Aida Tomomi 相田知海

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AIDA Tomomi 相田知海

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Researcher Number	50540481
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2018: 東京医科歯科大学, 難治疾患研究所, 准教授 2014: 東京医科歯科大学, 難治疾患研究所, 助教 2010 – 2011: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Laboratory animal science / Medical genome science / Neuroscience in general Except Principal Investigator System genome science / Biological Sciences
Keywords	Principal Investigator マウス / ノックイン / CRISPR / Exo1 / MMEJ / PITCh / long ssDNA / 緑内障 / CRISPR/Cas / バリアント … More / 変異 / 疾患モデル / レアバリアント / 疾患ゲノム / ゲノム編集 / TALEN / ノックインマウス / 興奮性-抑制性アンバランス / 広汎性発達障害 / GLAST / グルタミン酸受容体 / GLT1 / グルタミン酸輸送体 / トゥーレット症候群 / 強迫性障害 / 自閉症 / 繰り返し行動 / グルタミン酸トランスポーター … More Except Principal Investigator ゲノム編集 / バイオテクノロジー / ボルタンメトリ / 回路シフト / 機能シフト / うつ病 / セロトニン / 線条体 / 手綱核 / モノアミン / ドーパミン / ストレス Less

Ultra efficient knockin systemPrincipal Investigator
- Principal Investigator
  
  AIDA Tomomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo Medical and Dental University
Translating human genetics into mouse with genome editingPrincipal Investigator
- Principal Investigator
  
  Aida Tomomi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Tokyo Medical and Dental University
Role of neural pathway regulating monoaminergic system in disorders and recovery in stress-coping behaviors
- Principal Investigator
  
  Aizawa Hidenori
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
  Tokyo Medical and Dental University
Development of a novel genome editing-mediated gene knock-in system
- Principal Investigator
  
  Yamamoto Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  System genome science
- Research Institution
  Hiroshima University
Molecular pathophysiology of autism-like behavior in glutamate transporter knockout mice.Principal Investigator
- Principal Investigator
  
  AIDA Tomomi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Medical and Dental University

All 2018 2017 2016 2015 2014 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] CRISPR/Casでマウスゲノムを自在に操る、生化学2016
- Author(s)
  相田知海，田中光一
- Total Pages
  279
- Publisher
  日本生化学学会
- Data Source
  KAKENHI-PROJECT-26830131
[Book] Genome editing in mice using TALENs. Targeted Genome Editing Using Site-specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System2014
- Author(s)
  Aida T
- Total Pages
  205
- Publisher
  Springer Publishing Company
- Data Source
  KAKENHI-PROJECT-26830131
[Book] Clinical Neuroscinece Vol.29 No.7 Neuroplasticity-脳は実は柔らかい自閉症2011
- Author(s)
  相田知海
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22700328
[Book] グルタミン酸トランスポーターのノックアウトマウスが明らかにする中枢機能2011
- Author(s)
  相田知海、田中光一
- Total Pages
  21
- Data Source
  KAKENHI-PROJECT-22700328
[Book] 自閉症. Clinical Neuroscinece2011
- Author(s)
  相田知海、田中光一
- Total Pages
  832
- Data Source
  KAKENHI-PROJECT-22700328
[Book] 脳21 Vol.14 No.4グルタミン酸トランスポーターのノックアウトマウスが明らかにする中枢機能2011
- Author(s)
  相田知海
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-22700328
[Book] 生体の科学Vol.61 No.5シナプスをめぐるシグナリング 2.トランスポーターグルタミン酸トランスポーター2010
- Author(s)
  相田知海
- Publisher
  財団法人金原一郎記念医学医療振興財団/医学書院
- Data Source
  KAKENHI-PROJECT-22700328
[Book] Clinical Neuroscinece Vol.27 No.8シナプス・形態・機能・病態自閉症2010
- Author(s)
  相田知海
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22700328
[Book] グルタミン酸トランスポーター.生体の科学2010
- Author(s)
  相田知海、田中光一
- Data Source
  KAKENHI-PROJECT-22700328
[Book] 自閉症Clinical Neuroscinece2010
- Author(s)
  相田知海、田中光一
- Total Pages
  912
- Data Source
  KAKENHI-PROJECT-22700328
[Journal Article] DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma2018
- Author(s)
  Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 106-106
- DOI
  10.1038/s41598-017-18323-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-17K10689, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-15H04926, KAKENHI-PROJECT-18K19575
[Journal Article] Biased genome editing using the local accumulation of DSB repair molecules system.2018
- Author(s)
  Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T
- Journal Title
  
  Nature Communications
  
  Volume: 9(1) Issue: 1 Pages: 3270-3270
- DOI
  10.1038/s41467-018-05773-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07241, KAKENHI-PROJECT-18K19494, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-17H02216, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-17K15045
[Journal Article] Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins2017
- Author(s)
  Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB
- Journal Title
  
