Kobiyama Kouji 小檜山康司

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KOBIYAMA Kouji 小檜山康司

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Researcher Number	50547700
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 准教授 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所アジュバント開発プロジェクト, プロジェクト研究員
Affiliation (based on the past Project Information) *help	2012: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクト研究員 2010: National Institute of Biomedical Innovation, 研究員 2010: 独立行政法人医薬基盤研究所, アジュバント開発プロジェクト, 研究員 2009: Osaka University, 微生物病研究所, 特任研究員
Review Section/Research Field	Principal Investigator Virology
Keywords	Principal Investigator 自然免疫 / I型IFN / スクリーニング / 二本鎖DNA / ヒストンH2B / DNAセンサー / ヒストン / ワクチン / 感染防御 / 新規アジュバント開発 / NDH / N'-CARD-PTD / アジュバント

Research Projects
(2 results)
Research Products
(58 results)

Elucidation and application of histone-mediated anti-viral innate immune activation mechanisms.Principal Investigator
- Principal Investigator
  
  KOBIYAMA Kouji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  独立行政法人医薬基盤研究所
Research on mechanism of a novel signal polypeptide-induced innate immune activation.Principal Investigator
- Principal Investigator
  
  KOBIYAMA Kouji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  National Institute of Biomedical Innovation
  Osaka University

All 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book Patent

[Book] THE LUNG　「自然免疫メカニズムを利用するワクチンアジュバント開発.」2012
- Author(s)
  小檜山康司、石井　健.
- Total Pages
  8
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790520
[Book] 自然免疫メカニズムを利用するワクチンアジュバント開発2012
- Author(s)
  小檜山康司、石井健
- Publisher
  THE LUNG
- Data Source
  KAKENHI-PROJECT-23790520
[Book] 「バイオ医薬品における新規アジュバントの開発」次世代バイオ医薬品の製剤設計と開発戦略森下真莉子監修2011
- Author(s)
  小檜山康司、石井健
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-23790520
[Book] インフルエンザワクチン」ドラッグデリバリーシステムの新展開II 永井恒司、岡田弘晃監修2011
- Author(s)
  小檜山康司、石井健
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-23790520
[Book] 自然免疫とワクチン開発(Vol.234 No.5)2010
- Author(s)
  小檜山康司、石井健
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-21890125
[Book] アジュバントに関する最新の話題(37巻)2010
- Author(s)
  小檜山康司、石井健
- Publisher
  臨床と微生物
- Data Source
  KAKENHI-PROJECT-21890125
[Book] DNAセンサーとその生理的意義(Vol.29 No.10)2010
- Author(s)
  小檜山康司、石井健
- Publisher
  細胞工学
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.2013
- Author(s)
  Jounai N, Kobiyama K, Takeshita F, Ishii KJ*. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 2 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage.2013
- Author(s)
  Kobiyama K, Kawashima A, Jounai N, Takeshita F, Ishii KJ, Ito T, Suzuki K.
- Journal Title
  
  Front in Epigenomics and Epigenetics
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.2013
- Author(s)
  Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama, K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C and Ishii KJ.
- Journal Title
  
  PLoS one
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage2013
- Author(s)
  Kobiyama K, Kawashima A, Jounai N, Takeshita F, Ishii KJ, Ito T, Suzuki K
- Journal Title
  
  Front. Genet
  
  Volume: 4 Pages: 91-91
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant2013
- Author(s)
  Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C, Ishii KJ
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] NLRP4によるautophagyの抑制2012
- Author(s)
  城内直、小檜山康司、石井健、武下文彦
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 57 Pages: 95-103
- NAID
  40019192539
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination2012
- Author(s)
  Jounai N, Kobiyama K, Takeshita F, Ishii KJ
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 2 Pages: 168-168
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Innate and adaptive immune responses to viral infection and vaccination2012
- Author(s)
  Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ
- Journal Title
  
  Current Opinion in Virology
  
  Volume: 1(4) Pages: 226-232
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Intracellular inflammatory sensors for foreign invaders and substances of self-origin.2012
- Author(s)
  Jounai N, Kobiyama K, and Takeshita F.
- Journal Title
  
  Advances in experimental medicine and biology.
  
