Marunouchi Tetsurou 丸ノ内徹郎

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Marunouchi Tetsuro 丸ノ内徹郎

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Researcher Number	50548500
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京薬科大学, 薬学部, 講師 2019: 東京薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator 心不全 / Hsp90 / タンパク質間相互作用 / 心リモデリング / 慢性心不全 / シンバスタチン / NLRP3インフラマソーム / パイロトーシス / 心筋幹・前駆細胞 / 心筋細胞死 … More / 心筋リモデリング / 心線維化 / HSP90 / ネクロトーシス / HSP90AA1 Less

Research Projects
(2 results)
Research Products
(21 results)

Development of a Novel Chronic Heart Failure Therapy Focusing on Regulation of Hsp90-Client InteractionPrincipal Investigator
- Principal Investigator
  
  丸ノ内徹郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on the roles of HSP90AA1 in failing heartPrincipal Investigator
- Principal Investigator
  
  Marunouchi Tetsuro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Simvastatin attenuates the c-Raf/Erk and calcineurin-NFATc2 pathways via inhibition of Hsp90 activity during the development of heart failure2023
- Author(s)
  Marunouchi Tetsuro、Fujita Kyo、Takahashi Kirara、Namiki Shunsuke、Kyo Lina、Uchida Manami、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 151 Issue: 1 Pages: 17-27
- DOI
  10.1016/j.jphs.2022.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15297
[Journal Article] Simvastatin Attenuates Cardiac Fibrosis under Pathophysiological Conditions of Heart Failure with Preserved Left Ventricular Ejection Fraction by Inhibiting TGF-β Signaling2023
- Author(s)
  Marunouchi Tetsuro、Matsumura Kasumi、Fuji Eriko、Iwamoto Akihiro、Tanonaka Kouichi
- Journal Title
  
  Pharmacology
  
  Volume: 109 Issue: 1 Pages: 43-51
- DOI
  10.1159/000534933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15297
[Journal Article] Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats2023
- Author(s)
  Marunouchi Tetsuro、Iguchi Aika、Shindo Aono、Shimbo Nana、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 212 Pages: 115547-115547
- DOI
  10.1016/j.bcp.2023.115547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15297
[Journal Article] Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats2021
- Author(s)
  Marunouchi Tetsuro、Ito Takumi、Onda Sumika、Kyo Lina、Takahashi Kirara、Uchida Manami、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 147 Issue: 2 Pages: 192-199
- DOI
  10.1016/j.jphs.2021.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16379
[Journal Article] Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice2021
- Author(s)
  Marunouchi Tetsuro、Nishiumi Chiharu、Iinuma Saki、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 898 Pages: 173987-173987
- DOI
  10.1016/j.ejphar.2021.173987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16379
[Journal Article] Hsp90 Inhibitor Attenuates the Development of Pathophysiological Cardiac Fibrosis in Mouse Hypertrophy via Suppression of the Calcineurin-NFAT and c-Raf-Erk Pathways2021
- Author(s)
  Marunouchi Tetsuro、Nakashima Miyuki、Ebitani Saika、Umezu Sakiko、Karasawa Kasane、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  Journal of Cardiovascular Pharmacology
  
