Kimura Ayuko 木村鮎子

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KIMURA Ayuko 木村鮎子

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Researcher Number	50553616
Other IDs
Affiliation (Current)	2023: 群馬パース大学, 医療技術学部, 講師
Affiliation (based on the past Project Information) *help	2022: 群馬パース大学, 保健科学部, 講師 2021 – 2022: 群馬パース大学, 医療技術学部, 講師 2018 – 2020: 群馬パース大学, 保健科学部, 講師 2017: 横浜市立大学, 先端医科学研究センター, 特任助教 2013 – 2016: 横浜市立大学, 生命医科学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Functional biochemistry / Pathological medical chemistry Except Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator プロテオミクス / プロテアソーム / ユビキチン / 翻訳後修飾 / ユビキチン化 / 癌 / ミリストイル化 / Rpt2 / 核 / 細胞内局在 … More / リン酸化 / 悪性化 / クロマチン再構成複合体 / 卵巣明細胞癌 / 悪性度 / SWI/SNF複合体 / Brg1 / OCCC / 卵巣癌 / SWI/SNF / 質量分析 / N-ミリストイル化 / ストレス応答 / 微小環境ストレス / 老化 … More Except Principal Investigator 尿路感染症 / 薬剤耐性 / バイオフィルム / 病原性 / 情報伝達 / サイトカイン / 細胞性粘菌 / DIF誘導体 / 新規免疫制御剤 / セクリトーム解析 Less

細菌由来リスク因子に着目した尿路病原性大腸菌による腎盂腎炎発症と難治化機構の解明
- Principal Investigator
  
  平川秀忠
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gunma University
免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索
- Principal Investigator
  
  高橋克典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma Paz University
Analysis of cell aging mechanisms through posttranslational modification-induced downregulation of proteasome activityPrincipal Investigator
- Principal Investigator
  
  木村鮎子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma Paz University
N-myristoylation-induced nuclear localization of proteasome and stress response in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Kimura Ayuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma Paz University
Phosphorylation of SWI/SNF chromatin remodeling component Brg1 and mechanisms involved in malignant transformation of cancerPrincipal Investigator
- Principal Investigator
  
  KIMURA Ayuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yokohama City University
Functions of the nuclear ubiquitin proteasome system regulated by N-myristoylationPrincipal Investigator
- Principal Investigator
  
  KIMURA Ayuko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術2018
- Author(s)
  木村　鮎子
- Total Pages
  540
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-18K06966
[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節プロテオミクスによる疾病研究とバイオマーカー探索2018
- Author(s)
  木村　鮎子 (分担執筆)
- Total Pages
  540
- Publisher
  技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-15K19028
[Book] 医学のあゆみ 9章. 「疾患研究における翻訳後修飾の解析」2014
- Author(s)
  木村　鮎子、平野　久
- Total Pages
  1034
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-25840039
[Journal Article] Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma2021
- Author(s)
  Kawata Yuki、Hirano Hisashi、Takahashi Ren、Miyano Yukari、Kimura Ayuko、Sato Natsumi、Morita Yukio、Kimura Hirokazu、Fujita Kiyotaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Pages: 1766-1766
- DOI
  10.3390/ijms22041766
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06966
[Journal Article] Phosphorylation of Ser1452 on BRG1 inhibits the function of the SWI/SNF complex in chromatin activation2021
- Author(s)
  Kimura Ayuko、Arakawa Noriaki、Kagawa Hiroyuki、Kimura Yayoi、Hirano Hisashi
- Journal Title
  
  Journal of Proteomics
  
  Volume: 247 Pages: 1043-1043
- DOI
  10.1016/j.jprot.2021.104319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03774, KAKENHI-PROJECT-21K06859
[Journal Article] Phos-tag diagonal electrophoresis precisely detects the mobility change of phosphoproteins in Phos-tag SDS-PAGE2021
- Author(s)
  Okawara, Y., Hirano, H., Kimura, A., Sato, N., Hayashi, Y., Osada, M., Kawakami, T., Ootake, N., Eiji Kinoshita, Fujita, K.
- Journal Title
  
  Journal of Proteomics
  
  Volume: 231 Pages: 104005-104005
- DOI
  10.1016/j.jprot.2020.104005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07147, KAKENHI-PROJECT-18K06966
[Journal Article] Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice2021
- Author(s)
  Ohira, T., Y. Ino, Y. Kimura, Y. Nakai, A. Kimura, Y. Kurata, H. Kagawa, M. Kimura, K. Egashira, C. Matsuda, Y. Ohira, S. Furukawa, and H. Hirano
- Journal Title
  
  NPJ Microgravity
  
  Volume: 7 Pages: 34-34
- DOI
  10.1038/s41526-021-00164-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07291, KAKENHI-PROJECT-19H03774, KAKENHI-PROJECT-21K06859
[Journal Article] Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice2020
- Author(s)
  Ohira T, Ino Y, Nakai Y, Morita H, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Moriya S, Hiramatsu K, Kawakita M, Kimura Y, Hirano H
- Journal Title
  