  Volume: 738 Pages: 60-78
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Innate and adaptive immune responses to vial infection and vaccination.2011
- Author(s)
  Aoshi T, Koyama S, Kobiyama K, Akira S, and Ishii KJ.
- Journal Title
  
  Curr Opin Virol
  
  Volume: 1 Pages: 226-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] NLRP4 negatively regulates autophagic processes through an association with Beclin1.2011
- Author(s)
  Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F.
- Journal Title
  
  J.Immunol. 186
  
  Pages: 1646-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] NLRP4 negatively regulates autophagic processes through an association with Beclin12011
- Author(s)
  Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, and Takeshita F. contributed equally
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 1646-1655
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Novel strategies to improve DNA vaccine immunogenicity.2011
- Author(s)
  Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ.
- Journal Title
  
  Curr Gene Ther
  
  Volume: 11 Pages: 479-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid.2011
- Author(s)
  Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii KJ, Hirano H, Kimura H, Sakai T, Ishii N, and Suzuki K.
- Journal Title
  
  Endocriology
  
  Volume: 152 Pages: 1702-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] NLRP4 negatively regulates autophagic processes through an association with Beclin1.2011
- Author(s)
  Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F.
- Journal Title
  
  Journal of Immunology
  
  Volume: 186 Pages: 1646-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Novel Strategies to Improve DNA Vaccine Immunogenicity2011
- Author(s)
  Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ
- Journal Title
  
  Curr Gene Ther
  
  Volume: 11(6)
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Desmet CJ. DNA released from dying host cells mediates aluminum adjuvant activity2011
- Author(s)
  Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F
- Journal Title
  
  Nat Med
  
  Volume: 17(8) Pages: 996-1002
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] NLRP4 negatively regulates autophagic processes through an association with Beclin1.2011
- Author(s)
  Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, and Takeshita F.
- Journal Title
  
  J. Immunol
  
  Volume: 186 Pages: 1646-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] DNA released from dying host cells mediates aluminum adjuvant activity.2011
- Author(s)
  Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, and Desmet CJ.
- Journal Title
  
  Nat Med
  
  Volume: 17 Pages: 996-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid2011
- Author(s)
  Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii KJ, Hirano H, Kimura H, Sakai T, Ishii N, and Suzuki K
- Journal Title
  
  Endocriology
  
  Volume: 152(4) Pages: 172-12
- Data Source
  KAKENHI-PROJECT-23790520
[Journal Article] Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.2010
- Author(s)
  Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, Kawai T, Sasaki S, Hirano H, Ishii N, Okuda K, Suzuki K.
- Journal Title
  
  Journal of virology 84
  
  Pages: 822-832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] DNAセンサーとその生理的意義2010
- Author(s)
  小檜山康司、石井健
- Journal Title
  
  細胞工学
  
  Volume: 29 Pages: 1004-1013
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] 自然免疫とワクチン開発2010
- Author(s)
  小檜山康司、石井健
- Journal Title
  
  医学のあゆみ
  
  Volume: 234 Pages: 608-614
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.2010
- Author(s)
  Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ.
- Journal Title
  
  Science Translational Medicine
  
  Volume: 2 Pages: 24-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.2010
- Author(s)
  Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, Kawai T, Sasaki S, Hirano H, Ishii N, Okuda K, Suzuki K.
- Journal Title
  
  J.Virol. 84
  
  Pages: 822-832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Modulation of intracellular signaling using protein transduction technology.(Review)2010
- Author(s)
  Kobiyama K, Jounai N, Ishii KJ, Horii T, Suzuki K, Ryo A, Takeshita F.
- Journal Title
  
