OTOMO ASAKO 大友麻子

… Alternative Names

Otomo Asako 大友麻子

OTOMO Asako 大友麻子

ASAKO Otomo 大友麻子

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Researcher Number	50535226
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 東海大学, 医学部, 講師 2019 – 2020: 東海大学, 医学部, 助教 2013 – 2016: 東海大学, 医学部, 助教 2011: 北里大学, 理学部, 講座研究員 2011: 北里大学, 理学部, 講座研究生 2010: 東海大学, 医学部, 特定研究員 2009: Tokai University, 医学部, 奨励研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 59020:Sports sciences-related / Medium-sized Section 52:General internal medicine and related fields / Nerve anatomy/Neuropathology
Keywords	Principal Investigator ALS / iPS細胞 / 筋萎縮性側索硬化症 / 運動ニューロン / 筋萎縮性側索硬化症2型 / ALS2 / 細胞モデル / 骨格筋 / 下位運動ニューロン / 上位運動ニューロン … More / AD / シグナル伝達 / Rab タンパク質 / エンドソーム / 神経変性疾患 / 神経細胞 / Rab5 / 初期エンドソーム / 家族性筋萎縮性側索硬化症2型 / 末梢血 / 筋萎縮性側索硬化症２型 / iPS / iPS cell / ES細胞 / マーモセット … More Except Principal Investigator マイクロ流体デバイス / 運動ニューロン / iPS細胞 / 筋萎縮性側索硬化症 / 骨格筋 / 骨格筋オルガノイド / ３D培養筋 / 三次元培養筋 / オルガノイド / マイオカイン / 低酸素 / 選択的細胞死 / 治療薬 / 標的分子シグナル系 / 血液脳関門 / 細胞内オルガネラ動態 / ALS2 / 蛋白質 / 遺伝子 / ALS / 酸化ストレス / 蛋白質分解 / 遺伝子発現 / 神経科学 / 脳・神経 / 脳神経疾患 Less

Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems
- Principal Investigator
  
  秦野伸二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokai University
ヒト骨格筋オルガノイドを活用した低酸素依存性マイオカインの網羅的探索と評価
- Principal Investigator
  
  中村友浩
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka Institute of Technology
生理的機能を有するALS細胞モデルの構築とその病態解析Principal Investigator
- Principal Investigator
  
  大友麻子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokai University
A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier
- Principal Investigator
  
  秦野伸二
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tokai University
Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomesPrincipal Investigator
- Principal Investigator
  
  Otomo Asako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokai University
An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS
- Principal Investigator
  
  Hadano Shinji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokai University
Molecular mechanism for the maintenance of proteostasis in motor neurons
- Principal Investigator
  
  HADANO SHINJI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokai University
Establishment and Characterization of iPS cell lines from Japanese ALS2 patientsPrincipal Investigator
- Principal Investigator
  
  OTOMO Asako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokai University
Analysis of ALS2 function in motor neurons form common marmosetPrincipal Investigator
- Principal Investigator
  
  ASAKO Otomo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kitasato University
  Tokai University

[Book] Autophagy Dysfunction in Alzheimer's Disease and Dementia 担当:共著, 範囲:1. Degradation mechanisms of cells (Edited by Tadanori Hamano & Tatsuro Mutoh)2022
- Author(s)
  Asako Otomo, Shinji Hadano
- Total Pages
  356
- Publisher
  ELSEVIER/Academic Press
- ISBN
  9780323899062
- Data Source
  KAKENHI-PROJECT-22K07356
[Book] Autophagy dysfunction in Alzheimer's disease and dementia/ Chapter 1 Degradation mechanisms of cells2022
- Author(s)
  Otomo, A. and Hadano, S. (Edited by Hamano, T. and Mutoh, T.)
- Total Pages
  19
- Publisher
  ACADEMIC PRESS (Elsevier)
- Data Source
  KAKENHI-PROJECT-19H03551
[Book] すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患アクチュアル　脳・神経疾患の臨床　担当:分担執筆、 IV．ALSの病態関連遺伝子と遺伝子変異　ALS2/Alsin2013
- Author(s)
  大友麻子、白川健太郎、宮嶋裕明、秦野伸二
- Total Pages
  4
- Publisher
  山中書店
- Data Source
  KAKENHI-PROJECT-25830040
[Journal Article] Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.2024
- Author(s)
  Nami Motosugi , Akiko Sugiyama , Asako Otomo , Yuka Sakata , Takuma Araki , Shinji Hadano , Natsuhiko Kumasaka , Atsushi Fukuda
- Journal Title
  
  PNAS nexus
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07356
[Journal Article] Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes2023
- Author(s)
  Sato Kai、Suzuki-Utsunomiya Kyoko、Mitsui Shun、Ono Suzuka、Shimakura Kento、Otomo Asako、Hadano Shinji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 638 Pages: 168-175
- DOI
  10.1016/j.bbrc.2022.11.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
[Journal Article] High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device2022
- Author(s)
  Otomo Asako、Ono Suzuka、Sato Kai、Mitsui Shun、Shimakura Kento、Kimura Hiroshi、Hadano Shinji
- Journal Title
  
  Neuroscience Research
  
  Volume: 174 Pages: 46-52
- DOI
  10.1016/j.neures.2021.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
[Journal Article] Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies2022
- Author(s)
  Rossi Sebastiano Matteo、Ermondi Giuseppe、Sato Kai、Otomo Asako、Hadano Shinji、Caron Giulia
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 20 Pages: 7063-7063
- DOI
  10.3390/molecules27207063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
[Journal Article] SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron2022
- Author(s)
  Mitsui Shun、Otomo Asako、Sato Kai、Ishiyama Masahito、Shimakura Kento、Okada-Yamaguchi Chisa、Warabi Eiji、Yanagawa Toru、Aoki Masashi、Shang Hui-Fang、Hadano Shinji
- Journal Title
  