  Journal of Proteomics
  
  Volume: 217 Pages: 103686-103686
- DOI
  10.1016/j.jprot.2020.103686
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06850, KAKENHI-PROJECT-16K08957, KAKENHI-PROJECT-18K06966, KAKENHI-PROJECT-19H03774
[Journal Article] 健常人におけるCell-free DNAの特性：ヒストン結合部位の推定2020
- Author(s)
  田胡　裕章、長田　誠、古田島　伸雄、木村　鮎子、藤田　清貴
- Journal Title
  
  日本染色体遺伝子検査
  
  Volume: 38 Pages: 44-50
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06966
[Journal Article] Phos-tag対角線電気泳動により明らかになったプロテアソームサブユニットのリン酸化状態2020
- Author(s)
  平野　久、木村　鮎子、佐藤　夏美、長田　誠、木下　英司、藤田　清貴
- Journal Title
  
  育種学研究 22 (別1)
  
  Volume: 1 Pages: 204-204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06966
[Journal Article] Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer’s disease2019
- Author(s)
  Aladeokin Aderemi Caleb、Akiyama Tomoko、Kimura Ayuko、Kimura Yayoi、Takahashi-Jitsuki Aoi、Nakamura Haruko、Makihara Hiroko、Masukawa Daiki、Nakabayashi Jun、Hirano Hisashi、Nakamura Fumio、Saito Takashi、Saido Takaomi、Goshima Yoshio
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 132 Pages: 104603-104603
- DOI
  10.1016/j.nbd.2019.104603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14964, KAKENHI-PROJECT-19H03774, KAKENHI-PROJECT-18K06966
[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans2017
- Author(s)
  Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 158(12) Pages: 4152-4164
- DOI
  10.1210/en.2017-00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
[Journal Article] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2017
- Author(s)
  木村　鮎子、平野　久
- Journal Title
  
  Proteome Letters
  
  Volume: 2 Pages: 37-45
- NAID
  130007529343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19028
[Journal Article] Lyn Kinase Suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity2016
- Author(s)
  Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
- Journal Title
  
  Immunity
  
  Volume: 45 Pages: 319-32
- DOI
  10.1016/j.immuni.2016.07.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16H07105, KAKENHI-PROJECT-26460373, KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16K19161, KAKENHI-PROJECT-16H05230, KAKENHI-PLANNED-24118002
[Journal Article] Biological significance of co- and post-translational modifications of the yeast 26S proteasome2016
- Author(s)
  Hirano H, Kimura Y, Kimura A
- Journal Title
  
  Journal of Proteomics
  
  Volume: 134 Pages: 37-46
- DOI
  10.1016/j.jprot.2015.11.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
[Journal Article] N-myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system2016
- Author(s)
  Kimura A, Kurata Y, Nakabayashi J, Kagawa H, Hirano H.
- Journal Title
  