  Genome Biology
  
  Volume: 18 Issue: 1 Pages: 92-92
- DOI
  10.1186/s13059-017-1220-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16H04685, KAKENHI-PROJECT-16K18821, KAKENHI-PROJECT-17H04166
[Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.2017
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Issue: 2 Pages: 368-374
- DOI
  10.1016/j.bbrc.2017.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-16K19478
[Journal Article] Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ.2016
- Author(s)
  Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T, Aizawa H, Yamamoto T, Tanaka K.
- Journal Title
  
  BMC Genomics
  
  Volume: 17 Issue: 1 Pages: 979-979
- DOI
  10.1186/s12864-016-3331-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01383, KAKENHI-PLANNED-26112010, KAKENHI-PROJECT-16J03164, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26430008, KAKENHI-PROJECT-15K19988, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K18478
[Journal Article] Cloning-free CRISPR/Cas system facilitates functional cassette knockin in mice2015
- Author(s)
  Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka K, Sakuma T, Yamamoto T, Tanaka K
- Journal Title
  
  Genome Biol
  
  Volume: 16 Issue: 1 Pages: 87-87
- DOI
  10.1186/s13059-015-0653-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290021, KAKENHI-PLANNED-25117005, KAKENHI-PROJECT-15H03123, KAKENHI-PROJECT-26830131
[Journal Article] Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance.2014
- Author(s)
  Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R, Ozawa K, Tanaka K, and Aizawa H.
- Journal Title
  
  J. Neurosci.
  
  Volume: 34 Issue: 49 Pages: 16273-16285
- DOI
  10.1523/jneurosci.1465-14.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PLANNED-26112010, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26430008
[Journal Article] Overstimulation of NMDA Receptors Impairs Early Brain Development in vivo
- Author(s)
  Aida T, Ito M, Takahashi KY, Tanaka K.
- Journal Title
  
  Plos One
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700328
[Patent] 簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法2014
- Inventor(s)
  田中光一、相田知海、和田悠作
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学、株式会社ファスマック
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-232963
- Filing Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] 受精卵ノックインの分子機構2018
- Author(s)
  相田知海
- Organizer
  日本ゲノム編集学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07085
[Presentation] Making knock-in mice easy with Cloning-free CRISPR2017
- Author(s)
  Tomomi Aida
- Organizer
  JSGE Satellite Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07085
[Presentation] ゲノム編集技術を用いた成体脳におけるドーパミン受容体の機能解析2017
- Author(s)
  相澤秀紀、崔万鵬、相田知海、伊藤日加瑠、小林憲太、加藤成樹、和田悠作、中野高志、田中光一、伊佐正、小林和人
- Organizer
  第122回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PLANNED-26112010
[Presentation] Opportunities and challenges in animal model innovation in CRISPR-era2017
- Author(s)
  相田知海
- Organizer
  日本神経化学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07085
[Presentation] Role of dopamine signaling in the murine stress-coping behaviors2016
- Author(s)
  H. Aizawa, W. Cui, T. Aida, S. Kato, H. Ito, K. Tanaka, and K. Kobayashi
- Organizer
  Dissecting and Understanding Mechanisms for Functional Shift of Brain Network
- Place of Presentation
  京都市
- Year and Date
  2016-03-03
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26112010
[Presentation] Gene cassette knock-in in mice with cloning-free CRISPR/Cas system2016
- Author(s)
  Aida T
- Organizer
  13th Transgenic Technology Meeting
- Place of Presentation
  プラハ、チェコ
- Year and Date
  2016-03-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice2015
- Author(s)
  Aida T, Sakuma T, Yamamoto T, Tanaka K
- Organizer
  Cold Spring Harbor Laboratory Meeting - Genome Engineering: The CRISPR/Cas Revolution
- Place of Presentation
  ニューヨーク、アメリカ
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] Genome editing in mice with cloning-free CRISPR/Cas system2015
- Author(s)
  Aida T, Sakuma T, Yamamoto T, Tanaka K
- Organizer
  Transposon and Genome Engineering 2015
- Place of Presentation
  奈良春日野国際フォーラム甍（奈良市、奈良）
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] グルタミン酸トランスポータのうつ病様行動における役割2014
- Author(s)
  相澤秀紀、崔万鵬、水上浩明、柳澤美智子、相田知海、野村政壽、礒村宜和、高柳涼一、小澤敬也、田中光一
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2014-09-13
- Invited
- Data Source
  KAKENHI-PLANNED-26112010
[Presentation] グルタミン酸トランスポーターと精神神経疾患．2014
- Author(s)
  相田知海
- Organizer
  青山学院大学私立大学戦略的研究基盤形成プロジェクトワークショップ
- Place of Presentation
  青山学院大学
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] クローニングフリーゲノム編集による簡便・高効率の疾患モデルマウス作製2014
- Author(s)
  相田知海
- Organizer
  独）科学技術振興機構　研究開発戦略センター　「ゲノム編集研究開発戦略」に関する俯瞰ワークショップ
- Place of Presentation
  JST東京別館
- Year and Date
  2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] Overstimulation of NMDA receptors impairs early brain development in vivo2011
- Author(s)
  相田知海
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] NMDA受容体の過剰な活性化は脳形成を障害する2011
- Author(s)
  相田知海、伊東義真、高橋祐子、田中光一
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] 緑内障におけるグルタミン酸トランスホーターの役割2011
- Author(s)
  柳澤美智子、加藤さや佳、武田拓也、相田知海、原田高幸、布施昇男、田中光一
- Organizer
  日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] GLT1コンディショナルノックアウトマウスにおけるグルタミン酸神経伝達の障害とOCD様行動異常2011
- Author(s)
  吉田純一、相田知海、田中光一
- Organizer
  日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] グルタミン酸トランスポーターと精神・神経疾患2010
- Author(s)
  相田知海
- Organizer
  トランスポーター研究会
- Place of Presentation
  東京医科大学
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] グルタミン酸トランスポーターと精神・神経疾患2010
- Author(s)
  相田知海
- Organizer
  トランスポーター研究会
- Place of Presentation
  東京医科大学(東京都)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-22700328
[Presentation] 高速・高効率in vivoゲノム編集によるマウス遺伝子改変
- Author(s)
  相田知海
- Organizer
  生理学研究所研究会シナプス機能の普遍性と多様性
- Place of Presentation
  生理学研究所
- Year and Date
  2014-06-05 – 2014-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] Cloning-free genome editing in mice.
- Author(s)
  Tomomi Aida
- Organizer
  第5回新潟大学脳研究所共同研究拠点国際シンポジウム
- Place of Presentation
  新潟大学
- Year and Date
  2015-03-05 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] CRISPR/Cas mediated highly efficient generation of knockin mice carrying a gene cassette.
- Author(s)
  Tomomi Aida
- Organizer
  Keystone Symposia - Precision Genome Engineering and Synthetic Biology
- Place of Presentation
  Montana, USA
- Year and Date
  2015-01-11 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] グルタミン酸トランスポーターと精神神経疾患．
- Author(s)
  相田知海
- Organizer
  生理学研究所研究会　グリア細胞機能から迫る脳機能解明
- Place of Presentation
  生理学研究所
- Year and Date
  2014-10-23 – 2014-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] In vivo genome editing for knockin mice production
- Author(s)
  Tomomi Aida
- Organizer
  Therapeutics Discovery Symposia USA
- Place of Presentation
  Boston, USA
- Year and Date
  2014-05-05 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] 機能カセットノックインマウスのためのCRISPR/Casを用いたin vivoゲノム編集
- Author(s)
  相田知海
- Organizer
  分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26830131
[Presentation] CRISPR/Casによるノックインマウス作製の効率化
- Author(s)
  相田知海
- Organizer
  第4回ゲノム編集研究会
- Place of Presentation
  広島国際会議場
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-26830131