  Neurochemistry International
  
  Volume: 158 Pages: 105364-105364
- DOI
  10.1016/j.neuint.2022.105364
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
[Journal Article] De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs2022
- Author(s)
  Motosugi Nami、Sugiyama Akiko、Okada Chisa、Otomo Asako、Umezawa Akihiro、Akutsu Hidenori、Hadano Shinji、Fukuda Atsushi
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 12 Pages: 100352-100352
- DOI
  10.1016/j.crmeth.2022.100352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09555, KAKENHI-PROJECT-22K19409, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-19H03551, KAKENHI-PROJECT-20H03829
[Journal Article] The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS22021
- Author(s)
  Shimakura Kento、Sato Kai、Mitsui Shun、Ono Suzuka、Otomo Asako、Hadano Shinji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 569 Pages: 106-111
- DOI
  10.1016/j.bbrc.2021.06.095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
[Journal Article] SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells2021
- Author(s)
  Nozaki Masahisa、Otomo Asako、Mitsui Shun、Ono Suzuka、Shirakawa Ryohei、Chen YongPing、Hama Yutaro、Sato Kai、Chen XuePing、Suzuki Toshiyasu、Shang Hui-Fang、Hadano Shinji
- Journal Title
  
  eNeurologicalSci
  
  Volume: 22 Pages: 100301-100301
- DOI
  10.1016/j.ensci.2020.100301
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551, KAKENHI-PROJECT-18J20411
[Journal Article] Human PZP and common marmoset A2ML1 as pregnancy related proteins2020
- Author(s)
  Kashiwagi Hirofumi、Ishimoto Hitoshi、Izumi Sun-ichiro、Seki Toshiro、Kinami Rihito、Otomo Asako、Takahashi Kazumi、Kametani Fuyuki、Hirayama Noriaki、Sasaki Erika、Shiina Takashi、Sakabe Kou、Mikami Mikio、Kametani Yoshie
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5088-5088
- DOI
  10.1038/s41598-020-61714-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19K18709, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-17K11298, KAKENHI-PROJECT-20H03828, KAKENHI-PROJECT-16H06277
[Journal Article] ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes2020
- Author(s)
  Ono Suzuka、Otomo Asako、Murakoshi Shuji、Mitsui Shun、Sato Kai、Fukuda Mitsunori、Hadano Shinji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 4 Pages: 908-915
- DOI
  10.1016/j.bbrc.2019.12.122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
[Journal Article] Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss2020
- Author(s)
  Oka A、Takagi A、Komiyama E、Yoshihara N、Mano S、Hosomichi K、Suzuki S、Haida Y、Motosugi N、Hatanaka T、Kimura M、Ueda M、Nakagawa S、Miura H、Ohtsuka M、Tanaka M、Komiyama T、Otomo A、Hadano S、Mabuchi T、Beck S、Inoko H、Ikeda S.
- Journal Title
  
  EBioMedicine
  
  Volume: 57 Pages: 102810-102810
- DOI
  10.1016/j.ebiom.2020.102810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19K08802, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H03551
[Journal Article] PACT/PRKRA and p53 Regulate Transcriptional Activity of DMRT12020
- Author(s)
  Fujitani K、Otomo A、 Nagayama Y、 Tachibana T、 Kato R、Kawashima Y、 Kodera Y、 Kato T、 Takada S、 Tamura K、 Takamatsu N、 Ito M.
- Journal Title
  
  Genetics and Molecular Biology
  
  Volume: 43 Issue: 2
- DOI
  10.1590/1678-4685-gmb-2019-0017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-17H02206, KAKENHI-PROJECT-17K19926
[Journal Article] Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures.2020
- Author(s)
  Otomo Asako、Takahashi Ueda Mahoko、Fujie Toshinori、Hasebe Arihiro、Suematsu Yoshitaka、Okamura Yosuke、Takeoka Shinji、Hadano Shinji、Nakagawa So
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 6716-6716
- DOI
  10.1038/s41598-020-63537-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K20116, KAKENHI-PROJECT-19K07832, KAKENHI-PLANNED-18H05469, KAKENHI-PROJECT-19H03551
[Journal Article] Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B2020
- Author(s)
  Hayashi Hideki、Wang Ting、Tanaka Masayuki、Ogiwara Sanae、Okada Chisa、Ito Masatoshi、Fukunishi Nahoko、Iida Yumi、Nakamura Ayaka、Sasaki Ayumi、Amano Shunji、Yoshida Kazuhiro、Otomo Asako、Ohtsuka Masato、Hadano Shinji
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: e0234180-e0234180
- DOI
  10.1371/journal.pone.0234180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
[Journal Article] Theme 3 In vitro experimental models: ALS2 along with a novel ALS2 interacting protein RAB30 regulates morphological integrity and functions of the Golgi apparatus2019
- Author(s)
  Otomo A、Onodera W、Murakoshi S、 Matsui K、 Sato K、 Mitsui S、Ono S、Fukuda M、Hadano S.
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 20 Issue: sup1 Pages: 136-137
- DOI
  10.1080/21678421.2019.1646991
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832
[Journal Article] An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons2019
- Author(s)
  Yokoyama S.、Otomo A.、Hadano S.、Kimura H.
- Journal Title
  
  Biomicrofluidics
  
  Volume: 13 Issue: 3 Pages: 034104-034104
- DOI
  10.1063/1.5090968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
[Journal Article] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2 in recycling endosomes.2016
- Author(s)
  Suzuka Ono, Asako Otomo, Wakana Onodera, Kai Sato, Shun Mitsui, Mitsunori Fukuda, Shinji Hadano
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 16 Issue: sup1 Pages: 182-182
- DOI
  10.3109/21678421.2015.1098815
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830040
[Journal Article] Sexually dimorphic expression of Dmrt1 and H2AX in germ stem cells during gonadal development in Xenopus laevis2016
- Author(s)
  Kazuko Fujitani, Asako Otomo, Mikako Wada, Nobuhiko Takamatsu and Michihiko Ito
- Journal Title
  