  Journal of Proteomics
  
  Volume: 130 Pages: 33-41
- DOI
  10.1016/j.jprot.2015.08.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-26830099
[Journal Article] Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice2016
- Author(s)
  Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, Kawamoto Y, Jitsuki-Takahashi A, Yonezaki K, Takase K, Miyazaki T, Nakamura F, Tanaka F, Goshima Y.
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Pages: 1059-1079
- DOI
  10.1111/gtc.12403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
[Journal Article] Mass Spectrometric Analysis of the Phosphorylation Levels of the SWI/SNF Chromatin Remodeling/Tumor Suppressor Proteins ARID1A and Brg1 in Ovarian Clear Cell Adenocarcinoma Cell Lines.2014
- Author(s)
  Kimura, A., Arakawa, N., and Hirano, H.
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 13(11) Pages: 4959-4969
- DOI
  10.1021/pr500470h
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460695, KAKENHI-PROJECT-25840039
[Presentation] Phos-tag 対角線電気泳動を用いた血清中リン酸化タンパク質の解析法の検討2021
- Author(s)
  大川原佑季・木村　鮎子・林　由里子・平野　久・長田　誠
- Organizer
  第 72 回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-21K06859
[Presentation] 質量分析計によるmonoclonal IgA-アルブミン複合体の構造解析2019
- Author(s)
  川田　悠貴，宮野　ゆかり，木村　鮎子，古田島　伸雄，長田　　誠，平野　　久，藤田　清貴
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K06966
[Presentation] 定量プロテオーム解析による骨粗鬆症の血清バイオマーカー探索2019
- Author(s)
  中居佑介・木村鮎子・森山佳谷乃・香川裕之・井野洋子・熊谷研・齋藤知行・木村弥生・平野久
- Organizer
  日本プロテオーム学会2019年大会/第70回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-18K06966
[Presentation] プロテオミクスによる病態解析2018
- Author(s)
  木村　鮎子
- Organizer
  第26回日本臨床化学会関東支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06966
[Presentation] クロマチン再構成複合体因子BRG1のリン酸化修飾によるクロマチン関連タンパク質の変化と遺伝子発現制御2017
- Author(s)
  木村鮎子、中林潤、田村智彦、香川裕之、木村弥生、平野久
- Organizer
  2017年度生命科学系学会合同年次大会 (第40回日本分子生物学会年会)
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] Proteome and transcriptome analyses of phosphorylation site-specific mutants of BRG1, a chromatin remodeling component2017
- Author(s)
  Ayuko Kimura, Jun Nakabayashi, Tomohiko Tamura, Hiroyuki Kagawa, Yayoi Kimura, and Hisashi Hirano
- Organizer
  16th Human Proteome Organization World Congress (HUPO2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] Effects of phosphorylation site-specific mutations in a component of chromatin remodeling complex2017
- Author(s)
  Ayuko Kimura
- Organizer
  日本プロテオーム学会2017年大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  日本プロテオーム学会2016年大会（JHUPO第14回大会）
- Place of Presentation
  北里大学
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] (受賞講演)癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  日本プロテオーム学会2016年大会（JHUPO第14回大会）
- Place of Presentation
  北里大学白金キャンパス (東京都港区)
- Year and Date
  2016-07-29
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 卵巣明細胞腺癌の悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  第13回　北里疾患プロテオーム研究会/第66回　日本電気泳動学会シンポジウム
- Place of Presentation
  北里大学
- Year and Date
  2016-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 酵母26SプロテアソームサブユニットのN-ミリストイル化修飾とタンパク質品質管理2015
- Author(s)
  木村　鮎子、倉田　洋一、香川　裕之、平野　久
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] MRM法による卵巣明細胞腺癌細胞株特異的なSWI/SNFクロマチン再構成複合体因子Brg1のリン酸化レベル低下の解析2014
- Author(s)
  木村　鮎子, 荒川　憲昭, 平野　久
- Organizer
  日本プロテオーム学会第12回大会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25840039
[Presentation] 卵巣明細胞腺癌細胞株特異的なクロマチン再構成因子Brg1のリン酸化レベル低下2014
- Author(s)
  木村　鮎子, 荒川　憲昭, 平野　久
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25840039
[Presentation] Identification and Characterization of the Posttranslational Modifications of Yeast 26S Proteasome2013
- Author(s)
  Ayuko Kimura, Yu Kato, Yoichi Kurata, Yayoi Kimura, Hisashi Hirano
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  Pacifico Yokohama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25840039

1. 平川秀忠 (80431758)

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2. 鈴江一友 (00333485)

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3. 村上正巳 (30241871)

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4. 高橋克典 (90597551)

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5. 久保原禅 (00221937)

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6. 菊地晴久 (90302166)

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7. YANAI Hideyuki

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8. TAMURA Tomohiko

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9. NISHIYAMA Akira

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10. SATO Go

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11. YAMAMOTO Junichi

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12. SUZUKI Hidefumi

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13. BAN Tatsuma

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14. MORITA Hironobu

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15. OSHIMA Takashi

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16. 木村弥生

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17. 谷口維紹

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18. 山本一彦

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19. 松永智子

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20. 平松恭子

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21. 川喜田正夫

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22. 木下英司

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23. 荒川憲昭

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24. 倉田洋一

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25. 寺内康夫

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26. 白川純

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27. 富樫優

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28. 田島一樹

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29. 實木葵

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30. 大平充宣

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Kimura Ayuko 木村 鮎子

KIMURA Ayuko 木村 鮎子

Research Projects

Research Products

Co-Researchers

細菌由来リスク因子に着目した尿路病原性大腸菌による腎盂腎炎発症と難治化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cell aging mechanisms through posttranslational modification-induced downregulation of proteasome activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

N-myristoylation-induced nuclear localization of proteasome and stress response in tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phosphorylation of SWI/SNF chromatin remodeling component Brg1 and mechanisms involved in malignant transformation of cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functions of the nuclear ubiquitin proteasome system regulated by N-myristoylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術2018

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[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章 システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節 プロテオミクスによる疾病研究とバイオマーカー探索2018

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[Book] 医学のあゆみ 9章. 「疾患研究における翻訳後修飾の解析」2014

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[Journal Article] Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma2021

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[Journal Article] Phosphorylation of Ser1452 on BRG1 inhibits the function of the SWI/SNF complex in chromatin activation2021

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[Journal Article] Phos-tag diagonal electrophoresis precisely detects the mobility change of phosphoproteins in Phos-tag SDS-PAGE2021

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[Journal Article] Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice2021

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[Journal Article] Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice2020

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Kimura Ayuko 木村鮎子

KIMURA Ayuko 木村鮎子

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節プロテオミクスによる疾病研究とバイオマーカー探索2018

[Presentation] Phos-tag 対角線電気泳動を用いた血清中リン酸化タンパク質の解析法の検討2021