1. Aizawa Hidenori (80391837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. Yamamoto Takashi (90244102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SAKAMOTO NAOAKI (00332338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SUZUKI KENICHI (90363043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 谷口俊介 (00505331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANAKA kohichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. CUI wanpeng

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ITO hikaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KASARAGOD deepa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NOZAKI kanako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKANO takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SAIKI akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小澤敬也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐々木成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 佐久間哲史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aida Tomomi 相田 知海

AIDA Tomomi 相田 知海

Research Projects

Research Products

Co-Researchers

Ultra efficient knockin systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Translating human genetics into mouse with genome editingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of neural pathway regulating monoaminergic system in disorders and recovery in stress-coping behaviors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel genome editing-mediated gene knock-in system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathophysiology of autism-like behavior in glutamate transporter knockout mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] CRISPR/Casでマウスゲノムを自在に操る、生化学2016

Author(s)

Total Pages

Publisher

Data Source

[Book] Genome editing in mice using TALENs. Targeted Genome Editing Using Site-specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System2014

Author(s)

Total Pages

Publisher

Data Source

[Book] Clinical Neuroscinece Vol.29 No.7 Neuroplasticity-脳は実は柔らかい自閉症2011

Author(s)

Publisher

Data Source

[Book] グルタミン酸トランスポーターのノックアウトマウスが明らかにする中枢機能2011

Author(s)

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[Book] 自閉症. Clinical Neuroscinece2011

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[Book] 脳21 Vol.14 No.4グルタミン酸トランスポーターのノックアウトマウスが明らかにする中枢機能2011

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[Book] 生体の科学Vol.61 No.5シナプスをめぐるシグナリング 2.トランスポーターグルタミン酸トランスポーター2010

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[Book] Clinical Neuroscinece Vol.27 No.8シナプス・形態・機能・病態 自閉症2010

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[Book] グルタミン酸トランスポーター.生体の科学2010

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[Book] 自閉症Clinical Neuroscinece2010

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[Journal Article] DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma2018

Author(s)

Journal Title

DOI

Aida Tomomi 相田知海

AIDA Tomomi 相田知海

[Book] Clinical Neuroscinece Vol.27 No.8シナプス・形態・機能・病態自閉症2010