  FEBS Open Bio
  
  Volume: 6 Issue: 4 Pages: 276-284
- DOI
  10.1002/2211-5463.12035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830040
[Journal Article] Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice2016
- Author(s)
  Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 25 Issue: 15 Pages: 3321-3340
- DOI
  10.1093/hmg/ddw180
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26290018, KAKENHI-PROJECT-26460485
[Journal Article] GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.2014
- Author(s)
  Suyama K, Watanabe M, Sakabe K, Otomo A, Okada Y, Terayama H, Imai T, Mochida J.
- Journal Title
  
  PLoS One
  
  Volume: 24;9(1) Issue: 1 Pages: e86951-e86951
- DOI
  10.1371/journal.pone.0086951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25340050, KAKENHI-PROJECT-25462311, KAKENHI-PROJECT-25830040, KAKENHI-PROJECT-26460809
[Journal Article] Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice2012
- Author(s)
  潘麗、吉井康弘、大友麻子、小川温子、岩崎泰雄、秦野伸二
- Journal Title
  
  PLoS One
  
  Volume: 7巻、3号
- URL
  http://dx.doi.org/10.1371/journal.pone.0033409
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases2012
- Author(s)
  大友麻子、潘麗、秦野伸二
- Journal Title
  
  Neurology Research International
  
  Volume: (In press)
- URL
  http://www.hindawi.com/journals/nri/
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation2011
- Author(s)
  大友麻子
- Journal Title
  
  FEBS Letters
  
  Volume: 585 Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Defective relocalization of ALS2/alsin to Rac1-induced macropinosomes accounts for loss of its cellular function and leads to disturbed amphisome formation2011
- Author(s)
  Asako Otomo
- Journal Title
  
  Amyotrophic Lateral Sclerosis
  
  Volume: 12巻 Issue: sup1 Pages: 134-134
- DOI
  10.3109/17482968.2011.615526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation2011
- Author(s)
  大友麻子、國田竜太、鈴木(宇都宮)恭子、池田譲衛、秦野伸二
- Journal Title
  
  FEBS Lett
  
  Volume: 585巻、5号 Pages: 730-736
- URL
  http://dx.doi.org/10.1016/j.febslet.2011.01.045
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS2011
- Author(s)
  吉井康弘、大友麻子、潘麗、大塚正人、秦野伸二
- Journal Title
  
  Neuroscience Research
  
  Volume: 70巻、3号 Pages: 321-329
- URL
  http://dx.doi.org/10.1016/j.neures.2010.06.004
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice2010
- Author(s)
  秦野伸二、吉井康弘、大友麻子、國田竜太、鈴木(宇都宮)恭子、潘麗、角田茂、岩崎泰雄、岩倉洋一郎、池田譲衛
- Journal Title
  
  Neuroscience Research
  
  Volume: 68巻、2号 Pages: 131-136
- URL
  http://dx.doi.org/10.1016/j.neures.2010.06.004
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Loss of ALS2/Alsin exacerbates motordysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking2010
- Author(s)
  秦野伸二、大友麻子、國田竜太、鈴木(宇都宮)恭子、赤塚明、小池正人、青木正志、内山安男、糸山泰人、池田譲衛
- Journal Title
  
  PLoS One
  
  Volume: 5巻、3号
- URL
  http://dx.doi.org/10.1371/journal.pone.0009805
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Lower serum lipid levels are related to respiratory impairment in patients with ALS2010
- Author(s)
  吉井康弘、秦野伸二、大友麻子、川邉清一、池田憲、岩崎泰雄
- Journal Title
  
  Neurology
  
  Volume: 74巻、24号 Pages: 2027-2027
- URL
  http://www.neurology.org
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Natural history of young-adult amyotrophic lateral sclerosis2009
- Author(s)
  吉井康弘、秦野伸二、大友麻子, 鈴木恭子、池田憲、池田譲衛、岩崎泰雄
- Journal Title
  
  Neurology
  
  Volume: 73巻、8号 Pages: 648-649
- URL
  http://www.neurology.org
- Data Source
  KAKENHI-PROJECT-21700397
[Journal Article] Rac1-induced macropinosomal and endosomal localization of ALS2 underlies the pathogenesis for motor neuron diseases caused by missense mutations in the ALS2 gene2009
- Author(s)
  大友麻子
- Journal Title
  
  Amyotrophic Lateral Sclerosis 10(Suppl.1)
  