  Volume: 77 Issue: 6 Pages: 822-829
- DOI
  10.1097/fjc.0000000000001017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16379
[Journal Article] Transplantation of cardiac Sca-1-positive cells rather than c-Kit-positive cells preserves mitochondrial oxygen consumption of the viable myocardium following myocardial infarction in rats2019
- Author(s)
  Marunouchi Tetsuro、Sasaki Kyohei、Yano Emi、Tanonaka Kouichi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 140 Issue: 3 Pages: 236-241
- DOI
  10.1016/j.jphs.2019.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] ラット心筋梗塞後不全心でのネクロトーシス経路の活性化に及ぼす Hsp90 阻害薬の効果2023
- Author(s)
  倉澤南、丸ノ内徹郎、田野中浩一
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] シンバスタチンは、RAS/c-Raf/Erk経路の活性化を抑制して、心リモデリングを軽減する。2023
- Author(s)
  井口愛可、藤田喬、丸ノ内徹郎、田野中浩一
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] 圧負荷心臓でのネクロトーシス経路の活性化における Hsp90 の役割2023
- Author(s)
  進藤碧乃、丸ノ内徹郎、田野中浩一
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] 心不全進展でのインフラマソームの病態生理学的役割2023
- Author(s)
  丸ノ内徹郎
- Organizer
  第67回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] 駆出率が保たれた心不全（HFpEF）心臓での心線維化メカニズムの解明2023
- Author(s)
  岩本晃拓、丸ノ内徹郎、田野中浩一
- Organizer
  第148回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] ラット心筋梗塞後不全心での NLRP3依存性インフラマソームの役割2023
- Author(s)
  新保七奈、進藤碧乃、丸ノ内徹郎、田野中浩一
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] Simvastatin attenuates cardiac fibrosis during the development of chronic heart failure via an inhibition of Hsp90-regulated cell signaling.2022
- Author(s)
  丸ノ内徹郎、矢野絵美、田野中浩一
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K15297
[Presentation] 心筋リモデリングでのHsp90の役割の解明と新規治療法への応用2021
- Author(s)
  丸ノ内徹郎
- Organizer
  日本薬学会薬理系薬学部会生体機能と創薬シンポジウム 2021
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] Simvastatin attenuates cardiac remodeling via Hsp90 inhibition.2021
- Author(s)
  内田愛美、丸ノ内徹郎、藤田喬、矢野絵美、田野中浩一
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] シンバスタチンは，Hsp90の阻害を介して心線維化を抑制する2021
- Author(s)
  小野亜弓、藤田喬、丸ノ内徹郎、田野中浩一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] Hsp90 contributes to cardiac hypertrophy in the development of heart failure via regulating c-Raf.2020
- Author(s)
  Takumi Itoh, Tetsuro Marunouchi, Emi Yano and Kouichi Tanonaka
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] Tanshinone VI promotes the differentiation of cardiosphere-derived cells into cardiomyocytes.2020
- Author(s)
  Tetsuro Marunouchi, Minami Ikoshi, Emi Yano and Kouichi Tanonaka
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] Roles of Hsp90 on cardiac remodeling in the development of chronic heart failure.2019
- Author(s)
  Yumi Abe, Tetsuro Marunouchi, Emi Yano and Kouichi Tanonaka
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16379
[Presentation] マウス圧負荷誘発心不全へのネクロプトーシスの関与2019
- Author(s)
  丸ノ内徹郎，矢野絵美，田野中浩一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16379

Marunouchi Tetsurou 丸ノ内 徹郎

Marunouchi Tetsuro 丸ノ内 徹郎

Research Projects

Research Products

Development of a Novel Chronic Heart Failure Therapy Focusing on Regulation of Hsp90-Client InteractionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the roles of HSP90AA1 in failing heartPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Simvastatin attenuates the c-Raf/Erk and calcineurin-NFATc2 pathways via inhibition of Hsp90 activity during the development of heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simvastatin Attenuates Cardiac Fibrosis under Pathophysiological Conditions of Heart Failure with Preserved Left Ventricular Ejection Fraction by Inhibiting TGF-β Signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hsp90 Inhibitor Attenuates the Development of Pathophysiological Cardiac Fibrosis in Mouse Hypertrophy via Suppression of the Calcineurin-NFAT and c-Raf-Erk Pathways2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transplantation of cardiac Sca-1-positive cells rather than c-Kit-positive cells preserves mitochondrial oxygen consumption of the viable myocardium following myocardial infarction in rats2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] ラット心筋梗塞後不全心でのネクロトーシス経路の活性化に及ぼす Hsp90 阻害薬の効果2023

Author(s)

Organizer

Data Source

[Presentation] シンバスタチンは、RAS/c-Raf/Erk経路の活性化を抑制して、心リモデリングを軽減する。2023

Author(s)

Organizer

Data Source

[Presentation] 圧負荷心臓でのネクロトーシス経路の活性化における Hsp90 の役割2023

Author(s)

Organizer

Data Source

[Presentation] 心不全進展でのインフラマソームの病態生理学的役割2023

Author(s)

Organizer

Data Source

[Presentation] 駆出率が保たれた心不全（HFpEF）心臓での心線維化メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] ラット心筋梗塞後不全心での NLRP3依存性インフラマソームの役割2023

Author(s)

Organizer

Data Source

[Presentation] Simvastatin attenuates cardiac fibrosis during the development of chronic heart failure via an inhibition of Hsp90-regulated cell signaling.2022

Author(s)

Organizer

Data Source

[Presentation] 心筋リモデリングでのHsp90の役割の解明と新規治療法への応用2021

Marunouchi Tetsurou 丸ノ内徹郎

Marunouchi Tetsuro 丸ノ内徹郎