (Pro)renin receptor is essential for cell survival in murine cardiomyocytes.2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  64^<th> Annual High Blood Pressure Research Conference of the American Heart Association.
- Place of Presentation
  Washington, USA
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] Comparative effects of telmisartan-based therapy and calcium channel blockers-based therapy on cardio-ankle vascular index in hypertensive patients2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  The 23^<rd> Scientific Meeting of the International Society of Hypertension.
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] Cardiomyocyte-specific Ablation of (Pro)renin Receptor Caused Fulminant Heart Failure Due To Disruption of Intracellular Acidification2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] 心筋細胞特異的(プロ)レニン受容体ノックアウトマウスの解析2010
- Author(s)
  木内謙一郎
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] ATP6AP2/(Pro)renin receptor is essential for assembly of the V-ATPase in murine cardiomyocytes.2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  The 23^<rd> Scientific Meeting of the International Society of Hypertension.
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] 細胞内小器官における(プロ)レニン受容体の生理機能の解明2010
- Author(s)
  木内謙一郎
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension.2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  The 12^<th> Asian Pacific Congress of Nephrology.
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-06-06
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients.2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  The 12^<th> Asian Pacific Congress of Nephrology.
- Place of Presentation
  Seoul, Korea
- Year and Date
  2010-05-06
- Data Source
  KAKENHI-PROJECT-22790724
[Presentation] Physiological levels of prorenin and (pro)renin receptor influence the ZO-1 mRNA expression in human podocytes.2010
- Author(s)
  Kinouchi K, et al.
- Organizer
  The 8^<th> International Podocytes Conference Bristol.
- Place of Presentation
  Bristol, UK
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-22790724

1. Miyashita Kazutoshi (50378759)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. 土居雅夫 (20432578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 三上洋平 (80528662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 山口慎太郎 (50464855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 本間康一郎 (10383762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 久保亜紀子 (50455573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 伊藤裕 (40252457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 入江潤一郎 (70306687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 橋本寿之 (90528390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAYASHI Kaori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 吉野純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinochi Kenichiro 木内 謙一郎

Kinouchi Kenichiro 木内 謙一郎

木内 謙一郎 キノウチ ケンイチロウ

Research Projects

Research Products

Co-Researchers

妊娠母体概日リズムのエクソソームを介した次世代への疾患伝播の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dissecting the transcriptional network of organogenesis based on reprogramming factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

母児概日リズム同期と次世代疾患感受性の多層多元的代謝リズムパネルからの理解

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Circadian clock and proliferative metabolism in the intestinal T lymphocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心筋特異的(プロ)レニン受容体欠損により発症する心筋症の病態解明と標的治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in <i>Dpp-4</i> Promoter2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] エネルギー代謝・運動の日内ホメオスタシス制御の根幹を成す生体時計2021

Author(s)

Kinochi Kenichiro 木内謙一郎

Kinouchi Kenichiro 木内謙一郎

木内謙一郎キノウチケンイチロウ