  Pages: 42-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700397
[Patent] 細胞培養基材、細胞培養用樹脂薄膜、および細胞培養方法2020
- Inventor(s)
  木村啓志, 福田篤, 岡村陽介, 喜多理王, 大友麻子
- Industrial Property Rights Holder
  学校法人東海大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K07832
[Presentation] PDIはTDP-43のグアニン四重鎖依存的液液相分離を制御する2023
- Author(s)
  石黒亮、西島恵子、村上裕太、木村啓志、秦野伸二、大友麻子
- Organizer
  第46回日本分子生物学会年会 (MBSJ2023)
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] FUS遺伝子変異を原因とする筋萎縮性側索硬化症（ALS）細胞モデルの作出とマイクロデバイスを用いた軸索表現型の評価2023
- Author(s)
  西島　恵子、大友　麻子、村上　裕太、石川　充、木村　啓志、秦野　伸二
- Organizer
  15th Tokai University Micro/Nano Enlightenment
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1の時空間的動態解析2023
- Author(s)
  島倉健人、山口千沙、湯田平陽香、岡晃、大友麻子、秦野伸二
- Organizer
  第46回日本分子生物学会年会 (MBSJ2023)
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] ３次元培養筋OITem を活用した神経筋共培養の試み2023
- Author(s)
  大友　麻子
- Organizer
  第6回３次元培養筋OITem研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] マイクロデバイスを用いたFUS遺伝子変異を原因とする筋萎縮性側索硬化症（ALS）細胞モデルの評価2023
- Author(s)
  大友　麻子、西島　恵子、村上　裕太、石川　充、木村　啓志、秦野　伸二
- Organizer
  第46回日本分子生物学会年会 (MBSJ2023)
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1細胞内動態観察2022
- Author(s)
  島倉健人、岡田－山口千沙、湯田平陽香、岡晃、大友麻子、秦野伸二
- Organizer
  本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ヒトiPSCs由来下位運動ニューロンの培養と軸索表現型評価に適したマイクロデバイスの開発2022
- Author(s)
  大友麻子、西島恵子、村上裕太、石川充、木村啓志、秦野伸二
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 下位運動ニューロンと骨格筋の共培養による神経筋結合部の構築とその機能評価2022
- Author(s)
  内藤佳津子、大友麻子、村松優作、西島恵子、木村啓志、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第14回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] マウス由来骨格筋とヒト由来下位運動ニューロンの共培養による神経筋結合部の構築とその機能評価2022
- Author(s)
  内藤佳津子、大友麻子、秦野伸二
- Organizer
  日本実験動物技術者協会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 筋萎縮性側索硬化症責任遺伝子NEK1およびALS2の機能的連関が神経細胞表現型に及ぼす影響2022
- Author(s)
  湯田平　陽香、佐藤　海、　島倉　健人、石川　充、大友　麻子、秦野　伸二
- Organizer
  第45回日本分子生物学会年会 (MBSJ2022)
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] 筋萎縮性側索硬化症責任遺伝子NEK1およびALS2の機能的連関が神経細胞表現型に及ぼす影響2022
- Author(s)
  湯田平陽香、佐藤海、島倉健人、石川充、大友麻子、秦野伸二
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1細胞内動態観察2022
- Author(s)
  島倉　健人、山口　千沙、湯田平　陽香、岡　晃、大友　麻子、秦野　伸二
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] ヒトiPSCs由来下位運動ニューロンの培養と軸索表現型評価に適したマイクロデバイスの開発2022
- Author(s)
  大友　麻子、西島　恵子、村上　裕太、石川　充、木村　啓志、秦野　伸二
- Organizer
  第45回日本分子生物学会年会 (MBSJ2022)
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] 効率的下位運動ニューロン分化誘導法を用いたALS細胞モデルの作出2022
- Author(s)
  西島恵子、大友麻子、村松優作、木村啓志、石川充、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第14回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] マウス由来骨格筋とヒト由来下位運動ニューロンの共培養による神経筋結合部の構築とその機能評価2022
- Author(s)
  内藤　佳津子、大友　麻子、秦野伸二
- Organizer
  第56回日本実験動物技術者協会総会
- Data Source
  KAKENHI-PROJECT-22K07356
[Presentation] The intrinsically disordered region at the N-terminus of ALS2 acts as a determinant for the intracellular localization and oligomerization of ALS2.2021
- Author(s)
  Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
- Organizer
  PACTALS 2021 NAGOYA (Pan-Asian Consortium for Treatment and Research in ALS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 筋萎縮性側索硬化症（ALS）細胞モデルの構築を目指した骨格筋及下位運動ニューロン培養法の確立2021
- Author(s)
  内藤佳津子、加納葵、藤田紘暉、大友麻子、木村啓志、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第13回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2の天然変性領域はALS2細胞内局在および多量体形成に影響する2021
- Author(s)
  島倉健人、佐藤海、三井駿、小野鈴花、大友麻子、秦野伸二
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] マイクロ流体デバイスを用いた神経筋接合部モデルの確立2021
- Author(s)
  加納葵、藤田紘暉、大友麻子、秦野伸二、木村啓志
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第13回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons.2021
- Author(s)
  Mitsui, S., Otomo, A., Sato, K., Shimakura, K., Ishii, T., Yanagawa, T., Aoki, M., and Hadano, S.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Structural architecture and cellular functions of juvenile motor neuron disease-causative gene product ALS2: implication of endosome maturation and endocytic recycling.2021
- Author(s)
  Otomo, A., Ono, S., Sato, K., Mitsui, S. Shimakura, K., Fukuda, M., and Hadano, S.
- Organizer
  Keystone Symposia/eSymposia, Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2 forms a unique homophilic complex in the central nervous system, whose molecular weight is higher than those in the peripheral tissues.2021
- Author(s)
  Sato, K., Suzuki-Utsunomiya, K., Mitsui, S., Yudahira, H., Ono, S., Shimakura, K., Otomo, A., and Hadano, S.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Structural architecture and cellular functions of juvenile motor neuron disease-causative gene product ALS2: implication of endosome maturation and endocytic recycling.2021
- Author(s)
  Asako Otomo, Suzuka Ono, Kai Sato, Shun Mitsui, Kento Shimakura, Mitsunori Fukuda and Shinji Hadano
- Organizer
  Keystone Symposia/eSymposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07832
[Presentation] The intrinsically disordered region at the N-terminus of ALS2 acts as a determinant for the intracellular localization and oligomerization of ALS22021
- Author(s)
  Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] SQSTM1の欠損は神経細胞と末梢組織細胞のユビキチン化タンパク質動態に異なった影響をもたらす2020
- Author(s)
  三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.2020
- Author(s)
  Sato, K., Otomo, A., Ueda, M. T., Hiratsuka, Y., Suzuki-Utsunomiya, K., Sugiyama, J., Murakoshi, S., Mitsui, S., Ono, S., Nakagawa, S., Shang, H. -F., and Hadano, S.
- Organizer
  Experimental Biology 2020/2020 ASBMB Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 神経終末画分におけるALS2は細胞質画分とは異なる特異的高次構造を形成する2020
- Author(s)
  佐藤海、鈴木-宇都宮恭子、三井駿、小野鈴花、島倉健人、大友麻子、秦野伸二
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Neural cell-specific SQSTM1 deficiency accelerates the onset of disease in an ALS mouse model.2020
- Author(s)