  Crit Rev Immunol. 30
  
  Pages: 395-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] アジュバントに関する最新の話題2010
- Author(s)
  小檜山康司、石井健
- Journal Title
  
  臨床と微生物
  
  Volume: 37 Pages: 3-10
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.2010
- Author(s)
  Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ.
- Journal Title
  
  Sci Transl Med. 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Journal Article] Modulation of intracellular signaling using protein transduction technology.2010
- Author(s)
  Kobiyama K, Jounai N, Ishii KJ, Horii T, Suzuki K, Ryo A, Takeshita F.
- Journal Title
  
  Critical Reviews in Immunology
  
  Volume: 30 Pages: 395-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890125
[Patent] 染色体外ヒストンH2Bを介する二本鎖DNA認識機構の利用2011
- Inventor(s)
  武下文彦、小檜山康司、吉田篤司
- Industrial Property Rights Holder
  公立大学法人横浜市立大学
- Patent Publication Number
  2011-109982
- Acquisition Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21890125
[Patent] カスパーゼリクルートメントドメインを応用した新規リコンビナントタンパク及びその用途2010
- Inventor(s)
  武下文彦、小檜山康司、奥田研爾
- Industrial Property Rights Holder
  公立大学法人横浜市立大学
- Acquisition Date
  2010-03-04
- Data Source
  KAKENHI-PROJECT-21890125
[Patent] カスパーゼリクルートメントドメインを応用した新規リコンビナントタンパク及びその用途2008
- Inventor(s)
  武下文彦、小檜山康司、奥出研爾
- Industrial Property Rights Holder
  横浜市立大学
- Filing Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-21890125
[Presentation] 自然免疫シグナルを利用した新規アジュバント開発2013
- Author(s)
  小檜山　康司
- Organizer
  日本免疫治療学会研究会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant.2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ.
- Organizer
  日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant.2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ.
- Organizer
  Keystone symposia on Molecular and Cellular Biology.
- Place of Presentation
  カナダ
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Ishii KJ
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  5. Kobiyama K, Ishii KJ.
- Organizer
  THE 34th NAITO CONFERENCE on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine.
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Ishii KJ
- Organizer
  THE 34th NAITO CONFERENCE on Infection, Immunity and their Control for Health
- Place of Presentation
  Mucosal Barrier, Pathogen and Vaccine. Sapporo
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ
- Organizer
  Keystone symposia on Molecular and Cellular Biology
- Place of Presentation
  Ottawa, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ.
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium.
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant2012
- Author(s)
  Kobiyama K, Aoshi T, Ishii KJ
- Organizer
  日本ワクチン学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] NLRP4 negatively regulates autophagic process through an association with Beclin12012
- Author(s)
  Kouji Kobiyama, Nao Jounai, Fumihiko Takeshita, and Ken J. Ishii
- Organizer
  Keystone Symposia Innate Immunity: Sensing the Microbes and Damage Signals (Q7)
- Place of Presentation
  Keystone, Colorado
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] Characterization of STING phosphorylation mediated by cytosolic double stranded DNA2012
- Author(s)
  Jounai N, Kobiyama K, Takeshita F, Ishii KJ
- Organizer
  THE 34th NAITO CONFERENCE on Infection, Immunity and their Control for Health
- Place of Presentation
  Mucosal Barrier, Pathogen and Vaccine. Sapporo
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] The vascular disruptive agent DMXAA is an effective vaccine adjuvant2012
- Author(s)
  Tang C, Ito J, Jounai N, Aoshi T, Ohata K, Kobiyama K, Dessaolly B, Akira S, Mizuguchi K, Coban C, Ishii KJ
- Organizer
  Keystone symposia on Molecular and Cellular Keystone symposia on Molecular and Cellular
- Place of Presentation
  Ottawa, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] A Dectin-1-assisted APC-targeting TLR9-agonist as an adjuvant.2012
- Author(s)
  Kobiyama K, Ishii KJ.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] Differential Roles of Antigen Presentation and DNA Adjuvanticity in Immunogenicity of DNA vaccine2012
- Author(s)
  Tozuka M, Jounai N, Kobiyama K, Koyama S, Coban C, Ishii KJ
- Organizer
  Keystone symposia on Molecular and Cellular Biology
- Place of Presentation
  Ottawa, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] Hydroxypropyl-beta-cyclodextrin (HP-b-CD), a common additive acts as a vaccine adjuvant via a unique mode of innate immune activation2012
- Author(s)
  Onishi M, Kobiyama K, Aoshi T, Ishii KJ
- Organizer
  Keystone symposia on Molecular and Cellular Biology
- Place of Presentation
  Ottawa, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] NLRP4 negatively regulates autophagic process through an association with Beclin12011
- Author(s)
  Kobiyama K, Jounai N, Takeshita F, Ishii KJ
- Organizer
  Keystone Symposia Innate Immunity
- Place of Presentation
  Sensing the Microbes and Damage Signals. Keystone, Colorado
- Year and Date
  2011-05-06
- Data Source
  KAKENHI-PROJECT-23790520
[Presentation] Extra-chromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.2010
- Author(s)
  Kobiyama K, Takeshita F, Jounai N, Suzuki K, Ishii KJ.
- Organizer
  14th International Congress of Immunology.
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-21890125
[Presentation] Nuclear distribution of IPS-1 CARD activates distinct innate immune signaling to augment vaccine immunogenicity.2009
- Author(s)
  Kobiyama K, Ishii KJ, Takeshita F.
- Organizer
  Keystone Symposia on Molecular and Cellualr Biology.
- Place of Presentation
  Fairmont Banff Springs, Banff, Alberta, Canada.
- Year and Date
  2009-04-01
- Data Source
  KAKENHI-PROJECT-21890125