  Mitsui, S., Ishiyama, M., Shimakura, K., Sato, K., Ono, S., Otomo, A., Ishii, T., Yanagawa, T., Aoki, M., and Hadano, S.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, Brain Therapeutics: Disruptive Technologies and Opportunities
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2 controls the intracellular localization of small GTPase Rab17 and regulates endosome maturation.2019
- Author(s)
  Ono, S., Murakoshi, S., Sato, K., Mitsui, S., Otomo, A., Fukuda, M., and Hadano, S.
- Organizer
  ASCB/EMBO 2019 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2は神経終末画分において細胞質画分とは異なる特異的高次構造を形成する2019
- Author(s)
  佐藤海、鈴木-宇都宮恭子、島倉健人、三井駿、小野鈴花、大友麻子、秦野伸二
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Phosphorylation state of ALS2/alsin alters its intracellular localization and endosome dynamics.2019
- Author(s)
  Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 単量体Keima融合型LC3Bによるオートファジー・エンドリソソーム系モニタリング法の開発2019
- Author(s)
  秦野伸二、林英樹、王テイ、田中政之、荻原早苗、岡田千沙、伊藤誠敏、福西菜穂子、飯田裕美、中村彩花、佐々木亜由美、天野俊二、吉田和弘、大友麻子、大塚正人
- Organizer
  第12回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2疾患原因変異体の高次構造の変化はALS2が担うエンドソーム機能を喪失させる2019
- Author(s)
  佐藤海、大友麻子、上田-高橋真保子、平塚結衣、鈴木-宇都宮恭子、杉山純也、村越秀治、三井駿、小野鈴花、中川草、Hui-Fang Shang、秦野伸二
- Organizer
  第42回日本神経科学大会/第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALSマウスモデル由来初代神経培養細胞のマイクロデバイスを用いた定量的軸索輸送解析2019
- Author(s)
  大友麻子、串田隆志、石田智之、荒木良介、三井駿、小野鈴花、佐藤海、木村啓志、秦野伸二
- Organizer
  第42回日本神経科学大会/第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2 along with a novel ALS2 interacting protein RAB30 regulates morphological integrity and functions of the Golgi apparatus2019
- Author(s)
  Otomo A、Onodera W、Murakoshi S、 Matsui K、 Sato K、 Mitsui S、Ono S、Fukuda M、Hadano S.
- Organizer
  The 30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07832
[Presentation] A microdevice-based method for quantifying endolysosomal and mitochondrial axonal transport in neurons derived from a mouse model of ALS.2019
- Author(s)
  Otomo, A., Kushida, T., Ishida, T., Araki, R., Sato, K., Mitsui, S., Ono, S., Kimura, H., and Hadano, S.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 神経終末におけるALS2 は、特異的な高次構造を形成する2019
- Author(s)
  佐藤海、鈴木（宇都宮）恭子、島倉健人、大友麻子、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2タンパク質及び新規結合因子Rab17の分子機能解析2019
- Author(s)
  小野鈴花、大友麻子、福田光則、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALSマウスモデル由来初代神経培養細胞のマイクロデバイスを用いた定量的軸索輸送解析2019
- Author(s)
  大友麻子、串田隆志、石田智之、荒木良介、三井駿、小野鈴花、佐藤海、木村啓志、秦野伸二
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19K07832
[Presentation] 神経系特異的SQSTM1の欠損はALSマウスモデルの発症を早期化させる2019
- Author(s)
  三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
- Organizer
  第42回日本神経科学大会/第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] 神経系特異的SQSTM1の欠損はALSマウスモデルの発症を早期化させる2019
- Author(s)
  三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] マイクロデバイスによるALSマウスモデル由来初代神経培養細胞の定量的軸索輸送解析2019
- Author(s)
  大友麻子、串田隆志、石田智之、荒木良介、三井駿、佐藤海、小野鈴花、木村啓志、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2はRac1活性依存的に低分子量Gタンパク質Rab17の細胞内局在を調節する2019
- Author(s)
  小野鈴花、村越秀治、佐藤海、三井駿、大友麻子、福田光則、秦野伸二
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2 along with a novel ALS2 interacting protein Rab30 regulates morphological integrity and functions of the Golgi apparatus.2019
- Author(s)
  Otomo, A., Onodera, W., Matsui, K., Sato, K., Mitsui, S., Ono, S., Fukuda, M., and Hadano, S.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] ALS2のリン酸化修飾がエンドゾーム動態に及ぼす影響2019
- Author(s)
  島倉健人、佐藤海、大友麻子、秦野伸二
- Organizer
  東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
- Data Source
  KAKENHI-PROJECT-19H03551
[Presentation] Microdevice-based method for quantifying endolysosomal and mitochondrial axonal transport in neurons derived from a mouse model of ALS2019
- Author(s)
  Otomo A、Kushida T、 Ishida T、Araki R、Sato K、Mitsui S、Ono S、 Kimura H、 Hadano S.
- Organizer
  The 30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07832
[Presentation] Dichotomous effect of systemic overexpression of SQSTM1 on disease onset and post-onset survival in SOD1H46R mice.2017
- Author(s)
  Mitsui, S., Otomo, A., Nozaki, M., Ono, S., Sato, K., Shirakawa, R., Adachi, H., Aoki, M., Sobue, G., Shang, H. -F. and Hadano, S.
- Organizer
  第40回日本神経科学大会
- Place of Presentation
  幕張メッセ（千葉県・千葉市）
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] The ALS2-interacting protein Rab30 is a possible regulator for vesicular trafficking between early endosome and the Golgi apparatus.2017
- Author(s)
  Otomo, A., Matsui, K., Onodera, W., Sugiyama, J., Ishida, T., Sato, K., Mitsui, S., Shirakawa, R., Nozaki, M., Ono, S., Fukuda, M., and Hadano, S.
- Organizer
  第40回日本神経科学大会
- Place of Presentation
  幕張メッセ（千葉県・千葉市）
- Year and Date
  2017-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] 軸索輸送現象の定量評価に向けた開放型マイクロデバイスの開発および評価2017
- Author(s)
  横山奨，串田隆志，石田智之，大友麻子，秦野伸二，木村啓志
- Organizer
  シンポジウム「細胞アッセイ技術の現状と将来」、細胞アッセイ研究会
- Place of Presentation
  東京大学生産技術研究所コンベンションホール（東京都・目黒区）
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] 新規ALS2結合候補分子Rab30の発現及び細胞内動態解析2016
- Author(s)
  松井香奈、小野寺和歌奈、大友麻子、福田光則、秦野伸二
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] マイクロ流体デバイスを用いたALS疾患モデルの解析2016
- Author(s)
  石田智之、荒木良介、大友麻子、横山奨、串田隆志、杉山純也、秦野伸二、木村啓志
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Systemic overexpression of SQSTM1 accelerates age of disease onset and reduces survival in SOD1H46R mice.2016
- Author(s)
  Mitsui, S., Otomo, A., Nozaki, M., Ono, S., Sato, K., Shirakawa, R., Adachi, H., Aoki, M., Sobue, G., Shang, H. -F., and Hadano, S.
- Organizer
  27th International Symposium on ALS/MND
- Place of Presentation
  Dublin (Republic of Ireland)
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] SQSTM1の全身性高発現は変異SOD1発現ALSマウスモデルの発症を早める2016
- Author(s)
  三井駿、大友麻子、野崎昌久、小野鈴花、佐藤海、白川涼平、足立弘明、青木正志、祖父江元、Shang, H. -F.、秦野伸二
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Analysis of axonal transport in cultured neurons from ALS model mouse by using the microfluidic cell culture system.2016
- Author(s)
  Otomo, A., Araki, R., Yokoyama, S., Wada, J., Hadano, S., and Kimura, H.
- Organizer
  第39回日本神経科学大会（Neuroscience2016）
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] マイクロ流体デバイスを用いた神経疾患モデルの確立.2016
- Author(s)
  荒木良介、大友麻子、横山奨、和田純希、秦野伸二、木村啓志
- Organizer
  細胞アッセイ研究会
- Place of Presentation
  東京大学生産技術研究所コンベンションホール（東京都、文京区）
- Year and Date
  2016-01-19
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] A novel teaching approach based on a DNA experiment lesson in high school biology laboratory class: Scientific inquiry by visualization of DNA sequence conservation and diversity and a developmental lesson to understand genetic diagnosis.2016
- Author(s)
  Inoue, Y., Otomo, A., Takahashi, K., Moriya, H., Ohnuki, Y., Izumi, S., Miyachi, H., and Hadano, S.
- Organizer
  2016 International Conference of East-Asian Association for Science Education (EASE2016 Tokyo)
- Place of Presentation
  東京理科大学（東京都・新宿区）
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2/Alsin in recycling endosomes.2016
- Author(s)
  Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
- Organizer
  第39回日本神経科学大会（Neuroscience2016）
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2/Alsin in recycling endosomes.2016
- Author(s)
  Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Loss of SQSTM1/p62 but not NFE2L2/Nrf2 exacerbates motor neuron degeneration in a mutant SOD1-expressing mouse ALS model.2016
- Author(s)
  Hadano, S., Mitsui, S., Otomo, A., Sato, K., Ono, S., Chen, X. P., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
- Organizer
  15th Asian and Oceanian Congress of Neurology
- Place of Presentation
  Kuala Lumpur (Malaysia)
- Year and Date
  2016-08-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Loss of SQSTM1/p62 but not NFE2L2/Nrf2 exacerbates motor neuron degeneration in a mutant SOD1-expressing mouse ALS model.2016
- Author(s)
  Hadano, S., Mitsui, S., Otomo, A., Sato, K., Ono, S., Chen, X. P., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
- Organizer
  15th Asian and Oceanian Congress of Neurology
- Place of Presentation
  Kuala Lumpur Convention Centre (Kuala Lumpur, Malaysia)
- Year and Date
  2016-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] ALS2疾患原因変異体の高次構造および細胞内局在の変化はALS2関連運動ニューロン疾患の発症要因である2016
- Author(s)
  佐藤海、鈴木-宇都宮恭子、平塚結衣、三井駿、小野鈴花、大友麻子、秦野伸二
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Alterations of oligomeric states and subcellular localization of ALS2 mutants underlie the pathogenesis of ALS2-linked motor neuron diseases.2016
- Author(s)
  Sato, K., Suzuki-Utsunomiya, K., Hiratsuka, Y., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
- Organizer
  27th International Symposium on ALS/MND
- Place of Presentation
  Dublin (Republic of Ireland)
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Analysis of axonal transport in cultured neurons from ALS model mouse by using the microfluidic cell culture system.2016
- Author(s)
  Otomo, A., Araki, R., Yokoyama, S., Wada, J., Hadano, S., and Kimura, H.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] ALS患者由来SQSTM1/p62変異体の神経細胞における局在と機能の解析2016
- Author(s)
  白川涼平、濱祐太郎、大友麻子、Shang, H. -F.、秦野伸二
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Analysis of axonal transport in cultured neurons derived from an ALS mouse model by using the microfluidic cell culture system.2016
- Author(s)
  Otomo, A., Araki, R., Ishida, T., Shirakawa, R., Mitsui, S., Ono, S., Sato, K., Yokoyama, S., Kimura, H., and Hadano, S.
- Organizer
  27th International Symposium on ALS/MND
- Place of Presentation
  Dublin (Republic of Ireland)
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Development of novel device with high-throughout axonal transport quantification.2016
- Author(s)
  Yokoyama, S., Wada, J., Kushida, T., Araki, R., Ishida, T., Otomo, A., Hadano, S., and Kimura, H.
- Organizer
  The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
- Place of Presentation
  Dublin (Republic of Ireland)
- Year and Date
  2016-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] ALS2及び新規結合低分子量Gタンパク質Rab17はリサイクリングエンドソームに局在する2015
- Author(s)
  小野鈴花、大友麻子、福田光則、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] Pathogenic mutations in ALS2 alter the oligomeric states of the ALS2 complex and its subcellular localization.2015
- Author(s)
  Sato, K., Hiratsuka, Y., Suzuki-Utsunomiya, K., Otomo, A., and Hadano, S.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] SQSTM1/p62及びその変異体の神経細胞における局在解析.2015
- Author(s)
  白川涼平、濱祐太郎、大友麻子、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Pathogenic mutations in ALS2 alter the oligomeric states of the ALS2 complex and its subcellular localization2015
- Author(s)
  佐藤海、平塚結衣、鈴木（宇都宮）恭子、大友麻子、秦野伸二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場・神戸国際展示場(兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] SOD1H46R発現ALSマウスモデルの運動ニューロン変性はNrf2ではなく、p62/SQSTM1の機能喪失により悪化する.2015
- Author(s)
  三井駿、久保瑞希、潘雷、大友麻子、小池正人、内山安男、青木正志、山本雅之、石井哲郎、柳川徹、Hui-Fang Shang、吉井文均、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2 in recycling endosomes.2015
- Author(s)
  Suzuka Ono, Asako Otomo, Wakana Onodera, Kai Sato, Shun Mitsui, Mitsunori Fukuda, Shinji Hadano
- Organizer
  ALS/FTD
- Place of Presentation
  JW Marriott Orlando Grande Lakes (U.S.A)
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] ALS2疾患原因変異体はALS2複合体構造や細胞内局在を変化させる.2015
- Author(s)
  佐藤海、平塚結衣、大友麻子、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Loss of p62/SQSTM1 but not Nrf2 accelerates motor neuron degeneration in SOD1H46R transgenic mice.2015
- Author(s)