Kobiyama Kouji 小檜山 康司

KOBIYAMA Kouji 小檜山 康司

Research Projects

Research Products

Elucidation and application of histone-mediated anti-viral innate immune activation mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on mechanism of a novel signal polypeptide-induced innate immune activation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] THE LUNG 「自然免疫メカニズムを利用するワクチンアジュバント開発.」2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 自然免疫メカニズムを利用するワクチンアジュバント開発2012

Author(s)

Publisher

Data Source

[Book] 「バイオ医薬品における新規アジュバントの開発」次世代バイオ医薬品の製剤設計と開発戦略 森下真莉子監修2011

Author(s)

Publisher

Data Source

[Book] インフルエンザワクチン」ドラッグデリバリーシステムの新展開II 永井恒司、岡田弘晃監修2011

Author(s)

Publisher

Data Source

[Book] 自然免疫とワクチン開発(Vol.234 No.5)2010

Author(s)

Publisher

Data Source

[Book] アジュバントに関する最新の話題(37巻)2010

Author(s)

Publisher

Data Source

[Book] DNAセンサーとその生理的意義(Vol.29 No.10)2010

Author(s)

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[Journal Article] Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.2013

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[Journal Article] Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage.2013

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[Journal Article] The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.2013

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[Journal Article] Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage2013

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[Journal Article] The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant2013

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[Journal Article] NLRP4によるautophagyの抑制2012

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NAID

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[Journal Article] Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination2012

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[Journal Article] Innate and adaptive immune responses to viral infection and vaccination2012

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[Journal Article] Intracellular inflammatory sensors for foreign invaders and substances of self-origin.2012

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Kobiyama Kouji 小檜山康司

KOBIYAMA Kouji 小檜山康司

[Book] THE LUNG　「自然免疫メカニズムを利用するワクチンアジュバント開発.」2012

[Book] 「バイオ医薬品における新規アジュバントの開発」次世代バイオ医薬品の製剤設計と開発戦略森下真莉子監修2011