  Mitsui, S., Kubo, M., Pan, L., Otomo, A., Koike, M., Uchiyama, Y., Aoki, M., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., Yoshii, F., and Hadano, S.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] マイクロ流体デバイスを用いたALS疾患モデルの確立.2015
- Author(s)
  荒木良介、大友麻子、横山奨、和田純希、秦野伸二、木村啓志
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] マイクロ流体デバイスを用いたALS疾患モデルの確立2015
- Author(s)
  荒木良介、大友麻子、横山奨、和田純希、秦野伸二、木村啓志
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2 in recycling endosomes.2015
- Author(s)
  Ono, S., Otomo, A., Onodera, W., Sato, K., Mitsui, S., Fukuda, M., and Hadano, S.
- Organizer
  26th International Symposium on ALS/MND
- Place of Presentation
  JM Marriott Orlando Grande Lakes (Orlando, U.S.A.)
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] ALS2疾患原因変異体はALS2複合体構造や細胞内局在を変化させる2015
- Author(s)
  佐藤海、平塚結衣、大友麻子、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] ALS2及び新規結合低分子量Gタンパク質Rab17はリサイクリングエンドソームに局在する.2015
- Author(s)
  小野鈴花、大友麻子、福田光則、秦野伸二
- Organizer
  BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Defective relocalization of ALS2/alsin to Rac1-induced macropinosomes accounts for loss of its cellular function and leads to disturbed amphisome formation2011
- Author(s)
  大友麻子
- Organizer
  第22回ALS/MND国際シンポジウム
- Place of Presentation
  オーストラリア・シドニー
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] Defective relocalization of ALS2/alsin to Rac1-induced macropinosomes accounts for loss of its cellular function and leads to disturbed amphisome formation2011
- Author(s)
  大友麻子, 國田竜太, 鈴木(宇都宮)恭子、池田譲衛、秦野伸二
- Organizer
  22nd INTERNATIONAL SYMPODIUM on ALS/MND
- Place of Presentation
  Sidney, Australia
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] Rab5 and its activator ALS regulate autophagosome maturation and autophagoly2010
- Author(s)
  大友麻子, 國田竜太, 鈴木(宇都宮)恭子、池田譲衛、秦野伸二
- Organizer
  21st INTERNATIONAL SYMPODIUM on ALS/MND
- Place of Presentation
  orland, U. S. A
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] Rab5 and its activator ALS2 regulate autophagosome maturation and autophagolysosome-mediated protein degradation2010
- Author(s)
  大友麻子
- Organizer
  第21回ALS/MND国際シンポジウム
- Place of Presentation
  アメリカ合衆国・オーランド
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] Loss Of Rac1-induced macropinosomal and endosomal localization of ALS2 underlies the pathogenesis for motor neuron diseases caused by missense mutations in the ALS2 gene2009
- Author(s)
  大友麻子, 國田竜太, 鈴木(宇都宮)恭子、池田譲衛、秦野伸二
- Organizer
  20th INTERNATIONAL SYMPODIUM on ALS/MND
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] Rac1-induced macropinosomal and endosomal localization of ALS2 underlies the pathogenesis for motor neuron diseases caused by missense mutations in the ALS2 gene2009
- Author(s)
  大友麻子
- Organizer
  20th INTERNATIONAL SYMPODIUM on ALS/MND
- Place of Presentation
  ドイツ(ベルリン)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21700397
[Presentation] オートファジー関連因子p62/SQSTM1の機能喪失はALSマウスモデルの疾患症状を悪化させる
- Author(s)
  秦野伸二、潘雷、大友麻子、阿部幸一郎、小池正人、内山安男、青木正志、吉井文均、石井哲郎、柳川徹
- Organizer
  日本実験動物科学技術さっぽろ2014：第61回日本実験動物学会総会/第48回日本実験動物技術者協会総会
- Place of Presentation
  札幌
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] オートファジー基質であるp62/SQSTM1の機能喪失はALSマウスモデルの疾患症状を悪化させる
- Author(s)
  秦野伸二、潘雷、大友麻子、阿部幸一郎、小池正人、内山安男、青木正志、石井哲郎、柳川徹、Hui-Fang Shang、吉井文均
- Organizer
  第37回日本神経科学大会(Neuroscience2014)
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] 62/SQSTM1 DEFICIENCY ACCELERATES MOTOR NEURON DEGENERATION IN SOD1H46R TRANSGENIC MICE
- Author(s)
  PAN, L., OTOMO, A., KOIKE, M., UCHIYAMA,Y., AOKI, M., ABE., K., ISHII, T., YANAGAWA, T., SHANG, H.F.,YOSHII, F., HADANO, S.,
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] p62/SQSTM1の機能喪失はALSマウスモデルの疾患症状を悪化させる
- Author(s)
  秦野伸二、潘雷、大友麻子、阿部幸一郎、小池正人、内山安男、青木正志、吉井文均、石井哲郎、柳川徹
- Organizer
  日本実験動物科学技術さつぽろ2014:第61回日本実験動物学会総会/第48回日本実験動物技術者協会総会
- Place of Presentation
  さっぽろ
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] Generation and characterization of a novel transgenic mouse model for monitoring the autophagy-endolysosomal system.
- Author(s)
  Hadano, S., Wang, T., Tanaka, M., Hayashi, H., Ogiwara, S., Okada, C., Itoh, M., Fukunishi, N., Iida, Y., Nakamura, A., Otomo, A., and Ohtsuka, M.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Loss of p62/SQSTM1, an autophagy substrate, aggravates motor dysfunction in a SOD1H46R-expressing mouse ALS model.
- Author(s)
  Hadano, S., Pan, L., Otomo, A., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] p62/SQSTM1 deficiency accelerates motor neuron degeneration in SOD1H46R transgenic mice.
- Author(s)
  Pan, L., Otomo, A., Koike, M., Uchiyama, Y., Aoki, M., Abe, K., Ishii, T., Yanagawa, T., Shang, H. -F., Yoshii, F., and Hadano, S.
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] ALS2及び新規ALS2結合低分子量Gタンパク質Rab17の細胞内局在解析
- Author(s)
  小野鈴花、大友麻子、福田光則、秦野伸二
- Organizer
  第37回日本分子生物学会年回
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] Identification and characterization of a novel ALS2 interacting protein Rab30.
- Author(s)
  Onodera, W., Otomo, A., Fukuda, M., and Hadano, S.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Subcellular distribution of ALS2 and the novel ALS2-interacting small G protein Rab17.
- Author(s)
  Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26290018
[Presentation] Isolation and characterization of DMRT1-associated factors in Xenopus male gonads
- Author(s)
  藤谷和子、大友麻子、永山勇人、立花太郎、加藤朋子、高田修治、加藤利佳、小寺義男、高松信彦、伊藤道彦
- Organizer
  第37回日本分子生物学会年回
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] 筋萎縮性側索硬化症原因遺伝子産物ALS2に結合する新規調節因子Rab30の機能解析
- Author(s)
  小野寺和歌奈、大友麻子、福田光則、秦野伸二
- Organizer
  第37回日本分子生物学会年回
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830040
[Presentation] オートファジー動態の可視化を目的とした新規トランスジェニックマウスの作出
- Author(s)
  秦野伸二、王亭、田中政之、林英樹、荻原早苗、岡田千沙、伊藤誠敏、福西菜穂子、飯田裕美、中村彩花、大友麻子、大塚正人
- Organizer
  第37回日本分子生物学会年回
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25830040

1. HADANO SHINJI (60281375)

# of Collaborated Projects: 6 results

# of Collaborated Products: 93 results
2. 木村啓志 (40533625)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. 福田篤 (00638091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 中村友浩 (30217872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 奥崎大介 (00346131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 横山奨 (30760425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤里俊哉 (60270732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 橋本健志 (70511608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤枝俊宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 坂部貢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 本杉奈美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTOMO ASAKO 大友 麻子

Otomo Asako 大友 麻子

OTOMO Asako 大友 麻子

ASAKO Otomo 大友 麻子

Research Projects

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Co-Researchers

Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems

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ヒト骨格筋オルガノイドを活用した低酸素依存性マイオカインの網羅的探索と評価

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生理的機能を有するALS細胞モデルの構築とその病態解析Principal Investigator

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A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier

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Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomesPrincipal Investigator

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An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

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Molecular mechanism for the maintenance of proteostasis in motor neurons

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Establishment and Characterization of iPS cell lines from Japanese ALS2 patientsPrincipal Investigator

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Analysis of ALS2 function in motor neurons form common marmosetPrincipal Investigator

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[Book] Autophagy Dysfunction in Alzheimer's Disease and Dementia 担当:共著, 範囲:1. Degradation mechanisms of cells (Edited by Tadanori Hamano & Tatsuro Mutoh)2022

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[Book] Autophagy dysfunction in Alzheimer's disease and dementia/ Chapter 1 Degradation mechanisms of cells2022

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[Book] すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患 アクチュアル 脳・神経疾患の臨床 担当:分担執筆、 IV．ALSの病態関連遺伝子と遺伝子変異 ALS2/Alsin2013

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[Journal Article] Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.2024

Author(s)

Journal Title

OTOMO ASAKO 大友麻子

Otomo Asako 大友麻子

OTOMO Asako 大友麻子

ASAKO Otomo 大友麻子

[Book] すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患アクチュアル　脳・神経疾患の臨床　担当:分担執筆、 IV．ALSの病態関連遺伝子と遺伝子変異　ALS2/Alsin2013